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offers several workshops for doctoral students. You can find an up-to-date programm here . eLearning [...] Doctoral Studies" was developed by the Goethe University Frankfurt and is offered to doctoral students of the Saarland University via its GradUS programme.

of this interdisciplinary doctoral program, students of (typically, but not limited to) chemistry [...] name “TANDEM” suggests, each doctoral student is co-supervised by at least 2 PI’s, affiliated to either [...] out jointly by two or more doctoral students from different disciplines. Education Concept In order

09.2009−08.2010 European Post-Doctoral Institute (EPDI) Fellow, Max-Planck-Institut für Mathematik, [...] ), Universität Bonn Master students 12.2023–05.2024 Robin Lahni, dissertation Multiplier ideals and [...] Studi Superiori, Pavia Bachelor students 06.2023–09.2023 Laura Stokkermans, dissertation Around the

in Tucson, AZ, USA, 2014. Doctoral Fellowship of the German National Academic Foundation ( [...] 2012. Travel Grant of the Karl-Ziegler-Foundation for the EuCheMS congress in Nürnberg, Germany, 2010 [...] excursion 2023, 135 high-school students. Probestudium 2023, 40 high-school students (lead organizer: C

, Christiane Solte-Gresser und Laura Vodermayer herausgegeben wird. Das Buch enthält ein Dossier zum [...] , Christiane Solte-Gresser und Laura Vodermayer herausgegeben wird. In der Ausgabe des Jahres 2024 [...] Laura Vordermayer ist im Verlag Königshausen & Neumann erschienen. Sie

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Publikationen und Vorträge A. Monographien B. Herausgeberschaften und Sammelbände C. Aufsätze und Buchbeiträge D. Lexikon- und Handbuchartikel E. Rezensionen F. Sonstige Publikationen G. Wissenschaftliche Vorträge A. Monographien ● Traum und Reparation. Erzählte Shoah-Träume , 166 S., Berlin: Matthes & Seitz 2026. ● Raconter l’irréparable ou les rêves de la Shoah , aus dem Deutschen übersetzt von Slaven Waelti, 270 S., Paris: Hermann 2026. ● Shoah-Träume. Vergleichende Studien zum Traum als Erzählverfahren , 489 S., Paderborn: Fink 2021 (= Traum – Wissen – Erzählen 10). Rezensiert von: Aurélie Barjonet in: Revue de littérature comparée n o 382 (2022), H. 2, S. 240-242. Auch als PDF verfügbar. Claude Paul in: questions de communication 42 (2022), S. 576-580. Online unter https://journals.openedition.org/questionsdecommunication/30660 . Auch als PDF verfügbar. Magdalena Leichter in: Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft 2022, Bielefeld: Aisthesis 2023, S. 256-260. Auch als PDF verfügbar. Besprechungen: Interview von Sally-Charell Delin mit Christiane Solte-Gresser über ihr neues Buch „Shoah-Träume“ vom 19.1.2022 auf SR2 Kulturradio in der Sendung „Literatur im Gespräch“ (min. 17:00 bis 25:30), online unter http://www.sr-mediathek.de/index.php?seite=7&id=111700 . Gespräch zwischen Kristina Höfer und Christiane Solte-Gresser im Rahmen der Forschungspräsentationen anlässlich des 70-jährigen Bestehens der Saarbrücker Komparatistik, online als Text (PDF, 7 Seiten) und als Audio-Datei (MP3, 27:01 Minuten). ● Spielräume des Alltags. Literarische Gestaltung von Alltäglichkeit in deutscher, französischer und italienischer Erzählprosa (1929-1949) [Habilitationsschrift], 435 S., Würzburg: Königshausen & Neumann 2010 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 50). Rezensiert von: Fabien Pillet (Genève) in: Peter Hayes / Jean El Gammal (Hrsg.): Universitätskulturen / L’Université en perspective / The Future of the University, Bielefeld: transcript 2012 (= Frankreich-Forum. Jahr­buch des Frankreichzentrums der Universität des Saarlandes 11/2011), S. 300-302. Manfred Schmeling in: Revue de littérature comparée 88 (2014) H. 1, S. 113-116. Birte Christ in: Literary Research / Recherche littéraire 30 (2014), S. 3-7. ● Leben im Dialog. Wege der Selbstvergewisserung in den Briefen von Marie de Sévigné und Isabelle de Charrière [Dissertation, ausgezeichnet mit dem Elise-Richter-Forschungspreis des Deutschen Romanistenverbandes 2001], 279 S., Königstein: Helmer 2000 (= Frankfurter Feministische Texte 4). Rezensiert von: Silke Segler-Meßner in: Romanische Forschungen 114 (2002) H. 1, S. 123-126. B. Herausgeberschaften und Sammelbände ● A Cultural History of Sleep and Dreaming in the Age of Globalisation (1945 - present) , edited by Robert Meadows and Christiane Solte-Gresser (= Volume 6 of the Cultural History of Sleep and Dreaming), edited by Rafał Matuszewski and Brigitte Steger, London/New York: Bloomsbury Academic 2025 (im Druck). ● Komparatistik 2025. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft (zusammen mit Winfried Eckel und Laura Vordermayer), Bielefeld: Aisthesis 2025. ● Rhinozeros. Europa im Übergang , Heft 5: lügen, (zusammen mit Franck Hofmann und Markus Messling), Berlin: Matthes & Seitz 2025. Informationen zu dieser Ausgabe finden Sie hier , weitere Informationen zum Projekt hier . ● The True Size of Africa. Katalog zur Ausstellung im UNESCO Weltkulturerbe Völklinger Hütte, 9.11.2024 bis 18.8.2025, hrsg. zusammen mit Ralf Beil und Markus Messling, München: Hirmer 2025. ● Komparatistik 2024. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft (zusammen mit Winfried Eckel und Laura Vordermayer), Bielefeld: Aisthesis 2024. ● Rhinozeros. Europa im Übergang , Heft 4: wohnen, (zusammen mit Franck Hofmann und Markus Messling), Berlin: Matthes & Seitz 2024. Informationen zu dieser Ausgabe findet man hier , weitere Informationen zum Projekt hier . ● Rhinozeros. Europa im Übergang , Heft 3: träumen (zusammen mit Franck Hofmann und Markus Messling), Berlin: Matthes & Seitz 2023. Informationen zu dieser Ausgabe findet man hier , weitere Informationen zum Projekt hier . Besprechungen: Deutschlandfunk, Gespräch mit Maike Albath am 09.01.2024 (10:59 Minuten), online abrufbar in der DLF- Mediathek . SR2 Kulturradio, Sendung „Literatur im Gespräch“ vom 07.02.2024 (45:12 Minuten), online abrufbar in der SR- Mediathek . Rezensiert von: Kianush Ruf in: Komparatistik 2024. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft , Bielefeld: Aisthesis 2024, S. 378-384. ● Die Welt der Träume. Eine Reise durch alle Zeiten und Kulturen . Herausgegeben, kommentiert und mit einer Einleitung versehen von Christiane Solte-Gresser, Darmstadt: wissenschaftliche Buchgesellschaft 2023. Besprechungen: SR 2 Kulturradio, Sendung „Literatur im Gespräch“ vom 24.11.2023 (Minute 21:50 bis 28:00), online abrufbar in der SR-Mediathek . Deutschlandfunk, Gespräch mit Maike Albath am 27.11. 2023 (7:07 Minuten), online abrufbar in der DLF- Mediathek . rbb24, Sendung „Vis à vis" vom 04.12.2023 (17:52 Minuten), online abrufbar in der rbb24- Mediathek . Saarbrücker Zeitung, Interview mit Christoph Schreiner, erschienen auf der Hochschulseite am 11.12.2023. Radio Bremen Zwei, Interview mit Marion Cotta in der Sendung „Kultur am Mittag“ vom 14.1.2024. Saarländisches Künstlerhaus, Buchvorstellung am 18. März 2024. Rezensiert von: Franziska Rauh in: Komparatistik 2024. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft , Bielefeld: Aisthesis 2024, S. 358-362. ● Sébastian Thiltges / Christiane Solte-Gresser (Hrsg.): Kulturökologie und ökologische Kulturen in der Großregion / Écologie culturelle et cultures écologiques dans la Grande Région , 275 S., Berlin: Peter Lang 2020 (= Studies in Literature, Culture, and the Environment / Studien zu Literatur, Kultur und Umwelt 8). Rezensiert von: David Lombard & Hannah Klaubert in: Local Environment. The International Journal of Justice and Sustainability, Volume 26, Issue 7 (2021), S. 921-922. Online unter https://www.tandfonline.com/doi/full/10.1080/13549839.2021.1932780 (01.06.2021). Mylène Branco in: Hémecht. Zeitschrift für Luxemburger Geschichte. Transnational, lokal, interdisziplinär 2 /2022, S. 250-252. Auch als PDF verfügbar. ● Mauro Fosco Bertola / Christiane Solte-Gresser (Hrsg.): An den Rändern des Lebens. Träume vom Sterben und Geborenwerden in den Künsten , 419 S., Paderborn: Fink 2019 (= Traum – Wissen – Erzählen 5). ● Marlen Schneider / Christiane Solte-Gresser (Hrsg.): Traum und Inspiration. Transformationen eines Topos in Literatur, Kunst und Musik , 315 S., Paderborn: Fink 2018 (= Traum – Wissen – Erzählen 2). Rezensiert von: Iris Schäfer: "Intermediale und internationale Erkundungen dunkler Kontinente und fantastischer Welten. Die Mysterien von Traum und Schlaf als Themen einiger aktueller Bücher", in: literaturkritik.de 11/2018, https://literaturkritik.de/public/rezension.php?rez_id=25021 (01.11.2018). ● Claudia Schmitt / Christiane Solte-Gresser (Hrsg.): Literatur und Ökologie. Neue literatur- und kulturwissenschaftliche Perspektiven [Publikation der Akten der Jahrestagung der DGAVL 2014], 602 S., Bielefeld: Aisthesis 2017. Rezensiert von: Anna-Marie Humbert: " Ecocriticism in German Literary Studies ", in: Ecozon@ : European Journal of Literature, Culture and Environment 11 (2020) H. 2: 2020 Ecocriticism: in Europe and Beyond , S. 254-260. Helga G. Braunbeck: "Recent German Ecocriticism in Interdisciplinary Context", in: Monatshefte für deutschsprachige Literatur und Kultur 111 (2019) H. 1, S. 117-135. ● Hans-Joachim Backe / Claudia Schmitt / Christiane Solte-Gresser (Hrsg.): Vergleichen an der Grenze. Beiträge zu Manfred Schmelings komparatistischen Forschungen, 286 S., Würzburg: Königshausen & Neumann 2016 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 80). ● Christiane Solte-Gresser / Manfred Schmeling (Hrsg.): Theorie erzählen / Raconter la théorie / Narrating Theory. Fiktionalisierte Literaturtheorie im Roman , 285 S., Würzburg: Königshausen & Neumann 2016 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 79). Rezensiert von: Gerald Gillespie in: Literary Research / Recherche litteraire 33 (2017), S. 128-133. Beatrice Nickel in: Komparatistik 2017. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft , Bielefeld: Aisthesis 2018, S. 296-299. ● Le Dictionnaire universel des créatrices , hrsg. von Béatrice Didier / Antoinette Fouque / Mireille Calle-Gruber [Christiane Solte-Gresser: Directrice du secteur "Littérature d'Allemagne, d'Autriche et des pays de langues germaniques", verantwortlich für die Auswahl und Redaktion von 120 Lexikonartikeln zur Literatur der deutschsprachigen Länder (ca. 200 Seiten)], Paris: des femmes - Antoinette Fouque 2013. Rezensiert von: Sammlung von ca. 60 Rezensionen, Buchkritiken und Feuilletonmeldungen unter: https://www.uni-saarland.de/lehrstuhl/solte-gresser/forschung/abgeschlossene-projekte/dictionnairedescreatrices.html Englischer und französischer Pressespiegel auf der Webseite des Verlags unter: https://www.desfemmes.fr/dictionnaire-des-creatrices/ ● Christiane Solte-Gresser / Hans-Jürgen Lüsebrink / Manfred Schmeling (Hrsg.): Zwischen Transfer und Vergleich. Theorien und Methoden der Literatur- und Kulturbeziehungen aus deutsch-französischer Perspektive , 455 S., Stuttgart: Steiner 2013 (= VICE VERSA Deutsch-Französische Kulturstudien 5). Rezensiert von: Hubert Roland in: Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft 2014/2015, Bielefeld: Aisthesis 2015, S. 337-340. Friederike Schwabel: „Vom weiteren Zusammenwachsen der (Kultur-)wissenschaften“, in: I nternationales Archiv für Sozialgeschichte der deutschen Literatur , Berlin: de Gruyter 2015. Online unter: http://www.iaslonline.de/index.php?vorgang_id=3865 (20.11.2015). Christine Lombez (Nantes) in: Revue de Littérature Comparée 89 (2015) H. 3, S. 331-333. Jérôme Pascal: "Réflexions interculturelles. Apprentissage, recherche de compromis et transferts", in: Dokumente / Documents. Zeitschrift für den deutsch-französischen Dialog / Revue du dialogue franco-allemand (2014) H. 3, S. 71-74. ● Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe . Regards croisés sur son œuvre littéraire , 220 S., Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25). Rezensiert von: Christian von Tschilschke in: Valérie Deshoulières / Hans-Jürgen Lüsebrink / Christoph Vatter: Europa zwischen Text und Ort. Interkulturalität in Kriegszeiten (1914-1954) / L'Europe entre texte et lieu. Interculturalités en temps de guerre (1914-1954) , Bielefeld : transcript 2013 (= Frankreich-Forum. Jahrbuch des Frankreichzentrums der Universität des Saarlandes 12/2012), S. 285-287. Émilie Goin in: Textyles. Revue des lettres belges de langue française 42 | 2012, S. 169-174. Vincent Ferré in: fabula . La recherche en littérature. Online unter: www.fabula.org/actualites/c-kovacshazy-c-solte-gresser-dir-relire-madeleine-bourdouxhe-regards-croises-sur-son-oeuvre-_48599.php (03.01.2012) ● Elisabeth Arend / Elke Richter / Christiane Solte-Gresser (Hrsg.): Mittelmeerdiskurse in Literatur und Film / La Méditerranée: représentations littéraires et cinématographiques , 317 S., Frankfurt am Main: Peter Lang 2010 (= Méditerranée: Littératures – Cultures / Mittelmeer: Literaturen – Kulturen 2). Rezensiert von: Maria Oikonomou in: Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literatur­wissenschaft 2010, Heidelberg: Synchron 2011, S. 172-174. ● Christiane Solte-Gresser / Wolfgang Emmerich / Hans Wolf Jäger (Hrsg.): Eros und Literatur. Liebe in Texten von der Antike bis zum Cyberspace. Festschrift für Gert Sautermeister , 361 S., Bremen: edition lumière 2005. ● Christiane Solte-Gresser / Karen Struve / Natascha Ueckmann (Hrsg.): Von der Wirklichkeit zur Wissenschaft. Aktuelle Forschungsmethoden in den Sprach-, Literatur- und Kulturwissenschaften , 363 S., Münster: LIT 2005 (= FOLIES. Forum Literaturen Europas 1). ● Margot Brink / Christiane Solte-Gresser (Hrsg.): Écritures. Denk- und Schreibweisen jenseits der Grenzen von Literatur und Philosophie , 278 S., Tübingen: Stauffenburg 2004 (= Cahiers lendemains 5). Reihen- und Zeitschriftenherausgaben ● Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft , Bielefeld: Aisthesis, zusammen mit Winfried Eckel und Laura Vordermayer, seit 2024. ● Rhinozeros. Europa im Übergang , Berlin: Matthes & Seitz, Jahresschrift, zusammen mit Franck Hofmann, Markus Messling und Maria-Anna Schiffers. https://www.rhinozeros-projekt.de/zeitschrift/das-projekt ● Traum – Wissen – Erzählen, Schriftenreihe des Graduiertenkollegs „Europäische Traumkulturen“ (GRK 2021), Paderborn: Fink, zusammen mit Stefanie Kreuzer, seit 2015 [bisher 18 Bände erschienen – Stand 16.09.2024]. https://www.fink.de/view/serial/TK?rskey=ngY1a9&result=1 ● SOFIE. Schriftenreihe zur Geschlechterforschung , St. Ingbert: Röhrig, zusammen mit Astrid Fellner, Susanne Kleinert, Janett Reinstädler u. a., seit 2013 [bisher 27 Bände erschienen – Stand 16.09.2024]. ● Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft , Würzburg: Königshausen & Neumann, zusammen mit Manfred Schmeling, unter Mitarbeit von Hans-Jürgen Lüsebrink, seit 2009 [bisher 94 Bände erschienen – Stand 16.09.2024]. ● FOLIES. Forum Literaturen Europas , Münster: LIT, zusammen mit Gisela Febel, Mitherausgeberin von 2005 bis 2013. C. Aufsätze und Buchbeiträge Im Druck: ● Charlotte Delbo et Anna Langfus: deux rêveuses face à l’irréparable de la Shoah, in: Yona Hanhart-Marmor / Aurélie Barjonet (Hrsg.): Les femmes de la Shoah , Colloques en ligne de Fabula 2025 (im Druck). ● Pour un jeu de revenants. Le théâtre des victimes face à l’irréparable du génocide, in : Bernard Franco (éd.) : Le jeu : Game, Gambling and Play in Literature , Leiden, Brill, 2025 (im Druck). ● Introduction to Robert Meadows / Christiane Solte-Gresser (Hrsg.): Cultural History of Sleep and Dreaming in the Age of Globalization , vol. 6, London: Bloomsbury 2025 (im Druck). ● Written Representations of Sleep and Dreaming, in: Robert Meadows / Christiane Solte-Gresser (Hrsg.): Cultural History of Sleep and Dreaming in the Age of Globalization , vol. 6, London: Bloomsbury 2025 (im Druck). ● Geträumte Zwischenspiele auf der Bühne: Die Stimmen der Toten im Theater von Charlotte Delbo und Werner Fritsch, in: Johannes Ungelenk (Hrsg.): Zwischenspiele , Berlin: Kulturverlag Kadmos 2025 (im Druck). ● Zukunftsmusik. Träume gegen die Krisen der Spätmoderne in Arturo Márquez‘ Kantate Sueños , in: Janett Reinstädler / Romana Weiershausen (Hrsg.): Zukunftsträume. Visionäre Räume in Schrift, Bild und Klang , Paderborn: Fink 2025 (im Druck). ● Der Weltraum als Traumwelt. Zum Verhältnis von Traum und (abwesender) Emotion bei Ilse Aichinger und Liliana Colanzi, in: Caroline Franck / Laura Vordermayer (Hrsg.): Traum und Emotionen , Würzburg: Königshausen & Neumann 2025 (im Druck). ● Towards a Typology of Holocaust Nightmares, in: Sheila Dickson / Hans-Walter Schmidt-Hannisa (Hrsg.): Aesthetics of the Nightmare from the 20 th Century to the Present , Königshausen & Neumann 2025 (im Druck). Erschienen: ● Marlene Streeruwitz: Jessica, 30 . (2004). Politik und Poetik, in: Stefanie Kreuzer / Caroline Frank (Hrsg.): Klassiker österreichischer Literatur. Ein literaturgeschichtlicher Streifzug in Einzeltextanalysen, Würzburg: Königshausen & Neumann 2026, S. 769-788. ● Can Music Repair the World? Dreams Against the Crises of Late Modernity in Arturo Márquez’ Cantata Sueños : in: Sheila Dickson / Tina-Karen Pusse (Hrsg.): “Ein Traum, was sonst?”. Beiträge zur Literatur-, Kultur- und Mediengeschichte des Traums , Würzburg: Königshausen & Neumann 2025, S. 183-196. ● Materialität von Schrift und Weltwissen, in: Vittoria Borsò / Schamma Schahadat (Hrsg.): Grundthemen der Literaturwissenschaft: Weltliteratur , Berlin/New York: De Gruyter Brill 2025, S. 221-241. ● Arts of Repair. On crises, resentment, and the power of creativity (zusammen mit Markus Messling), in: The True Size of Afrika . Ausstellungskatalog zur Ausstellung im UNESCO Weltkulturerbe Völklinger Hütte, 9.11.2024 bis 18.8.2025, hrsg. Ralf Beil, Markus Messling und Christiane Solte-Gresser, München: Hirmer 2025, S. 484-489. ● "Zermürbt von Alpträumen“. Träume der Nazitäter in Romanen von Olivier Guez, Jonathan Littell und Daša Drndić, in: Dominic Angeloch / Marie Guthmüller / Hans-Walter Schmidt-Hannisa (Hrsg.): Das nächtliche Wir. Traumwissen und Traumkunst nach dem Jahrhundert der Psychologie , Göttingen: Wallstein 2024, S. 118-142. ● Qu’est-ce qu’une pratique culturelle de réparation? La réstitution de la stèle d‘Axum et le récit „L‘icona“ d‘Igiaba Scego, in: Mario Laarmann, Carla Seemann, Laura Vordermayer (Hrsg.): Restitution, Réparations, Reparation. Towards a New Global Society ?, Berlin: De Gruyter 2023, S. 33-61. Gekürzte, überarbeitete und übersetzte Fassung in: ● Was ist eine kulturelle Praxis der Reparation? Die Stele von Axum und Igiaba Scegos Erzählung „Die Ikone“, in: Figurationen. Gender – Literatur – Kultur 2 (2024), Literarische Reparaturen / Literary Repairs , hrsg. v. Christian Metz, S. 15-36. ● Dinge (auf) der Flucht. Teppiche als Gegenstände einer intermedialen Flucht-Poetik (zusammen mit Kristina Höfer und Jonas Nesselhauf), in: Comparatio. Zeitschrift für Vergleichende Literaturwissenschaft 14 (2022) H. 2, S. 211-237. ● Verblendung, Verdrängung, Heimsuchung. Träume in Täterromanen von Edgar Hilsenrath und Marcel Beyer, in: Sebastian Donat / Beate Eder-Jordan / Alena Heinritz / Magdalena Leichter und Martin Sexl (Hrsg.): Alles Verblendung? Was wir (nicht) wahrnehmen können, sollen, wollen , Bielefeld: Aisthesis 2022 (= Studien zur vergleichenden Literatur- und Kulturwissenschaft 4), S. 485-496. ● Marlene Streeruwitz‘ Erfahrungspoetik des Lebenswissens, in: Mandy Dröscher-Teille / Birgit Nübel (Hrsg.): Marlene Streeruwitz. Perspektiven auf Autorin und Werk , Berlin: Springer – J. B. Metzler 2022 (= Kontemporär. Schriften zur deutschsprachigen Gegenwartsliteratur 12), S. 47-63. ● Kopräsenz denken! Ein Ansatz für die interdisziplinäre Fluchtforschung (zusammen mit Dominik Brodowski, Jonas Nesselhauf, Florian Weber und Romana Weiershausen), in: KulturPoetik . Zeitschrift für kulturgeschichtliche Literaturwissenschaft / Journal for Cultural Poetics 22 (2022) H. 2, S. 258-292. ● History as Dreamed Anticipation. On a Type of Paradoxical Dream Experience in Narrative Fiction by André Schwarz-Bart, D. M. Thomas, and Jonathan Safran Foer, in: Bernard Dieterle / Manfred Engel (Hrsg.): Typologizing the Dream / Le rêve du point de vue typlogique , Würzburg: Königshausen & Neumann 2022 (=Cultural Dream Studies / Kulturwisssenschaftliche Traum-Studien / Études culturelles sur le rêve 5), S. 209-231. ● Sporen van slavernij in Belle van Zuylens Geschiedenis van Constance , in: „Wat Belle van Zuylen schreef over slavernij“, Belle van Zuylen-Lesung im Rahmen des Internationalen Literaturfestivals Utrecht 2021, Leitung: Michael Stoker, https://platform.ilfu.com/wat-belle-van-zuylen-schreef-over-de-slavernij (Überarbeitung und Übersetzung des Aufsatzes „Sklavengeschichte als deutsch-französischer Dialog“). ● Traumzeit und Geschichtserfahrung. Zu Anna Seghers' Der Ausflug der toten Mädchen , in: Laura Vordermeyer / Christian Quintes (Hrsg.): Zeiterfahrung im Traum . Was war, was ist, was sein wird , Paderborn: Fink 2021 (= Traum – Wissen – Erzählen 8), S. 179-197. ● Vom Bild über den Text zur Musik: Frans Masereels Die Passion eines Menschen und ihre Adaptionen, in: Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft 2019 , hrsg. von Annette Simonis, Martin Sexl und Alexandra Müller, Bielefeld: Aisthesis 2021, S. 225-247. ● Genres littéraires et rêves concentrationnaires ou les formes oniriques de l’innommable : (protocole – transcription littéraire – récit autobiographique – poème – poème en prose – jeu du rêve – grotesque – roman), in: Bernard Dieterle / Manfred Engel (Hrsg.): Mediating the Dream / Les genres et médias du rêve , Würzburg: Königshausen & Neumann 2020 (= Cultural Dream Studies / Kulturwissenschaftliche Traum-Studien / Études culturelles sur le rêve 4), S. 181-218. ● Traumdiskurse des beschädigten Selbst. Traumwissen in Konzentrationslagerträumen vor 1950, in: Jörn Steigerwald / Hendrik Schlieper / Leonie Süwolto (Hrsg.): Komparatistik heute. Aktuelle Positionen der Vergleichenden Literatur- und Kulturwissenschaft , Paderborn: Fink 2020, S. 175-203. ● Comment le cauchemar traumatique désagrège-t-il l'universalisme européen?, in: Franck Hofmann / Markus Messling (Hrsg.): The Epoch of Universalism 1769-1989 / L'époque de l'universalisme 1769-1989 , Berlin: De Gruyter 2020 (= Beyond Universalism / Partager l'universel 1), S. 179-192. ● Der Wolf: Mythos – Märchen – Management (zusammen mit Peter Fischer-Stabel) in: Sébastian Thiltges / Christiane Solte-Gresser (Hrsg.): Kulturökologie und ökologische Kulturen in der Großregion / Écologie culturelle et cultures écologiques dans la Grande Region , Berlin: Peter Lang 2020 (= Studies in Literature, Culture, and the Environment / Studien zu Literatur, Kultur und Umwelt 8), S. 161-191. ● Ökologie, Kultur, Großregion: Einführende Überlegungen zu einem komplexen und vielschichtigen Verhältnis / Écologie, culture, Grande Région : remarques introductives sur une relation plurielle et complexe (zusammen mit Sébastian Thiltges), in: Sébastian Thiltges / Christiane Solte-Gresser (Hrsg.): Kulturökologie und ökologische Kulturen in der Großregion / Écologie culturelle et cultures écologiques dans la Grande Region , Berlin: Peter Lang 2020 (= Studies in Literature, Culture, and the Environment / Studien zu Literatur, Kultur und Umwelt 8), S. 7-68. ● Sklavengeschichte als deutsch-französischer Dialog: Spuren der Sklaverei im Erzählen der Spätaufklärung am Beispiel von Isabelle der Charrières "Histoire de Constance", in: Natascha Ueckmann / Romana Weiershausen (Hrsg.): Sklavenaufstände in der Literatur / Les révoltes d'esclaves dans la littérature , Berlin: Metzler 2020, S. 63-80. ● Von Afrika nach Europa. Fluchtperspektiven in Wort und Bild, in: Patricia Oster / Christoph Vatter (Hrsg.): Fluchtraum Europa. Interdisziplinäre Perspektiven , Baden-Baden: Nomos 2020 (= Denkart Europa / Mindset Europe 31), S. 205-233. ● Von Narren und Dibbuks. Komisch-provozierende Perspektiven auf die Shoah, in: Katharina Meiser / Sikander Singh (Hrsg.): Narren, Clowns, Spaßmacher. Studien zu einer Sozialfigur zwischen Mittelalter und Gegenwart , Hannover: Wehrhahn 2020, S. 207-241. ● Körpersprachen der Unsagbarkeit. Leibliche Grenzerfahrungen in literarischen Texten über die Shoah, in: Cahier d'études germaniques n o 78 (2020): Corps-frontière. Perspectives littéraires, artistiques et anthropologiques , hrsg. von Hélène Barrière / Susanne Böhmisch, S. 111-125. ● Das Sterben der Anderen. Zur Traum-Sprache des ‚Muselmanns’ bei Delbo und Vercors, in: Mauro Fosco Bertola / Christiane Solte-Gresser (Hrsg.): An den Rändern des Lebens. Träume vom Sterben und Geborenwerden in den Künsten , Paderborn: Fink 2019 (= Traum – Wissen – Erzählen 5), S. 263-283. ● Traumwissen und Traumerfahrung an den Rändern des Lebens (zusammen mit Mauro Fosco Bertola), in: Mauro Fosco Bertola / Christiane Solte-Gresser (Hrsg.): An den Rändern des Lebens. Träume vom Sterben und Geborenwerden in den Künsten , Paderborn: Fink 2019 (= Traum – Wissen – Erzählen 5), S. 7-17. ● Geträumte Schrift. Von der Materialität der Zeichen in literarischen Traumberichten, in: Monika Schmitz-Emans / Linda Simonis / Simone Sauer-Kretschmer (Hrsg.): Schrift und Graphisches im Vergleich, Bielefeld: Aisthesis 2019, S. 75-87. ● Cauchemars d'après-guerre. Approches d'une poétique concentrationnaire (1953-1963), in: Bernard Dieterle / Manfred Engel (Hrsg.): Historizing the Dream / Le Rêve du point de vue historique , Würzburg : Königshausen & Neumann 2019, S. 291-309. ● Träume(n) an der Grenze. Politik und Poetik in Charlotte Beradts Das Dritte Reich des Traums , in: Hermann Gätje / Sikander Singh (Hrsg.): Grenze als Erfahrung und Diskurs. Literatur- und geschichtswissenschaftliche Perspektivierungen , Tübingen: Narr Francke Attempto 2018 (= Passagen 2), S. 87-99. ● Traum-Bilder-Bücher. Wie Text und Bild gemeinsam das Träumen inszenieren, in: Patricia Oster / Janett Reinstädler (Hrsg.): Traumwelten. Interferenzen zwischen Text, Bild, Musik, Film und Wissenschaft , München: Fink 2017 (= Traum – Wissen – Erzählen 1), S. 345-373. ● Zum Verhältnis von Literatur und Ökokritik aus komparatistischer Perspektive (zusammen mit Claudia Schmitt), in: Claudia Schmitt / Christiane Solte-Gresser (Hrsg.): Literatur und Ökologie. Neue literatur- und kulturwissenschaftliche Perspektiven [Publikation der Akten der Jahrestagung der DGAVL 2014], Bielefeld: Aisthesis 2017, S. 13-52. ● Fluchtgeschichten: Erzählen vom Zweiten Weltkrieg bei Irène Némirovsky und Anna Seghers, in: Manfred Leber / Sikander Singh: Erkundungen zwischen Krieg und Frieden, Saarbrücken: Universaar 2017 (= Saarbrücker literaturwissenschaftliche Ringvorlesungen 6), S. 191-222. ● Les confusions de l’adolescence : Pinocchio entre formation et déformation, in: Revue Luxembourgeoise de Littérature Générale et Comparée 2013-2014 [2016]: Littérature et jeunesse / Literature and Youth – Passages & Transitions , hrsg. von Marie-Anne Hansen-Pauly, S. 102-114. ● Pazifistisches Engagement in Text und Bild: Romain Rolland und Frans Masereel, in: Hans-Jürgen Lüsebrink / Manfred Schmeling (Hrsg.): Romain Rolland. Ein transkultureller Denker – Netzwerke, Schlüsselkategorien, Rezeptionsformen / Romain Rolland. Une pensée transculturelle – réseaux, notions clés, formes de réception , Stuttgart: Steiner 2016 (= VICE VERSA Deutsch-französische Kulturstudien 6), S. 165-183. ● Im Bergwerk der Träume. Traumschürfen zwischen Selbstverlust und Selbsterkenntnis in Michael Endes Unendlicher Geschichte , in: Kinder-/Jugendliteratur und Medien in Forschung, Schule und Bibliothek 68 (2016) H. 4: Im Wunder-Schlummer-Land. Traum und Träumen in Kinder- und Jugendmedien , S. 45-53. ● Deutsch-französische Salon-Gespräche. Weltliteratur als literarische Praxis bei Manfred Schmeling und Isabelle de Charrière, in: Hans-Joachim Backe / Claudia Schmitt / Christiane Solte-Gresser (Hrsg.): Vergleichen an der Grenze. Beiträge zu Manfred Schmelings komparatistischen Forschungen, Würzburg: Königshausen & Neumann 2016 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 80), S. 271-286. ● Wie lässt sich erzählte Literaturtheorie analysieren? Ein methodischer Vorschlag für den modernen und postmodernen Roman, in: Christiane Solte-Gresser / Manfred Schmeling (Hrsg.): Theorie erzählen / Raconter la théorie / Narrating Theory. Fiktionalisierte Literaturtheorie im Roman , Würzburg: Königshausen & Neumann 2016 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 79), S. 27-44. ● Autobiographische Geschichtsdarstellung in Literatur und Bildender Kunst: Mai/Juni 1940, in: Françoise Lartillot / Frédéric Teinturier (Hrsg.): Autobiographie et textualité de l’événement au XX e siècle dans les pays de langue allemande , Bern: Peter Lang 2016 (= Genèses de Textes / Textgenesen 7), S. 103-127. ● Migration et précarité. Récits migratoires dans la littérature, le cinéma et la bande déssinée, in: Roswitha Böhm / Cécile Kovacshazy (Hrsg.): Précarité. Littérature et cinéma de la crise au XXI e siècle , Tübingen: Narr Francke Attempto 2015 (= edition lendemains 38), S. 67-87. ● Literatur Denken Erzählen. Wechselseitige Herausforderungen zwischen Literatur und Literaturtheorie am Beispiel von André Gide und Gilbert Adair, in: Henning Hufnagel / Barbara Ventarola (Hrsg.): Literatur als Herausforderung. Zwischen ästhetischem Autonomiestreben, kontextueller Fremdbestimmung und dem Gestaltungsanspruch gesellschaftlicher Zukunft , Würzburg: Königshausen & Neumann 2015 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 71), S. 303-322. ● Tränen wie Lavaströme: Anmerkungen zur neorealistischen Träne am Beispiel von Rossellinis Stromboli. Terra di Dio , in: Renate Möhrmann (Hrsg.): „So muss ich weinen bitterlich“. Zur Kulturgeschichte der Tränen , Stuttgart: Kröner 2015 (= Kröners Taschenausgabe 433), S. 308-333. ● Stoffgeschichte als transnationales Phänomen. Germanistische und außergermanistische Perspektiven auf Amphitryon, in: Zeitschrift des Verbandes Polnischer Germanisten / Czasopismo Stowarzyszenia Germanistów Polskich 4 (2015), H. 3, S. 199-216. ● Begabte Schwindlerinnen. Über die Inszenierungen der Lüge bei Ljudmila Ulickaja, in: Cahiers d'études germaniques n o 68 (2015): Quelques vérités à propos du mensonge? Volume II, hrsg. von Hélène Barrière / Susanne Böhmisch / Karl Heinz Götze / Ingrid Haag, S. 191-205. ● La littérature comparée dans les pays germanophones : Histoire, état actuel et perspectives, in: Revue de littérature comparée 88 (2014) H. 4, S. 419-434. ● Literaturwissenschaftliche Masculinity Studies am Beispiel der Erzähltexte von Natalia Ginzburg, in: Astrid M. Fellner / Anne Conrad / Jennifer J* Moos (Hrsg.): Gender überall? Beiträge zur interdisziplinären Geschlechterforschung , St. Ingbert: Röhrig 2014 (= SOFIE. Schriftenreihe zur Geschlechterforschung 19), S. 65-94. ● Lebens-Welt-Verlust? Literarische Formen postmoderner Welterzeugung am Beispiel von Marlene Streeruwitz, in: Christian Moser / Linda Simonis (Hrsg.): Figuren des Globalen. Weltbezug und Welterzeugung in Literatur, Kunst und Medien , Göttingen: V&R unipress 2014 (= Global Poetics 1), S. 413-424. ● Texte mit nachhaltiger Wirkung? Literatur, Nachhaltigkeit und Ökologie (zusammen mit Claudia Schmitt), erschienen als Ausgabe 1 der von Solange Landau und Jonas Nesselhauf herausgegebenen Online-Reihe SAAR.D.I.N.E. ( Saarbrücker Digitale Interdisziplinäre Nachwuchsbeiträge zum Ecocriticism ), (o. J. [2014]), 30 S. ● Patriarchen, Widerstandskämpfer, Künstler. Männlichkeitsentwürfe im Werk von Natalia Ginzburg, in: Renate Möhrmann (Hrsg.): Frauenphantasien. Der imaginierte Mann im Werk von Film- und Buchautorinnen , Stuttgart: Kröner 2014 (= Kröners Taschenausgabe 304), S. 390-417. ● Schicksalsgemeinschaften. Solidarität und Differenz bei Isabelle de Charrière, in: Margot Brink / Sylvia Pritsch (Hrsg.): Gemeinschaft in der Literatur. Zur Aktualität poetisch-politischer Interventionen , Würzburg: Königshausen & Neumann 2013 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 57), S. 137-151. ● Potenziale und Grenzen des Vergleichs. Versuch einer literatur- und kulturwissenschaftlichen Systematik, in: Christiane Solte-Gresser / Hans-Jürgen Lüsebrink / Manfred Schmeling (Hrsg.): Zwischen Transfer und Vergleich. Theorien und Methoden der Literatur- und Kulturbeziehungen aus deutsch-französischer Perspektive , Stuttgart: Steiner 2013 (= VICE VERSA Deutsch-französische Kulturstudien 5), S. 23-35. ● Einführung: Zwischen Transfer und Vergleich (zusammen mit Hans-Jürgen Lüsebrink und Manfred Schmeling) in: Christiane Solte-Gresser / Hans-Jürgen Lüsebrink / Manfred Schmeling (Hrsg.): Zwischen Transfer und Vergleich. Theorien und Methoden der Literatur- und Kulturbeziehungen aus deutsch-französischer Perspektive , Stuttgart: Steiner 2013 (= VICE VERSA Deutsch-französische Kulturstudien 5), S. 9-19. ● Ikarus. Eine Denkfigur für die Herausforderungen und Risiken der Literatur, in: Monika Schmitz-Emans (Hrsg.): Literatur als Wagnis / Literature as a Risk . DFG-Smyposium 2011 , Berlin: De Gruyter 2013, S. 654-677. ● Deutsch-französische Spiegelverhältnisse bei Jean de La Fontaine, in: Wolfgang Fink / Ingrid Haag / Katja Wimmer (Hrsg.): Frankreich – Deutschland: Transkulturelle Perspektiven. Literatur, Kunst und Gesellschaft. Festschrift für Karl Heinz Götze / France – Allemagne: Perspectives transculturelles. Littérature, arts, société. Mélanges en l'honneur de Karl Heinz Götze, Frankfurt am Main: Peter Lang Edition 2013, S. 21-35. ● Écrire à l’autre : Concepts d’alterité dans des textes philosophiques, autobiographiques et littéraires, Online-Publikation der Ecole Doctorale Transfrontalière LOGOS der Universität der Großregion, Abruf im Abschnitt "Programme d'actions et publications" durch den Link "Contributions 2011", http://www.uni-gr.eu/fr/chercheures-et-enseignantes/activites-projets-et-reseaux/ecole-doctorale-transfrontaliere-logos (o. J. [2013]), 17 S. ● Alltagsbewältigung als (Über-)Lebensaufgabe: Flauberts Madame Bovary und Fontanes Mathilde Möhring , in: Ralf Bogner / Manfred Leber (Hrsg.): Klassiker Neu-Lektüren , Saarbrücken: universaar 2013 (= Saarbrücker literaturwissenschaftliche Ringvorlesungen 3), S. 149-175. ● Fabelhafte Selbstbilder aus dem Blickwinkel der Anderen. Zu La Fontaines „Paysan du Danube“, in: Susanne Greilich / Karen Struve (Hrsg.): Das Andere Schreiben. Diskursivierungen von Alterität in Texten der Romania (16.-19. Jahrhundert) , Würzburg: Königshausen & Neumann 2013 (= Saarbrücker Beiträge zur Vergleichenden Literatur- und Kulturwissenschaft 58), S. 59-72. ● Der Sturz aus dem Elfenbeinturm: Komparatistische Begegnungen mit Professorenfiguren der Gegenwart, in: Comparatio. Zeitschrift für Vergleichende Literaturwissenschaft 4 (2012) H. 1, S. 25-52. ● Wirklichkeit zwischen Zeugnis und Kunst. Primo Levi und Natalia Ginzburg, in: Claudia Öhlschläger / Lucia Perrone Capano / Vittoria Borsò (Hrsg.): Realismus nach den europäischen Avantgarden. Ästhetik, Poetologie und Kognition in Film und Literatur der Nachkriegszeit , Bielefeld: transcript 2012, S. 63-85 . ● « Anna ». La poétique du quotidien, in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 99-106. ● « Blanche ». Manœuvrer des objets de menage, in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 77-83. ● Raconter le silence, in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 137-144. ● Sous le Pont Mirabeau. Grande histoire – petite histoire, in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 63-69. ● Découvertes et redécouvertes (zusammen mit Cécile Kovacshazy), in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 9-11. ● Bibliographie [Madeleine Bourdouxhe : œuvres, traductions, adaptations, littérature secondaire] (zusammen mit Cécile Kovacshazy), in: Cécile Kovacshazy / Christiane Solte-Gresser (Hrsg.): Relire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire , Bruxelles: Peter Lang 2011 (= Documents pour l'Histoire des Francophonies / Europe 25), S. 209-217. ● Gelehrte am Rande des Abgrunds. Über Professoren in Literatur und Film , Saarbrücken: universaar 2011 (= Universitätsreden 88), 47 S. ● „Alptraum mit Aufschub“. Ansätze zur Analyse literarischer Traumerzählungen, in: Susanne Goumegou / Marie Guthmüller (Hrsg.): Traumwissen und Traumpoetik. Onirische Schreibweisen von der literarischen Moderne bis zur Gegenwart , Würzburg: Königshausen & Neumann 2011, S. 239-262. ● Lust und Gefahr des Erzählens. Balzacs Sarrasine aus psychoanalytischer Perspektive, in: Elke Richter / Karen Struve / Natascha Ueckmann (Hrsg.): Balzacs „Sarrasine“ und die Literaturtheorie. Zwölf Modellanalysen , Stuttgart: Reclam 2011, S. 201-216. ● Textbilder und Bildtexte im Angesicht des Unsagbaren. Autopoetische Dimensionen in Brechts Fotoepigrammen, Spiegelmans ‚Comix’ und Herta Müllers Gedichtcollagen, in: Achim Hölter (Hrsg.): Comparative Arts. Universelle Ästhetik im Fokus der Vergleichenden Literaturwissenschaft , Heidelberg: Synchron 2011 (= HERMEIA. Grenzüberschreitende Studien zur Literatur- und Kulturwissenschaft 12), S. 177-187. ● Literatur zwischen œuvre und foyer . Simone de Beauvoirs Kritik des Alltags in Le Deuxième Sexe , in: Stephanie Bung / Romana Weiershausen (Hrsg.): Simone de Beauvoir – Schreiben zwischen Theorie und Erzählun g, Göttingen: Wallstein 2010 (= Quer elles . Jahrbuch für Frauen- und Geschlechterforschung 15), S. 228-231. ● Zerschnipselter Sinn. Buchstabierte Angst. Geklebte Ordnung. Zu den Gedichtcollagen der Nobelpreisträgerin Herta Müller, in: Germanisch-Romanische Monatsschrift 59 (2009) H. 4, S. 565-567. ● Zerschnipselter Sinn. Buchstabierte Angst. Geklebte Ordnung. Zu den Gedichtcollagen der Nobelpreisträgerin Herta Müller, in: Die Horen. Zeitschrift für Literatur, Kunst und Kritik 54 (2009) H. 4 , S. 203-206. ● Mittelmeerbilder in der französischen und italienischen Lyrik: Raum-Zeit-Konstruktionen, Mythologie, Autopoetik, in: Elisabeth Arend / Elke Richter / Christiane Solte-Gresser (Hrsg.): Mittelmeerdiskurse in Literatur und Film / La Méditerranée: représentations littéraires et cinématographiques , Frankfurt am Main: Peter Lang 2010 (= Méditerranée: Littératures – Cultures / Mittelmeer: Litteraturen – Kulturen 2), S. 35-54. ● Einleitung [1. Repräsentationen des Mittelmeers – Vorüberlegungen. 2. Das Mittelmeer aus systematischer Perspektive: Themen und Topoi, Raum- und Zeitkonstruktion, Textsorten und Diskurse] (zusammen mit Elisabeth Arend und Elke Richter), in: Elisabeth Arend / Elke Richter / Christiane Solte-Gresser (Hrsg.): Mittelmeerdiskurse in Literatur und Film / La Meditérranée: répresentations littéraires et cinématographiques , Frankfurt am Main: Peter Lang 2010 (= Méditerranée: Littératures – Cultures / Mittelmeer: Litteraturen – Kulturen 2), S. 7-17. ● La creazione letteraria della quotidianità in Inverno in Abruzzo di Natalia Ginzburg, in: Cristina Albizu / Larissa Birrer u. a. (Hrsg.): Alltag – Quotidien – Quotidiano – Cotidiano. Akten – Actes – Atti – Actas. III Dies Romanicus Turicensis (Zürich, 16.-17. Juni 2006), Aachen: Shaker 2009 (= Sprache & Kultur), S. 85-98. ● Relire Madeleine Bourdouxhe (zusammen mit Cécile Kovacshazy), in: Indications : La revue des romans n o 376 (2009) : Relire Madeleine Bourdouxhe , hrsg. von Thierry Leroy, S. 32-34. ● Vom Schweigen erzählen. Eine kleine Typologie des Schweigens im Werk von Madeleine Bourdouxhe, in: Kathrina Reschka (Hrsg.): "Stille : Stimme". Zum Moment des Schweigens aus Sicht romanistischer Sprach-, Literatur- und MedienwissenschaftlerInnen. Festschrift für Renate Kroll , Siegen: universi 2008, S. 279-296. ● Liebesdiskurse der Sprachlosigkeit: Zur Poetik der Dienstmädchenliebe, in: Cahiers d'études germaniques n o 55 (2008): L'Amour entre deux guerres – 1918-1945 – Concepts et représentations , hrsg. von Karl Heinz Götze und Ingrid Haag, S. 49-61. ● Familien – Geschichte – Schreiben: Natalia Ginzburgs Lessico famigliare , in: Christian von Zimmermann / Nina von Zimmermann (Hrsg.): Familiengeschichten. Biographie und familiärer Kontext seit dem 18. Jahrhundert , Frankfurt am Main / New York: Campus 2008, S. 99-115. ● Vom italienischen Nationalkino zum Gedächtnis des europäischen Films. Das Kino des Neorealismo , in: Gisela Febel / Natascha Ueckmann (Hrsg.): Europäischer Film im Kontext der Romania . Geschichte und Innovation , Münster: LIT 2008 (= FOLIES. Forum Literaturen Europas 5), S. 67-81. ● Expérience historique et refus historiographique : La perception de la Seconde Guerre mondiale chez Claude Simon et Madeleine Bourdouxhe, in: Elisabeth Arend / Dagmar Reichardt / Elke Richter (Hrsg.): Histoires inventées. La représentation du passé et de l'histoire dans les littératures française et francophones , Frankfurt am Main: Peter Lang 2007, S. 197-210. ● "Es ist überhaupt nichts los in der Nacht". Text-Bild-Relationen im Kinderbuch, in: Kind – Bild – Buch . Zeitschrift des BIBF – Bremer Institut für Bilderbuch- und Erzählforschung 3 (2007): Von der Flüchtigkeit zur Betrachtung , S. 24-32. ● Krug und Henkel, Topf und Teller. Über das Lesen und Handhaben von Alltagsgegenständen in Kulturphilosophie und Literatur. Bloch – Simmel – Bourdouxhe, in: Heinz-Peter Preußer / Matthias Wilde (Hrsg.): Kulturphilosophen als Leser. Portraits literarischer Lektüren , Göttingen: Wallstein 2006, S. 105-119. ● Inszenierungs-Spiele zwischen Sein und Schein: Das literarische Portrait im 17. Jahrhundert, in: Christian von Zimmermann / Nina von Zimmermann (Hrsg.): Frauenbiographik. Lebensbeschreibungen und Porträts , Tübingen: Narr 2005 (= Mannheimer Beiträge zur Sprach- und Literaturwissenschaft 63), S. 175-203. ● Fiktionen des Forschungsgegenstands. Werk, Autorschaft und Literaturgeschichte aus unterschiedlichen Perspektiven der gender-Forschung, in: Christiane Solte-Gresser / Karen Struve / Natascha Ueckmann (Hrsg.): Von der Wirklichkeit zur Wissenschaft. Aktuelle Forschungsmethoden in den Sprach-, Literatur- und Kulturwissenschaften , Münster: LIT 2005 (= FOLIES. Forum Literaturen Europas 1), S. 57-77. ● Intertextuelle Erotik. Zu Roland Barthes' Fragments d'un discours amoureux , in: Christiane Solte-Gresser, Wolfgang Emmerich, Hans Wolf Jäger (Hrsg.): Eros und Literatur. Liebe in Texten von der Antike bis zum Cyberspace. Festschrift für Gert Sautermeister , Bremen: edition lumière 2005, S. 311-324. ● Pinocchio. Die Unvernunft der Puppe, die Unordnung im Text und das "Unbehagen in der Kultur", in: Cerstin Bauer-Funke / Gisela Febel (Hrsg.): Der automatisierte Körper. Literarische Visionen des künstlichen Menschen vom Mittelalter bis zum 21. Jahrhundert , Berlin: Weidler 2005 (= Körper – Zeichen – Kultur 17), S. 77-94. ● "Denkerische Dialektik" oder "unsentimentale Zwiesprache"? Identität und Alterität in philosophischen und autobiographischen Entwürfen, in: Christiane Solte-Gresser / Margot Brink (Hrsg.): Écritures. Denk- und Schreibweisen jenseits der Grenzen von Literatur und Philosophie , Tübingen: Stauffenburg 2004 (= Cahiers lendemains 5), S. 231-246. ● Grenzen und Entgrenzungen. Zum Verhältnis von Literatur und Philosophie (zusammen mit Margot Brink), in: Christiane Solte-Gresser / Margot Brink (Hrsg.): Écritures. Denk- und Schreibweisen jenseits der Grenzen von Literatur und Philosophie , Tübingen: Stauffenburg 2004 (= Cahiers lendemains 5), S. 9-29. ● Critique littéraire, études féminines et gender studies : Le champ actuel des théories et des méthodes en Allemagne, in: Rotraud von Kulessa (Hrsg.): Études féminines – gender studies en littérature en France et en Allemagne , Freiburg im Breisgau: Frankreich-Zentrum (= Journée d'études 3), S. 23-40. ● A la recherche d'une morale prise sur le vif: Trois femmes et le discours éthique actuel, in: Lettre de Zuylen et du Pontet , Bulletin 27 (2002), S. 7-10. ● Wo das wahre Leben abwesend ist. Zur Präsenz des Todes bei Paul Nizan und Colette Peignot, in: Helga Bories-Sawala (Hrsg.): Ansichten vom Frankreich der 30er Jahre. Beiträge aus einem interdisziplinären Projekt an der Universität Bremen / Aspects de la France des années trente. Contributions à un projet interdisciplinaire de l'université de Brême, Bremen: Universität Bremen 2000, S. 112-123. ● Wider den Sonntag im Buch. Überlegungen zum Thema des Alltags in der Literatur, in: STiNT. Zeitschrift für Literatur 14 (2000), Nr. 28: Alltag , S. 127-133. ● "Im Leben verschwinden". Biographie und Alltag in Marlene Streeruwitz' "Nachwelt", in: STiNT. Zeitschrift für Literatur 14 (2000), Nr. 28: Alltag , S. 140-141. ● "Cette différence prétendue". Zur Problematik einer ‘weiblichen’ Subjektivität in den Texten Isabelle de Charrières (1740-1805), in: Katharina Hanau / Volker Rivinius u. a. (Hrsg.): GeschlechterDifferenzen, Beiträge zum 14. Nachwuchskolloquium der Romanistik Greifswald , 4. – 6. Juni 1998, Bonn: Romanistischer Verlag 1999 (= Forum Junge Romanistik 5), S. 61- 69. ● Außer sich sein. Dialogisches Selbstverständnis in den Briefen von Marie de Sévigné und Isabelle de Charrière, in: Renate Kroll / Margarete Zimmermann (Hrsg.): Gender Studies in den Romanischen Literaturen: Revisionen, Subversionen . Band 2 , Frankfurt am Main: dipa 1999 (= Siegener Frauenforschungsreihe 7), S.11-34. ● Von Müttern und Mythen. Mit Marie de Sévigné auf der Suche nach einer weiblichen Genealogie, in: Romanische Forschungen 111 (1999) H. 1, S. 587-599. D. Lexikon- und Handbuchartikel ● „Traum“, in: Christian A. Bachmann / Simone Sauer-Kretschmer (Hrsg.): MSE-ABC. Lektüren und Begegnungen , Berlin: Christian A. Bachmann Verlag 2022, S. 181-183. ● Formen der Inszenierung von Geschichten durch buchgestalterische Mittel im Bilderbuch, in: Literatur, Buchgestaltung und Buchkunst. Ein Kompendium , hrsg. von Monika Schmitz-Emans, Berlin: De Gruyter 2019 (= De Gruyter reference), S. 491-510. ● „Das Dritte Reich des Traums“ (Charlotte Beradt), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 16. Februar 2017. ● „Les jours de la femme Louise et autres nouvelles (Madeleine Bourdouxhe), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 30. Dezember 2016. ● „Se questo è un uomo“ (Primo Levi), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 5. August 2016. ● „La Tregua" (Primo Levi), in: Lexikon Traumkultur, Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 5. August 2016. ● „Les bagages de sable“ (Anna Langfus), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 5. August 2016. ● „Träume“ (Günter Eich), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 8. August 2016. ● „Le Songe“ (Vercors), in: Lexikon Traumkultur. Ein Wiki des Graduiertenkollegs „Europäische Traumkulturen“ , 11. August 2016. ● Frankreich und der französische Sprachraum (Rubrik: B. Ausrichtungen der literaturwissenschaftlichen Komparatistik. 3. Räumlich-sprachliche Ausrichtung), in: Metzler-Handbuch Komparatistik. Theorien, Arbeitsfelder, Wissenspraxis, hrsg. von Rüdiger Zymner / Achim Hölter, Stuttgart: Metzler 2013, S. 24-29. ● Le Dictionnaire universel des créatrices , hrsg. von Béatrice Didier / Antoinette Fouque / Mireille Calle-Gruber [Christiane Solte-Gresser: Directrice du secteur "Littérature d'Allemagne, d'Autriche et des pays de langues germaniques", verantwortlich für die Auswahl und Redaktion von 120 Lexikonartikeln zur Literatur der deutschsprachigen Länder (ca. 200 Seiten)], Paris: des femmes - Antoinette Fouque 2013. Redaktion eigener Artikel im Rahmen dieses Lexikonprojekts: Marieluise Fleißer, S. 1576. Marlene Streeruwitz, S. 4129. Birgit Vanderbeke, S. 4451. ● Metzler-Lexikon Gender Studies / Geschlechterforschung. Ansätze, Personen, Grundbegriffe , hrsg. von Renate Kroll, Stuttgart: Metzler 2002. Artikel: Frauenbuchhandlungen, Frauenverlage, Frauenbuchkritik, S. 119. Höfische Liebe, S. 178 f. Salonkultur, S. 348. E. Rezensionen ● Der Traum als Forschungsgegenstand literatur- und kulturwissenschaftlicher Romanistik: ein Rundflug mit Zwischenstopps, Sammelrezension zusammen mit Marie Bonnot, Kristina Höfer, Agnes Karpinski, Martin Meiser, Janett Reinstädler und Sigrid Ruby, in: Romanische Studien Nr. 5 (2016) S. 465-484. Online unter: http://www.romanischestudien.de/index.php/rst/article/view/240 ● Ralph Winter: Generation als Strategie. Zwei Autorengruppen im literarischen Feld der 1920er Jahre. Ein deutsch-französischer Vergleich , Göttingen: Wallstein 2012, 430 S., in: Dietmar Hüser / Ulrich Pfeil (Hrsg.): Populärkultur und deutsch-französische Mittler / Culture de masse et médiateurs franco-allemands. Akteure, Medien, Ausdrucksformen / Acteurs, médias, articulations, Bielefeld: transcript 2015 (= Frankreich-Forum. Jahrbuch des Frankreichzentrums der Universität des Saarlandes 14/2014), S. 316-318. ● Susanne Mildner: L’Amour à la Werther. Liebeskonzeptionen bei Goethe, Villers, de Staël und Stendhal – Blickwechsel auf einen deutsch-französischen Mythos. Göttingen: Wallstein 2012, 360 S., in: Goethe-Jahrbuch 130 (2013), Göttingen: Wallstein 2014, S. 273-275. ● Cornelia Klettke / Georg Maag (Hrsg.): Reflexe eines Umwelt- und Klimabewusstseins in fiktionalen Texten der Romania . Eigentliches und uneigentliches Schreiben zu einem sich verdichtenden globalen Problem. Berlin: Frank & Timme 2010, 478 S., Abb., in: Romanische Forschungen 126 (2014) H. 4, S. 567-569. ● Tania Woloshyn / Nicholas Hewitt (Hrsg.): ‘L’invention du Midi’: The Rise of the South of France in the National and International Imagination ( Nottingham French Studies 50/1), Nottingham: University of Nottingham 2011, 119 S., in: Zeitschrift für Französische Sprache und Literatur 124 (2014) H. 1, S. 106-109. ● Götze, Karl-Heinz / Haag, Ingrid / Neumann, Gerhard / Sautermeister, Gert: Zur Literaturgeschichte der Liebe , Würzburg: Königshausen & Neumann 2009, 441 S., in: Claudia Polzin-Haumann / Dietmar Osthus (Hrsg.): Sprache und Sprachbewusstsein in Europa / Langues et conscience linguistique en Europe. Beiträge aus Wissenschaft, Öffentlichkeit und Politik / Une approche pluridisciplinaire: entres sciences, opinion publique et politique , Bielefeld: transcript 2011 (= Frankreich-Forum. Jahrbuch des Frankreichzentrums der Universität des Saarlandes 10/2010), S. 188-190. ● Nutzen und Grenzen der Biographie. Jörg Aufenanger: Heinrich Heine in Paris , in: France-Mail-Forum 41 (April 2006). ● Michael Einfalt / Joseph Jurt (Hrsg.): Le texte et le contexte. Analyses du champ littéraire français (XIXe et XXe siècle) , Berlin: Verlag Arno Spitz, Paris: Editions MSH 2002, in: Archiv für das Studium der neueren Sprachen und Literaturen 157 (2005), Bd. 242, S. 463-466. ● Herbert Wiesner / Ernest Wichner / Johann P. Tammen (Hrsg.): Der Flaneur und die Memoiren der Augenblicke . Die Horen. Zeitschrift für Literatur, Kunst und Kritik 45 (2000) H. 4, in: France-Mail-Forum 4 (Dezember 2003). ● Stefan Hartung: Parnasse und Moderne. Théodore de Banvilles "Odes funambulesques" (1857) . Stuttgart: Franz Steiner 1997, 285 S., 1 Abb. (ZfSL Beihefte 25), in: Romanische Forschungen 112 (2000) H. 1, S. 127-129. ● Doris Kolesch: Das Schreiben des Subjekts. Zur Inszenierung ästhetischer Subjektivität bei Baudelaire, Barthes und Adorno , Wien: Passagen 1996, in: Archiv für das Studium der neueren Sprachen und Literaturen 150 (1998), Bd. 235, S. 460-463. ● Christa Bürger: Diese Hoffnung, eines Tages nicht mehr allein zu denken. Lebensentwürfe von Frauen aus vier Jahrhunderten , Stuttgart: Metzler 1996, in: Metis. Zeitschrift für historische Frauenforschung und feministische Praxis, Nr. 12 (1997), S.118-120. ● Gila Lustiger: Aus einer schönen Welt , Berlin: Aufbau 1997, in: Virginia. Zeitschrift für Frauenbuchkritik , Nr. 26 (1999) H. 1, S. 9. ● Nikola Anne Mehlhorn: Brachmond , Hamburg: Rospo 1998, in: GrauZone. Zeitschrift über neue Literatur , Nr. 16/17 (1998) H. 4: Junge deutsche Gegenwartsautorinnen, S. 26-27. F. Sonstige Publikationen ● [Interview, geführt von Sally-Charell Delin: ] Christiane Solte-Gresser über ihr neues Buch „Shoah-Träume“, 19.1.2022 auf SR2 Kulturradio in der Sendung „Literatur im Gespräch“ (min. 17:00 bis 25:30), online unter: http://www.sr-mediathek.de/index.php?seite=7&id=111700 . ● [Tagungsbericht:] Zwischen Transfer und Vergleich. Theorien und Methoden der Literatur- und Kulturbeziehungen aus deutsch-französischer Perspektive. Internationale und interdisziplinäre Tagung an der Universität des Saarlandes vom 9. bis 11. Februar 2012, in: Komparatistik. Jahrbuch der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaft 2012, Heidelberg: Synchron 2013, S. 151-153. ● [Interview, geführt von Lea Wagner: ] Bilder trotz allem, in: Süddeutsche Zeitung Magazin , Heft 16: Solange sie noch leben (22. April 2010), online unter: https://sz-magazin.sueddeutsche.de/literatur/bilder-trotz-allem-77199 . ● [Editorial:] Was gesagt werden will und sich doch nicht sagen lässt, in: Italienisch. Zeitschrift für italienische Sprache und Literatur 31 (2009) H. 2, S. 1. ● [Tagungsbericht:] Compte rendu de l'atelier 12 "Mittelmeerdiskurse in Literatur und Film". XXX. Romanistentag in Wien, in: Romanistische Zeitschrift für Literaturgeschichte / Cahiers d'Histoire des Littératures Romanes 32 (2008) H. 1/2, S. 215-216. ● [Tagungsbericht:] Kanon vielstimmig? Tagungsbericht zur 2. Bremer Tagung zu Fragen der literaturwissenschaftlichen Lexikographie: Autorinnen in der Literaturgeschichte. Konsequenzen der Frauenforschung für die Literaturgeschichtsschreibung und Literaturdokumentation (30.9. bis 2.10.1998), in: SCRIPT. Frau – Literatur – Wissenschaft im alpen-adriatischen Raum Nr. 15 (Dez. 1998), S. 62 - 65 und in: Metis. Zeitschrift für historische Frauenforschung und feministische Praxis Nr. 15 (1999), S. 99-103. ● [Zeitungsartikel:] Auf Leben und Tod. Das Literaturhaus befaßt sich mit selbstmörderischen Literatinnen des 20. Jahrhunderts, in: Hamburger Rundschau. Die Wochenzeitung für Politik und Kultur Nr. 37 (10. September 1998), S. 49-50. G. Wissenschaftliche Vorträge (2025) Kultur und Reparation. Das Käte Hamburger Kolleg CURE und seine Projekte. Vortrag im Literatur- und Kulturwissenschaftlichen Kolloquium der Europa-Universität Flensburg, dem International Center for European Studies und der European Wasatia-Graduate School for Peace and Conflict Resolution, zusammen mit Markus Messling, 23. April 2025. (2024) Pratique de l’interdisciplinarité en contexte franco-allemand et projets du Käte Hamburger Kolleg für kulturelle Praktiken der Reparation. Vortrag zusammen mit Markus Messling auf der Tagung „Faire discipline. Les approches franco-allemandes en sciences humaines et sociales“, Maison Interuniversitaire des Sciences de l’Homme Alsace, Universität Straßburg, 18. bis 19. November 2024. (2024) Jouer les revenants – jouer au revenant. Le théâtre des victimes face à l’irréparable du génocide, Vortrag auf dem 10 ième Congrès de la Société Européenne de Littérature Comparée (SELC) : « Le jeu : gaming, gambling and play in literature », Paris, Sorbonne, 2. bis 6. September 2024. (2024) Eine Reise in die Welt der Träume, Vortrag und Diskussion im Rahmen der Reihe “Auf ein Glas Wein mit …” der Evangelischen Studierendengemeinde Saarbrücken, 18. Juli 2024. (2024) Holocaust Nightmares. Dream Reports as War Historiography, Keynote-Vortrag, Lisbon Summer School for the Study of Culture, 2024: Culture at War, 23. bis 29. Juni 2024. (2024) Can War be Repaired (through Culture)? Lecture and Discussion with Isabel Capeloa Gil and Christiane Solte-Gresser, Transform4Europe Science Café, Gulbenkian Foundation Lisboa, 25. Juni 2024. (2024) Rêver est-ce réparer? Les rêves de la Shoah face à l'irréparable, Käte Hamburger Lecture #2, Universität des Saarlandes, 19. Juni 2024. (2024) Die Welt der Träume. Eine Reise durch alle Zeiten und Kulturen, Vortrag und Gespräch im Saarländischen Künstlerhaus, 18. März 2024. (2024) Zukunftsmusik. Träume gegen die Krisen der Spätmoderne in Arturo Márquez' Kantate Sueños , Vortrag auf der Abschlusstagung des Graduiertenkollegs “Europäische Traumkulturen” zum Thema “Zukunftsträume”, Universität des Saarlandes, 8. bis 10. Februar 2024. (2023) Der Weltraum als Traumwelt. Zum Verhältnis von Traum und (abwesender) Emotion bei Ilse Aichinger und Liliana Colanzi, Vortrag auf der Tagung “Traum und Emotionen”, Universität des Saarlandes, 7. bis 9. September 2023. (2023) Das Unvollständige schreiben: Trauma, Traum und Literatur, Vortrag im Rahmen der Ringvorlesung „Das Ganze der Literatur – Für eine Allgemeine und Vergleichende Literaturwissenschaft“, Goethe-Universität Frankfurt, 5. Juli 2023. (2023) Geträumte Zwischenspiele auf der Bühne: Die Stimmen der Toten im Theater von Charlotte Delbo und Werner Fritsch, Vortrag auf der XIX. Tagung der DGAVL, Universität Potsdam, 30. Mai bis 2. Juni 2023. Der Vortrag ist auch online abrufbar. (2023) Towards a Typology of Holocaust Nightmares, Vortrag auf der Tagung "Dark Fantasies. Aestetics of the Nightmare in the 20 th century", Goethe Institute Glasgow, 11. bis 12. Mai 2023. (2022) Traumwelten von der Keilschrift bis zum Computerspiel. Vortrag auf dem Herbstworkshop des GRK 2021 „Europäische Traumkulturen“, Universität des Saarlandes, 7. bis 8. November 2022. (2022) ‚Miné par des cauchemars‘. Träume der Nazi-Täter in den Romanen von Olivier Guez, Jonathan Littell und Dasa Drndic, Vortrag auf der Tagung „Zwischen Psychoanalyse, virtuellem Experiment und Schlaflabor. Traumwissen und Traumkunst nach dem Jahrhundert der Psychologie (1950-2021)“, Humboldt-Universität zu Berlin, 13. bis 15. Mai 2022. (2021) Qu’est-ce qu’une pratique culturelle de réparation? La réstitution de la stèle d‘Axum et le récit „L‘icona“ d‘Igiaba Scego, Keynote-Vortrag auf der internationalen Summer School " Restitution, Réparations, Reparation. Towards a New Global Society ?“ (zusammen mit Markus Messling), 9. bis 13. September 2021, Villa Vigoni — Deutsch-Italienisches Zentrum für den Europäischen Dialog. (2021) Nachts. Wort-Bild-Verhältnisse in Traum-Bilderbüchern, Vortrag innerhalb der Ringvorlesung „Ästhetische Traumdarstellungen im europäischen Kontext. Theorien — Methoden — Analysen“ am Graduiertenkolleg „Europäische Traumkulturen“, 8. Juni 2021, Universität des Saarlandes. (2020) Täter-Träume: Verzerrte Wahrnehmung zwischen Verblendung, Verdrängung und Heimsuchung, Vortrag im Rahmen der 18. Tagung der DGAVL zum Thema „Alles Verblendung? – Was wir (nicht) wahrnehmen können, wollen, sollen“, 2. bis 5. Juni 2020, Universität Innsbruck (pandemiebedingt verschoben). (2020) Protokolliertes Traumwissen der Shoah: Charlotte Beradt, Paula Ludwig, Ingeborg Bachmann, Hélène Cixous, Vortrag auf der Tagung „Traumnotate von Autorinnen des 20. Jahrhunderts in komparatistischer Perspektive“, 28. bis 29. Mai 2020, Università di Verona (pandemiebedingt verschoben). (2020) Zum Schreiben von Marlene Streeruwitz aus erfahrungspoetischer Perspektive, Vortrag im Rahmen des Festkolloquiums zum 70. Geburtstag von Marlene Streeruwitz, Universität Hannover, 25. März 2020 (pandemiebedingt nur schriftlich). (2019) Comment le cauchemar traumatique désagrège l’universalisme européen, Vortrag auf dem internationalen Symposium "1769/1989: The Epoch of Universalism – L’époque de l’universalisme – Die Epoche des Universalismus", Villa Europa Saarbrücken, 24. bis 25. September 2019. (2019) Traumzeit und Geschichtserfahrung. Zu Anna Seghers‘ Der Ausflug der toten Mädchen , Vortrag innerhalb der Sektion „Zeit im Traum“ auf dem 26. Deutschen Germanistentag, 21. bis 24. September 2019, Saarbrücken. (2019) Rêves prémonitoires de l'Histoire. Un type paradoxal d'expérience onirique dans la fiction narrative, Vortrag auf der Tagung „Typologizing the Dream“, Villa Vigoni. Centro italiano per l’excellenza, 2. bis 5. September 2019. (2019) Von Narren und Dibbuks. Komisch-provozierende Perspektiven auf die Shoah, Vortrag im Rahmen der Ringvorlesung "Narren, Clowns, Spaßmacher", Literaturwissenschaftliche Ringvorlesung im Rathausfestsaal der Stadt Saarbrücken, 27. Mai 2019. (2018) Théâtre, poème, roman, compte rendu, récit autobiographique. Le rêve concentrationnaire à travers ses genres, Vortrag auf der Tagung "Mediating the Dream / Les genres et médias du rêve“ des ICLA Research Commettee Dream Cultures. Cultural and Literary History of the Dream, Universität des Saarlandes, 29. bis 31. August 2018. (2018) Text-Bild-Verhältnisse. Traumgestaltung im Bilderbuch, Vortrag im Rahmen der Ringvorlesung „Europäische Traumkulturen: Theorien, Methoden, Analysen“, Universität des Saarlandes, 17. Juli 2018. (2018) Körpersprachen der Unsagbarkeit. Leibliche Grenzerfahrungen in literarischen Texten über die Shoah, Vortrag auf der Tagung „Le corps-frontière“, Université Aix-Marseille, 15. bis 16. Juni 2018. (2018) Europäischer Fluchtraum Marseille: Anna Seghers' Roman Transit – mit einem Ausblick auf die Verfilmung von Christian Petzold, Vortrag auf der Jahrestagung der Association des Germanistes des l’Enseignement Supérieur, Paris, Université de la Sorbonne, 7. bis 9. Juni 2018. (2018) Das Sterben der Anderen. Zur Traum-Sprache des ‚Muselmanns’ bei Vercors und Delbo, Vortrag auf der Abschlusstagung „Träume vom Sterben und Geborenwerden. Körperliche Grenzerfahrungen in Literatur, Kunst, Theater, Film und Musik“ des Graduiertenkollegs „Europäische Traumkulturen“, 21. bis 23. März 2018. (2018) Traumdiskurse des beschädigten Selbst. Traumwissen in Konzentrationslagerträumen vor 1950, Vortrag auf der Abschlusstagung des DFG-Netzwerkes „Das nächtliche Selbst. Traumwissen und Traumkunst im Jahrhundert der Psychologie“, Universität Tübingen, 14. bis 16. März 2018. (2017) Der Wolf: Mythos, Märchen, Management (zusammen mit Peter Fischer-Stabel), Vortrag im Kulturlandschaftszentrum Haus Lochfeld, Biosphärenreservat Bliesgau, 8. September 2017. (2017) Geträumte Schrift, Von der Materialität der Zeichen in literarischen Traumberichten. Vortrag auf der DGAVL-Jahrestagung „Schrift und Graphisches im Vergleich“, 6. bis 9. Juni 2017 in Bochum. (2017) Wölfe in der Großregion: Zwischen Mythos und Management (zusammen mit Peter Fischer-Stabel), Vortrag auf der Tagung „Culture écologique et écologie de la culture dans la Grande Region“, 1. bis 2. Juni 2017, Nature Musée und Université du Luxembourg. (2017) Shoah – Traum – Literatur. Literarische Zugträume im Vergleich, Vortrag im Rahmen der Ringvorlesung „Komparatistik heute“ der Universität Paderborn, SoSe 2017, am 2. Mai 2017. (2017) Träume(n) an der Grenze: Politik und Poetik in Charlotte Beradts „Das Dritte Reich des Traums“, Vortrag auf der Jahrestagung der deutschen Gesellschaft für Exilforschung zum Thema „Grenze als Erfahrung und Diskurs“, 23. bis 26. März 2017, Universität des Saarlandes. (2016) Zwischen Afrika und Europa. Fluchtperspektiven in Wort und Bild, Vortrag im Rahmen der Ringvorlesung „Fluchtraum Europa: Interdisziplinäre Perspektiven“ des Europa-Kollegs CEUS (Collegium Europaeum Universitatis Saraviensis), Rathausfestsaal Saarbrücken, 5. Dezember 2016. (2016) „Vielleicht existieren wir nur in den Träumen der Toten?“ Traumverwirrungen in der Literatur, Vortrag und Diskussionsabend in der Evangelischen Studierendengemeinde Saarbrücken, 24. November 2016. (2016) Sklavengeschichten im deutsch-französischen Dialog: Karibische Spuren der Sklaverei im Roman "Trois Femmes" von Isabelle de Charrière, Vortrag innerhalb der Sektion "Sklavenaufstände" (organisiert von Romana Weiershausen und Natascha Ueckmann) auf dem Frankoromanistentag in Saarbrücken, 30. September bis 3. Oktober 2016. (2016) Cauchemars d’après-guerre. Approches d’une poétique onirique 1953-1963, Vortrag auf dem Weltkongress der International Comparative Literature Association, Wien, 20. bis 27. Juli 2016 innerhalb der Sektion „Historiser le rêve“. (2016) Fluchtgeschichten. Erzählen vom Zweiten Weltkrieg bei Irène Némirovsky, Anna Seghers und anderen, Vortrag im Rahmen der Saarbrücker literatur­wissenschaftlichen Ringvorlesung „Erkundungen über Krieg und Frieden“ im Rathaus der Stadt Saarbrücken, SoSe 2016, 30. Mai 2016. (2016) Der Traum als Kunstwerk. Literatur- und kulturwissenschaftliche Perspektiven, Vortrag auf den 14. Hallenser Gesprächen zu Psychotherapie, Religion und Natur­wissenschaften, Katholische Akademie des Bistums Magdeburg-Halle, 26. bis 27. Feb­ruar 2016. (2016) Marlene Streeruwitz: Jessica, 30, Vortrag im Rahmen der Ringvorlesung „Klassiker Österreichischer Literatur“, WS 2015/16, Universität des Saarlandes, 11. Februar 2016. (2015) Text-Bild-Relationen, Vortrag im Rahmen der Ringvorlesung „Interdisziplinäres Traumdenken. Theorien, Methoden, Analysen“, SoSe 2015, Universität des Saarlandes, 14. Juli 2015. (2015) Erzählliteratur, Vortrag im Rahmen der Ringvorlesung „Interdisziplinäres Traumdenken. Theorien, Methoden, Analysen“, SoSe 2015, Universität des Saarlandes am 30. Juni 2015. (2014) „Begabte kleine Schwindlerinnen“. Über die Inszenierungen der Lüge bei Ludmila Ulitzkaja, Vortrag auf der Tagung "Mensonge et genre / Lüge und Geschlecht", Université Aix-Marseille I, 26. bis 27. September 2014. (2014) Europäische Traumkulturen: Forschungsperspektiven (zusammen mit Stefanie Kreuzer), hochschulöffentlicher Vortrag und Präsentation im Rahmen der Vor-Ort-Begehung eines Graduiertenkollegantrags der UdS durch die Deutsche Forschungsgemeinschaft, 11. September 2014 . (2014) Traum-Bilder-Bücher: Wie Text und Bild gemeinsam das Träumen inszenieren, Vortrag im Rahmen der Ringvorlesung "Traumwelten. Texte, Bilder und cinematographische Visionen", SoSe 2014, im Rathausfestsaal der Landeshauptstadt Saarbrücken, 21. Juli 2014. (2014) Stoffgeschichte als transnationales Phänomen. Germanistische und außergermanistische Perspektiven auf Amphitryon, Plenarvortrag auf der Tagung des Verbandes polnischer Germanisten, Universität Rzeszów, 9. bis 11. Mai 2014. (2013) Texte mit nachhaltiger Wirkung? Lesung und Kommentare zum Thema Literatur, Nachhaltigkeit und Ökologie (zusammen mit Dr. Claudia Schmitt), Vortrag im Rahmen der Ringvorlesung „Nachhaltigkeit. Mehr als eine Vision?", Rathausfestsaal der Landeshauptstadt Saarbrücken, 16. Dezember 2013. (2013) Pazifistisches Engagement in Text und Bild: Romain Rolland und Frans Masereel, Vortrag auf der Tagung „Romain Rolland als transkultureller Denker. Netzwerke, Schlüsselkategorien, Rezeptionsformen / Romain Rolland, une pensée transculturelle. Réseaux, notions clés, formes de réception, Universität des Saarlandes, 18. bis 19. Oktober 2013. (2013) Literatur Denken Erzählen. Wechselseitige Herausforderungen zwischen Literatur und Literaturtheorie, Vortrag auf dem Romanistentag Würzburg, innerhalb der Sektion "Literatur als Herausforderung" (Henning Hufnagel / Kai Nonnenmacher / Barabara Ventarola), September 2013. (2013) Quand la théorie se fait roman. Approches systématiques au champ de la théorie racontée, Einleitungsvortrag innerhalb der Sektion „La théorie racontée / Narrated theory“ auf dem Weltkongress der ICLA /AILC „Le comparatisme comme approche critique“, Paris, 20. bis 25. Juli 2013. (2013) Propositions pour l’analyse de la dimension théorique du roman, Einführungsvortrag innerhalb der Sektion „Raconter la théorie dans le roman“ auf dem Weltkongress der International Comparative Literature Association, Paris, 18. bis 24. Juli 2013. (2013) Patriarchen, Widerstandskämpfer, Künstler: Literaturwissenschaftliche masculinity studies am Beispiel der Erzähltexte von Natalia Ginzburg, Vortrag im Rahmen der Ringvorlesung „Gender Studies interdisziplinär“, SoSe 2013, an der Universität des Saarlandes, 15. Mai 2013. (2013) Vom Bild über den Text zur Musik: Frans Masereels „Die Passion eines Menschen“ und ihre Adaptionen, Vortrag im Rahmen der Ringvorlesung "In Bildern erzählen. Frans Masereel im intermedialen Kontext", Universität des Saarlandes, WS 2012/13, 28. Januar 2013. (2012) Identifizierungen auf der Bühne. Amphitryon zwischen Ordnung, Umordnung und Unordnung, Vortrag am Institut für Allgemeine und Vergleichende Literaturwissenschaft der Goethe-Universität Frankfurt am Main, 14. Dezember 2012. (2012) Belgien, Mai 1940: Subjektive Geschichtsdarstellung in Literatur und Bildender Kunst, Vortrag auf dem Colloque du CEGIL "Autobiographies et traces événementielles" (Mimesis 3), 26. Oktober 2012. (2012) Alltagsbewältigung als (Über-)Lebensaufgabe: Flauberts Madame Bovary und Fontanes Mathilde Möhring , Vortrag im Rahmen der interdisziplinären Ringvorlesung "Klassiker-Neulektüren" im Rathaussaal der Stadt Saarbrücken, 18. Juni 2012. (2012) Prekariat und Migration. Ästhetische Verfahren zur Darstellung prekärer Lebens- und Arbeitsverhältnisse von Migrant/innen in Erzählung, Comic und Film, Vortrag auf dem Frankoromanistentag September 2012 in Leipzig, innerhalb der von Roswitha Böhm und Cécile Kovacshazy geleiteten Sektion "'Prekarität’. Texte und Bilder der Krise in der französischen Kultur der Gegenwart". (2012) Filmästhetik der kulturellen Differenz: Fassbinders Angst essen Seele auf , Einführungsvortrag zur Veranstaltungsreihe "Meilensteine der Filmgeschichte" des Kinos Achteinhalb, Saarbrücken, 19. September 2012. (2012) Potenziale und Grenzen des Vergleichs. Versuch einer literatur- und kulturwissenschaftlichen Systematik, Vortrag auf der Tagung "Zwischen Transfer und Vergleich. Theorien und Methoden der Literatur- und Kulturbeziehungen aus deutsch-französischer Perspektive", Saarbrücken, 9. bis 11. Februar 2012. (2011) Les confusions de l’adolescence. Pinocchio entre formation et déformation, Vortrag auf der Tagung „Literature and young adults. A multi-lingual and cross-cultural conference / Littérature et jeunes adultes. Colloque plurilingue et transculturel“, Université du Luxembourg, Centre national de littérature, Mersch, 20. bis 21. Oktober 2011. (2011) Ikarus. Eine Denkfigur für die Herausforderungen und Risiken der Literatur, Vortrag auf dem DFG-Symposium „Literatur als Wagnis / Literature as a Risk“, Villa Vigoni (Loveno/Italien), 3. bis 7. Oktober 2011. (2011) Fabelhafte Selbstbilder aus dem Blickwinkel der Anderen. Zu La Fontaines „Le Paysan du Danube“, Vortrag innerhalb der Sektion „Überall der Andere / Ceci n’est pas l’Autre. Diskursivierung von Alterität in Schriften des 16. bis 19. Jahrhunderts“ auf dem XXXII. Romanistentag in Berlin, 26. bis 29. September 2011. (2011) Lebens-Welt-Verlust? Postmoderne Formen der Welterzeugung am Beispiel von Marlene Streeruwitz, Vortrag auf der XX. Tagung der DGAVL „Figuren des Globalen“, Bonn, 15. bis 18. Juni 2011. (2011) Anderen schreiben. Konzepte der Alterität in literarischen, philosophischen und autobiographischen Texten, Vortrag auf den Journées de l’École Doctorale Transfrontalière LOGOS, Liège, 12. Mai 2011. (2011) Gelehrte am Rande des Abgrunds. Über Professoren in Literatur und Film, Antrittsvorlesung an der Universität des Saarlandes, 31. Januar 2011. (2010) Schicksalsgemeinschaften. Solidarität und Differenz in Isabelle de Charrières Briefromanen, Vortrag auf der Tagung „Konzepte von Gemeinschaft in der Literatur“, Osnabrück, 28. bis 30. Oktober 2010. (2010) Wirklichkeit zwischen Zeugnis und Kunst: Primo Levi und Natalia Ginzburg, Vortrag auf der Tagung „Realismus nach den europäischen Avantgarden“, Paderborn 6. bis 9. Oktober 2010. (2010) Balzacs Sarrasine aus psychoanalytischer Perspektive, Vortrag auf der Tagung "Balzacs Sarrasine. 12 Modellanalysen in der Diskussion", Bremen 24. bis 25. April 2010. (2009) "Träume, die zwangen, Leben und Natur zu ändern". Ansätze zu einer Typologie des Traumerzählens an Beispielen italienischer, französischer und deutschsprachiger Prosa, Vortrag auf dem XXXI. Romanistentag, Bonn, 27. September bis 1. Oktober 2009. (2009) Objets. Odeurs. Bruits. L'écriture du quotidien dans l'œuvre de Madeleine Bourdouxhe, "Relire Madeleine Bourdouxhe dans le contexte de la littérature belge. Colloque international", Paris, Centre Wallonie-Bruxelles, 2. bis 3. April 2009. (2009) Réception et recherche sur l'œuvre de Madeleine Bourdouxhe (zusammen mit Cécile Kovacshazy), introduction au colloque international "Relire Madeleine Bourdouxhe dans le contexte de la littérature belge", Paris, Centre Wallonie-Bruxelles, 2. bis 3. April 2009. (2009) "Vuole la Musa ch'io dica parole". Beispiellektüren moderner italienischer Lyrik, Vortrag auf Einladung des Italienischen Generalkonsulats und der Deutsch-Italienischen Vereinigung e.V. Frankfurt am Main anlässlich des 30-jährigen Bestehens der Zeitschrift Italienisch am 13. Februar 2009. (2008) Textbilder und Bildtexte im Angesicht des Unsagbaren. Autopoetische Dimensionen in Brechts Fotoepigrammen, Spiegelmans ‚Comix' und Herta Müllers Gedichtcollagen, Vortrag auf der XIV. Tagung der Deutschen Gesellschaft für Allgemeine und Vergleichende Literaturwissenschaften "Comparative Arts. Neue Ansätze zu einer universellen Ästhetik", Münster, 26. bis 28. November 2008. (2008) Transferts culturels franco-allemands au 18e siècle : Kant mis à l'épreuve par la littérature française, Vortrag innerhalb des Forschungskolloquiums "Transferts culturels et lieux de mémoire", Littérature et civilisation allemandes, Université Aix-Marseille I, 28. März 2008. (2008) Literatur und Kultur des Mittelmeers aus romanistischer Perspektive, Vortrag auf der Tagung der Forschungsgruppe "La Méditérranée dans les arts, littératures et cultures allemandes" am Département d'Allemand der Université Aix-Marseille I, 7. März 2008. (2007) Les amours des bonnes. Pouvoir, amour et sexualité chez Fleißer et Bourdouxhe. Colloque international "L'amour autour des années vingt et trente. Concepts et représentations", Aix-en-Provence, 11. bis 13. Oktober 2007. (2007) Das Mittelmeer in Literatur und Film: Themen und Topoi, Textsorten und Diskurse. Vortrag auf dem XXX. Romanistentag, 23. bis 27. September 2007 in Wien, innerhalb der Sektion "Mittelmeerdiskurse in Literatur und Film". (2007) Baudelaire: Ein Klassiker auf der Bühne. Wissenschaftlicher Kommentar zur Szenischen Lesung aus den Fleurs du Mal im Rahmen der Reihe "Wort Wörtlich. Literatur trifft Wissenschaft – Theater trifft Universität", Veranstaltung zum Jahr der Geisteswissenschaften, (18. Juni 2007, zusammen mit Dr. Elke Richter und dem Bremer Theater). (2006) Über das Werk von Marlene Streeruwitz, Einführungsvortrag zur Lesung der Autorin im Rahmen der "Literatour Nord", Bremen, 3. Dezember 2006. (2006) Familien - Geschichte - Schreiben. Natalia Ginzburgs Lessico famigliare (1963), "Familiengeschichten. Familienstrukturen in autobiographischen Texten", Internationale Tagung, Universität Bern, 4. bis 7. Oktober 2006. (2006) Literarische Verfahren zur Darstellung des Alltags am Beispiel von Natalia Ginzburgs "Inverno in Abruzzo", Vortrag beim "Dies Academicus Turicensis", Universität Zürich 16. bis 17. Juni 2006. (2005) Vom italienischen Nationalkino zum Gedächtnis des europäischen Films. Das Kino des neorealismo , Vortrag auf der Sektion "Europäischer Film (seit 1945) im Kontext der Romania. Geschichte und Innovation", XXIX. Deutscher Romanistentag, Saarbrücken, September 2005. (2005) Intertextuelle Erotik. Zu Roland Barthes' Fragments d'un discours amoureux , Vortrag auf dem Kolloquium ‚Eros und Literatur' anlässlich der Emeritierung von Prof. Gert Sautermeister, Bremen, 24. Juni 2005. (2004) Entre expérience historique et refus historiographique. La perception subjective de la Seconde Guerre mondiale chez Claude Simon et Madeleine Bourdouxhe, Vortrag innerhalb der Sektion 3 (Literarisierte Geschichtserfahrung in französischsprachigen Texten des 20. Jahrhunderts) des 4. Frankoromanistentages, 28. September bis 1. Oktober 2004 in Freiburg im Breisgau. (2004) Gesetz, Macht und Bildung. Intertextualität in der Fabel, Vortrag mit anschließendem Seminar im Rahmen des studentischen "Bildungsmarathons" anlässlich der geplanten Hochschulreformen, Universität Bremen, 6. bis 7. Januar 2004. (2003) Krise? Trouble? Querelles? Kritik und Perspektiven feministischer Literaturwissenschaft in Deutschland, Vortrag auf der deutsch-französischen Tagung "Une Pensée de la Différence? Deutsch-französischer Dialog über zentrale Begriffe gender-orientierter Theorie", Institut français Bremen, 29. Oktober 2003. (2003) Fiktionen des Forschungsgegenstands. Zur Konstruktion von Werk, Autorschaft und Literaturgeschichte aus unterschiedlichen Perspektiven der gender -Forschung, Vortrag im Rahmen der Ringvorlesung "Empiriebegriffe und Forschungsmethoden in den neueren Philologien", 3-semestrige Veranstaltung des FB 10 der Universität Bremen, 8. Juli 2003. (2003) "Denkerische Dialektik" oder "unsentimentale Zwiesprache"? Zum Verhältnis von Identität und Alterität in philosophischen und autobiographischen Entwürfen, Vortrag auf der Tagung "Erinnerung und Identitätsbildung im autobiographischen Schreiben", Kulturwissenschaftliches Institut Essen, 7. bis 8. März 2003. (2002) Critique littéraire, études féminines et gender studies . Le champ actuel des théories et des méthodes en Allemagne, Vortrag auf der Tagung "Etudes féminines en littérature", Frankreich-Zentrum der Universität Freiburg, 6. bis 7. Dezember 2002. (2002) Inszenierungs-Spiele zwischen Sein und Schein. Das literarische Portrait im 17. Jahrhundert, Internationale Tagung der Universität Bern "Biographien von/für/über Frauen", 6. bis 10. November 2002. (2002) Das Feld der Beziehungen zwischen Literatur und Philosophie, Einleitungsvortrag auf dem 3. Aachener Frankoromanistentag innerhalb der Sektion "Auf der Grenze zwischen Literatur und Philosophie. Konkurrierende, komplementäre oder synergetische Formen der Sinnerschließung?" 26. bis 29. September 2002. (2001) Über das Handhaben von Alltagsgegenständen in Philosophie und Literatur. Ernst Bloch, Georg Simmel, Theodor W. Adorno und Madeleine Bourdouxhe, Vortrag auf der Tagung "Ablösung oder Erneuerung. Zur Literaturwissenschaft als Kulturwissenschaft", Universität Siegen, 14. bis 16. November 2001 und 19. bis 21. Januar 2002. (2001) Pinocchio und die Funktion der Puppe im risorgimento , Vortrag auf dem XXVII. Deutschen Romanistentag "Die Einheit der Vernunft in der Vielzahl ihrer Stimmen", innerhalb der Sektion "Das Andere der Vernunft: Puppen, Automaten, Marionetten", München 7. bis 10. Oktober 2001. (1998) "Cette différence prétendue". Zur Problematik einer ‚weiblichen' Subjektivität in den Texten von Isabelle de Charrière, Vortrag beim Nachwuchskolloquium der Romanistik "Geschlechterdifferenzen", Greifswald, 4. bis 6. Juni 1998. (1998) Von Müttern und Mythen. Mit Marie de Sévigné auf der Suche nach einer weiblichen Genealogie, Vortrag innerhalb der Vortragsreihe: "‚Ich ohne Gewähr’. Relektüren weiblicher Subjektivität. Feministische Theorie und Literaturwissenschaft im Dialog", Universität Bremen, Sommersemester 1998.

and Synchronic Evidence." Doctoral dissertation, University of Tübingen. 6. [J] (2004) "Short-distance [...] (Bachelor thesis) 2025 Becker, Laura: A multimodal linguistic analysis of ring and finger bunch gestures [...] in children's recipes and students' recipes - a corpus-based study (second supervisor) (Staatsexamen

Archiv News © André Schäfer 09.02.2026 | Promotion von Anna Michaely Wir gratulieren Anna Michaely herzlich zur erfolgreich abgeschlossenen Doktorarbeit im Bereich der mechanochemischen Reduktion von Metalloxiden . In ihrer Forschung gelang es ihr, neue synthetische Zugänge zu reduzierten Titan‑, Vanadium‑ und Nioboxiden zu entwickeln. Die Ergebnisse eröffnen vielversprechende Perspektiven für nachhaltigere Reduktionsprozesse, da sie zeigen, dass durch mechanochemische Verfahren deutlich niedrigere Temperaturen und somit ein geringerer Energieeinsatz möglich sind als bei klassischen Reduktionsmethoden. Wir freuen uns über diesen wichtigen wissenschaftlichen Beitrag und wünschen Anna alles Gute für ihren weiteren Lebensweg! © André Schäfer 29.01.2026 | Promotion von Svenja Pohl In ihrer Doktorarbeit befasste sich Svenja Pohl mit der Synthese sogenannter Melting Gele aus Trialkoxysilanen sowie der detaillierten Aufklärung ihrer Struktur und der zugrunde liegenden Struktur‑Eigenschafts‑Beziehungen. Ihre Forschung lieferte entscheidende Erkenntnisse zur Ursache der Bildung dieser besonderen thermoplastischen Hybridpolymere, die aus einem Sol‑Gel‑Prozess hervorgehen. Svenja gelang es dabei nicht nur, grundlegende Mechanismen der Bildung zu identifizieren, sondern auch das Potenzial der gewonnenen Erkenntnisse für Anwendungen im Bereich optischer Materialien aufzuzeigen. Wir freuen uns über diesen bedeutenden wissenschaftlichen Beitrag und wünschen Svenja alles Gute für ihre Zukunft! © M. Gießelmann 09.01.2026 | Promotion von Elias C. J. Gießelmann Wir gratulieren Elias C. J. Gießelmann zum erfolgreichen Abschluss seiner Promotion die mit der Bestnote summa cum laude ausgezeichnet wurde! In seiner Doktorarbeit konzentrierte Elias sich auf die Synthese und Charakterisierung intermetallischer Aluminiumverbindungen und deren Oxidationsverhalten. In etwas mehr als drei Jahren entstanden dabei zehn Publikationen bei denen er Erstautor ist, darüber hinaus noch neun weitere Arbeiten bei denen er Untersuchungen beigesteuert hat. Dies betrifft insbesondere die Festkörper-NMR-Spektroskopie an verschiedenen Kernen. Wir freuen uns über diese wichtigen wissenschaftlichen Beiträge und wünschen Elias alles Gute für seine Zukunft! © Guido Kickelbick Die Projektverantwortlichen für das Verbundprojekt (v. links): Prof. Ralf Kautenburger (UdS), Prof. Guido Kickelbick (UdS), Angelika Meyer (UdS), Heinrich Becker (MUKMAV), Dr. Jens Götzinger (MUKMAV). 17.12.2025 | Gemeinsam für saubere Gewässer: Wegweisendes Projekt stärkt Gewässerschutz im Saarland Die Anorganische Chemie der Universität des Saarlandes und das Ministerium für Umwelt, Klima, Mobilität, Agrar und Verbraucherschutz (MUKMAV) setzen ihre langjährige erfolgreiche Zusammenarbeit fort. Mit dem Abschluss des bisherigen Projekts und dem Start eines neuen fünfjährigen Verbundprojekts Mitte 2026 wird die Forschung zur Bewertung des Zustands saarländischer Gewässer intensiviert. Ein Schwerpunkt liegt auf den Auswirkungen neuer Anforderungen der EU-Kommunalabwasserrichtlinie und der Umsetzung der Wasserrahmenrichtlinie im Saarland. Hierbei sollen neben den etablierten Echtzeit-Messungen mittels mobiler Messstationen auch automatische Probenehmer zum Einsatz kommen, um organische und anorganische Mikroschadstoffe („emerging pollutants“) aus diffusen und punktuellen Quellen zu erfassen. Ergänzend dazu widmet sich das Projekt der Analyse kleiner Einzugsgebiete, um spezifische umweltrelevante Fragestellungen zu beantworten. Mit diesem Projekt leisten die Partner einen entscheidenden Beitrag zur nachhaltigen Entwicklung und zum Schutz der saarländischen Gewässer. 02.10.2025 | Neue Publikation zur mechanochemischen Aktivierung von NaTi₂(PO₄)₃ In einer neuen Veröffentlichung untersuchten Tobias Straub und Elias Gießelmann, wie sich die mechanochemische Aktivierung (MCA) auf die Natrium-Interkalation in NaTi₂(PO₄)₃ (NTP) auswirkt – einem vielversprechenden Material aus der NASICON-Familie für die Natrium-Ionen-Energiespeicherung. In der Studie wurde gezeigt, dass durch gezieltes Mahlen die Kristallitgröße deutlich reduziert und die spezifische Oberfläche erhöht werden kann. Diese strukturellen Veränderungen beeinflussen maßgeblich die Fähigkeit des Materials, Natriumionen aufzunehmen. Besonders deutlich wurde, dass die Effizienz der Interkalation nicht nur von der mechanischen Aktivierung abhängt, sondern auch stark durch die chemische Natur des verwendeten Natriumquellen bestimmt wird. Die Studie ist in der Fachzeitschrift RSC Mechanochemistry erschienen. Zur Publikation . 02.10.2025 | Erstmalige mechanochemische Synthese von MgV₂O₄ In einer aktuellen Publikation berichtet unsere Arbeitsgruppe in Zusammenarbeit mit den Gruppen von Prof. Chris Kay (Universität des Saarlandes) und Prof. Oliver Clemens (Universität Stuttgart) über die erfolgreiche Synthese von Magnesiumvanadat (MgV₂O₄) mittels mechanochemischer Verfahren. Im Rahmen der Arbeit untersuchte Anna Michaely, wie sich die Wahl der Ausgangsstoffe sowie die Intensität des Mahlvorgangs auf die Phasenbildung, Mikrostruktur und elektrochemischen Eigenschaften von MgV₂O₄ auswirken. Die Synthese erfolgte durch Hochenergie-Kugelmühlen, wobei insbesondere die exotherme Reaktion zwischen V₂O₅ und Mg innerhalb von nur 20 Minuten zur Bildung der gewünschten Spinellphase führte. Begleitende DFT-Berechnungen lieferten wichtige thermodynamische Hinweise zur Reaktivität der verschiedenen Eduktkombinationen. Die Ergebnisse zeigen, dass moderate Mahlbedingungen zu einer verbesserten Leitfähigkeit führen, während zu intensive Mahlprozesse strukturelle Defekte und eine erhöhte Korngrenzenresistenz verursachen. Zur Publikation . © Oliver Janka 19.-22. Juni 2025 | Elias Gießelmann und Oliver Janka nehmen am 52.ten Ferstkörperseminar in Hirschegg teil Elias Gießelmann und Oliver Janka nahmen auch in diesem Jahr wieder am Festkörperseminar in Hirschegg teil. Elias Gießelmann präsentierte seine Forschungsergebnisse in einem Vortrag zum Thema „Frank-Kasper-Phasen im ternären System Hf-Nb-Al”. © Guido Kickelbick, Lena Ruck 18.06.2025 | Gemeinsam aktiv: Die Arbeitsgruppe beim Firmenlauf 2025 Der Firmenlauf ist mittlerweile ein fester Bestandteil im Jahreskalender unserer Arbeitsgruppe – und auch in diesem Jahr war wieder ein motiviertes Team am Start. Dabei ging es nicht um sportliche Höchstleistungen, sondern um den Spaß am gemeinsamen Laufen und Ankommen. Mit viel Teamgeist und guter Laune zeigte die Gruppe, dass Gemeinschaft auch außerhalb des Labors eine wichtige Rolle spielt. Ein herzliches Dankeschön an alle Teilnehmenden für ihren Einsatz und die tolle Atmosphäre! 26.05.2025 | Mechanochemisches Defekt-Engineering von Nb₂O₅: Neue Studie zur Strukturmodifikation und Photokatalyse In einer aktuellen Studie wurde die mechanochemische Teilreduktion von Niobpentoxid (Nb₂O₅) mithilfe der Reduktionsmittel LiBH₄ und NaBH₄ systematisch untersucht. Ziel war es, durch gezieltes Defekt-Engineering die elektronischen und photokatalytischen Eigenschaften des Materials zu verbessern. Die Ergebnisse zeigen, dass eine mechanochemische Reduktion unter den verwendeten Bedingungen möglich ist. Überraschenderweise führen jedoch höhere Konzentrationen der Hydride nicht zwangsläufig zu einer stärkeren Reduktion, da sie mechanische Energie puffern und somit die Effizienz des Prozesses mindern. Die reduzierten Proben zeigten eine deutlich verbesserte photokatalytische Aktivität bei der Zersetzung von Methylenblau unter sichtbarem Licht – ein vielversprechender Ansatz für Anwendungen in der Umwelttechnik. Die vollständige Studie wurde in der Fachzeitschrift Solids veröffentlicht. Zur Publikation © David Aaron Schaaf 24.05.2025 | Faszination Chemie - Beteiligung am Offenen Campus 2025 Auch in diesem Jahr beteiligte sich Prof. Guido Kickelbick aktiv am Offenen Campus 2025 der Universität des Saarlandes und präsentierte gleich zwei spannende Beiträge aus der Welt der Chemie. In seiner Experimentalvorlesung „Chemiker haben für alles eine Lösung: Wasserstoff und Wasserstofftechnologie“ führte er die Besucherinnen und Besucher zusammen mit der Laborantin Henrike Waller in die faszinierende Welt des Wasserstoffs ein. Dabei zeigte er eindrucksvoll das Potenzial dieses Elements für eine nachhaltige Energiezukunft – insbesondere mit Blick auf die Region Saarland. Zusätzlich lud Prof. Kickelbick unter dem Titel „Das Universum auf einen Blick: Das Periodensystem der Elemente“ zu einer interaktiven Entdeckungsreise durch das Periodensystem ein. Im Foyer des Hörsaalgebäudes Chemie konnten Interessierte anhand eines großformatigen, interaktiven Periodensystems die Vielfalt und Bedeutung der chemischen Elemente erleben. 24.05.2025 | Superparamagnetische Ferrit-Nanopartikel: Neue Syntheseroute verbessert Eigenschaften In einer aktuellen Studie von Kimia Moghaddari wurden superparamagnetische Ferrit-Nanopartikel mit Durchmessern zwischen 5 und 8 nm mittels thermischer Zersetzung und Mikrowellen-gestützter Synthese hergestellt und systematisch hinsichtlich ihrer strukturellen und magnetischen Eigenschaften verglichen. Die Ergebnisse zeigen, dass die Wahl der Metallionen und der Synthesemethode entscheidenden Einfluss auf die Eigenschaften der Partikel hat. Besonders Co-substituierte Ferrite überzeugten durch eine deutlich verbesserte Aufheizfähigkeit im magnetischen Wechselfeld und eine erhöhte spezifische Absorptionsrate (SAR). Die Mikrowellen-gestützte Synthese führte zu einer gleichmäßigeren Partikelgröße, einer optimierten Zusammensetzung und einer erhöhten Magnetisierung. Die Studie unterstreicht die Bedeutung der gezielten Materialentwicklung für Anwendungen in der Materialwissenschaft, insbesondere im Bereich der induktiven Erwärmung. Die vollständige Studie wurde veröffentlicht in Nanoscale Advances . Zur Publikation 30.04.2025 | Neue Publikation zum 65.ten Geburtstag von Prof. Gordon Miller in der ZAAC erschienen In einer gemeinsamen Publikation der UdS und der Universität Münster konnte Elias Gießelmann zeigen, dass Hf 6 Al 7 und die ternäre Colorierungsvariante Hf 4.44(1) Nb 1.56(1) Al 7 existieren. Die Verbindungen wurden aus den Elementen hergestellt und röntgenographisch und spektroskopisch auf verschiedenste Weise untersucht. Die Arbeit wurde Prof. Gordon Miller zum 65.ten Geburtstag gewidmet. https://onlinelibrary.wiley.com/doi/10.1002/zaac.202500044 30.04.2025 | Stefan Engel verteidigt erfolgreich seine Dissertation Im Rahmen seiner Doktorarbeit hat Stefan Engel den Elektronenübertrag in intermetallischen Aluminiumverbindungen sowohl aus explorativer als auch aus systematisch präparativer Sicht beleuchtet. Dabei hat erausgewählte und bislang nur wenig untersuchte ternärer Systeme M – T –Al genauer unter die Lupe genommen und dabei eine Vielzahl neuer Verbindungen synthetisiert. Herzlichen Glückwunsch zur erfolgreichen Promotion! Seit Anfang Mai 2025 ist er nun am Heinz Maier-Leibnitz Zentrum in Garching in der Advanced Materials Group unter Leitung von PD Dr. Ralph Gilles. 9.04.2025 | Schnelle mechanochemische Reduktion von V₂O₅ mit Natriumhydrid realisierbar In ihrer aktuellen Publikation berichtet Anna Michaely über die mechanochemische Reduktion von Vanadiumpentoxid (V₂O₅) mit Natriumhydrid (NaH) – ein hoch exothermer Prozess, der bereits nach wenigen Minuten bei Raumtemperatur abläuft und neue Wege für die energieeffiziente Materialumwandlung eröffnet. Im Gegensatz zu klassischen Hochtemperaturverfahren ermöglicht die mechanochemische Methode eine schnelle und ressourcenschonende Synthese. Dabei entstehen verschiedene Vanadiumoxide und Natriumvanadate mit Oxidationsstufen von +V bis +III. Die Reaktionen sind so energiereich, dass sie sogar in einem einfachen Pistill-Mörser-Setup beobachtet werden konnten. Die Studie zeigt, dass die Konzentration des Reduktionsmittels NaH einen entscheidenden Einfluss auf die Zusammensetzung der Endprodukte hat – deutlich stärker als die mechanischen Parameter des Mahlprozesses. Mit zunehmender NaH-Menge werden bevorzugt Natriumvanadate mit Vanadium in der Oxidationsstufe +V gebildet. Theoretische Berechnungen bestätigen, dass diese Verbindungen die treibende Kraft hinter den beobachteten exothermen Reaktionen sind. Die Ergebnisse liefern wertvolle Einblicke in die Defekt- und Interkalationschemie von Vanadiumoxiden und eröffnen neue Perspektiven für deren Einsatz in der elektrochemischen Energiespeicherung. Die Studie wurden in der Zeischrift Inorganic Chemistry veröffentlicht. Zur Publikation Elias Gießelmann beim Vortrag auf dem ACS Spring Meeting in San Diego, CA 23.-27.03.2025 | Elias Gießelmann und Oliver Janka präsentieren ihre Ergebnisse auf dem ACS Spring Meeting in San Diego, CA, USA Elias Gießelmann und Oliver Janka haben im Rahmen des ACS Spring Meetings in San Diego, CA, USA ihre Forschungsergebnisse vorgestellt. Elias Gießelmann sprach dabei über “Oxidation Behavior of Intermetallic Aluminum Compounds”, Oliver Janka über “Intermetallic aluminum compounds – structures and properties”. 20.01.2025 | Neue Studie zu thermoplastischen Polysilsesquioxanen mit aromatischen Substituenten veröffentlicht In einer aktuellen Publikation untersuchte Svenja Pohl in Kooperation mit Prof. Markus Gallei, wie sich die Größe und Isomerie polyzyklischer aromatischer Gruppen auf die Struktur und die thermischen Eigenschaften von Polysilsesquioxanen auswirken. Diese Materialien sind bekannt dafür, dass sie sich oberhalb ihrer Glasübergangstemperatur reversibel erweichen und bei höheren Temperaturen irreversibel vernetzen lassen – ein Verhalten, das sie für Anwendungen als thermoplastische und duroplastische Werkstoffe interessant macht. Die Studie zeigt, dass die Wahl des Substituenten entscheidenden Einfluss auf die Kondensationsreaktion, die Molekülstruktur und die Verarbeitbarkeit der resultierenden Materialien hat. Während die sperrigen Substituenten die Kettenbeweglichkeit stark einschränken und zu starren, käfigartigen Strukturen führen, ermöglichen die kleineren Naphthyl-Derivate die Bildung von thermoplastischen Gläsern mit hoher thermischer Stabilität bis zu 460 °C. Besonders hervorzuheben ist, dass die modifizierten Polysilsesquioxane neben ihrer thermoplastischen Verformbarkeit auch optische Eigenschaften wie Fluoreszenz und einen hohen Brechungsindex aufweisen. Diese Kombination macht sie zu vielversprechenden Kandidaten für Anwendungen in der Optoelektronik und anderen Bereichen der siloxanbasierten Materialentwicklung. Die vollständige Studie wurde in der Fachzeitschrift Macromolecules veröffentlicht. Zur Publikation 14.01.2025 | Intermetallische Phasen können selektiv sulfidiert und in Silicium-basierte Polymere eingearbeitet werden. In einer gemeinsamen Studie der Gruppen von Prof. Kickelbick (UdS), Prof. Jörn Schmedt auf der Günne (Uni Siegen), Mitarbeitern der Uni Münster und PD Dr. Janka (UdS) konnte gezeigt werden, dass die intermetallischen Verbindungen CaAl 2 , SrAl 2 und EuAl 2 selektiv in die Sulfide MAl 2 S 4 überführt werden können. EuAl 2 S 4 zeigt hierbei eine grüne Lumineszenz und kann in sogenannte “Melting Gele” eingearbeitet werden, welche das Material vor Feuchtigkeit schützen und Formgebung erlauben. Detailierte NMR Untersuchungen wurden in Siegen, magnetische und Mößbauer spektroskopische Untersuchungen in Münster durchgeführt. Die Arbeit ist im Journal Chemistry of Materials erschienen. Link zur Arbeit 09.01.2025 | Photokatalytisch aktive Oberflächen mittels direkter Laserinterferenzstrukturierung In einem gemeinsamen Projekt mit Tobias Fox aus der Arbeitsgruppe Funktionsmaterialien von Prof. Mücklich wurde die Methode der direkten Laserinterferenzstrukturierung (DLIP) eingesetzt, um in einem einzigen Verarbeitungsschritt photokatalytisch aktive TiO₂-Oberflächen zu erzeugen. Diese innovativen Oberflächen sind vielversprechende Kandidaten für selbstreinigende oder antifouling Anwendungen sowie für die photokatalytische Wasseraufbereitung. Die Studie zeigt, wie Wärmebehandlungen während und nach der Laserbearbeitung die photokatalytische Aktivität gezielt beeinflussen können. Zur Demonstration der Skalierbarkeit wurde zudem ein kompakter Prototyp eines Reaktors aus kostengünstigen Materialien entwickelt. Die Ergebnisse wurden in der renommierten Fachzeitschrift Advanced Materials Interfaces veröffentlicht. Zur Publikation 13.12.2024 | Intermetallische Phasen zwischen Zirkonium, Vanadium und Aluminium zeigen interessante Strukturen und Eigenschaften Elias Gießelmann konnte in einer Studie zeigen, dass neue intermetallische Phasen mit den Elementen Zirkonium, Vanadium und Aluminium entstehen. Die Verbindungen zeigen eine interessante Strukturchemie, Pauli-Paramagnismus und Supraleitfähigkeit mit einer Sprungtemperatur von 4,17(1) K. Die Studie wurde zusammen mit Dr. Oliver Janka veröffentlicht in Chemistry - A European Journal (siehe: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202404248 ). 15.11.2024 | Großer Erfolg für den Standort: Chemie Graduiertenkolleg zum Thema Konstruktion von kovalenten Bindungen in Molekülen und Materialien wird über fünf Jahre von der Deutschen Forschungsgemeinschaft gefördert. Die Deutsche Forschungsgemeinschaft (DFG) fördert ab 01. Oktober 2025 das Graduiertenkolleg 3082 „Engineering of Covalent Bonds in Molecules and Materials – Ec=m 2 ” in Saarbrücken mit rund 6,3 Millionen Euro. Die Arbeitsgruppe Kickelbick ist mit mehreren Projekten beteiligt. Herzlichen Glückwunsch an alle Beteiligten. Näheres unter https://ecm2.org oder in der Pressemitteilung der UdS . November 2024 |Alexander-von-Humboldt Forschungsaufenthalt von Dr. Mathilde Laird endet Mathilde Laird war fast zwei Jahre lang Postdoktorandin in unserer Gruppe. In dieser Zeit hat sie an Silsesquioxan-Materialien als Ausgangsstoff für verschiedene Funktionsmaterialien gearbeitet. Wir haben alle sehr viel voneinander gelernt. Vielen Dank für die fruchtbare gemeinsame Zeit. Mathilde beginnt jetzt ihre eigene Forschungskarriere am CNRS in Frankreich. Viel Erfolg für die Zukunft. Wir werden auch in Zukunft zusammenarbeiten. 23.10.2024 | Polymere mit Germanium Doppelbindungssystemen – Gemeinsamer Artikel mit Arbeitsgruppe Scheschkewitz Der Arbeitsgruppe von Scheschkewitz gelang es, ein konjugiertes Polymer mit Ge=Ge-Doppelbindungen herzustellen. Wir konnten bei der Aufklärung der Struktur helfen. Die Arbeit ist in der Zeitschrift Angewandte Chemie veröffentlich worden (siehe: https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202415103 ) Oktober 2024 | Paula Mayer beginnt Masterarbeit zum Thema „Spaltbare Disulfid-Funktionalitäten auf superparamagnetischen Nanopartikeln“ 27.09.2024 | Kontinuierliche nasschemische Herstellung von Zinnoxid Nanopartikeln für Sensoranwendungen Mit unserem etablierten Mikrojet-Verfahren konnte Christina Odenwald Zinnoxid-Nanopartikel mit einer Größe von 3 nm herstellen. Das Verfahren erlaubt ein einfaches Upscaling der Synthese. Gemeinsam mit der Arbeitsgruppe von Dr. Tilman Sauerwald am Fraunhofer-Institut für Verfahrenstechnik und Verpackung (IVV) in Freising konnten wir nachweisen, dass diese Partikel direkt für die Anwendung in Ethanol-Gassensoren eingesetzt werden können. Die Arbeit ist in der Zeitschrift für anorganische und allgemeine Chemie veröffentlicht worden (siehe: https://onlinelibrary.wiley.com/doi/full/10.1002/zaac.202400145 ) und wurde Prof. Michael Veith zum 80. Geburtstag gewidmet. 28.08.2024 | Kontinuierliche Herstellung von Vorstufen für Batteriematerialien Molybdänkarbide, -nitride, -oxide und deren gemischte Verbindungen Mo(C,N,O)x sind vielversprechendes Anodenmaterialien für Lithiumbatterien. Mana Abdirahman Mohamed gelang es, Vorstufen dieser Materialien aus wässrigen Lösungen mit Hilfe des Mikrojet-Prozesses herzustellen, der die Synthese dieser Vorläuferverbindungen im Gramm-Maßstab innerhalb von Minuten ermöglicht. Die Pyrolyse dieser Vorstufen führt zu den gewünschten Feinkörnigen Pulvern, die als Batteriematerialien Anwendung finden können. Die Studie wurde in der Zeitschrift Solids veröffentlicht (siehe: https://www.mdpi.com/2673-6497/5/3/30 ). 08.07.2024 | SR3 Bericht zu Gefahren beim Vermischen von Putzmitteln Henrike Waller und Prof. Guido Kickelbick haben in einem Bericht für das Radioprogramm SR3 Saarlandwelle über die Gefahren der Mischung verschiedener Putzmittel im Haushalt aufgeklärt. Moderator Max Zettler erlebte die Risiken dieser Mischungen hautnah bei Experimenten in den Laboren der Anorganischen Chemie. ( Link zum Bericht ) 26.06.2024 | Prof. Guido Kickelbick wieder in den Senat der Universität des Saarlandes gewählt Prof. Guido Kickelbick wurde für eine zweite Amtszeit in den Senat der Universität des Saarlandes gewählt. Zusammen mit Prof. Volkhard Helms vertritt er die Interessen der Naturwissenschaftlich-Technischen Fakultät. 13.-15.06.2024 | Teilnahme am 51. Hirschegg-Festkörperseminar Auch in diesem Jahr haben sich wieder zahlreiche Festkörperchemiker im Marburger Haus in Hirschegg, AT zum bereits 51. Hirschegg-Festkörperseminar getroffen. Aus Saarbrücken waren dieses Mal Anna Michaely, Elias Gießelmann, Stefan Engel und Oliver Janka dabei. Wie in Hirschegg üblich, werden die Vorträge überwiegend vom wissenschaftlichen Nachwuchs bestritten und so haben natürlich auch Anna, Elias und Stefan ihre Forschungsergebnisse vorgestellt. Am Freitag Vormittag ging es wieder traditionell wandern, dieses Mal wurde, bei leider eher durchwachsenem Wetter, der 2058 Meter hohe Gipfel der Kanzelwand (siehe Bild) erklommen. 13.06.2024 | Vortrag beim Rotary Club St. Ingbert Prof. Guido Kickelbick hält einen Vortrag beim Rotary Club St. Ingbert zum Thema „Im Kreislauf denken - Die Rolle der Naturwissenschaften im gesellschaftlichen Transformationsprozess“. © Bastian Popp 8.06.2024 | Wasserstoff und Periodensystem – Themen am Tag der offenen Tür Wasserstoff, das leichteste und häufigste Element im Universum, ist ein Schlüsselfaktor für eine grünere und nachhaltigere Zukunft. Doch was steckt hinter diesem faszinierenden Element? Wie wird es hergestellt und wofür wird es verwendet? Prof. Guido Kickelbick gibt in einem Vortrag, gespickt mit Experimenten, Einblicke in die Chemie des Wasserstoffs. Am Tag der offenen Tür können die Besucherinnen und Besucher im Foyer des Chemie-Hörsaalgebäudes auch mehrere Kurzvorträge vor dem neuen Periodensystem der Elemente erleben. Diese Präsentationen enthüllen nicht nur die Geheimnisse des Universums, sondern auch die Wissenschaft hinter alltäglichen Gegenständen, die wir täglich nutzen. 24.04.2024 | Mechanochemie erzeugt schnell und energiesparend reduzierte Vanadiumoxide Vanadiumoxide zeigen vielversprechende Eigenschaften für die elektrochemische Energiespeicherung, da sie in Kombination mit Alkalimetallen zwischen verschiedenen Oxidationszuständen wechseln können. In einer systematischen Untersuchung konnte Anna Michaely nachweisen, dass Vanadium(V)oxid auf einfache Weise mechanochemisch reduziert werden kann. Durch dieses neue Reaktionsverfahren lassen sich im Vergleich zu herkömmlichen Hochtemperatursynthesemethoden sowohl Energie als auch Zeit einsparen. Die reduzierten Vanadiumoxide entstehen sogar in einer sich selbst ausbreitenden Reaktion in einem einfachen Kolben-Mörser-Aufbau. Diese umfassende Studie beleuchtet die mechanochemische Reduktion von Vanadiumoxiden und unterstreicht ihr Potenzial für die Weiterentwicklung elektrochemischer Energiespeichersysteme. Die Arbeit wurde heute in Inorganic Chemistry publiziert (siehe https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.4c00200 ). 23.04.2024 | Vorlesungsreihe Raumschiff Erde - Nachhaltigkeit startet wieder Auch in diesem Sommersemester wird wieder die interdisziplinäre Vorlesungsreihe "Raumschiff Erde – Nachhaltigkeit" unter der Organisation von Prof. Kickelbick angeboten. Diese Reihe bietet ein vielfältiges Programm, das das Thema Nachhaltigkeit aus verschiedenen wissenschaftlichen Perspektiven beleuchtet. Hier finden Sie das detaillierte Programm. 2022/23/24 19.04.2024 | Promotion von Bastian Oberhausen Selbstheilende Nanokomposite auf Polymerbasis sind eine vielversprechende Klasse von Werkstoffen, die durch ihre deutlich längere Lebensdauer im Vergleich zu herkömmlichen Materialien zur Ressourcenschonung und somit zu einer nachhaltigeren Zukunft beitragen können. In seiner Dissertation untersuchte Bastian Oberhausen die Integration von superparamagnetischen Eisenoxid-Nanopartikeln als Vernetzungspunkte in Polymere. Die resultierenden Nanokomposite zeigen unter dem Einfluss eines magnetischen Wechselfeldes ein selbstheilendes Verhalten nach Beschädigung. Heute findet das abschließende Rigorosum seiner Promotion statt. 08.04.2024 | Wie beeinflusst die chemische Verarbeitung dielektrische Membranen? Dielektrische Elastomerwandler (DETs), d.h. hoch dehnbare dielektrische Membranen zwischen zwei nachgiebigen Elektroden, ermöglichen die Entwicklung von Sensoren, Aktoren und Generatorsystemen. Die Leistung von DETs hängt stark von den Materialeigenschaften des Dielektrikums und der Elektroden sowie vom Herstellungsprozess ab. Die Herstellung von Elektroden im Siebdruckverfahren erfordert erhebliche Mengen an Lösungsmitteln, um die Viskosität der Druckmaterialien einzustellen, wodurch sich die Eigenschaften der DETs möglicherweise verändern können. Dieser Effekt ist bisher wenig erforscht. In einer gemeinsamen Studie mit den Arbeitsgruppen von Prof. Gianlucca Rizzello, Prof. Paul Motzki und Prof. Stefan Seelecke wurde der Einfluss verschiedener Lösungsmittel auf ein DET untersucht. Die Ergebnisse zeigen, dass das verwendete Lösungsmittel den elektrischen Widerstand der Elektroden stark beeinflusst, aber die Durchschlagsfestigkeit des reinen Dielektrikums nicht verändert. Diese Erkenntnisse liefern systematische Leitlinien für die Auswahl von Lösungsmitteln bei der Herstellung von DET-Elektroden. Die Studie wurde heute in der Zeitschrift Advanced Engineering Materials veröffentlicht (siehe: https://onlinelibrary.wiley.com/doi/10.1002/adem.202301736 ). 03.04.2024 | Übersichtsartikel zu intermetallischen Yb-Verbindungen veröffentlicht Stefan Engel, Elias Gießelmann und Oliver Janka haben, in Zusammenarbeit mit Maximilian Reimann und Rainer Pöttgen von der Universität Münster, einen Übersichtsartikel zum Thema "Über die Ytterbium-Valenz und die physikalischen Eigenschaften in ausgewählten Intermetallischen Phasen" verfasst. Dieser wurde nun im Open-Access Journal "ACS Organic & Inorganic Au" veröffentlicht. Darüber hinaus wurde den Autoren die Ehre zu teil, das Titelbild für diesen Artikel gestalten zu dürfen. DOI: 10.1021/acsorginorgau.3c00054 21./22.03.2024 | Die Arbeitsgruppe Kickelbick nimmt an der ATC2024 in Würzburg teil Die Tagung Anorganische Technische Chemie (ATC) fand am 21. und 22. Februar 2024 am Fraunhofer-Institut für Silicatforschung in Würzburg statt. Sie stand unter dem Thema "Anorganische Chemie im Dienste der Nachhaltigkeit". Anna Miachaely präsentierte in einem Vortrag ihre Arbeit zur mechanochemischen Herstellung von photokatalytisch aktivem schwarzen Titandioxid. Kimia Moghaddari präsentierte ein Poster über ihre Arbeit zur Herstellung von superparamagnetischen Nanopartikeln für selbstheilende Materialien. 08.03.2024 | Prof. Kickelbick zu Gast am Albertus-Magnus-Gymnasium St. Ingbert Prof. Guido Kickelbick besuchte den Leistungskurs Chemie von Frau Silke Erlemeier am Albertus-Magnus Gynasium in St. Ingbert. Er stellte das Fach Chemie an der Universität des Saarlandes und den typischen Ablauf eines Chemiestudiums vor und sprach über mögliche Berufe für Chemiker. Außerdem berichtete er über seine Forschungsgebiete und es bestand die Möglichkeit zur direkten Diskussion. 06.03.2023 | Prof. Kickelbick nimmt an Dialogabend zum Thema „Wasserstoff – Chance oder Illusion?“ teil Die Frage „Wasserstoff – Chance oder Illusion?“ stand am Mittwoch, den 6. März, ab 18 Uhr im Saarbrücker Schlosskeller im Fokus eines Vortrages mit anschließender Podiumsdiskussion, an der sich unter anderem der saarländische Minister für Wirtschaft, Innovation, Digitales und Energie, Jürgen Barke, und Vertreter aus der saarländischen Wirtschaft und Wissenschaft beteiligten, darunter auch Prof. Guido Kickelbick. Der Abend war Teil der Vortragsreihe "Baustelle Nachhaltigkeit - Wege zu einer klimagerechten Gesellschaft" aus der Dialogreihe am Saarbrücker Schloss. Zunächst ging Dr. Joachim Fünfgelt, Referent für Energiepolitik im Referat Wirtschaft und Nachhaltigkeit bei der NGO Brot für die Welt, in seinem Vortrag auf die Chancen und Herausforderungen von Wasserstoff als Energieträger ein. In der anschließenden Podiumsdiskussion wurden Fragestellungen zum Thema des Abends diskutiert. 27.02.2024 | Synthese von Titandioxid Nanopartikeln mit zwei unterschiedlichen Funktionen auf gegenüberliegenden Seiten gelungen Wie kann man Nanopartikel selektiv auf ihren gegenüberliegenden Seiten mit unterschiedlichen chemischen Funktionen versehen? Diese Frage hat Lucas Niedner in seiner aktuellen Studie untersucht. Ihm gelang es, die sogenannte Janus-Modifikation mithilfe eines einfachen einstufigen Pickering-Emulsionsverfahrens zu erreichen. Durch die Modifikation der Partikel auf der einen Seite mit hydrophoben Gruppen und auf der anderen Seite mit ionischen Gruppen erhielten die Nanopartikel einen amphiphilen Charakter. Dank dieser unterschiedlichen Funktionalitäten konnten die Janus-Partikel mittels eines einfachen Schicht-für-Schicht-Ansatzes auf Glassubstraten abgeschieden werden. Die Ergebnisse dieser Arbeit wurden heute in der Fachzeitschrift Nanoscale veröffentlicht (siehe: https://pubs.rsc.org/en/content/articlelanding/2024/nr/d3nr04907h ). 20.02.2024 | Laborantinnen Traudel Allgeyer und Christel Hassler verabschiedet Die Laborantinnen Traudel Allgeyer und Christel Hassler wurden in den Ruhestand verabschiedet. Beide haben jahrzehntelang Studierende in Chemiepraktika betreut und die Forschung am Institut unterstützt. 12.01.2024 | Prof. Kickelbick als DJ bei der Night of the Profs Prof. Kickelbick trat als DJ Chemical Brother bei der "Night of the Profs" auf. Die Unterstützung durch die Studierenden und Mitarbeiterinnen und Mitarbeiter des Fachbereichs Chemie war immens. Fotos von der Veranstaltung finden Sie hier daneben gab es auch einen Bericht über die Veranstaltung im Saarländischen Rundfunk . 08.01.2024 | Vortrag bei UdS - Korean Winter School Im Rahmen der UdS - Korean Winter School hielt Prof. Kickelbick einen Vortrag über grüne Chemie und Materialien. Während der Veranstaltung wurden die Teilnehmer in die Chemie des Klimawandels eingeführt und Konzepte vorgestellt, wie die Chemie als Wissenschaft Lösungen bieten kann. Darüber hinaus wurden die Ideen einer nachhaltigeren Materialchemie und der Kreislaufwirtschaft diskutiert. 26.12.2023 | Jan-Falk Kannengießer publiziert Artikel zur lösungsmittelfreien Festkörperpolymerisation von Silanolen Stabile Silanole können ohne Lösungsmittel im Festkörper polymerisiert werden. Diese Methode erlaubt in einigen Fällen sogar die Beibehaltung der Stereochemie aus dem Kristall. Die Studie wurde imn der Zeitschrift Chemistry - A European Journal veröffentlicht (siehe https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202303343) 14.07.2023 | Studierendengruppe besucht den BASF-Standort Ludwigshafen 29 Chemiestudierende aus Saarbrücken verbrachten einen informativen Tag bei BASF in Ludwigshafen. Neben dem Besuch des Besucherzentrums standen eine Rundfahrt auf dem Werksgelände, die Besichtigung einer petrochemischen Anlage und eine Informationsveranstaltung über die Karrieremöglichkeiten als Industriechemiker auf dem Programm. Prof. Guido Kickelbick begleitete die Studentengruppe und bedankte sich besonders bei Dr. Alexander Düfert von BASF für die Mitorganisation der Exkursion. Gemeinsam mit Dr. Alexander Traut, Dr. Dorothea Ziegler und Dr. Geogios Dodekatos stand er den Studierenden für Fragen zu Bewerbungsverfahren und Entwicklungsmöglichkeiten bei BASF zur Verfügung. 12.07.2023 | Arbeitsgruppe Kickelbick nimmt an den 10. Europäischen Silicium-Tagen teil Mitglieder der Arbeitsgruppe Kickelbick nahmen vom 10. bis 12. Juli 2023 zusammen mit Mitgliedern der Arbeitsgruppe Scheschkewitz an den 10. Europäischen Siliciumtagen in Montpellier teil. Prof. Kickelbick hielt einen eingeladenen Vortrag und Svenja Pohl und Jan-Falk Kannengießer präsentierten ihre Forschungsarbeiten als Posterbeiträge. 16.06.2023 | Arbeitsgruppen-Team nimmt am Firmenlauf in Saarbrücken teil Ein Team der Arbeitsgruppe Kickelbick hat am 16.06.2023 am Firmenlauf in Saarbrücken teilgenommen. Bei hohen Temperaturen haben alle Teilnehmer das Ziel erreicht. Herzlichen Glückwunsch für die großartige Leistung! 08.06. - 10.06.2023 | Stefan Engel und Elias Gießelmann präsentieren ihre Forschungsergebnisse auf dem Hirschegg-Seminar Zum 50.ten Jubiläum des Hirschegg-Seminars präsentierten Stefan Engel und Elias Gießelmann ihre Forschungsergebnisse im Rahmen von wissenschaftlichen Vorträgen. Das jährliche "Hirschegg-Seminar" ist eine alteingesessene Institution der deutschsprachigen Festkörperchemie auf der Doktorand*innen ihre Forschungsergebnisse vorstellen und ausgiebig diskutieren. 13.05.2023 | Die Arbeitsgruppe beteiligt sich mit mehreren Aktionen am Tag der offenen Tür Die Arbeitsstelle Umweltanalytik steht mit einem Messcontainer an der Festwiese und erläutert, wie das Online-Monitoring von Fließgewässern im Saarland durchgeführt wird. Gleich zwei Vorträge zum Thema "Nachhaltigkeit und die Rolle der Chemie" werden von Prof. Kickelbick gehalten. 10.05.2023 | Publikation von Elias Gießelmann in Inorganic Chemistry angenommen Die Arbeit „Formation of the Sub-Oxide Sc 4 Au 2 O 1–x and Drastically Negative 27 Al NMR Shift in Sc 2 Al”, die auf den Forschungsergebnissen von Elias Gießelmann beruht, wurde von Inorganic Chemistry angenommen. Die Arbeit entstand in Zusammenarbeit mit Samir F. Matar von der Lebanese German University, LGU in Jounieh, Libanon. 02.05.2023 | Dr. Mathilde Laird beginnt ihr Alexander-von-Humboldt Forschungsstipendium Dr. Mathilde Laird startet einen zweijährigen Forschungsaufenthalt in unserer Arbeitsgruppe über ein Alexander-von-Humboldt Forschungsstipendium mit einem Thema zur Thermoreversiblen Bindungsbildung in Silsesquioxanen. Herzlich Willkommen Mathilde! 28.04.2023 | Organische Gruppen haben einen großen Einfluss auf die Bildung von Silsesquioxanen mit besonderen Eigenschaften In einer heute im Journal of Sol-Gel Science and Technology akzeptierten Veröffentlichung zeigt Svenja Pohl in einer systematischen Vergleichsstudie, dass bei Silsesquioxan-Polymeren der organische Rest an den Siliziumatomen einen wesentlichen Einfluss auf den Kondensationsgrad der Polymere hat. Dieser ist auch entscheidend für den Erweichungsbereich der Polymere. Die Studie trägt zum Verständnis bei, wie die Eigenschaften in sogenannten "Melting Gels", die in einem bestimmten Temperaturbereich thermoplastisches Verhalten zeigen, durch die chemische Zusammensetzung beeinflusst werden können (siehe https://link.springer.com/article/10.1007/s10971-023-06126-6 ) 08.03.2023 | Anorganisch-organische Hybridmaterialien zeigen außergewöhnliche elektrochemische Eigenschaften So genannte lumineszierende Solarkonzentratoren ermöglichen das Einfangen von diffusem Sonnenlicht, um es für die Erzeugung von Elektrizität zu verwenden. Die Sonnenstrahlung wird durch farbige Kunststoffplatten aufgefangen, und an den Rändern wandeln Mikrosolarzellen das entstandene Licht in Elektrizität um. In einer Kooperation mit der Arbeitsgruppe von Prof. Andrea Pucci an der Universität Pisa wurde ein an der UdS entwickeltes Material erstmals für flexible Solarkonzentratoren eingesetzt. Die dazugehörige Arbeit erschien in der Zeitschrift Polymer Chemistry (siehe: https://pubs.rsc.org/en/content/articlelanding/2023/py/d2py01428a ). Weitere Informationen sind in einer Pressmitteilung (siehe https://www.uni-saarland.de/aktuell/chemiker-solarzellen-farbig-26511.html ) und in einem Fernsehbeitrag (siehe https://www.sr-mediathek.de/index.php?seite=7&id=127114&startvid=10 ) zugänglich. März 2023 | Johannes Krebs startet Masterarbeit In der Masterarbeit von Johannes Krebs wird die mechanochemische Oberflächenfunktionalisierung von Nanopartikeln mit Methoden der traditionellen Oberflächenfunktionalisierung verglichen. 06.03.2023 | Elias Gießelmann nimmt an NMR Workshop teil Elias Gießelmann nimmt an der fünften G-NMR School an der Heinrich Heine Universität Düsseldorf teil. 02.03.2023 | Publikation von Stefan Engel & Elias Gießelmann in Inorganic Chemistry angenommen Die Review-Artikel „Trivalent Europium – A scarce case in intermetallics”, verfasst von Stefan Engel, Elias Gießelmann und Oliver Janka, in Zusammenarbeit mit Rainer Pöttgen von der Westfälischen Wilhelms-Universität Münster ist in der Zeitschrift Reviews in Inorganic Chemistry angenommen worden. 10.02.2023 | Mechanochemie ermöglicht eine schnelle und energieeffiziente Herstellung von schwarzen Metalloxiden Metalloxide sind herkömmlicherweise farblose Feststoffe. Wenn es gelingt die Metallionen zu reduzieren entstehen so genannte schwarze Metalloxide. Diese besitzen häufig herausragende elektronische und katalytische Eigenschaften. In einer Studie von Anna Michaely mit einem Team von weiteren Koautoren ist es nun gelungen bereits nach zehn Minuten in einer Kugelmühle mit einer einfachen chemischen Umsetzung schwarzes Titandioxid (TiO 2 ) und schwarzes Nioboxid (Nb 2 O 5 ) herzustellen. Diese zeigen die erwarteten Veränderungen in ihren elektronischen Eigenschaften und für das Titandioxid konnte eine bedeutend höhere Aktivität in den photokatalytischen Eigenschaften nachgewiesen werden. Die Studie wurde in der Zeitschrift Chemistry – A European Journal veröffentlicht (siehe https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202300223 ) 09.02.2023 | Publikation von Elias Gießelmann in Dalton Transactions angenommen Die Arbeit „Raman and NMR spectroscopic and theoretical investigations of the cubic laves-phases REAl 2 (RE = Sc, Y, La, Yb, Lu)” die auf den Forschungsergebnissen von Elias Gießelmann beruht wurde von Dalton Transactions angenommen. 09.01.2023 | Publikation von Stefan Engel in der Zeitschrift für Naturforschung B angenommen Die Arbeit „Eu 4 Al 13 Pt 9 – a coloring variant of the Ho 4 Ir 13 Ge 9 type structure”, die auf den Forschungsergebnissen von Stefan Engel beruht, wurde von der Zeitschrift für Naturforschung B angenommen. 03.01.2023 | Zusammensetzung von Nahrungsergänzungsmitteln für die Silicium-Aufnahme aufgeklärt Nahrungsergänzungsmittel werden oft als gesundheitsfördernd angepriesen. Ob die enthaltenen Inhaltsstoffe jedoch tatsächlich vom Körper aufgenommen werden, hängt meist stark von ihrer chemischen Zusammensetzung und Struktur ab. In einer neuen Studie untersuchten Yannic Curto und Dr. Marcus Koch vom Leibniz-Institut für Neue Materialien Nahrungsergänzungsmittel auf die Aufnahme von Silizium. Dabei wurden signifikante Unterschiede zwischen den Präparaten festgestellt, die auch einen Einfluss auf die biologische Aufnahme von Silizium haben können. Die Studie wurde in der Zeitschrift Solids veröffentlicht (siehe https://www.mdpi.com/2673-6497/4/1/1 ) 21.12.2022 | Anorganisch-organische Hybridmaterialien zeigen außergewöhnliche elektrochemische Eigenschaften In einem Kooperationsprojekt mit der Arbeitsgruppe von Prof. Volker Presser am Leibniz-Institut für Neue Materialien konnten anorganisch-organische Hybridmaterialien hergestellt werden, die sowohl redoxaktive anorganische als auch entsprechende organische Komponenten enthalten. Mana Abdirahman Mohamed und Stefanie Arnold konnten in einem Team mit weiteren Wissenschaftlerinnen und Wissenschaftlern diese Materialien kontinuierlich nasschemisch synthetisieren und elektrochemisch charakterisieren. Die erhaltenen Materialien stellen eine neue Klasse von Elektrodenmaterialien für Lithium-Ionen-Batterien dar. Die Materialien können im sogenannten Mikrojet-Reaktor durch eine effiziente, skalierbare Fällungsreaktion bei Raumtemperatur unter Verwendung kostengünstiger Reaktanten synthetisiert werden. Die Studie wurde in der Zeitschrift ChemSusChem veröffentlicht (siehe https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202202213 ). 16.12.2022 | Neues Projekt soll die Anwendbarkeit von so genannten Melting Gelen für optische Linsen untersuchen In dem neuen Projekt wird ein 1-Komponenten-Silikon als Ausgangsmaterial für die spritzgießtechnische Herstellung von transparenten, farblosen Sensorlinsen mit hohem Brechungsindex und hoher Temperaturbeständigkeit entwickelt. Aufgrund der hohen Temperaturbeständigkeit nach der Verfestigung können die Linsen im Reflow-Verfahren verarbeitet werden. Es soll getestet werden, ob die entstehenden Linsen beispielsweise in der medizinischen Optik unter Sterilisationsbedingungen (Wasserdampf, UV-Strahlung, Wasserstoffperoxid) eingesetzt werden können. Das Projekt wird im Rahmen des Zentralen Innovationsprogramms Mittelstand (ZIM) des Bundesministeriums für Wirtschaft und Klimaschutz gefördert. 08.11.2022 | Vorlesungsreihe Raumschiff Erde Die Vorlesungsreihe Raumschiff Erde geht in die nächste Runde. Im Fokus steht der Klimawandel, der weit mehr Wissenschaftsfelder als die (physikalische) Klimaforschung im eigentlichen Sinne betrifft. Chemie, Informatik, Medizin, Wirtschaftswissenschaften und viele weitere haben ihren ganz eigenen Blick auf Klimawandel und Klimaschutz. In einer 12-teiligen Vortragsreihe beleuchten Fachleute aus unterschiedlichen Feldern ihre Perspektiven auf diese Themen. Die Öffentlichkeit kann die Vorträge ab dem 08. November live online mitverfolgen. Die von Prof. Guido Kickelbick organisierte Vorlesungsreihe startet heute mit einem Vortrag von Prof. Guido Kickelbick zum Thema „Klimaaktive Gase – Wirkung, Entstehung, Vermeidung“. Programm der Vorlesungsreihe: https://www.uni-saarland.de/verwaltung/nachhaltigkeit/veranstaltungen.html 13.10.2022 | Prof. Guido Kickelbick stellt sein Fachgebiet Anorganischen Festkörperchemie in „Der Zeit“ vor Worum geht’s in der Anorganischen Festkörperchemie? Dieser Frage nähert sich die Wochenzeitung "Die Zeit" durch ein Interview mit dem Professor für Anorganische Festkörperchemie Dr. Guido Kickelbick und dem saarländischen Chemie-Studenten Christopher Luckas. 01.10.2022 | Prof. Guido Kickelbick zum Sprecher der Konferenz der Fachbereiche Chemie gewählt Die Konferenz der Fachbereiche Chemie (KFC) ist die Vereinigung der chemischen Fachbereiche und Abteilungen der Universitäten und wissenschaftlichen Hochschulen in Deutschland. Sie umfasst circa 60 Hochschulen. Ihre wichtigste Aufgabe ist es, sich um gemeinsame Angelegenheiten der Forschung und Lehre der beteiligten Fachbereiche zu kümmern. Sie vertritt dabei die Interessen der Chemie-Fachbereiche gegenüber der Politik, der Fachgesellschaften und der Gesellschaft. Link zum News-Beitrag 30.09.2022 | Achim Koch promoviert Achim Koch wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautet „Lithiierung und anionische grafting-from-Polymerisation auf Siliciumdioxid-Nanopartikeln“ 27-29.09.2022 | Prof. Guido Kickelbick hält einen Vortrag auf dem Materials Science and Engineering Congress in Darmstadt Der Vortrag findet in einem Symposium zum Thema Materialien für die Kreislaufwirtschaft statt und hat den Titel „Surface-Functionalized Metal Oxide Nanoparticles as Building Blocks for more Sustainable Materials“ 07.09.2022 | Helferfest für die Unterstützer der Chemiedozententagung in Saarbrücken Als Dankeschön für alle Hellfer der Chemiedozententagung in Saarbrücken vom 21. - 23. März 2022 wurde ein Helferfest vor dem Institutsgebäude der Anorganischen Chemie durchgeführt. 02.09.2022 | Dr. André Schäfer hält Antrittsvorlesung Nach Abschluss seines Habilitationsverfahrens hält heute Dr. André Schäfer seine Antrittsvorlesung zum Thema „Main-Group Metallocenophanes – From Interesting Molecules to Catalysis and Polymers“. Nach der Vorlesung wird ihm die Lehrbefugnis für Anorganische Chemie erteilt und er wird vom Dekan zum Privatdozenten ernannt. 02.08.2022 | Umweltministerin Frau Petra Berg besucht Messstelle zum Gewässermonitorin Die flexible Online-Überwachung verknüpft mit einer ausgefeilten Messstrategie ist bundesweites Vorbild. Die saarländische Umweltministerin Petra Berg wird sich auf ihrer Sommertour an der mobilen Messstation an der Oster in Wiebelskirchen über das Projekt informieren. Thema wird dabei unter anderem sein, wie die Arbeitsgruppe Gewässermonitoring die Daten der mobilen Messstationen auswertet und wie verschiedene Maßnahmen rund um kleinere Fließgewässer die Gewässergüte verbessern und zum Hochwasserschutz sowie zum Klimaschutz beitragen können. Link zum News-Beitrag 24.07.-29.07.2022 | Svenja Pohl und Prof. Guido Kickelbick nehmen an der Sol-Gel Tagung der Internationalen Sol-Gel Society in Lyon teil Svenja Pohl präsentiert dort ein Poster zum Thema „An Investigation of the Influence of Polycyclic Aromatic Groups on the Structure and Properties of Polysilsesquioxane Melting Gels“ und Prof. Kickelbick hält einen Vortrag zum Thema „Controlled Formation of Polysilsesquioxane Structures applying Stabilized Silanol Groups“ 14.11.2022 | Prof. Holger Kohlmann hält Vortrag im Anorganik Kolloquium Der ehemalige wissenschaftliche Mitarbeiter am Institut für Anorganische Festkörperchemie Prof. Holger Kohlmann, hält heute einen Vortrag im Kolloquium der Anorganischen Chemie zum Thema: „Silicate hydrides, hydridosilicates, silicane and polysilylenides – new combinations of silicon and hydrogen“. Holger Kohlmann ist seit 2012 Professor für Anorganische Chemie an der Universität Leipzig. 27.06.2022 | Elias Gießelmann nimmt an der Lindauer Nobelpreisträger-Tagung teil Selten hat man als Studierender oder Nachwuchswissenschaftler*in die Gelegenheit Nobelpreisträger*innen persönlich kennenzulernen und sich von ihren Forschungsleistungen inspirieren zu lassen. Noch seltener ist es mehrere Nobelpreisträger gleichzeitig an einem Ort anzutreffen. Eine seit 1951 bestehende Tagung in Lindau macht das jedoch einem ausgewählten Kreis von Nachwuchswissenschaftler*innen möglich. In diesem Jahr wurde Elias Gießelmann, Doktorand aus unserer Gruppe, als einer von 600 Teilnehmern aus der ganzen Welt auserwählt, um an der Tagung teilzunehmen. Weitere Infos zur Lindauer Nobelpreisträgertagung finden sie hier . 16.06. – 18.06.2022 | Mana Mohamed und Stefan Engel präsentieren ihre Forschungsergebnisse auf dem Hirschegg-Seminar Das Hirschegg-Seminar ist eine alteingesessene Institution der deutschsprachigen Festkörperchemie auf der Doktorand*innen ihre Forschungsergebnisse vorstellen und diskutieren. Die Konferenz existiert bereits seit den 1970er Jahren. Mana Mohamed und Stefan Engel werden dort ihre Forschungsergebnisse im Rahmen von wissenschaftlichen Vorträgen präsentieren. 06.06. – 10.06.2022 | Anna Michaely und Tobias Straub präsentieren ihre Forschungsergebnisse auf INCOME2022 Die 10. Konferenz für Mechanochemie und mechanochemisches Legieren findet in diesem Jahr in Caligari, Italien statt. Anna Michaely und Tobias Straub präsentieren dort ihre wissenschaftlichen Ergebnisse. Die Reise wurde kofinanziert durch ein Gradus-Stipendium (bitte Link zu Gradus einfügen: https://www.uni-saarland.de/forschen/gradus.html ). Vielen Dank dafür! 26.05.2022 | Doktorandenstelle im Bereich Polysiloxan-basierte anorganisch-organische Hybridmaterialien zu besetzen 19.05.2022 | Neue thermisch stabile Einkomponenten-vernetzende Silikone mit hohem Brechungsindex Silicone mit hohem Brechungsindex spielen für viele optische Anwendungen eine wichtige Rolle. In einer soeben erschienen Arbeit konnten wir zeigen, dass polycyclische aromatische Systeme als Substituenten an den Silicium-Atomen in den Siliconen den Brechungsindex erheblich steigern können. Max Briesenick verwendete dazu eine in unserer Gruppe optimierte Synthesestrategie, welche es erlaubt die Silicone ohne Katalysator, rein thermisch zu vernetzen. Die vernetzten Harze zeigten Brechungsindizes von über 1,6, eine sehr hohe optische Transparenz und thermische Stabilitäten bis zu 470 °C auf und können damit für optische Hochtemperaturanwendungen interessant sein. Die Studie wurde in Macromolecules publiziert ( https://pubs.acs.org/doi/full/10.1021/acs.macromol.2c00265 ). 09.05.2022 | Elias Gießelmann beginnt mit seiner Dissertation Elias Gießelmann beginnt mit seiner Dissertation zum Thema „Strukturelle und spektroskopische Untersuchungen von (oxidierten) intermetallischen Aluminiumverbindungen der frühen Übergangsmetalle“ 26.04.2022 | Vorlesungsreihe Raumschiff Erde - Nachhaltigkeit Die Vorlesungsreihe Raumschiff Erde – Nachhaltigkeit startet heute mit einem Vortrag von Prof. Guido Kickelbick zum Thema „Nachhaltige Rohstoffgewinnung und Urban Mining“. Zum Thema gab es ein kurzes Radiointerview in SR2 mit Prof. Guido Kickelbick. Die gesamte Vorlesungsreihe wird wieder von Prof. Guido Kickelbick organisiert und beschäftigt sich interdisziplinär mit dem Thema Nachhaltigkeit in 12 Vorträgen während des Sommersemesters. 06.04.2022 | Preise für Arbeitsgruppenmitglieder beim Promovierendentag der Naturwissenschaftlich-Technischen Fakultät Svenja Pohl hat beim heute stattgefundenen Promovierendentag der Naturwissenschaftlich Technischen Fakultät den ersten Platz beim Posterwettbewerb mit ihrem Poster „Synthesis and Characterization of Polysilsesquioxane Hybrid Melting Gels“ gewonnen. Tobias Straub erhielt mit seinem Posterbeitrag „Mechanochemical activation of metal oxides - Synthesis, modification and application of manganese oxides“ einen weiteren Preis. Herzlichen Glückwunsch an beide Mitarbeiter. 28.03.2022 | Antrittsvorlesung Privatdozent Oliver Janka Nach einem Umhabilitationsverfahren von der Universität Münster an die Universität des Saarlandes hält heute Dr. Oliver Janka seine Antrittsvorlesung ab, die mit der Ernennung zum Privatdozenten an der UdS einhergeht. 21.-23.03.2022 | Chemiedozententagung 2022 in Saarbrücken Vom 21. bis 23. März kommt der wissenschaftliche Nachwuchs der Chemie aus Universitäten und Instituten nach Saarbrücken, um neueste Forschungsergebnisse vorzustellen, sich auszutauschen und zu vernetzen. Die diesjährige Tagung der Gesellschaft Deutscher Chemiker (GDCh), die zusammen mit der Arbeitsgemeinschaft Deutscher Universitätsprofessoren und -professorinnen (ADUC) veranstaltet wird, findet unter Federführung von Prof. Guido Kickelbick statt. Nach Corona-bedingten Absagen bzw. virtuellen Tagungen in den vergangenen Jahren, findet die Tagung erstmalig wieder mit über 300 Teilnehmerinnen und Teilnehmern in Präsenz statt. Über 100 Vorträge der Nachwuchsforscherinnen und -forscher zu neuesten Forschungserkenntnissen stehen auf dem Programm. In diesem Jahr wird auch der Elisabeth und Prof. Dr. Horst-Dietrich Hardt-Preis, den die Anorganische Chemie der Universität des Saarlandes vergibt, an Prof. Dr. Katja Heinze von der Johannes Gutenberg-Universität Mainz für wegweisende Forschungsarbeiten auf dem Gebiet der Anorganischen Chemie im Rahmen der Chemiedozententagung verliehen 04.03.2022 | Margarita Shchurkina als ERASMUS-Gast in der Gruppe Wir begrüßen Margarita Shchurkina als neue ERASMUS-Studierende von der ITMO Universität in St. Petersburg. 23.-25.02.2022 | Teilnahme an der 30. ATC 2022: Industrielle anorganische Chemie - Materialien und Prozesse Svenja Pohl und Jan-Falk Kannengießer präsentieren Beiträge aus ihren Forschungsarbeiten sowohl auf der 30. ATC Tagung im DECHEMA-Haus in Frankfurt am Main als auch auf dem vorgeschalteten Doktorandenworkshop. 2020/2021 30.12.2021 | Patent zur Herstellung von Mikropartikeln veröffentlicht Ein Patent basierend auf den von uns entwickelten Melting-Gel Hybridsystemen wurden veröffentlicht. Damit gelingt es beispielsweise sehr hydrophobe Fluoreszenz-Farbstoffe stabil in eine schützende Matrix einzuschließen. 08./09.12.2021 | Erste Doktoranden-Konferenz der Transform4Europe Alliance Die Hochschulallianz Transform4Europe, in der auch die Universität des Saarlandes integriert ist, hält ihre erste Konferenz für Doktorandinnen und Doktoranden ab. Aus unserer Arbeitsgruppe halten Angelika Meyer, Anna Michaely, Kristina Brix und Tobias Straub Vorträge zu ihren Forschungsarbeiten aus dem Themenbereich Umwelt und Nachhaltigkeit. 30.11.2021 | Vortrag in der Reihe #Meerwissen zum Thema Biomineralisation Prof. Guido Kickelbick erläutert heute in einem 30-minütigen Kurzvortrag im Rahmen des Programms #Meerwissen (Link zu: www.uni-saarland.de/page/meerwissen/veranstaltungen.html ) die Faszination der Biomineralisation. Der Titel des Vortrags lautet „Baumeister im Meer - Wie entstehen Mineralien aus Wasser?“. 27.10.2021 | Vorlesungsreihe Raumschiff Erde Der Klimawandel betrifft weit mehr Wissenschaftsfelder als die (physikalische) Klimaforschung im eigentlichen Sinne. Chemie, Informatik, Medizin, Wirtschaftswissenschaften und viele weitere haben ihren ganz eigenen Blick auf Klimawandel und Klimaschutz. In einer 13-teiligen Vortragsreihe beleuchten Fachleute aus unterschiedlichen Feldern ihre Perspektiven auf diese Themen. Die Öffentlichkeit kann die Vorträge ab dem 27. Oktober jeden Mittwoch live online mitverfolgen. Die von Prof. Guido Kickelbick und Dr. Susanne Mantel organisierte Vorlesungsreihe startet heute mit einem Vortrag von Prof. Guido Kickelbick zum Thema „Klimaaktive Gase – Wirkung, Entstehung, Vermeidung“. Link zur Vorlesungsreihe: www.uni-saarland.de/verwaltung/nachhaltigkeit/veranstaltungen/raumschiff-erde-klimaschutz.html 01.10.2021 | Wir begrüßen Kimia Moghaddari als neue Gastwissenschaftlerin Kimia Moghaddari aus dem Iran arbeitet als neue Gastwissenschaftlerin in unserer Arbeitsgruppe am Thema selbstheilenden Nanokomposite. 01.10.2021 | Anna Michaely beginnt mit ihrer Dissertation Anna Michaely beginnt mit ihrer Dissertation zum Thema „Reduktives Reaktivvermahlen von Metalloxiden“. 21.09.2021 | Stabile Organosilanole – die etwas anderen Homologe der Alkohole Organosilanole, die Silicium Homologe der Alkohole, sind typischerweise nicht isolierbare Moleküle und zeigen eine hohe Kondensationstendenz zu oligomeren oder polymeren Strukturen. Als stabile isolierbare Moleküle sind sie nur unter sehr spezifischen sterischen und elektronischen Bedingungen am Siliciumatom bekannt. Jan-Falk Kannengießer synthetisierte eine Reihe von Aryl-substituierten Vertretern dieser Verbindungsklasse durch Hydrolyse der Alkoxy- oder Chlorverbindungen. Die erhaltenen Produkte bilden im Festkörper starke Wasserstoffbrückenbindungen mit verschiedenen strukturellen Motiven aus. Die Studie wurde in Chemistry - A European Journal publiziert ( https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202102729 ) 16.08.2021 | Forschungsprojekt zum Thema Wasserglas Yannic Curto beginnt mit seiner Masterarbeit zu strukturellen Untersuchungen an gefällten Natriumsilicaten. 14.08.2021 | Fluoreszierende SiO 2 -Partikel – die Bindung macht den Unterschied Fluoreszierende Nanopartikel sind wichtige Analyseinstrumente speziell in biologischen Anwendungen. Eine hier speziell genutzte Klasse sind Siliziumdioxid-Nanopartikel mit eingebetteten Fluoreszenzfarbstoffen. Solche Partikel sind einfach zugänglich und werden vielfach eingesetzt. In einer neuen Studie konnte Nadja Klippel zusammen mit Prof. Gregor Jung zeigen, dass die Anbindung der Farbstoffe an den Partikelkern wichtig für deren Stabilität ist. Dabei wurden verschiedenen Einbaumechanismen von fluoreszierenden Xanthen-Farbstoffen in 30-40 nm große Silika-Nanopartikel untersucht und verglichen. Systematische Auslaugungsstudien über Zeitspannen von bis zu 4 Tagen zeigten, dass die kovalente Anbindung der Farbstoffe für die Fluoreszenzstabilität notwendig ist, da Farbstoffe, die lediglich durch physikalische Wechselwirkung gebunden sind, dazu neigen, aus porösen Silika-Netzwerken auszulaugen. Die Beschichtung der Silikapartikel mit hydrophoben oder hydrophilen Schutzschichten führte zu einer besseren Retention von lediglich physisorbierten Farbstoffen und bietet die Möglichkeit, die Partikel an die Polarität des Mediums anzupassen. Die Studie wurde im Journal of Sol-Gel Science and Technology veröffentlicht ( https://link.springer.com/article/10.1007%2Fs10971-021-05578-y ). 12.08.2021 | Polysiloxane mit hohem Brechungsindex Polyzyclische aromatische Kohlenwasserstoffe können als Substituenten in Polysiloxanen, allgemein unter dem Namen Silikone bekannt, den Brechungsindex bis auf Werte von 1,63 erhöhen. Herkömmliche kommerziell erhältliche Polysiloxane besitzen lediglich Brechungsindices kleiner als 1,5. Die Polymere wurden von Dennis Meier aus Phenanthrenyl-substituierten Monomeren hergestellt und durch Polykondensationsreaktionen mit weiteren Dialkoxysilanen erhalten. Die entstandenen Polymere konnten thermisch vernetzt werden und so konnten Polysiloxanharze mit hohem Brechungsindex, hoher optischer Durchlässigkeit und hoher thermischer Stabilität von bis zu 420°C erhalten werden. Solche Materialien werden vor allem in optischen Anwendungen eingesetzt. Neben einer Publikation in der Zeitschrift Journal of Polymer Science (siehe: https://onlinelibrary.wiley.com/doi/full/10.1002/pol.20210316 ) wurden die Materialien auch patentiert. 05.08.2021 | Selbstheilung von Nanokompositen durch Induktionsheizung Selbstheilende Materialien stellen eine wichtige Möglichkeit dar die Lebensdauer von Gegenständen zu verlängern. Damit können Sie einen Beitrag zur ressourcenschonenden Nutzung von Rohstoffen und damit auch einer nachhaltigeren Materialentwicklung sein. In einer neuen Studie konnte Bastian Oberhausen zeigen, dass die Einbettung von superparamagnetischen Nanopartikeln in eine Polymermatrix ermöglicht, eine Selbstheilung durch Induktionsheizung zu induzieren. Dafür wurden die Partikel an der Oberfläche mit positiv geladenen organischen Gruppen modifiziert und die Polymermatrix enthielt die entsprechenden anionischen Ladungen. Nach einem Auseinanderschneiden des Probenkörpers konnte dieser durch Induktionsheizung wieder zusammengefügt werden und zeigte seine ursprünglichen Eigenschaften. Die Studie wurde in der Zeitschrift Nanoscale Advances veröffentlicht (siehe: https://pubs.rsc.org/en/content/articlelanding/2021/na/d1na00417d ). 01.08.2021 | Beginn Dissertation Stefan Engel Stefan Engel beginnt seine Dissertation in unserer Arbeitsgruppe zum Thema „Studien zur Bindungssituation und zum Elektronenübertrag in elektronenarmen intermetallischen Verbindungen“, gefördert durch eine DFG Sachbeihilfe, welche von Dr. Oliver Janka eingeworben wurde. 02.07.2021 | Christina Odenwald promoviert Christina Odenwald wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautet „Continuous and Wet-Chemical Synthesis of Micro- and Nanoparticles in a Microreactor“ 30.06.2021 | Nadja Klippel promoviert Nadja Klippel wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautet „Synthese und Charakterisierung von Perylendiimid- und Xanthen-funktionalisierten Silica-Nanopartikeln sowie Untersuchungen zu der Farbstoff-Partikel-Wechselwirkung“ 13.04.2021 | Neues Hybridmaterial zeigt Thermoplastisches Verhalten In einer heute publizierten Studie zu Polysilsesquioxan-Materialien, die über eine sehr einfache Polymerisationsmethode hergestellt werden können, konnten wir zeigen, dass sich unter bestimmten Bedingungen Materialien erzeugen lassen, die ein thermoplastisches Verhalten zeigen. Dies ist zwar von herkömmlichen organischen Polymeren bekannt, aber nicht von Silikon-ähnlichen Strukturen. Während sich die Materialien bei 110 °C aufschmelzen lassen, sind sie bei Raumtemperatur fest. Auch die anderen Eigenschaften dieser Systeme sind für technologische Anwendungen interessant, so besitzen sie eine hohe optische Transparenz und sehr niedrige Durchlässigkeit für gasförmige Moleküle, wie z.B. Sauerstoff oder Wasserdampf. Sie können in optischen Anwendungen herkömmliche Silikone ersetzen und sparen dabei Ressourcen ein, da sie keinen Platinkatalysator zur Vernetzung benötigen. In einer Studie in der Zeitschrift Macromolecules konnten wir die Eigenschaften dieser Materialien mit Ihrer Struktur korrelieren. ( https://pubs.acs.org/doi/abs/10.1021/acs.macromol.1c00310 ) 08.04.2021 | Dennis Meier promoviert Dennis Meier wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautete „New polysiloxane based encapsulation materials for high energy LEDs“ 15.02.2021 | Jan-Falk Kannengießer beginnt mit Promotion Heute beginnt Jan-Falk Kannengießer mit seiner Promotionsarbeit zum Thema „Stabile Silanole und Ihre Reaktivität in Polykondensationsreaktionen“. Herzlich willkommen! 16.02.2021 | Abformung von Superhydrophoben Oberflächen des Johannisbrotbaums Die Pflanzen und Tierwelt hat über Jahrmilliarden Oberflächenstrukturen geschaffen, welche das Überleben unter besonderen Umweltbedingungen ermöglichen. Viele dieser mikroskopisch kleinen Oberflächenstrukturen sind auch für technologische Anwendungen von Vorteil, z.B. in Bezug auf Haftung oder Lichtreflektionen. Häufig ist es jedoch schwierig diese Strukturen aufgrund ihrer mikroskopischen Feinheiten und ihrer Oberflächenchemie abzuformen. In einem internationalen Forschungsprojekt mit Forschergruppen aus Portugal und Schweden gelang es uns auch feinste Strukturen mittels besonderer Polymerkombinationen abzuformen und auf eine neue Form zu übertragen. Dabei mussten die Eigenschaften der Polymere, wie z.B. deren gegenseitige Haftung und die mechanischen Eigenschaften sehr genau aufeinander abgestimmt werden. Die Forschungsarbeit wurde in der Zeitschrift Langmuir veröffentlicht ( https://pubs.acs.org/doi/10.1021/acs.langmuir.0c02806 ). 09.02.2021 | Thomas Klein promoviert Thomas Klein wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautete „Wet Chemical Synthesis of Nano and Submicron Al Particles for the Preparation of Ni and Ru Aluminides“. 07.02.2021 | Schaltbare Anbringung von Farbstoffen an Eisenoxid Nanopartikel-Oberflächen Eine heute veröffentlichte Publikation von Siyang He zeigt, dass fluoreszierende Farbstoffe an Oberflächen von Eisenoxid-Nanopartikeln angebracht werden können und es gelingt durch temperaturabhängiges Schalten die Farbstoffe wieder von der Oberfläche zu lösen. Bei Temperaturen über 130°C wird die Bindung zwichen Farbstoff und Oberfläche gespalten und dieser kann in die Umgebung diffundieren. Beim Abkühlen wird die Bindung zur Oberfläche wieder neu gebildet. Dieser Vorgang ist vielfach durchführbar. Die Anbringung des Farbstoffes an magnetische Nanopartikel eröffnet die Möglichkeit die Partikel nach der Farbstoffseparation magnetisch abzutrennen. Damit können die Partikel als Transportmittel für verschiedene Substanzen eingesetzt werden. Die Studie wurde in der Open Access Zeitschrift Molecules publiziert ( https://www.mdpi.com/1420-3049/26/4/877/htm ). 21.12.2020 | Guido Kickelbick Editor in Charge der neuen Zeitschrift Solids Prof. Guido Kickelbick wird Gründungs-Editor der neuen Golden Open Access Zeitschrift Solids ( https://www.mdpi.com/journal/solids ). Der Fokus der wissenschaftlichen Zeitschrift ist die Publikation von Forschungsergebnissen aus dem Bereich der Chemie und Physik der Festkörper. 12.12.2020 | Verteilung von Nanopartikeln in Nanokompositen abhängig von chemischer Oberflächenfunktionalisierung In einer Studie unserer Arbeitsgruppe zusammen mit zwei Arbeitsgruppen aus Österreich von der Universität und der Technischen Universität in Wien konnte systematisch nachgewiesen werden, dass die Wechselwirkung zwischen der Oberfläche von Nanopartikeln und der polymeren Matrix einen wesentlichen Einfluss auf die homogene Verteilung der Partikel in der Matrix hat. Dabei spielen chemische Wechselwirkungen, aber auch die Morphologie der Partikel eine erhebliche Rolle. Die Studie wurde in der Open Access Zeitschrift Surfaces ( https://www.mdpi.com/2571-9637/3/4/44 ) veröffentlicht. 26.10.2020 | Dekanatsamt von Prof. Guido Kickelbick endet turnusgemäß Nach zwei Amtszeiten endet das Dekanatsamt von Prof. Guido Kickelbick. Der neue Dekan der Fakultät NT ist Prof. Jörn Walter aus den Biowissenschaften. 21.08.2020 | Dennis Becker promoviert Dennis Becker wurde heute promoviert. Herzlichen Glückwunsch! Das Thema der Dissertation lautete „Mechanochemical Synthesis, Phase Transformation and Surface Functionalization of Metal Oxides“ 31.07.2020 | Dr. Robert Haberkorn geht in Ruhestand Der Akademische Oberrat Dr. Robert Haberkorn geht zum heutigen Tag in Pension. Herr Haberkorn hat sich in den vergangenen Jahrzehnten speziell um die Betreuung der Röntgengeräte in der Arbeitsgruppe und der Vermittlung von Festkörperchemischen Grundlagen an Studierende verdient gemacht. 21.07.2020 | Einfluss von Synthesebedingungen auf Größe, Morphologie und Reaktivität von Aluminium-Nanopartikeln In einem heute erschienenen Artikel in Dalton Transactions zeigt Thomas Klein durch systematische Untersuchungen, wie sich Reaktionsbedingungen in einer katalytischen Zersetzungsreaktion auf die Eigenschaften von Aluminium-Nanopartikeln auswirken. Titel: „Aluminum nanoparticle preparation via catalytic decomposition of alane adducts – Influence of reaction parameters on nanoparticle size, morphology and reactivity“, https://doi.org/10.1039/D0DT01820A 14.07.2020 | Prof. Guido Kickelbick hält Festvortrag an der TU Kaiserslautern „Raumschiff Erde – Beiträge der Chemie für eine bessere Ressourcennutzung“ war der Titel des Festvortrages zur Verleihung des Steinhofer-Preises 2019 an der TU Kaiserslautern. 12.07.2020 | Herstellung von Aluminiden aus Nanopartikeln Können Ruthenium und Nickelaluminide aus Nanopartikeln erzeugt werden und welchen Vorteil hat dies gegenüber anderen Synthesemethoden? Thomas Klein zeigt in zwei Artikeln, die zusammen mit der Arbeitsgruppe von Prof. Mücklich veröffentlicht wurden, wie es durch intelligente chemische Synthese gelingt, die gewünschten Aluminide mittels sogenannten selbsterhaltenden Reaktionen zu erzeugen. Aluminide sind intermetallische Verbindungen mit ganz besonderen mechanischen und thermischen Eigenschaften. Mittels eines neuen Synthesekonzepts konnten die Materialien aus Nanopartikeln erzeugt werden. Besonders erwähnenswert ist hierbei, dass die Zündtemperatur für die selbsterhaltenden Reaktionen unter Ausnutzung der Nanometerskala wesentlich herabgesetzt werden konnte. Die Studien wurden in zwei Artikeln in Intermetallics veröffentlicht: Titel: „Al and Ru nanoparticles as precursors for Ru–Al intermetallics“ https://doi.org/10.1016/j.intermet.2020.106851 und „Al and Ni nanoparticles as precursors for Ni aluminides“ https://doi.org/10.1016/j.intermet.2020.106839 1. Juli 2020 | Jan-Falk Kannengießer beginnt mit Masterarbeit zum Thema Organosilanolate mit hohem Brechungsindex 20.04.2020 | Einfache und schnelle Synthese von Aluminium-Partikeln Ein neu erschienener Artikel von Thomas Klein zeigt, wie Submikron- und Nanometer-große Aluminium-Partikeln durch thermische Zersetzung von Organoaluminumverbindungen hergestellt werden können. In der Zeitschrift Nanotechnology publiziert. Titel: “Synthesis of submicron aluminum particles via thermal decomposition of alkyl aluminum precursors in the presence of metal seeds and their application in the formation of ruthenium aluminides” https://doi.org/10.1088/1361-6528/ab7ef5 15.04.2020 | Gemeinsame Publikation mit der Arbeitsgruppe von Prof. Volker Presser zu Batteriematerialien Aus Carbiden hergestellte Nb2O5 Phasen zeigen verbessertes Verhalten in Batterieanwendungen. Dies konnte in einer Studie nachgewiesen werden, die in der Zeitschrift ACS Applied Energy Materials von der Arbeitsgruppe um Prof. Presser publiziert wurde. Unsere Arbeitsgruppe lieferte hierzu wichtige strukturelle Erkenntnisse aus der Röntgenpulverdiffraktometrie. Titel: „Carbide-Derived Niobium Pentoxide with Enhanced Charge Storage Capacity for Use as a Lithium-Ion Battery Electrode“, https://doi.org/10.1021/acsaem.9b02549 26.02.2020 | Zwei neue Patente zu Materialien aus unserer Arbeitsgruppe veröffentlicht Wir sind stolz auf zwei heute veröffentlichte Patente zu Polysiloxan-Polysilsesquioxan-Materialien, die für optoelektronische Anwendungen verwendet werden können. Die von uns patentierten Materialien haben im Vergleich zu konventionellen Materialien folgende Vorteile: (i) es handelt sich um Einkomponenten-Materialien mit hocher Transmission im optischen Bereich, (ii) sie besitzen eine hohe thermische Stabilität, (iii) ihre Viskositäten und ihr Brechungsindex ist nahezu frei einstellbar und (iv) sie benötigen keinen Katalysator um auszuhärten. Die Patente sind unter folgenden Patentnummern zu finden: EP3613793A1; WO2020038935A1 bzw. EP3613809A1; WO2020038940A1 . 17.02.2020 | Dr. Oliver Janka verstärkt unser Team im Bereich Röntgendiffraktion Wir freuen uns, Dr. Oliver Janka in unserem Team begrüßen zu können. Seine Aufgaben liegen im Bereich der Betreuung unserer Großgeräte und der Unterstützung in der Lehre. In seiner Forschung beschäftigte sich Oliver Janka bisher mit intermetallischen Phasen. Februar 2020 | Lucas Niedner beginnt seine Dissertation in unserer Arbeitsgruppe zum Thema anorganisch-organische Janus-Nanopartikel mit stabilen ionischen Gruppen auf der Oberfläche. 10.02.2020 | Neuer Artikel in Zusammenarbeit mit Saeed Ahmad Khan und der Arbeitsgruppe von Prof. Marc Schneider veröffentlicht Der Titel des Papers lautet: Ketoconazole-loaded PLGA nanoparticles and their synergism against Candida albicans when combined with silver nanoparticles. Weitere Informationen sind hier zu finden. 7.11.2019 | Neuer Artikel zum Thema Reaktionsvermahlung erschienen Dennis Becker konnte in der wissenschaftlichen Abhandlung zeigen, wie sich die Parameter einer Vermahlung mit einer Hochenergiekugelmühle auf die strukturellen Eigenschaften von Li 2 Mn 2 O 4 , einem potentiellen Material für Batteriespeicher, auswirken. Das Paper ist im European Journal of Inorganic Chemistry unter dem Titel "Reactive Milling Induced Structure Changes in Phenylphosphonic Acid Functionalized LiMn 2 O 4 Nanocrystals – Synthesis, Rietveld Refinement, and Thermal Stability" erschienen. Weitere Informationen sind hier zu finden. 2018/2019 7.11.2019 Neuer Artikel zum Thema Reaktionsvermahlung erschienen Dennis Becker konnte in der wissenschaftlichen Abhandlung zeigen, wie sich die Parameter einer Vermahlung mit einer Hochenergiekugelmühle auf die strukturellen EIgenschaften von Li 2 Mn 2 O 4 , einem potentiellen Material für Batteriespeicher, auswirken. Das Paper ist im European Journal of Inorganic Chemistry unter dem Titel "Reactive Milling Induced Structure Changes in Phenylphosphonic Acid Functionalized LiMn 2 O 4 Nanocrystals – Synthesis, Rietveld Refinement, and Thermal Stability" erschienen. Weiter Informationen sind hier zu finden. 18.07.2019 Neues Patent mit der BASF Zusammen mit der BASF konnten wir ein neues Material patentieren, mit dem es möglich wird, organische Fluoreszenzfarbstoffe, die beispielsweise als Konversionsfarbstoffe in LEDs agieren, stabil in eine Polysiloxanmatrix einzubetten. Dies ermöglicht es, Seltenerd-reduzierte oder freie LEDs herzustellen. Die Patente sind unter folgenden Patentnummern zu finden: WO2019137975A2; WO2019137975A3; TW201938695A 18.01.2019 Neues Material zur Verkapselung von LEDs entwickelt Unsere Arbeitsgruppe hat mit Partnern aus der Industrie (Osram, BASF) ein Verkapselungsmaterial entwickelt, das LEDs ohne Seltene Erden langlebiger und günstiger machen könnte. Dazu haben wir auch zwei Patente angemeldet. Das neue Material basiert auf einem speziellen Silikon, dessen Eigenschaften sich durch die chemische Synthese nahezu beliebig festlegen lassen, je nach Anforderungen. Die wichtigsten Parameter sind erfüllt: Das Material ist thermisch sehr beständig, weist eine hohe Transparenz auf und ist leicht zu verarbeiten. Nebenbei spart das Material auch noch weitere Ressourcen. Bei konventionellen Materialien wird Platin als Katalysator für die Vernetzung der flüssigen Vorstufen eingesetzt, in dem neu entwickelten Material kann darauf komplett verzichtet werden. Hier geht es zur Pressemeldung: https://www.uni-saarland.de/universitaet/aktuell/artikel/nr/17391.html 1. November 2018: Mana Mohamed beginnt ihre Doktorarbeit auf dem Gebiet der Herstellung von Partikeln mit geringem Löslichkeitsprodukt und Metallcarbid-Vorstufen auf dem MicroJet-Reaktor 27. September 2018: Nils Steinbrück präsentiert die Ergebnisse des Projektes „ORCA - Organische und Seltenerd-reduzierte Konversionsmaterialien für LED- basierte Beleuchtung“ auf dem BMBF-MatRessource-FORUM „Materialien für eine ressourceneffiziente Industrie und Gesellschaft – MatRessource“ im Rahmen der MSE 2018 September 2018: Gabriela Moreira Lana beginnt Masterarbeit in Kooperation mit dem Leibniz-Institut für neue Materialien zum Thema silikatische Schutzschichten 9.-12. September 2018: Die Arbeitsgruppen Kickelbick und Scheschkewitz richten gemeinsam die European Silicon Days in Saarbrücken aus Silicium ist für unseren Alltag von größter Bedeutung. Das Element steckt in Computerchips, Solaranlagen, Baustoffen und vielen anderen Dingen unseres Alltags. Die Erforschung des zweithäufigsten Elementes ist für die Wissenschaft ebenso interessant wie für die Industrie. Aus diesem Grund dienen die „European Silicon Days“ als Forum des Austausches zwischen Akademie und Industrie. Der alle zwei bis drei Jahre stattfindende Kongress findet in wechselnden europäischen Ländern statt. Im Jahr 2018 trafen sich die Vertreter von Wissenschaft und Industrie vom 9. bis 12. September an der Universität des Saarlandes. 1. September 2018: Max Briesenick beginnt Doktorarbeit auf dem Gebiet der Synthese von LED-Verkapselungsmaterialien mit hohem Brechungsindex August 2018: Jan-Falk Kannengießer beginnt Bachelor-Arbeit zum Thema Hochbrechende LED Verkapselungsmaterialien Juli 2018: Anahita Emminghaus beginnt Bachelorarbeit zum Thema Kombination von Fluoreszierenden Nanopartikeln für Weißlicht Emission Mai 2018: Mike Nadig beginnt Masterarbeit in Kooperation mit dem Leibniz-Institut für neue Materialien zum Thema Polymerkomposite mit verbesserten Barriereeigenschaften 12. April 2018: Guido Kickelbick wird Mitglied im Arbeitskreis Hybride der Forschungsgesellschaft Kunststoffe e.V. (FGK) 1. April 2018: Bastian Oberhausen startet mit seiner Promotion zum Thema Selbstheilende Nanokomposite auf Basis von ionisch oberflächenfunktionalisierten Partikeln 2016/2017 2017 21. Dezember 2017: Prof. Kickelbick hält Weihnachtsvorlesung unter dem Motto: „Advent, Advent es knallt und brennt“ Prof. Guido Kickelbick und Andreas Adolf zeigen wieder viele spektakuläre Experimente, bei denen chemische Energie in Feuer und Schall verwandelt wird. 27. Oktober 2017: Tag der Chemie 2017 Die zwei Highlights am Tag der Chemie 2017 sind die Einweihung des renovierten Gebäudes C4.1 und das Festsymposium anlässlich der Verleihung des Horst-Dietrich Hardt-Preises an Prof. Lutz Gade (Universität Heidelberg). Pressemitteilung (Link: www.uni-saarland.de/aktuelles/artikel/nr/18154.html) 4.-8. September 2017: Teilnahme an der 19. International Sol-Gel Conference in Liege, Belgien September 2017: Michael Alexander Klos beginnt Bachelor-Arbeit auf dem Themengebiet der Mechanochemische Synthese und Oberflächenfunktionalisierung von Manganoxiden August 2017: Svenja Pohl beginnt mit Bachelor-Arbeit auf dem Gebiet der LED Verkapselungsmaterialien 20. Juli 2017: Exkursion führt die Arbeitsgruppe Kickelbick mit dem Boot auf die Saar Juli 2017: Michelle Arweiler beginnt eine Masterarbeit in einer Kooperation mit der Dillinger Hütte im Themenbereich der Analytik von Stahlproben mittels optischer Emissionsspektroskopie 13. Juni 2017: Prof. Kickelbick nimmt an Podiumsdiskussion zum Thema „Humboldt Reloaded“ teil Humboldt definierte die Universität nicht als Ort der Hierarchie, sondern als Ort des gemeinsamen Lehren und Lernens. In vielen Studiengängen erhalten die Studierenden nur Zugang zu Lehrveranstaltungen und wenig Einblicke in die Forschung. Das humboldtsche Bildungsideal würde heute den offenen Zugang für Forschung für Studenten zum frühest möglichen Zeitpunkt empfehlen. Wie dies verwirklicht werden kann, ist Thema dieser Veranstaltung. 5.-7. April 2017 : Lehrstuhl für Anorganische Festkörperchemie ist Mitausrichter der 13. Zsigmondy Kolloquium der Deutschen Kolloidgesellschaft Die Tagung ermöglicht es jungen Wissenschaftlern aus den Bereichen der Kolloid-, Oberflächen- und Grenzflächenforschung ihre Forschungsergebnisse als Vorträge oder Posterbeiträge einem internationalen Publikum zu präsentieren. Ziel des Kolloquiums ist es, eine Plattform für einen Austausch zwischen Forschern aus unterschiedlichen Forschungseinrichtungen mit der Industrie zu schaffen. März 2017: Lucas Niedner und Lucas Huppert beginnen mit Bachelorarbeiten in der Arbeitsgruppe auf Themengebieten der Herstellung von Nanopartikeln mit der Microjet-Technologie und Selbstheilenden Materialien ______ 2016 15. Dezember 2016: Prof. Guido Kickelbick hält Weihnachtvorlesung vor vollbesetztem Chemiehörsaal zum Thema „Engel im (Gold)Rausch“ 1. Dezember 2016: Charlotte Heinrich verteidigt erfolgreich ihre Dissertation zum Thema „Isotrope und anisotrope Oberflächenmodifizierungen von oxidischen Nanopartikeln mit ionischen Funktionalitäten“ 6.-11. November 2016: Prof. Guido Kickelbick ist eingeladener Vortragender auf dem Sino-German Symposium “Precursor derived ceramics and advanced hybrid materials” in Freiberg, Sachsen 1. November 2016: Einrichtung einer Emmy Noether-Nachwuchgruppe am Lehrstuhl Dr. André Schäfer erhält eine Emmy Noether-Förderung der Deutschen Forschungsgemeinschaft zur Einrichtung einer unabhängigen Nachwuchsgruppe im Bereich Organometallchemie der Hauptgruppenelemente. Pressemeldung Campus Web-Magazin 26. Oktober 2016: Prof. Guido Kickelbick wird zum ersten Dekan der neugegründeten Naturwissenschaftlich-Technischen Fakultät gewählt 4. Oktober 2016: Thomas Klein beginnt seine Promotion auf dem Themengebiet „Nasschemische Herstellung von hochreaktiven metallischen Nanopartikeln“ Oktober 2016: Einzug in die neu renovierten Laboratorien im Gebäude C4 1 auf dem Campus 9. Juli 2016: Experimentalvortrag von Prof. Guido Kickelbick und Andreas Adolf am Tag der Offenen Tür zur Chemie des Lichtes 2. Juni 2016: Vortrag von Prof. Guido Kickelbick auf den MINT-Days saarländischer Schulen am Campus, Thema: „Vom Feuer zur OLED – Chemie und Physik der Lichterzeugung“ 1. Mai 2016: Nils Steinbrück startet seine Promotion auf dem Themengebiet „Neue Hybridmaterialien für Seltenerd-reduzierte LEDs“ 1. Mai 2016: Neue Hybridmaterialien für Seltenerd-reduzierte LEDS In einem neuen vom Bundesforschungsministerium (BMBF) finanzierten Projekt untersucht die Arbeitsgruppe Kickelbick in Kooperation mit den Industriepartnern OSRAM GmbH, OSRAM Opto Semiconductors GmbH und BASF SE Möglichkeit, Seltene Erden in LED-Beleuchtung zu reduzieren. Der Part auf Seiten der Universität des Saarlandes liegt in der Entwicklung neuer anorganisch-organischer Hybridmaterialien, welche die Stabilität der Seltenerd-reduzierten LEDs erhöhen sollen. Das Projekt läuft unter dem Akronym ORCA „Organische und Seltenerd-reduzierte Konversionsmaterialien für LED-basierte Beleuchtung (ORCA)“. Weitere Informationen sind auf der Projekthomepage zu finden ( http://www.matressource.de/projekte/orca/ ). 1. März 2016: Dennis Becker beginnt seine Promotion auf dem Themengebiet „Herstellung von Festkörperionenleitern durch Reaktivvermahlung“ 2013/14/15 2015 10.-15. November 2015: Sino-German Symposium on Design, Processing and Application of Advanced Ceramic Materials Prof. Kickelbick ist eingeladener Vortragender des ersten chinesisch-deutschen Symposiums zum Thema Neuartige Keramische Materialien an der Zhengzhou University of Aeronautics. 3. November 2015: Kristina Brix startet ihre Doktorarbeit mit dem Thema "Charakterisierung von Ca-Bentonit als geotechnische Barriere einer Lagerstätte für hochradioaktive Abfälle" 2. November 2015: Sascha Verwaayen beginnt Masterarbeit mit dem Thema "Kondensationsreaktionen von Phosphonaten" 30. Oktober 2015: Promotionskolloquium von Tom Engel 20. Oktober 2015: Eröffnungsfeier des neuen Studiengangs BachelorPlus MINT Der neue Studiengang BachelorPlus MINT wird feierlich im Graduate Center der UdS eröffnet. Dieser neue Studiengang bietet eine zweisemestrige Orientierungsphase, in der die Studierenden Einblick in alle MINT-Fächer bekommen und sich anschließend für einen Bachelorstudiengang aus dem MINT-Bereich entscheiden müssen. Das Konzept des durch die Studienstiftung ausgezeichneten Studiengangs wurde am Lehrstuhl mit entworfen. 22. Oktober 2015: Verleihung des Eduard Martin Preises der Universität des Saarlandes an Nathalie Kunkel 20. Oktober 2015: Begrüßungsveranstaltung der neuen Studierenden des Masterstudiengangs Materialchemie 15. Oktober 2015: Prof. Kickelbick ist Gastredner beim Herbstkolloquium des Center for Interdisciplinary Nanostructure Science and Technology an der Universität Kassel 6. - 15. Oktober 2015: Summer School Materialwissenschaften und Chemie zusammen mit der East China University of Science and Technology (ECUST) im Graduate Center der UdS In Zusammenarbeit mit der Arbeitsgruppe von Prof. Springborg (Physikalische Chemie) wurde als Auftaktveranstaltung einer Kooperation mit der ECUST eine Summer School zu Themen der Chemie und Materialwissenschaften ausgetragen. Insgesamt nahmen an dieser Veranstaltung 16 Dozenten und Studierende der ECUST und 20 Professoren und Doktoranden der UdS teil. 9. Oktober 2015: Lise Boulard verteidigt erfolgreich ihre Masterarbeit "Characterization of the leaching behavior of portland cement concrete" an der École européenne de chimie, polymères et matériaux (ECPM) in Strasbourg 1. Oktober 2015: Achim Koch startet seine Doktorarbeit mit dem Thema „Ionische Grafting-From Polymerisationen von Nanopartikeln der Metalloxide“ 24./25. September 2015: New Energies. The Future of Energy at the Interface of Technology, Culture, and Society.Interdisciplinary Workshop for PhD Students of the Greater Region Einige Arbeitsgruppenmitglieder und Prof. Kickelbick beteiligen sich aktiv an dem Workshop, der sich unter anderem auch mit der Ressourceneffizienz der Synthese und der Langlebigkeit von Materialien beschäftigt. 21. September 2015 : In der Vortragsreihe Rent-a-Prof hält Prof. Kickelbick einen Vortrag zum Thema "Es werde Licht" am Marie-Luise-Kaschnitz-Gymnasium Völklingen 1. September 2015: Start des Verbundprojektes GRaZ (Geochemische Radionuklidrückhaltung an Zementalterationsphasen) mit Beteiligung der Universität des Saarlandes als Teilprojekt D: „Untersuchung von Zement- und Ton- Korrosionsprodukten und deren Einfluss auf die Rückhaltung von endlagerrelevanten Elementen“ (BMWi-Projekt 02E11415D, Laufzeit bis zum 31.08.2018) 17. August 2015: Nadja Klippel startet ihre Doktorarbeit mit dem Thema: „Fluoreszierende Silica Nanopartikel als Sonden in Nanokompositen“ 3. August 2015: Christina Odenwald startet ihre Doktorarbeit mit dem Thema „Das Microjet-Verfahren als Tool zur Herstellung nanopartikulärer Materialien“ Juli 2015: Nicole Bauer, Laura Jochum und Michelle Arweiler beginnen Bachelorarbeiten in der Arbeitsgruppe 10. Juli 2015: Promotionskolloquium von Nina Zahn 4. Juli 2015: Tag der offenen Tür der UdS Prof. Kickelbick hält zusammen mit Andrease Adolf Experimentalchemievortrag zum Thema "Independence Day: bekannte Produkte und Entdeckungen, unbekannte Forscher und Erfinder aus den USA" 16. Juni 2015: Lise Boulard beginnt ihre Masterarbeit im Projekt zur Endlagerforschung im Rahmen des Deutsch-Französischen Studiengangs Chemie 10. Juni 2015: Dennis Becker startet seine Masterarbeit über Batteriewerkstoffe 23./24. April 2015: Workshop: Festkörper-NMR Spektroskopie als Werkzeug in der Charakterisierung von Materialien Der Lehrstuhl richtet zusammen mit dem SYCMA-Doktorandenprogramm einen Workshop zum Thema Festkörper-NMR-Spektroskopie zur Charakterisierung von Materialien aus. Der Dozent ist Dr. Thierry Azais vom Laboratoire Chimie de la Matière Condensée de Paris, Collège de France. 31. März 2015: Prof. Kickelbick hält Vortrag auf der Bundestagung Mathematisch-Naturwissenschaftlicher Unterricht in Saarbrücken zum Thema „Selbstheilende Materialien“ 30. März -3. April 2015: Prof. Devon Shipp, Clarkson University (Potsdam, USA) Gastprofessor am Lehrstuhl 1. März 2015: Dr. André Schäfer beginnt als Nachwuchswissenschaftler und Akademischer Rat auf Zeit seine Habilitation in der Arbeitsgruppe 28. Februar 2015: Verleihung der Wilhelm-Klemm-Promotionspreises der Universität Münster an Nathalie Kunkel 22.-26. Februar 2015: Poster-Präsentationen von Dr. Christina Hein und MSc Ramona Hahn sowie Vortrag von Dr. Kautenburger bei der EWCPS 2015 (European Winter Conference on Plasma Spectrochemistry mit über 700 Teilnehmern aus 45 Ländern) an der Universität Münster 4. Februar 2015: Prof. Kickelbick hält Vortrag bei der Kinderuni der UdS zum Thema „Kratzer auf dem Handy: Wie kann ich die vermeiden?“ 22. Januar 2015: GDCh-Vortrag von Prof. Kickelbick an der Universität Chemnitz zum Thema „Chemisches Design von Anorganischen-Organischen Grenzflächen“ 15. Januar 2015: Night of the Profs Bei der gemeinsamen Party des AStA, der UdS und des Radiosenders 103.7 UnserDing betätigt sich Prof. Kickelbick als DJ und legt Platten auf. 5. Januar 2015: Dennis Meier startet seine Doktorarbeit mit dem Thema „Neue Polysiloxan-basierte Materialien für das LED-Packaging“ ______ 2014 12. November 2014: Verleihung des Elisabeth und Dr. Horst-Dietrich Hardt-Promotionspreises der Universität des Saarlandes an Nathalie Kunkel 29. Oktober 2014: Prof. Kickelbick wird zum Prodekan der naturwissenschaftlich-Technischen Fakultät III der UdS gewählt 28./29. Oktober 2014: Organisation und Ausrichtung des 7. Workshops des BMWi-Verbundprojekts „Rückhaltung endlagerrelevanter Radionuklide im natürlichen Tongestein und in salinaren Systemen“ an der Universität des Saarlandes 21.-23. Oktober 2014: Prof. Kickelbick Referent bei der 5. Sol-Gel Fachtagung der Technischen Akademie Wuppertal 24.-26. September 2014: 17. Vortragstagung der Wöhler-Vereinigung für Anorganische Chemie in Saarbrücken Die Wöhler-Tagung mit den bisher meisten Teilnehmern in der Geschichte dieser Veranstaltungsreihe findet unter Leitung der Anorganischen Chemie an der UdS statt. Neueste Trends aus der Hauptgruppen- und Komplexchemie sowie der Chemie von Festkörper und Materialien in Bezug auf Grundlagenforschung und industrielle Anwendung werden in Vorträgen und Postern von Wissenschaftlern aus Deutschland und dem benachbarten Ausland vorgestellt. 16.-19. September 2014: Jubiläumstagung zum 40-jährigen Bestehen der Gesellschaft für Thermische Analyse Prof. Kickelbick ist einer der Dozenten bei einem Workshop zum Thema Anwendung von Verfahren der thermischen Analyse bei Hybridmaterialien. 8. September 2014: Promotionskolloquium von Annika Betke 17. August 2014: Martin Geiger startet seine Masterarbeit zur ICP-MS Analyse von Dialyselösungen in Kooperation mit Fresenius Medical Care Deutschland GmbH 28. Juli -01. August 2014: Prof. Michel Wong Chi Man Institut Charles Gerhardt Montpellier (ICGM), Equipe Architectures Moléculaires et Matériaux Nanostructurés, Gastprofessor am Institut 23. Juli 2014: Vortragstagung der Doktorandenschule Doktorandenschule SYCMA „Synthese und Charakterisierung von Materialien und Werkstoffen“ zum Thema Moderne Materialien 5. Juli 2014: Tag der offenen Tür der UdS Prof. Kickelbick hält Vortrag zum Thema „Das Universum auf DIN A4 - Ein experimenteller Streifzug durch das Periodensystem“ 4. Juli 2014: Promotionskolloquium von Patrick Wenderoth 1. Juli 2014: Erfolgreiche 15-monatige Verlängerung und Aufstockung für das Saarbrücker BMWi-Projekt zur Endlagerforschung bis zum 30.09.2015 23. Juni 2014: Kerstin Keßler-Neufang startet ihre Bachelorarbeit zu Apatit-Verbindungen 11. Juni 2014: Ramona Hahn startet ihre Masterarbeit zum Thema: "Untersuchungen zur Metallkomplexierung von Europium und Uran mit organischen Komplexliganden mittels Dialyse und Ultrafiltration" im BMWi-Projekt zur Endlagerforschung 26.-30. Mai 2014: Prof. Kickelbick eingeladener Vortragender auf dem E-MRS Spring Meeting in Lille in der Sektion „Hybrid materials engineering in biology, chemistry and physics“ 25. Mai 2014: Promotionskolloquium von Nathalie Kunkel 30. April -04. Mai 2014: Prof. Kickelbick eingeladener Vortragender auf dem 3rd International Symposium on Controlled/Living Polymerization: From Synthesis to Applications, CLP’14 in Belek, Türkei 1. April 2014: Sandra Schäfer startet ihre Doktorarbeit zum Thema „Selbstheilende Nanokomposite“ 14. Februar 2014: Promotionskolloquium von Christian Reichert 28. Januar2014: Dennis Becker startet seine Bachelor-Arbeit zu Apatit-Verbindungen ______ 2013 1. November 2013: Neues Projekt beschäftigt sich mit der Verwertung von Flugaschen Ein neues industrienahes Forschungsprojekt beschäftigt sich mit der Aufarbeitung von Flugaschen aus Verbrennungsanlagen. 28. Oktober 2013: Dr. Oliver Clemens erhält Eduard Martin - Preis 2011/2012. Der Institutsmitarbeiter Oliver Clemens erhält für seine Dissertation zum Thema "Synthese und Charakterisierung von Lithium-haltigen Übergangsmetall-Phosphaten und -Vanadaten sowie von deren Mischkristallreihen" den Eduard Martin - Preis 2011/2012. Dieser Preis wird jedes Jahr an die beste Doktorandin oder den besten Doktoranden aus den einzelnen Fakultäten der Universität des Saarlandes vergeben. 1. Oktober 2013: Jessica Bauer startet ihre Doktorarbeit zum Thema "Vergleich von Synthese und Eigenschaften potentieller Batteriewerkstoffe auf der Basis von Na- und Li-Ionenleitern" 9. Juli 2013: Bessere Materialien für LED Packaging LEDs werden in transparente Polymermaterialien eingebettet. Ein neues industrienahes Forschungsprojekt widmet sich der Verbesserung dieser Materialien im Hinblick auf Haftung und Transparenz. 30. Mai 2013: Guido Kickelbick wird Mitglied des Editorial Boards von Inorganics Inorganics ist eine Open Access Zeitschrift, die aus allen Bereichen der anorganischen Chemie publiziert und sich einen strikten Peer-Review-Kodex auferlegt hat. ( http://www.mdpi.com/journal/inorganics ) 1. März 2013: Dr. Kai Abersfelder startet als Mitarbeiter am INM Im Rahmen des INM Fellowships von Prof. Guido Kickelbick startet Dr. Kai Abersfelder ein Projekt zum Thema "Herstellung und Selbstanordnung von Janus-Nanopartikeln" am INM. 2011/2012 20. Dezember 2012: Weihnachtsvorlesung - Reloaded „Es werde Licht – Weihnachtsvorlesung reloaded“ lautet das Motto der diesjährigen Weihnachtsvorlesung der Anorganischen Chemie. In anschaulichen und teils spektakulären Experimenten geben das Team um Professor Guido Kickelbick und seinem Assistenten Andreas Adolf – nicht immer ernst gemeinte – Tipps, wie durch Reaktionen die Energiewende chemisch gelöst werden kann. „Chemie ist dort, wo es stinkt und kracht. Zumindest den letzten Aspekt werden wir auch in der diesjährigen Weihnachtsvorlesung exzessiv berücksichtigen“, gibt Professor Guido Kickelbick vorab über den Inhalt preis. Die Weihnachtsvorlesung der Anorganischen Chemie zählt zu einem der Publikumsmagneten auf dem Campus. 2011 musste sie aufgrund von Baumaßnahmen ausfallen, umso größer ist die Freude der Chemiker, sie in diesem Jahr wieder aufleben zu lassen. Der große Chemiehörsaal im Gebäude C4 3 ist zur wohl aufsehenerregendsten Vorlesung des Jahres traditionell bis auf den letzten Platz besetzt. Teilweise stehen Studenten und Mitarbeiter der Uni schon stundenlang an, um die besten Plätze zu ergattern. „Wir freuen uns selbst immer auf diese Veranstaltung, weil wir dann in der Lage sind, endlich wieder einmal spektakuläre Experimente selbst durchzuführen“, so Kickelbick. In diesem Jahr soll sich alles um die Energiewende drehen. Daher machen Kickelbick und sein Team vor allem Experimente, bei denen in irgendeiner Form Energie freigesetzt wird, zum Beispiel in Form von Licht, Wärme oder als Explosion. Dabei sollen wissenschaftliche Prinzipien in unterhaltsamer Form präsentiert werden, ohne die fundamentalen Hintergründe der vorgeführten Experimente zu verheimlichen. 10.-12. Oktober 2012: Gesellschaften für Thermische Analyse und Kalorimetrie aus Deutschland und der Schweiz tagen in Saarbrücken Die nationalen Gesellschaften für Thermische Analyse und Kalorimetrie in Deutschland und der Schweiz veranstalten eine bilaterale Konferenz unter Leitung von Prof. Kickelbick in Saarbrücken. Die thematischen Schwer- punkte der Tagung liegen in den Bereichen der Thermischen Analyse und Kalorimetrie von Hybrid-, Nano- und Biomaterialien. Bei der Saarbrücker Tagung werden neben Experten aus der Wissenschaft auch Unternehmen neue Entwicklungen auf dem Gebiet der instrumentellen thermischen Analytik vorstellen. Damit bietet sie auch Neueinsteigern einen grund- legenden Einblick in diese Technologie. 1. Oktober 2012: Laborgespräche Materialoptimierung durch Nanotechnologie In Zusammenarbeit mit der Kontaktstelle für Wissens- und Technologie- transfer (KWT) der Universität des Saarlandes und der Zentrale für Produktivität und Technologie Saar e. V. (ZPT) fand mit Firmen der Region eine Vortragsveranstaltung aus der Reihe Laborgespräche am Institut statt. In Kurzvorträgen und einer anschließenden Laborbegehung mit den Teilnehmern wurden die anwendungsnahen Forschungstätigkeiten des Instituts vorgestellt. 1. Oktober 2012: Prof. Holger Kohlmann tritt Stelle an der Universität Leipzig an Dr. Holger Kohlmann – bisheriger Privatdozent an unserem Institut – tritt eine Stelle als Professor für Funktionsmaterialien an der Universität Leipzig an. Das Institut verliert damit eine tragende Säule in Forschung und Lehre. Wir wünschen Prof. Kohlmann alles Gute für seine neue Position in Leipzig. 26. /27. September 2012: So l-Gel Tagung in Saarbrücken Das Institut organisiert in Zusammenarbeit mit der Technischen Akademie Wuppertal (TAW) unter Leitung von Prof. Kickelbick die 4. Sol-Gel Fachtagung mit dem thematischen Spektrum: Grundlagen, Technologien, Anwendungen. Die Vorträge behandeln neben grundlegenden Untersuchungen vor allem Themen, die entweder den Einzug der Sol-Gel-Verfahren in die Industrie demonstrieren, oder bei denen die Einführung dieser Technik in die Industrie in greifbare Nähe gerückt ist. Der Fachkongress befasst sich mit Themenkomplexen in den Bereichen: Funktionelle Beschichtungen Partikel und Kapseln Hybridmaterialien und Nanokomposite Oberflächendeterminierte Materialien Die Anwendungen des Sol-Gel Prozesses reichen von mechanischen Verbesserungen von Oberflächen, optischen und elektronischen Anwendungen bis hin zu Formulierungen im Self-Care und medizinisch-pharmazeutischen Bereich. 3. September 2012: U nterzeichnung eines Kooperationsvertrages mit der Dillinger Hütte Ein neuer Kooperationsvertrag zwischen der Anorganischen Festkörper- chemie und dem saarländischen Traditionsunternehmen Dillinger Hütte steckt den Rahmen für eine engere zukünftige Zusammenarbeit ab. Besondere Schwerpunkte der Kooperation sind die Element- und Strukturanalytik. 10. Juli 2012: Guido K ickelbick wird zum INM Fellow berufen Mit einem besonderen Vertragsmodell verstärkt das INM (Leibniz-Institut für Neue Materialien) seine Zusammenarbeit mit der Universität des Saarlandes. Guido Kickelbick, wird als erster „INM Fellow“ mit dem INM in einer strategischen Partnerschaft zusammenarbeiten. Beide Partner erhoffen sich dadurch sowohl gegenseitige Impulse im wissenschaftlichen Arbeiten, als auch größere Chancen auf die Förderung wissenschaftlicher Projekte. 6. Juli 2012: Antrittsvorlesung PD Dr. Ralf Kautenburger Durch ein erfolgreiches Umhabilitationsverfahren von Herrn Kautenburger besitzt dieser nun die Lehrbefugnis für das Fach Analytische Chemie an der Universität des Saarlandes und wird unser Team zukünftig in der Lehre in diesem Fachgebiet unterstützen. Herrn Kautenburgers Forschungsgebiete sind Element-, Bio- und Umweltanalytik sowie hierbei insbesondere die Speziationsanalytik. Juni 2012: Neues Röntgenpulverdiffraktometer geht in Betrieb Durch einen erfolgreichen Großgeräteantrag bei der Deutschen Forschungsgemeinschaft (DFG) konnte ein neues Röntgenpulverdiffraktometer vom Typ Bruker D8 angeschafft und in Betrieb genommen werden. Mit diesem Gerät steht dem Institut nun ein hochmodernes, leistungsfähiges Diffraktometer zur Verfügung, mit dem kristalline Materialien unter Umgebungs-, Inertgas- und Hochtemperaturbedingungen charakterisiert werden können. 23. Mai 2012: Neuer Master-Studiengang Materialchemie Der Studiengang Materialchemie, der zum Wintersemester 2012/13 aufgenommen werden kann, bietet eine vertiefende Ausbildung mit hohem Forschungsbezug im interdisziplinären Feld zwischen Natur- und Werkstoffwissenschaften. Der Masterstudiengang will den Studierenden die Breite von materialchemischen und ingenieurwissenschaftlichen Betrachtungen näherbringen und das in den Bachelor-Studiengängen erworbene Wissen der Synthese und Charakterisierung auf materialchemische Problemstellungen anwenden. Nähere Infos und Ansprechpartner auf der Seite www.uni-saarland.de/materialchemie _______ 2. Dezember 2011: N eues Praktikumsgebäude für Anorganische Chemie eingeweiht Bachelor-Studenten der Chemie und Studenten anderer Fakultäten, die im Verlauf Ihres Studiums ein chemisches Grundpraktikum absolvieren müssen, finden nun ein modernes Gebäude mit funktionalen Praktikums- bedingungen vor. Der Bund und das Saarland haben in den Bau rund 6,6 Millionen Euro investiert. Die Bundesmittel sind Bestandteil des Konjunkturpakets II. Weitere 143.000 Euro flossen in die Erstausstattung des 855 Quadratmeter großen, sechsstöckigen Gebäudes. Baubeginn für das Praktikumsgebäude war im Juni 2010. Eine Besonderheit des Gebäudes ist dessen Eignung für gehbehinderte Studenten. Absenkbare Arbeitsflächen in den Laboratorien, eine an deutschen Universitäten noch kaum vorhandene Technik, ermöglichen die Einstellung der Arbeitsumgebung im Laboratorium auf besondere Bedürfnisse. 2. Dezember 2011: J onas Sander erhält GDCh-Preis Jonas Sander, Diplomand in der Arbeitsgruppe von PD Kohlmann, erhält einen der GDCh-Preise für die besten Studienleistungen, welcher bei der feierlichen Zeugnisübergabe überreicht wurde. 25. November 2011: Diesjährige Weihnachtsvorlesung fällt aus Aufgrund von Verzögerungen in den Baumaßnahmen im Vorbereitungslabor der Experimentalchemievorlesungen muss die diesjährige Weihnachtsvorlesung ausfallen. 19. Oktober 2011: Ringvorlesung "Chemie - nichts geht ohne sie!" startet Eine Ringvorlesung im internationalen Jahr der Chemie 2011 soll die Breite der Chemie ins Bewusstsein der Öffentlichkeit rücken. Die Professoren der Chemie und Pharmazie der Universität des Saarlandes stellen im Haus der Zukunft in Saarbrücken beginnend mit dem 19.10. die Faszination in 15 populärwissenschaftlichen Vorträgen dar. Nähere Informationen sind auf der Homepage der Veranstaltung www.uni-saarland.de/alles -chemie zu finden. Die Ringvorlesung wird von Prof. Kickelbick koordiniert. 1. Juli 2011: Universität des Saarlandes an einem vom BMWi geförderten Projektverbund zur Endlagerforschung beteiligt Wie in vielen anderen Ländern ist man auch in Deutschland auf der Suche nach einem geeigneten untertägigen Lager, in dem hochradioaktive Abfälle für Hunderttausende von Jahren sicher aufbewahrt werden können. Im Rahmen von Forschungsprojekten werden analytische Methoden (Sorptions- bzw. Desorptions-Experimente für Radionuklide an Tongestein sowie Bestimmung der Metall-Speziation mit organischen und anorganischen Komplexliganden) und Werkzeuge (beispielsweise 2D-NMR oder CE-ICP-MS-Kopplung) entwickelt, die es im Falle der Auswahl potentieller Standorte in Tongestein erlauben, möglichst schnell und zuverlässig standortbezogene Untersuchungen für die Langzeitsicherheitsanalyse durchzuführen. Das Bundesministerium für Wirtschaft und Technologie (BMWi) fördert im Rahmen eines deutschlandweiten Verbundes das Projekt an der Universität des Saarlandes für weitere drei Jahre mit etwa 583.000 Euro. Mit dieser Anschlusszuwendung wurden seit August 2006 insgesamt über 1.279.000 Euro an Drittmittel für die Saarbrücker Chemiker (PD Dr. Ralf Kautenburger, Prof. Dr. H.P. Beck und Prof. Dr. G. Kickelbick) bewilligt. 1. Juli 2011: DFG genehmigt gemeinsames Projekt zwischen Chemikern und Ingenieuren zum Thema "Selbstheilende Nanokomposite" Die Arbeitsgruppen von Prof. Wenz, Prof. Stommel und Prof. Kickelbick widmen sich in einem gemeinsamen Forschungsprojekt im Rahmen des DFG-Schwerpunktprogramms "Design and Generic Principles of Self-healing Materials" (DFG SPP 1568) der Synthese von neuartigen Nanokompositen aus Cellulose und anorganischen Partikeln als selbstheilende Materialien. Letzteres bedeutet, dass z.B. entstehende Risse im Polymer gestoppt werden können und durch thermoreversible Reaktionen eine Selbstheilung herbeigeführt werden kann. 1. Juli 2011: Gene hmigung zur Anschaffung eines neuen Pulverdiffraktometers Ein neues leistungsfähiges Pulverdiffraktometer wurde genehmigt. Das Gerät wird aus Mitteln des Bundes und der Universität im Programm Forschungsgroßgeräte nach Art. 91b GG angeschafft. Das theta-theta-Diffraktometer mit schnellem 1D-Detektor kann im Routinebetrieb über einen automatischen Probenwechsler Reihen von Messungen an polykristallinem Material durchführen. Messungen an luftempfindlichen Proben sind über spezielle Probenträger mit Dom-Konstruktion möglich. Sowohl Planpräparate als auch Kapillarpräparate können bei hohen Temperaturen, teilweise bis 1200°C, gemessen werden. 18. Juni 2011: Chemie Show am Tag der offenen Tür Prof. Guido Kickelbick und Andreas Adolf präsentieren am Tag der offenen Tür eine Chemie-Show zum Thema "Magische Chemie - Zauberhafte Experimente aus der Chemie". 25. Mai 2011: Erstes Doktorandentreffen im strukturierten, interdisziplinären Doktorandenprogramm "Synthese und Charakterisierung von Materialien und Werkstoffen" (SYCMA) Das strukturierte Doktorandenprogramm ermöglicht Doktoranden der Fachrichtungen Chemie und Material- und Werkstoffwissenschaften, interdisziplinäre Einblicke in die unterschiedlichen Denkweisen der Fachdisziplinen durch gemeinsame Veranstaltungen und Forschungsprojekte. Die Teilnehmer an der Graduiertenschule sollen durch engen Kontakt zu Doktoranden anderer Fachrichtungen in einer wissenschaftlichen Diskussionskultur ihren Horizont erweitern und neue interdisziplinäre Projektideen generieren. Das Doktorandenprogramm wird koordiniert durch Prof. Kickelbick. Weitere Informationen sind auf der SYCMA-Homepage zu finden. 10. Mai 2011: Fl orian Wisser erhält GDCh-Preis Florian Wisser, Diplomand in der Arbeitsgruppe von Prof. Kickelbick, erhält einen der begehrten GDCh-Preise für die besten Studienleistungen, welcher bei der feierlichen Zeugnisübergabe überreicht wurde. 26. April 2011: Prof. Guido Kickelbick und PD Holger Kohlmann am "Rent a Prof"-Programm beteiligt Im Rahmen des Programms "Rent a Prof" der Chemie-Professoren der Universität des Saarlandes werden Schulbesuche und Vorträge zu verschiedenen Themen der Chemie angeboten, um den Schülern zu zeigen, wie wichtig Chemie für das tägliche Leben ist. An diesem Programm beteiligt sich auch der Lehrstuhl mit Themen wie "Chemiker als Architekten für neue High-Tech Materialien" und "Symmetrie in der Chemie - von Strukturen zu Eigenschaften". 2009/2010 16. Dezember 2010: Weihnachtsvorlesung "Feuer und Eis" Zur diesjährigen Weihnachtsvorlesung luden Prof. Dr. Guido Kickelbick und Herr Andreas Adolf alle Chemieinteressierten ein. Im bis zum letzten Sitzplatz gefüllten Hörsaal wurden spektakuläre Experimente zum Thema Feuer und Eis gezeigt. 1. November 2010: Patrick Wenderoth erhält Promotions-Stipendium Patrick Wenderoth, Doktorand in der Arbeitsgruppe von PD Kohlmann, wird für die Dauer von zwei Jahren über ein Promotions-Stipendium nach dem Landesgraduiertenförderungsgesetz gefördert. 22. Oktober 2010: Lehrstuhl richtet Doktorandentag der Chemie aus Der diesjährige Doktorandentag in der Fachrichtung Chemie wurde vom Lehrstuhl für Anorganische Festkörperchemie ausgerichtet. Zu diesem waren Professoren, Studierende, Kooperationspartner aus der Industrie und alle weiteren Interessierten eingeladen. Im Rahmen dieses Tages, der alleine von den Doktoranden organisiert und durchgeführt wird, wurden Vorträge und Poster zu den verschiedenen Forschungsthemen der Promovierenden in der Chemie prässentiert. Dadurch wurde den Studierenden und anderen Interessierten ein Bild der bestehenden Forschungsrichtungen der Chemie gezeigt. Insbesondere bot der Doktorandentag Bachelorstudenten, die in ihren Praktika bislang nur wenig Einblick in die Forschungsschwerpunkte der Arbeitskreise erhalten konnten, die Gelegenheit, sich über mögliche Themen für die anstehende Bachelor-Arbeit zu informieren. In Gastvorträgen stellte Dr. Theo Jäger das GradUS-Programm der UdS vor und Prof. Dr. Guido Kickelbick berichtete in seinem Vortrag "Mad Scientists - Attraktivität einer wissenschaftlichen Karriere an der Hochschule" über Alternativen zu einer Karriere in der Industrie. 21. Oktober 2010: Neues Großgerät für thermische Analyse installiert Das Institut ist um ein Großgerät zur Kopplung von thermischer Gravimetrie und Infrarotspektroskopie reicher. Das Gerät ermöglicht den Massenverlust einer Probe beim Erhitzen zu bestimmen und die dabei freigesetzten Gase durch Infrarotspektroskopie zu analysieren. Damit ist es möglich, chemische Prozesse nachzuweisen, die bei der thermischen Alterung einer Probe ablaufen. Das Gerät soll vor allem in Projekten im Bereich der Oberflächenfunktionalisierung von Nanopartikeln und der Herstellung von Nanokompositen eingesetzt werden. 26. Juni 2010: Teilnahme am Tag der Offenen Tür Unter dem Thema "Hinter den Kulissen einer chemischen Experimentalshow" hat sich die Abteilung am Tag der Offenen Tür der Universität beteiligt. In kleinen Arbeitsgruppen konnten die Teilnehmer unter Anleitung chemische Versuche vorbereiten und anschließend selbst im Rahmen einer kleinen Show dem Publikum präsentieren. 28. Mai 2010: Genehmigung für ein neues Großgerät Im Rahmen der Fördermaßnahme "Großgeräte der Länder" wurde eine Kopplung zwischen thermischer Gravimetrie und FT-IR-Spektrometer genehmigt. Mit diesem Gerät wird es in Zukunft möglich sein, die bei einer thermischen Zersetzung von Materialien entstehenden Gase chemisch zu analysieren. ______ 23. November 2009 : Antrittsvorlesung von Prof. Kickelbick Herr Kickelbick gab im Rahmen seiner Antrittsvorlesung einen Einblick in seine Forschungsgebiete. Der Titel der Vorlesung war "Komplexe Materialien aus einfachen Bausteinen: Anorganisch-organische Hybridmaterialien und Nanokomposite". Nach der Veranstaltung bestand im Rahmen eines kleinen Empfangs die Möglichkeit des gegenseitigen Kennenlernens. 15. November 2009: Neue wissenschaftliche Geräte Laserheizung (2*40W) und automatische Gasdruckregelung zur Hydrierung intermetallischer Phasen (PD Dr. Holger Kohlmann) 1. November 2009: Neues DFG-Projekt Beginn des neuen DFG-Prpjekts “Mechanismen der Bildung metastabiler Hydride und Nitride mittels in situ-Neutronenbeugung von Fest-Gas-Reaktionen” (Kohlmann, Saarbrücken; Niewa, Stuttgart; Rosner, Dresden) im Rahmen des Schwerpunktprogramms 1415 “Kristalline Nichtgleichgewichtsphasen” unter der Leitung von PD Dr. Holger Kohlmann 20. Juli 2009: Prof. Kickelbick neuer GDCh-Ortsverbandsvorsitzender Im Rahmen einer außerordentlichen Mitgliederversammlung wurde Prof. Kickelbick zum neuen GDCh-Ortsverbandsvorsitzenden gewählt. Er tritt damit die Nachfolge von Prof. Hempelmann an. 2. Juni 2009: Dienstantrit von Professor Kickelbick Der neue Inhaber der Professur für Anorganische Festkörperchemie, Dr. Guido Kickelbick, tritt seinen Dienst in Saarbrücken an. © André Schäfer 02.10.2025 | Promotion von Max Briesenick Wir gratulieren Max Briesenick zum erfolgreichen Abschluss seiner Promotion! In seiner nun abgeschlossenen Doktorarbeit konzentrierte er sich auf die Synthese transparenter Silsesquioxan-Siloxan-Oligomere für optische Anwendungen mit einstellbarem Brechungsindex. Seine Forschung zeigte, dass hochbrechende und thermisch stabile Systeme realisiert werden können – allerdings erfordern einige dieser Materialien eine spezielle Nachbehandlung. Max gelang es nicht nur, kettenförmige Oligomere zu synthetisieren, sondern er konnte auch die Bildung polyedrischer Strukturen nachweisen, was neue Perspektiven für die Materialentwicklung eröffnet. Wir freuen uns über diesen wichtigen wissenschaftlichen Beitrag und wünschen Max alles Gute für seine Zukunft! 22.09.2025 | Schmelzen, Mischen, Fluoreszieren - ein neues Verfahren ermöglicht die Verkapselung von Fluoreszenzfarbstoffen In einer heute publizierten Arbeit haben Svenja Pohl, Nils Steinbrück und Michal Pachnicz erstmals eine Schmelz-Emulsions-Strategie zur Herstellung von Polyphenylsilsesquioxan (PPSQ)-Mikrosphären mit eingebetteten hydrophoben Farbstoffen vorgestellt. Ausgangspunkt war ein thermoplastischer, niedrig vernetzter PPSQ-Vorläufer – das sogenannte „Melting Gel“ – das sich oberhalb von 70 °C in heißem Wasser mit Triton™ X-405 emulgieren lässt. Die anschließende Kondensation mit Natronlauge führt zur Bildung fester Mikrosphären mit einem mittleren Durchmesser von ca. 3 μm. Durch gezielte Wärmebehandlung wurde die Vernetzung weiter erhöht und die Tensidrückstände entfernt, wodurch die Partikeloberfläche von hydrophil zu hydrophob überführt wurde. Die phenylreiche Matrix ermöglicht eine effiziente Einbettung von hydrophoben Fluoreszenzfarbstoffen. Besonders hervorzuheben ist die hohe Quantenausbeute des Farbstoffs in der Matrix sowie die gute Farbstoffverteilung. Diese neue Methode eröffnet innovative Wege für optoelektronische Anwendungen wie LED-Verkapselungen und lumineszente Solarkonzentratoren. Die Studie ist in der Zeitschrift Materials Advances erschienen. Zur Publikation . 29.08.2025 | Optimierte Synthesestrategie für transparente Hochtemperaturmaterialien in optischen Anwendungen Eine neue Studie von Max Briesenick untersucht, wie Strategien nach der Vernetzung die thermischen und mechanischen Eigenschaften von Siloxan/Silsesquioxan-Hybridmaterialien verbessern können. Diese Hybride, die sterisch anspruchsvolle aromatische Einheiten enthalten, unterliegen während der thermischen Konsolidierung häufig keiner vollständigen Vernetzung, was ihre Leistungsfähigkeit in Hochtemperaturumgebungen einschränkt. Durch Zugabe spezifischer Additive gelang es, Materialien mit verbesserter struktureller Integrität, hohem Kondensationsgrad und bemerkenswerter thermischer Stabilität – bis zu 453 °C – zu entwickeln. Die resultierenden Polymere behielten nicht nur ihre langfristige optische Transparenz bei 200 °C mit minimaler Vergilbung bei, sondern zeigten auch ein elastisches Verhalten bei erhöhten Temperaturen. Diese Elastizität, zusammen mit einer verbesserten Viskosität und einer verringerten Sprödigkeit, macht sie für anspruchsvolle thermische Anwendungen geeignet. Die Studie ist in der Zeitschrift Molecules erschienen. Zur Publikation . 28.08.2025 | Publikation in Chemical Science erschienen In Zusammenarbeit mit der Gruppe von Prof. Richard Dronskowski von der RWTH Aachen konnte die Bindung in intermetallische Verbindungen des Systems Ca-Pt-Al im Detail untersucht werden. Die Verbindungen wurden von Dr. Stefan Engel während seiner Dissertation hergestellt und strukturell untersucht, nun konnte mit Hilfe quantenchemischer Rechnungen und des Programm-Pakets LOBSTER der Aachener Kollegen ein deutlich tieferer Einblick in die komplexe Bindungssituation dieser Verbindungen gewonnen werden. Die Arbeit konnte im Flaggschiff-Journal Chemical Science der Royal Society of Chemistry (RSC) plaziert werden. Zur Publikation © Elias Gießelmann 08.08.2025 | Promotion von Mana Abdirahman Mohamed Im Rahmen ihrer Doktorarbeit hat Mana Mohamed die kontinuierliche nasschemische Synthese von anorganisch-organischen Hybridmaterialien untersucht. Die Materialien basieren auf Polyoxomolybdaten und zeigen vielversprechende Eigenschaften als Elektrodenmaterialien für Lithium-Ionen-Batterien. Besonders bemerkenswert: Die Materialien können sowohl mit als auch ohne Temperaturbehandlung eingesetzt werden, was ihre Anwendungsmöglichkeiten deutlich erweitert. Ihre Forschung liefert wichtige Beiträge zur Entwicklung effizienter und nachhaltiger Energiespeichertechnologien. Herzlichen Glückwunsch zur erfolgreichen Promotion! © Guido Kickelbick 10.07.2025 | Lorenzo Alberti als ERAMSUS+ Student verabschiedet Für sechs Monate war Lorenzo Alberti, Doktorand an der Università degli Studi di Milano-Bicocca, in unserer Arbeitsgruppe zu Gast. Während seines Forschungsaufenthalts arbeitete er an einem spannenden Projekt zur Entwicklung selbstheilender Polymere auf Basis metallvermittelter Vernetzungsreaktionen. Die Zeit war nicht nur wissenschaftlich äußerst produktiv, sondern auch persönlich bereichernd für das gesamte Team. Wir danken Lorenzo herzlich für die tolle Zusammenarbeit und wünschen ihm weiterhin viel Erfolg auf seinem akademischen Weg!

Publikationen 1. Finite element simulations of smart fracture plates capable of cyclic shortening and lengthening: which stroke for which fracture? Front Bioeng Biotechnol. 2024 Jul 23:12:1420047. doi: 10.3389/fbioe.2024.1420047. eCollection 2024. Authors Michael Roland 1 , Stefan Diebels 1 , Kerstin Wickert 1 , Tim Pohlemann 2 , Bergita Ganse 2 3 Affiliations 1 Chair of Applied Mechanics, Saarland University, Saarbrücken, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg, Germany. 3 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Departments and Institutes of Surgery, Saarland University, Homburg, Germany. PMID: 39108595 PMCID: PMC11300273 DOI: 10.3389/fbioe.2024.1420047 Abstract Introduction: Bone healing can be improved by axial micromovement, as has been shown in animals and human patients with external fixators. In the development of smart fracture plates, the ideal amount of stroke for different fracture types in the different healing stages is currently unknown. It was hypothesized that the resulting strain in the fracture gap of a simple tibial shaft fracture does not vary with the amount of axial stroke in the plate, the fracture gap size, and the fracture angle. Methods: With finite element simulations based on body donation computed tomography data, the second invariant of the deviatoric strain tensor (J2), strain energy density, hydrostatic strain, octahedral shear strain, and percentage of the fracture gap in the "perfect healing window" were computed for different gap sizes (1-3 mm), angles (5°-60°), and plate stroke levels (0.05-0.60 mm) in three healing stages. Multiple linear regression analyses were performed. Results: Findings showed that an active fracture plate should deliver an axial stroke in the range of 0.10-0.45 mm. Different optimal stroke values were found for each healing phase, namely, 0.10-0.25 mm for the first, 0.10 mm for the second, and 0.35-0.45 mm for the third healing phase, depending on the fracture gap size and less on the fracture angle. J2, hydrostatic strain, octahedral shear strain and the strain energy density correlated with the fracture gap size and angle (all p < 0.001). The influence of the fracture gap size and angle on the variability (adjusted R 2 ) in several outcome measures in the fracture gap was shown to vary throughout healing. The contribution to the variability of the percentage of the fracture gap in the perfect healing window was greatest during the second healing phase. For J2, strain energy density, hydrostatic strain, and octahedral shear strain, the fracture gap size showed the greatest contribution in the third fracture healing phase, while the influence of fracture angle was independent of the healing phase. Discussion: The present findings are relevant for implant development and to design clinical studies that aim to accelerate fracture healing using axial micromovement. Keywords: active implant; biomechanics; bone regeneration; computer simulation; digital health; fracture healing; osteosynthesis; smart implant. Copyright © 2024 Roland, Diebels, Wickert, Pohlemann and Ganse. Conflict of interest statement TP is president and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopaedic Trauma Surgery (DGU), the German Society of Orthopaedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defence. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest 62 references 4 figures Full text links 2. [National challenges for trauma surgery in Germany due to violence and war] Unfallchirurgie (Heidelb). 2024 Jul;127(7):492-499. doi: 10.1007/s00113-024-01442-0. Epub 2024 Jun 11. [Article in German] Authors Axel Franke 1 2 , Dan Bieler 3 , Wolfgang Lehmann 4 , Tim Pohlemann 5 , Benedikt Friemert 6 , Gerhard Achatz 7 Affiliations 1 Klinik für Unfallchirurgie und Orthopädie, Rekonstruktive und Septische Chirurgie, Sporttraumatologie, Bundeswehrkrankenhaus Ulm, Ulm, Deutschland. axel1franke@bundeswehr.org. 2 Sektion Septische‑, Rekonstruktive- und Handchirurgie, Klinik für Unfallchirurgie und Orthopädie, Rekonstruktive und Septische Chirurgie, Sporttraumatologie am Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081, Ulm, Deutschland. axel1franke@bundeswehr.org. 3 Klinik für Unfallchirurgie und Orthopädie, Rekonstruktive Chirurgie, Handchirurgie und Verbrennungsmedizin, Bundeswehrzentralkrankenhaus Koblenz, Koblenz, Deutschland. 4 Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie, Universitätsmedizin Göttingen, Göttingen, Deutschland. 5 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg, Deutschland. 6 Zentrales Klinisches Management, Bundeswehrkrankenhaus Ulm, Ulm, Deutschland. 7 Klinik für Unfallchirurgie und Orthopädie, Rekonstruktive und Septische Chirurgie, Sporttraumatologie, Bundeswehrkrankenhaus Ulm, Ulm, Deutschland. PMID: 38860995 DOI: 10.1007/s00113-024-01442-0 Abstract in English, German Due to the war in Ukraine and the treatment of patients with war wounds in the hospitals of the TraumaNetworks of the German Society for Trauma Surgery (TraumaNetzwerke DGU®), injuries from life-threatening mission situations (LebEL), terrorism, violence and war have become a matter of daily professional life. Furthermore, the societal and global feeling of security has fundamentally changed. The much-cited term "turning point in history", the reorientation of the Armed Forces and the investigation of the resilience of the healthcare system with respect to the "fitness for war", approximate to the description of the current challenges for trauma surgery (UCH) in Germany. Based on the developments following the terrorist attacks in Paris in 2015 and in Brussels in 2016, a clarification is given as to which adaptations have already been successful and how quickly an improvement could successfully be achieved. In this context, the concept of tactical care and the course on Terror and Disaster Surgical Care (TDSC), for example, have been game changing. The main challenge currently lies in overcoming the structural alterations in the German healthcare system and professionally in the treatment of war wounded personnel from Ukraine. The knowledge gained from these two national tasks must be analyzed for the future development and adaptation of established treatment structures, e.g., of the TraumaNetzwerke DGU®, under the requirements of the increased resilience against war, terrorism and violence. The aim is to name that which has already been achieved with respect to the national challenges for UCH and at the same time to outline or discuss further necessities for improvements and elimination of possible gaps in capabilities. Durch den Krieg in der Ukraine und die Behandlung der Kriegsverletzten in den Kliniken der TraumaNetzwerke der Deutschen Gesellschaft für Unfallchirurgie (TraumaNetzwerke DGU®) sind Verletzungen durch lebensbedrohliche Einsatzlagen (LebEL), Terror, Gewalt und Krieg zum Gegenstand des täglichen fachlichen Lebens geworden. Darüber hinaus hat sich das gesellschaftliche und globale Sicherheitsgefühl grundlegend verändert. Der viel zitierte Begriff „Zeitenwende“, die Neuausrichtung der Bundeswehr und die Überprüfung der Resilienz des Gesundheitssystems bezüglich der „Kriegstüchtigkeit“ legen die Beschreibung der aktuellen Herausforderungen für die Unfallchirurgie (UCH) in Deutschland nahe. Anhand der Entwicklungen nach den Terroranschlägen von Paris 2015 und Brüssel 2016 wird erläutert, welche Anpassungen bereits erfolgt sind, und wie erfolgreich zeitnah eine Verbesserung erreicht werden konnte. Hier sind z. B. das Konzept der taktischen Versorgung und der Kurs Terror and Disaster Surgical Care (TDSC) wegweisend gewesen. Aktuell besteht die Hauptherausforderung in der Bewältigung der Strukturveränderungen des deutschen Gesundheitssystems und fachlich in der Versorgung der Kriegsverletzten aus der Ukraine. Die Erkenntnisse aus diesen beiden nationalen Aufgaben gilt es, für die zukünftige Weiterentwicklung und Anpassung etablierter Versorgungsstrukturen, wie z. B. der TraumaNetzwerke DGU®, unter den Erfordernissen der Resilienzsteigerung gegenüber Krieg, Terror und Gewalt zu analysieren. Es ist das Ziel, bereits Erreichtes bezüglich der nationalen Herausforderungen für die UCH zu benennen sowie gleichzeitig weitere Notwendigkeiten für eine Verbesserung und die Beseitigung von möglichen Fähigkeitslücken zu skizzieren bzw. zu diskutieren. Keywords: Disaster planning; Healthcare; Humanitarian aid; Life-threatening event; Terrorism. © 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. 21 references 3. Characteristic Changes of the Stance-Phase Plantar Pressure Curve When Walking Uphill and Downhill: Cross-Sectional Study J Med Internet Res. 2024 May 8:26:e44948. doi: 10.2196/44948. Authors Christian Wolff 1 , Patrick Steinheimer 2 , Elke Warmerdam 3 , Tim Dahmen 1 , Philipp Slusallek 1 , Christian Schlinkmann 1 , Fei Chen 1 , Marcel Orth 2 , Tim Pohlemann 2 , Bergita Ganse 2 3 Affiliations 1 German Research Center for Artificial Intelligence (DFKI), Saarbrücken, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg/Saar, Germany. 3 Innovative Implant Development (Fracture Healing), Departments and Institutes of Surgery, Saarland University, Homburg/Saar, Germany. PMID: 38718385 PMCID: PMC11112465 DOI: 10.2196/44948 Abstract Background: Monitoring of gait patterns by insoles is popular to study behavior and activity in the daily life of people and throughout the rehabilitation process of patients. Live data analyses may improve personalized prevention and treatment regimens, as well as rehabilitation. The M-shaped plantar pressure curve during the stance phase is mainly defined by the loading and unloading slope, 2 maxima, 1 minimum, as well as the force during defined periods. When monitoring gait continuously, walking uphill or downhill could affect this curve in characteristic ways. Objective: For walking on a slope, typical changes in the stance phase curve measured by insoles were hypothesized. Methods: In total, 40 healthy participants of both sexes were fitted with individually calibrated insoles with 16 pressure sensors each and a recording frequency of 100 Hz. Participants walked on a treadmill at 4 km/h for 1 minute in each of the following slopes: -20%, -15%, -10%, -5%, 0%, 5%, 10%, 15%, and 20%. Raw data were exported for analyses. A custom-developed data platform was used for data processing and parameter calculation, including step detection, data transformation, and normalization for time by natural cubic spline interpolation and force (proportion of body weight). To identify the time-axis positions of the desired maxima and minimum among the available extremum candidates in each step, a Gaussian filter was applied (σ=3, kernel size 7). Inconclusive extremum candidates were further processed by screening for time plausibility, maximum or minimum pool filtering, and monotony. Several parameters that describe the curve trajectory were computed for each step. The normal distribution of data was tested by the Kolmogorov-Smirnov and Shapiro-Wilk tests. Results: Data were normally distributed. An analysis of variance with the gait parameters as dependent and slope as independent variables revealed significant changes related to the slope for the following parameters of the stance phase curve: the mean force during loading and unloading, the 2 maxima and the minimum, as well as the loading and unloading slope (all P<.001). A simultaneous increase in the loading slope, the first maximum and the mean loading force combined with a decrease in the mean unloading force, the second maximum, and the unloading slope is characteristic for downhill walking. The opposite represents uphill walking. The minimum had its peak at horizontal walking and values dropped when walking uphill and downhill alike. It is therefore not a suitable parameter to distinguish between uphill and downhill walking. Conclusions: While patient-related factors, such as anthropometrics, injury, or disease shape the stance phase curve on a longer-term scale, walking on slopes leads to temporary and characteristic short-term changes in the curve trajectory. Keywords: baropedography; digital health; gait; gait analysis; ground reaction forces; injury; monitoring; movement; movement analysis; pedography; personalized medicine; podiatric medicine; podiatry; postoperative treatment; rehabilitation; sensor; sensors; slope; treatment; wearables. ©Christian Wolff, Patrick Steinheimer, Elke Warmerdam, Tim Dahmen, Philipp Slusallek, Christian Schlinkmann, Fei Chen, Marcel Orth, Tim Pohlemann, Bergita Ganse. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 08.05.2024. Conflict of interest statement Conflicts of Interest: TP is President and Board Member of the AO-Foundation, Switzerland, and Extended Board Member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the Medical Advisory Board of the German Ministry of Defence. The other authors do not have a conflict of interest. 34 references 3 figures Full text links 4. Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement Front Bioeng Biotechnol. 2024 Mar 8:12:1370837. doi: 10.3389/fbioe.2024.1370837. eCollection 2024. Authors Kerstin Wickert 1 , Michael Roland 1 , Annchristin Andres 1 , Stefan Diebels 1 , Bergita Ganse 2 , Dorothea Kerner 3 , Felix Frenzel 3 , Thomas Tschernig 4 , Manuela Ernst 5 , Markus Windolf 5 , Max Müller 6 , Tim Pohlemann 6 , Marcel Orth 6 Affiliations 1 Applied Mechanics, Saarland University, Saarbrücken, Germany. 2 Werner Siemens Endowed Chair of Innovative Implant Development (Fracture Healing), Saarland University, Homburg, Germany. 3 Clinic of Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, Germany. 4 Institute of Anatomy and Cell Biology, Saarland University, Homburg, Germany. 5 AO Research Institute Davos (ARI), Davos, Switzerland. 6 Department of Trauma, Hand and Reconstruction Surgery, Saarland University Hospital, Homburg, Germany. PMID: 38524192 PMCID: PMC10958423 DOI: 10.3389/fbioe.2024.1370837 Abstract Introduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better understand the local mechanics of fracture gaps, which is crucial for comprehending mechanotransduction, a key factor in bone healing. Through a series of experiments and corresponding simulations, the study tests four hypotheses to determine the relationship between physical measurements and the predictive power of biomechanical models. Methods: Employing the AO Fracture Monitor and Digital Image Correlation techniques, the study demonstrates a significant correlation between the surface strain of implants and interfragmentary movements. This provides a foundation for utilizing one-dimensional AO Fracture Monitor measurements to predict three-dimensional fracture behavior, thereby linking mechanical loading with fracture gap dynamics. Moreover, the research establishes that finite element simulations of bone-implant systems can be effectively validated using experimental data, underpinning the accuracy of simulations in replicating physical behaviors. Results and Discussion: The findings endorse the combined use of monitoring technologies and simulations to infer the local mechanical conditions at the fracture site, offering a potential leap in personalized therapy for bone healing. Clinically, this approach can enhance treatment outcomes by refining the assessment precision in trauma trials, fostering the early detection of healing disturbances, and guiding improvements in future implant design. Ultimately, this study paves the way for more sophisticated patient monitoring and tailored interventions, promising to elevate the standard of care in orthopedic trauma surgery. Keywords: biomechanical simulation; bone healing; experimental biomechanics; orthopedic trauma surgery; osteosynthesis; patient monitoring; smart implant. Copyright © 2024 Wickert, Roland, Andres, Diebels, Ganse, Kerner, Frenzel, Tschernig, Ernst, Windolf, Müller, Pohlemann and Orth. Conflict of interest statement TP is president and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defense. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 1 article 26 references 10 figures Full text links 5. Long-term continuous instrumented insole-based gait analyses in daily life have advantages over longitudinal gait analyses in the lab to monitor healing of tibial fractures Front Bioeng Biotechnol. 2024 Mar 1:12:1355254. doi: 10.3389/fbioe.2024.1355254. eCollection 2024. Authors Elke Warmerdam 1 , Christian Wolff 2 , Marcel Orth 3 , Tim Pohlemann 3 , Bergita Ganse 1 3 Affiliations 1 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Departments and Institutes of Surgery, Saarland University, Homburg, Germany. 2 German Research Center for Artificial Intelligence (DFKI), Saarbrücken, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg, Germany. PMID: 38497053 PMCID: PMC10940326 DOI: 10.3389/fbioe.2024.1355254 Abstract Introduction: Monitoring changes in gait during rehabilitation allows early detection of complications. Laboratory-based gait analyses proved valuable for longitudinal monitoring of lower leg fracture healing. However, continuous gait data recorded in the daily life may be superior due to a higher temporal resolution and differences in behavior. In this study, ground reaction force-based gait data of instrumented insoles from longitudinal intermittent laboratory assessments were compared to monitoring in daily life. Methods: Straight walking data of patients were collected during clinical visits and in between those visits the instrumented insoles recorded all stepping activities of the patients during daily life. Results: Out of 16 patients, due to technical and compliance issues, only six delivered sufficient datasets of about 12 weeks. Stance duration was longer ( p = 0.004) and gait was more asymmetric during daily life (asymmetry of maximal force p < 0.001, loading slope p = 0.001, unloading slope p < 0.001, stance duration p < 0.001). Discussion: The differences between the laboratory assessments and the daily-life monitoring could be caused by a different and more diverse behavior during daily life. The daily life gait parameters significantly improved over time with union. One of the patients developed an infected non-union and showed worsening of force-related gait parameters, which was earlier detectable in the continuous daily life gait data compared to the lab data. Therefore, continuous gait monitoring in the daily life has potential to detect healing problems early on. Continuous monitoring with instrumented insoles has advantages once technical and compliance problems are solved. Keywords: digital medicine; fracture; ground reaction force; injury; pedography; postoperative treatment; rehabilitation; wearable sensors. Copyright © 2024 Warmerdam, Wolff, Orth, Pohlemann and Ganse. Conflict of interest statement TP is president and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defence. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 1 article 44 references 5 figures Full text links 6. Reappraisal of clinical trauma trials: the critical impact of anthropometric parameters on fracture gap micro-mechanics-observations from a simulation-based study Sci Rep. 2023 Nov 22;13(1):20450. doi: 10.1038/s41598-023-47910-2. Authors Michael Roland 1 , Stefan Diebels 2 , Marcel Orth 3 , Tim Pohlemann 3 , Bertil Bouillon 4 , Thorsten Tjardes 4 Affiliations 1 Chair of Applied Mechanics, Saarland University, Campus A4 2, 1. OG, 66123, Saarbrücken, Germany. michael.roland@uni-saarland.de. 2 Chair of Applied Mechanics, Saarland University, Campus A4 2, 1. OG, 66123, Saarbrücken, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Strasse 100, 66421, Homburg, Germany. 4 Chair for Orthopedic Surgery, Trauma Surgery and Sportstraumatology, Department of Orthopedic Surgery, Trauma Surgery and Sportstraumatology, Cologne Merheim Medical Center, University Witten/Herdecke, Ostmerheimerstrasse 200, 51109, Cologne, Germany. PMID: 37993727 PMCID: PMC10665421 DOI: 10.1038/s41598-023-47910-2 Abstract The evidence base of surgical fracture care is extremely sparse with only few sound RCTs available. It is hypothesized that anthropometric factors relevantly influence mechanical conditions in the fracture gap, thereby interfering with the mechanoinduction of fracture healing. Development of a finite element model of a tibia fracture, which is the basis of an in silico population (n = 300) by systematic variation of anthropometric parameters. Simulations of the stance phase and correlation between anthropometric parameters and the mechanical stimulus in the fracture gap. Analysis of the influence of anthropometric parameters on statistical dispersion between in silico trial cohorts with respect to the probability to generate two, with respect to anthropometric parameters statistically different trial cohorts, given the same power assumptions. The mechanical impact in the fracture gap correlates with anthropometric parameters; confirming the hypothesis that anthropometric factors are a relevant entity. On a cohort level simulation of a fracture trial showed that given an adequate power the principle of randomization successfully levels out the impact of anthropometric factors. From a clinical perspective these group sizes are difficult to achieve, especially when considering that the trials takes advantage of a "laboratory approach ", i.e. the fracture type has not been varied, such that in real world trials the cohort size have to be even larger to level out the different configurations of fractures gaps. Anthropometric parameters have a significant impact on the fracture gap mechanics. The cohort sizes necessary to level out this effect are difficult or unrealistic to achieve in RCTs, which is the reason for sparse evidence in orthotrauma. New approaches to clinical trials taking advantage of modelling and simulation techniques need to be developed and explored. © 2023. The Author(s). Conflict of interest statement The authors declare no competing interests. Cited by 1 article 37 references 5 figures Full text links 7. Improved weight bearing during gait at 6 weeks post-surgery with an angle stable locking system after distal tibial fracture Gait Posture. 2024 Jan:107:169-176. doi: 10.1016/j.gaitpost.2023.09.013. Epub 2023 Sep 27. Authors Alison N Agres 1 , Sónia A Alves 1 , Dankward Höntzsch 2 , René El Attal 3 , Tim Pohlemann 4 , Klaus-Dieter Schaser 5 , Alexander Joeris 6 , Denise Hess 7 , Georg N Duda 8 Affiliations 1 Julius Wolff Institute, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. 2 BG Unfallklinik and University Hospital Tübingen, Schnarrenbergstraße 95, 72076 Tübingen, Germany. 3 Orthopaedics, Traumatology and Sport Traumatology, Akademisches Lehrkrankenhaus, Carinagasse 47, 6800 Feldkirch, Austria. 4 Department for Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 1, 66421 Homburg, Germany. 5 University Center of Orthopaedic, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, Fetscherstraße 74, 01307 Dresden, Germany. 6 AO Innovation Translation Center, AO Foundation, Stettbachstrasse 6, 8600 Dübendorf, Switzerland. 7 AO Education Institute, AO Foundation, Stettbachstrasse 6, 8600 Dübendorf, Switzerland. 8 Julius Wolff Institute, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: georg.duda@charite.de. PMID: 37845132 DOI: 10.1016/j.gaitpost.2023.09.013 Abstract Background: Functional recovery after intramedullary nailing of distal tibial fractures can be monitored using ipsilateral vertical ground reaction forces (vGRF), giving insight into recovery of patients' gait symmetry. Previous work compared patient cohorts to healthy controls, but it remains unclear if these metrics can identify treatment-based differences in return to function post-surgery. Research question: Is treatment of a distal tibial fracture with intramedullary nailing with an angle stable locking system (ASLS) associated with higher ipsilateral vGRF and improved symmetry compared to conventional intramedullary nailing at an early time point? Methods: Thirty-nine patients treated with ASLS intramedullary nailing were retrospectively compared to thirty-nine patients with conventional locking. vGRFs were collected at 1, 6, 12, 26, and 52 weeks post-surgery during standing and gait. Discrete metrics of ipsilateral vGRF (maximal force, impulse) and asymmetry were compared between treatments at each time point. Time-scale comparisons of ipsilateral vGRF and lower limb asymmetry were additionally performed for gait trials. Mann-Whitney Test or a two-way analysis of variance tested discrete comparisons; statistical non-parametric mapping tested time-scale data between treatment groups. Results: During gait, ASLS-treated patients applied more load on the operated limb (17-38% stance, p = 0.015) and consequently loaded limbs more symmetrically (8-37% stance, p = 0.008) during the loading response at 6 weeks post-surgery compared to conventional IM treatment. Discrete measures of symmetry at the same time point identified treatment-based differences in maximal force (p = 0.039) and impulse (p = 0.012), with ASLS-treated patients exhibiting more symmetry. No differences were identified in gait trials at later time points nor from all standing trials. Significance: During the initial loading response of gait, increased ipsilateral vGRF and improved weightbearing symmetry were identified in ASLS patients at 6 weeks post-surgery compared to conventional IM nailing. Early and objective metrics of dynamic movement are suggested to identify treatment-based differences in functional recovery. Keywords: Fracture fixation; Gait analysis; Ground reaction force; Intermedullary nail; Tibia fracture. Copyright © 2023 Elsevier B.V. All rights reserved. Conflict of interest statement Declaration of Competing Interest A.A., S.A., R.E.A., K-D.S., G.D. have no conflicts of interests to declare. D. Höntzsch serves as a consultant at the AO, Member of the AO technical Commission. Consultant of DePuy Synthes, Ceramtec, Rimasys. TP was head of the AO Foundation TK system when the study was initiated and partially funded by the TK-System. A.J. and D. Hess are employees in the AO Foundation. Cited by 1 article Full text links 8. "Fall Risk Scoring" in Outpatient Gait Analysis: Validation of a New Fall Risk Assessment for Nursing Home Residents Z Orthop Unfall. 2023 Oct 9. doi: 10.1055/a-2151-4709. Online ahead of print. [Article in English, German] Authors Eduard Witiko Unger 1 , Tim Pohlemann 1 , Marcel Orth 1 , Mika F R Rollmann 2 , Maximilian M Menger 2 , Steven C Herath 2 , Tina Histing 3 , Benedikt J Braun 3 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg, Deutschland. 2 Klinik für Unfall- und Wiederherstellungschirurgie, BG Unfallklinik Tübingen, Tübingen, Deutschland. 3 Klinik für Unfall- und Wiederherstellungschirurgie, BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Germany. PMID: 37813360 DOI: 10.1055/a-2151-4709 Abstract in English, German Falls in senior home residents are common. Individual preventive training can lower the fall risk. To detect the need for training, a systematic assessment of the individual fall risk is needed. The aim of this study was thus to assess whether a fall risk score based on free field insole measurements can distinguish between an at-risk group of senior home residents and a healthy young control group. A published fall risk score was used in senior home residents over the age of 75 and a young (< 40 years) control group to determine the individual fall risk. In addition, the fall events over 12 months were assessed. Statistical analysis including ROC analysis was performed to determine the ability of the score to detect participants at heightened fall risk. In total, 18 nursing home residents and 9 young control participants were included. Of the nursing home residents, 15 had at least one fall, with a total of 37 falls recorded over 12 months. In the control group, no falls were recorded. The fall risk score was significantly different between nursing home residents and the control group (9.2 + 3.2 vs. 5.7 ± 2.2). Furthermore, the score significantly differentiated fallers from non-fallers (10.3 ± 1.8 vs. 5.2 ± 2.5), with a cut-off > 7.5 (AUC: 0.95) and a sensitivity of 86.7% (specificity 83.3%). The fall risk score is able to detect the difference between senior nursing home residents and young, healthy controls, as well as between fallers and non-fallers. Its main proof of concept is demonstrated, as based on movement data outside special gait labs, and it can simplify the risk of fall determination in geriatric nursing home residents and can now be used in further, prospective studies. Stürze von älteren Heimbewohnern sind häufig. Individuelle Prävention kann die Wahrscheinlichkeit zu stürzen senken. Um den Präventionsbedarf zu erkennen, bedarf es einer systematischen Erfassung des individuellen Sturzrisikos. In dieser Studie soll daher untersucht werden, inwiefern ein Sturzrisikoscore, gebildet aus mit einer erhöhten Sturzneigung assoziierten Gangparametern, zwischen einer hoch sturzgefährdeten Gruppe und einer jungen gesunden Kontrollgruppe unterscheiden kann. Ein bereits publizierter Sturzrisikoscore wurde bei über 75-jährigen, sturzgefährdeten Heimbewohnern sowie bei einer jungen, gesunden unter 40-jährigen Kontrollgruppe angewendet und ein individueller Score gebildet. Zusätzlich wurden die Sturzereignisse über einen Zeitraum von 12 Monaten erfasst. Nach Prüfung auf Normalverteilung wurde mittels Mittelwertvergleich und ROC-Analyse die Möglichkeit, Teilnehmer mithilfe des Scores zwischen älteren sturzgefährdeten Teilnehmern und jungen, gesunden Personen zu differenzieren, getestet. Es wurden 18 Heimbewohner und 9 junge, gesunde Teilnehmer in die Analyse einbezogen. Unter den Älteren stürzten 15 mindestens einmal, wobei insgesamt 37 Stürze innerhalb der 12 Monate erfasst wurden (2,06 ± 2,16; Range: 0–8). Unter den Jüngeren stürzte niemand. Dabei unterschied sich der Sturzrisikoscore der Heimbewohner von dem der Jüngeren signifikant (9,2 ± 3,2 vs. 5,7 ± 2,2). Ebenso unterschied sich der Score zwischen Gestürzten und nicht Gestürzten signifikant (10,3 ± 1,8 vs. 5,2 ± 2,5). Die Gestürzten und nicht Gestürzten konnte der Score mit einem Cut-off > 7,5 (AUC: 0,95) und einer Sensitivität von 86,7% differenzieren (Spezifität: 83,3%). Der gebildete Score erlaubt grundsätzlich die Differenzierung zwischen älterem und jüngerem Studienkollektiv, wie auch zwischen Gestürzten und nicht Gestürzten. Der gebildete Score basiert auf Bewegungsdaten, die außerhalb spezieller Ganglabore erhoben wurden, kann die Detektion von sturzrisikogefährdeten Heimbewohnern erleichtern und nun in prospektiven Studien weiter etabliert werden. Thieme. All rights reserved. Conflict of interest statement Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht. Full text links 9. A novel minimally invasive and press-fit method for symphysiodesis - a biomechanical analysis J Exp Orthop. 2023 Sep 28;10(1):98. doi: 10.1186/s40634-023-00660-6. Authors Tobias Fritz 1 , Marcel Orth 2 , Sascha J Hopp 2 3 , Jeremy Briem 2 4 , Jill Hahner 2 , David Osche 2 , Tim Pohlemann 2 , Antonius Pizanis 2 Affiliations 1 Department for Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 1, Homburg, Saarland, 66421, Germany. tobias.fritz@uks.eu. 2 Department for Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 1, Homburg, Saarland, 66421, Germany. 3 Lutrina Hospital, Kaiserslautern, Brüsseler Str. 7, 67655, Kaiserslautern, Germany. 4 Department of Trauma and Reconstructive Surgery, BG Trauma Center Tuebingen, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany. PMID: 37768379 PMCID: PMC10539247 DOI: 10.1186/s40634-023-00660-6 Abstract Purpose: Does the cylindrical shaped bone block allow a stable construct for the arthrodesis of the pubic symphysis compared to a rectangular shaped bone block. The cylindrical shaped bone block stabilized by a 3.5 symphyseal plate is inferior to the stabilization with an internal fixator. Methods: This study analyzed the arthrodesis of the pubic symphysis on 24 synthetic pelvises, using a rectangular shaped bone block (control group) or a cylindrical shaped bone block, stabilized with a symphysis locking plate (n = 8) as the standard clinical procedure. Additionally we analyzed the stability using an internal fixator. Results: This study showed that utilizing a cylindrical shaped synthetic bone graft results in a significant higher contact area and compression force compared to the classical rectangular shaped graft. Furthermore, the stabilization with an internal fixator had the tendency for increases of compression force and contact area, yet without a statistical significance, when compared to the plate fixation. Conclusion: The novel method of cylindrical symphysis resection and cylindrical bone block implantation allowed an increased biomechanical stability compared to using a classical rectangular bone graft, also resulting in higher contact area. Moreover, this technique would also allow a minimally invasive approach for this purpose, which in turn could preserve perisymphyseal ligaments, thereby improving healing in a clinical context. Keywords: Arthrodesis symphysis; Bone transplant; Internal fixator; Pubic symphysis; Symphysiodesis; Symphysis. © 2023. European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Conflict of interest statement None. 16 references 5 figures Full text links 10. Lower oxygen saturation with higher rates of norepinephrine in bone fractures of polytrauma patients: a pilot study Crit Care. 2023 Sep 25;27(1):367. doi: 10.1186/s13054-023-04657-6. Authors Laura Koch 1 , Marcel Orth 2 , Tobias Fink 3 , Andreas Meiser 3 , Thomas Volk 3 , Michael D Menger 4 , Matthias W Laschke 4 , Torsten Pastor 5 , Matthias Knobe 6 7 8 , Tim Pohlemann 2 , Bergita Ganse 9 10 Affiliations 1 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Departments and Institutes of Surgery, Saarland University, Homburg, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg, Germany. 3 Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University, Homburg, Germany. 4 Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany. 5 Department of Orthopaedic and Trauma Surgery, Lucerne Cantonal Hospital, Lucerne, Switzerland. 6 Department of Orthopaedic and Trauma Surgery, Westmuensterland Hospital, Ahaus, Germany. 7 Medical Faculty, University of Zurich, Zurich, Switzerland. 8 Medical Faculty, RWTH University Aachen, Aachen, Germany. 9 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Departments and Institutes of Surgery, Saarland University, Homburg, Germany. bergita.ganse@uks.eu. 10 Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg, Germany. bergita.ganse@uks.eu. PMID: 37743472 PMCID: PMC10518976 DOI: 10.1186/s13054-023-04657-6 No abstract available Keywords: Catecholamines; Fracture healing; Injury; Mean arterial pressure; Microcirculation; Multiple trauma; Non-union; Noradrenaline; O2C; Perfusion. Conflict of interest statement TP is president and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopaedic Trauma Surgery (DGU), the German Society of Orthopaedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defence. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 5 references 1 figure Full text links 11. [Clavicle fractures: practical approach in clinical routine] Chirurgie (Heidelb). 2023 Dec;94(12):1045-1056. doi: 10.1007/s00104-023-01958-y. Epub 2023 Sep 13. [Article in German] Authors M Müller 1 , Y Bullinger 2 , T Pohlemann 2 , M Orth 2 Affiliations 1 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Straße 100, 66421, Homburg/Saar, Deutschland. max.mueller@uks.eu. 2 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Straße 100, 66421, Homburg/Saar, Deutschland. PMID: 37702744 DOI: 10.1007/s00104-023-01958-y Abstract in English, German Fractures of the clavicle are among the most common fractures. They typically result from a fall onto the lateral shoulder or the extended arm and are often related to sports and bicycle accidents. Obtaining the exact trauma mechanism, proper clinical findings and adequate X‑rays usually lead to the correct diagnosis. Non-displacement fractures can be treated conservatively with good results. Unstable and displaced fractures should be treated operatively. Open fractures or looming penetration are emergencies und should be treated immediately. In addition to fracture classification and morphology, other factors such as additional injuries and patient-related factors need to be considered in order to make an individualized therapy decision. In operative treatment, angular stable plating is the therapy of choice, and in most cases early functional aftercare is possible. Die Klavikulafraktur ist eine der häufigsten Frakturen des Menschen. Typische Unfallmechanismen sind Stürze auf die Schulter oder den ausgestreckten Arm, häufig bei Sport- oder Zweiradunfällen. Auf Basis einer genauen Anamnese, zielgerichteten klinischen Untersuchung und adäquaten Röntgendiagnostik kann meist die Diagnose gestellt werden. Bei nichtdislozierten Frakturen führt die konservative Therapie in der Regel zu guten Ergebnissen. Bei dislozierten, instabilen Frakturen sollte die Indikation zur operativen Versorgung gestellt werden. Offene Verletzungen sowie eine drohende Durchspießung stellen Notfallindikationen dar. Neben der Frakturklassifikation und -morphologie spielen auch andere Faktoren eine Rolle bei der individuellen Therapieentscheidung, so etwa bestehende Begleitverletzungen und patientInnenspezifische Faktoren (Alter, Komorbiditäten, funktioneller Anspruch). Bei der operativen Versorgung ist die Plattenosteosynthese die Therapie der Wahl, meist kann eine funktionelle Nachbehandlung erfolgen. Keywords: Clavicle fracture, displaced; Clavicle fracture, pediatric; Clavicle fracture/Treatment algorithm; Non union; Plate osteosynthesis. © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. 38 references 12. Both-Column Acetabular Fractures: Does Surgical Approach Vary Based on Using Virtual 3D Reconstructions? Diagnostics (Basel). 2023 May 5;13(9):1629. doi: 10.3390/diagnostics13091629. Authors Judith F Leemhuis 1 , Nick Assink 1 2 , Inge H F Reininga 1 , Jean-Paul P M de Vries 1 , Kaj Ten Duis 1 , Anne M L Meesters 1 2 , Frank F A IJpma 1 ; The Pelvic Fracture Consortium Collaborators The Pelvic Fracture Consortium : J Biert , T S Bijlsma , D van Embden , G A M Govaert , S C Herath , E Hermans , T Hagenaars , S H van Helden , F Hietbrink , M Hogervorst , S Meylaerts , R J Nijveldt , P Pieroh , T Pohlemann , K J Ponsen , I B Schipper , F J van der Sluis , S F L van Stigt , V M A Stirler , D O Verbeek , J P A M Verbruggen , M H J Verhofstad , B van Wageningen , K W Wendt , P van der Zwaal Affiliations 1 Department of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands. 2 3D Lab, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands. PMID: 37175020 PMCID: PMC10178242 DOI: 10.3390/diagnostics13091629 Abstract Displacement of the anterior and posterior column complicates decision making for both-column acetabular fractures. We questioned whether pelvic surgeons agree on treatment strategy, and whether the use of virtual 3D reconstructions changes the treatment strategy of choice. A nationwide cross-sectional survey was performed in all pelvic trauma centers in the Netherlands. Twenty surgeons assessed 15 both-column fractures in 2D as well as 3D. Based on conventional imaging, surgical treatment was recommended in 89% of cases, and by adding 3D reconstructions this was 93% ( p = 0.09). Surgical approach was recommended as anterior (65%), posterior (8%) or combined (27%) (poor level of agreement, κ = 0.05) based on conventional imaging. The approach changed in 37% ( p = 0.006), with most changes between a combined and anterior approach (still poor level of agreement, κ = 0.13) by adding 3D reconstructions. Additionally, surgeons' level of confidence increased from good in 38% to good in 50% of cases. In conclusion, surgeons do not agree on the treatment strategy for both-column acetabular fractures. Additional information given by 3D reconstructions may change the chosen surgical approach and increase surgeons' confidence about their treatment decision. Therefore, virtual 3D reconstructions are helpful for assessing both-column fracture patterns and aid in the choice of treatment strategy. Keywords: 3D; acetabular fracture; acetabulum; both column; surgical approach; survey; three-dimensional. Conflict of interest statement The authors declare no conflict of interest. Cited by 1 article 21 references 2 figures Full text links 13. Occurrence, resistance patterns, and management of carbapenemase-producing bacteria in war-wounded refugees from Ukraine Int J Infect Dis. 2023 Jul:132:89-92. doi: 10.1016/j.ijid.2023.04.394. Epub 2023 Apr 16. Authors Fabian K Berger 1 , Georges P Schmartz 2 , Tobias Fritz 3 , Nils Veith 3 , Farah Alhussein 1 , Sophie Roth 1 , Sophie Schneitler 1 , Thomas Gilcher 4 , Barbara C Gärtner 1 , Vakhtang Pirpilashvili 3 , Tim Pohlemann 3 , Andreas Keller 2 , Jacqueline Rehner 1 , Sören L Becker 5 Affiliations 1 Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany. 2 Chair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Homburg/Saar, Germany. 4 Hospital Pharmacy, Saarland University, Homburg/Saar, Germany. 5 Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany. Electronic address: soeren.becker@uks.eu. PMID: 37072055 DOI: 10.1016/j.ijid.2023.04.394 Free article Abstract We analyzed consecutive clinical cases of infections due to carbapenemase-producing gram-negative bacteria detected in war-wounded patients from Ukraine who were treated at one university medical center in southwest Germany between June and December 2022. The isolates of multiresistant gram-negative bacteria were subjected to a thorough microbiological characterization and whole genome sequencing (WGS). We identified five war-wounded Ukrainian patients who developed infections with New Delhi metallo-β-lactamase 1-positive Klebsiella pneumoniae. Two isolates also carried OXA-48 carbapenemases. The bacteria were resistant to novel antibiotics, such as ceftazidime/avibactam and cefiderocol. The used treatment strategies included combinations of ceftazidime/avibactam + aztreonam, colistin, or tigecycline. WGS suggested transmission during primary care in Ukraine. We conclude that there is an urgent need for thorough surveillance of multiresistant pathogens in patients from war zones. Keywords: Antimicrobial resistance; Carbapenemase; Cefiderocol; Ceftazidime/avibactam; Klebsiella pneumoniae; Pseudomonas aeruginosa. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. Conflict of interest statement Declaration of competing interest Fabian K. Berger has received consultant fees from MSD and Pfizer (pertaining both to Clostridioides difficile). B.C. Gärtner has received honoraria from Pfizer, outside the submitted work. S.L. Becker has received speaker fees and advisory board participation fees from Pfizer (pertaining to ceftazidime/avibactam) and Shionogi (pertaining to cefiderocol). All other authors have no competing interests to declare. Cited by 4 articles Full text links 14. Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics Front Bioeng Biotechnol. 2023 Feb 20:11:1067845. doi: 10.3389/fbioe.2023.1067845. eCollection 2023. Authors Marcel Orth 1 , Bergita Ganse 1 2 , Annchristin Andres 3 , Kerstin Wickert 3 , Elke Warmerdam 2 , Max Müller 1 , Stefan Diebels 3 , Michael Roland 3 , Tim Pohlemann 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Saarbrücken, Germany. 2 Werner Siemens Endowed Chair of Innovative Implant Development (Fracture Healing), Saarland University, Saarbrücken, Germany. 3 Chair of Applied Mechanics, Saarland University, Saarbrücken, Germany. PMID: 36890916 PMCID: PMC9986461 DOI: 10.3389/fbioe.2023.1067845 Abstract Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high. The aim of this study was to simulate and compare different mechanical conditions after lower leg fractures to assess the effects of postoperative motion, weight-bearing restrictions and fibular mechanics on the strain distribution and the clinical course. Based on the computed tomography (CT) data set of a real clinical case with a distal diaphyseal tibial fracture, a proximal and a distal fibular fracture, finite element simulations were run. Early postoperative motion data, recorded via an inertial measuring unit system and pressure insoles were recorded and processed to study strain. The simulations were used to compute interfragmentary strain and the von Mises stress distribution of the intramedullary nail for different treatments of the fibula, as well as several walking velocities (1.0 km/h; 1.5 km/h; 2.0 km/h) and levels of weight-bearing restriction. The simulation of the real treatment was compared to the clinical course. The results show that a high postoperative walking speed was associated with higher loads in the fracture zone. In addition, a larger number of areas in the fracture gap with forces that exceeded beneficial mechanical properties longer was observed. Moreover, the simulations showed that surgical treatment of the distal fibular fracture had an impact on the healing course, whereas the proximal fibular fracture barely mattered. Weight-bearing restrictions were beneficial in reducing excessive mechanical conditions, while it is known that it is difficult for patients to adhere to partial weight-bearing recommendations. In conclusion, it is likely that motion, weight bearing and fibular mechanics influence the biomechanical milieu in the fracture gap. Simulations may improve decisions on the choice and location of surgical implants, as well as give recommendations for loading in the postoperative course of the individual patient. Keywords: biomechanics; fibula; finite element analysis; gait analysis; lower leg injury; motion; prognosis of bone healing; tibial fracture. Copyright © 2023 Orth, Ganse, Andres, Wickert, Warmerdam, Müller, Diebels, Roland and Pohlemann. Conflict of interest statement TP is president elect and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defense. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 3 articles 37 references 6 figures Full text links 15. Effects of age, body height, body weight, body mass index and handgrip strength on the trajectory of the plantar pressure stance-phase curve of the gait cycle Front Bioeng Biotechnol. 2023 Feb 15:11:1110099. doi: 10.3389/fbioe.2023.1110099. eCollection 2023. Authors Christian Wolff 1 , Patrick Steinheimer 2 , Elke Warmerdam 3 , Tim Dahmen 1 , Philipp Slusallek 1 , Christian Schlinkmann 1 , Fei Chen 1 , Marcel Orth 2 , Tim Pohlemann 2 , Bergita Ganse 2 3 Affiliations 1 German Research Center for Artificial Intelligence (DFKI), Saarbrücken, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 3 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Saarland University, Homburg, Germany. PMID: 36873371 PMCID: PMC9975497 DOI: 10.3389/fbioe.2023.1110099 Abstract The analysis of gait patterns and plantar pressure distributions via insoles is increasingly used to monitor patients and treatment progress, such as recovery after surgeries. Despite the popularity of pedography, also known as baropodography, characteristic effects of anthropometric and other individual parameters on the trajectory of the stance phase curve of the gait cycle have not been previously reported. We hypothesized characteristic changes of age, body height, body weight, body mass index and handgrip strength on the plantar pressure curve trajectory during gait in healthy participants. Thirty-seven healthy women and men with an average age of 43.65 ± 17.59 years were fitted with Moticon OpenGO insoles equipped with 16 pressure sensors each. Data were recorded at a frequency of 100 Hz during walking at 4 km/h on a level treadmill for 1 minute. Data were processed via a custom-made step detection algorithm. The loading and unloading slopes as well as force extrema-based parameters were computed and characteristic correlations with the targeted parameters were identified via multiple linear regression analysis. Age showed a negative correlation with the mean loading slope. Body height correlated with Fmean load and the loading slope. Body weight and the body mass index correlated with all analyzed parameters, except the loading slope. In addition, handgrip strength correlated with changes in the second half of the stance phase and did not affect the first half, which is likely due to stronger kick-off. However, only up to 46% of the variability can be explained by age, body weight, height, body mass index and hand grip strength. Thus, further factors must affect the trajectory of the gait cycle curve that were not considered in the present analysis. In conclusion, all analyzed measures affect the trajectory of the stance phase curve. When analyzing insole data, it might be useful to correct for the factors that were identified by using the regression coefficients presented in this paper. Keywords: ageing; gait; ground reaction (forces); handgrip strengh; insoles; motion analysis; obesity; smart healthcare. Copyright © 2023 Wolff, Steinheimer, Warmerdam, Dahmen, Slusallek, Schlinkmann, Chen, Orth, Pohlemann and Ganse. Conflict of interest statement TP is president elect and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defense. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 7 articles 41 references 2 figures Full text links 16. Gait Analysis to Monitor Fracture Healing of the Lower Leg Bioengineering (Basel). 2023 Feb 15;10(2):255. doi: 10.3390/bioengineering10020255. Authors Elke Warmerdam 1 , Marcel Orth 2 , Tim Pohlemann 2 , Bergita Ganse 1 2 Affiliations 1 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Clinics and Institutes of Surgery, Saarland University, 66421 Homburg, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Clinics and Institutes of Surgery, Saarland University, 66421 Homburg, Germany. PMID: 36829749 PMCID: PMC9952799 DOI: 10.3390/bioengineering10020255 Abstract Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness. Since union problems frequently occur after fractures, better and timelier methods to monitor the healing process are required. In this review, we provide an overview of the changes in gait parameters following lower leg fractures to investigate whether gait analysis can be used to monitor fracture healing. Studies assessing gait after lower leg fractures that were treated either surgically or conservatively were included. Spatiotemporal gait parameters, kinematics, kinetics, and pedography showed improvements in the gait pattern throughout the healing process of lower leg fractures. Especially gait speed and asymmetry measures have a high potential to monitor fracture healing. Pedographic measurements showed differences in gait between patients with and without union. No literature was available for other gait measures, but it is expected that further parameters reflect progress in bone healing. In conclusion, gait analysis seems to be a valuable tool for monitoring the healing process and predicting the occurrence of non-union of lower leg fractures. Keywords: implant; malunion; motion capture; movement analysis; non-union; rehabilitation; tibial fracture; trauma; wearables. Conflict of interest statement T.P. is president elect and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). T.P. is also the speaker of the medical advisory board of the German Ministry of Defense. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The other authors declare no conflict of interest. Cited by 9 articles 76 references 5 figures Full text links 17. [Management of complications of acetabular fractures] Unfallchirurgie (Heidelb). 2023 Feb;126(2):109-118. doi: 10.1007/s00113-022-01256-y. Epub 2022 Dec 7. [Article in German] Authors M Orth 1 , D Osche 2 , T Pohlemann 2 Affiliations 1 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg, Deutschland. marcel.orth@uks.eu. 2 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg, Deutschland. PMID: 36477256 DOI: 10.1007/s00113-022-01256-y Abstract in English, German Surgical treatment of acetabular fractures represents a special challenge in the field of trauma surgery. Complications are mostly due to the trauma itself or are iatrogenic. The handling and strategy to overcome complications in acetabular surgery are oriented towards the type of complication and the time of occurrence. Generally, a differentiation is made between early perioperative complications and late complications. The present article describes the most frequent complications during the surgical treatment of acetabular fractures, discusses the various treatment options based on individual case examples and gives differentiated recommendations to overcome the complications. The treatment concept should initially comprise a comprehensive primary prophylaxis to prevent complications. In cases of early perioperative complications, e.g. postoperative wound infections, hemorrhage or incorrect implant positioning, rapid and systematic surgical revision should be performed. In contrast, the treatment of late complications (e.g. implant associated failures, secondary osteoarthrosis of the hip, periarticular heterotopic ossification, non-unions and late infections) depends on the clinical and functional condition of the patient. In symptomatic elderly patients secondary total hip replacement is usually a valid option, whereas younger patients with late complications can be candidates for joint-preserving procedures. The management of complications in acetabular surgery regularly requires intense patient guidance as well as thorough clarification and should be performed in specialized centers. Die operative Behandlung von Acetabulumfrakturen stellt eine besondere Herausforderung in der Unfallchirurgie dar. Komplikationen sind meist durch den Unfall selbst oder iatrogen bedingt. Der Umgang und die Strategie zur Bewältigung von Komplikationen in der Acetabulumchirurgie richten sich nach der Art und dem Zeitpunkt ihres Auftretens. Generell werden perioperative Frühkomplikationen von Spätkomplikationen unterschieden. Der vorliegende Beitrag stellt die häufigsten Komplikationen in der operativen Behandlung von Acetabulumfrakturen dar, diskutiert die verschiedenen Therapiemöglichkeiten anhand einzelner Fallbeispiele und gibt differenzierte Empfehlungen. Das Versorgungskonzept sollte zunächst eine umfassende Primärprophylaxe zur Vermeidung von Komplikationen umfassen. Eingetretene Frühkomplikationen wie z. B. postoperative Infektionen, Blutungen oder Implantatfehllagen sollten rasch und konsequent im Sinne einer Sekundärprophylaxe chirurgisch behandelt werden. Hingegen richtet sich die Behandlung von Spätkomplikationen (Implantatlockerungen und -brüche, sekundäre Koxarthrose, heterotope Ossifikationen, Pseudarthrosen und Spätinfektionen) nach dem klinischen und funktionellen Beschwerdebild des Patienten. Bei älteren Patienten mit entsprechenden Beschwerden stellt die sekundäre Versorgung mit einer Hüfttotalendoprothese oftmals eine gute Behandlungsmöglichkeit dar, wohingegen bei jüngeren Patienten nach Spätkomplikationen auch gelenkerhaltende Verfahren infrage kommen. Das Management von Komplikationen in der Acetabulumchirurgie erfordert regelhaft eine enge Patientenführung sowie die ausführliche Aufklärung und Beratung der Patienten und sollte in spezialisierten Zentren erfolgen. Keywords: Patient guidance; Pelvis; Perioperative care; Prophylaxis; Total hip arthroplasty. © 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. 15 references 18. Figure skating: Increasing numbers of revolutions in jumps at the European and World Championships PLoS One. 2022 Nov 30;17(11):e0265343. doi: 10.1371/journal.pone.0265343. eCollection 2022. Authors Thomas Rauer 1 , Hans-Christoph Pape 1 , Matthias Knobe 2 , Tim Pohlemann 3 , Bergita Ganse 3 4 Affiliations 1 Department of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland. 2 Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, Lucerne, Switzerland. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 4 Werner Siemens Foundation Endowed Chair of Innovative Implant Development, Saarland University, Homburg, Germany. PMID: 36449462 PMCID: PMC9710745 DOI: 10.1371/journal.pone.0265343 Abstract Figure skating is associated with a high prevalence of sport-specific injuries and overuse symptoms. Impacts are of greater magnitude in jumps with more revolutions that are thus connected to a greater risk of injury. While figure skating programs seem to have recently increased in difficulty, performance trends have not yet been reported in the literature. We hypothesized increasing performance and decreasing age trends of the best athletes who competed at international level in recent years. Furthermore, we aimed to identify and analyse objective performance parameters and to assess a potential link between age and the risk of injury. The development of the number of double, triple and quadruple jumps in the singles figure skating events at the World and European Championships since the introduction of the new ISU Judging System in the 2004/2005 season was analysed using regression statistics and Student's T-Tests. In all groups, the numbers of jumps with fewer rotations significantly decreased in the favour of jumps with more rotations. Women only started to perform jumps with four rotations in 2019. In the men, the number of quadruple jumps increased from an average of less than one to more than three in recent years (European and World Championships, both p < 0.001). In the European, but not in the World Championships, the average age increased in the men and decreased in the women (European Championships, men and women p = 0.006). Our study was the first to assess performance trends in elite figure skating. The incidence of injuries and overuse syndromes in figure skating needs to be monitored cautiously, as increases can be expected following recent gains in performance and jump complexity. Copyright: © 2022 Rauer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Conflict of interest statement The authors have declared that no competing interests exist. 37 references 2 figures Full text links 19. Recurring Osteomyelitis Caused by Clostridium celerecrescens in an Adolescent After Motocross Trauma: The Importance of Multidisciplinary Care Pediatr Infect Dis J. 2022 Dec 1;41(12):e547-e548. doi: 10.1097/INF.0000000000003687. Epub 2022 Oct 12. Authors Katharina Last 1 , Fabian K Berger 1 , Sören L Becker 1 , Cihan Papan 1 , Benedikt J Braun 2 , Philipp Mörsdorf 3 , Tim Pohlemann 3 , Katrin Altmeyer 4 , Arne Simon 5 Affiliations 1 Center for Infectious Diseases, Institute of Medical Microbiology and Hygiene Saarland University, Homburg, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen Tübingen, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 4 Department of Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, Germany. 5 Pediatric Oncology and Hematology Saarland University Hospital, Homburg Germany. PMID: 36375107 DOI: 10.1097/INF.0000000000003687 No abstract available Conflict of interest statement The authors have no funding or conflicts of interest to disclose. 7 references Full text links 20. Locking Nail versus Plate Fixation in Calcaneal Fractures: Brief report on a Retrospective Analysis of Treatment Characteristics and Radiographic Correction Potential Acta Chir Orthop Traumatol Cech. 2022;89(5):349-352. Authors N Stachel 1 , B J Braun 2 , M Orth 3 , S C Herath 2 , M F R Rollmann 2 , M M Menger 2 , T Histing 2 , T Pohlemann 3 Affiliations 1 Saarland University Hospital; Department of Orthopaedics and Orthopaedic Surgery, Homburg, Germany. 2 Department of Trauma and Reconstructive Surgery, BG Unfallklinik Tuebingen, University of Tuebingen, Germany. 3 Saarland University Hospital; Department of Trauma, Hand and Reconstructive Surgery, Homburg, Germany. PMID: 36322035 Abstract PURPOSE OF THE STUDY Minimal and limited access techniques are gaining increasing interest for the treatment of displaced intra-articular calcaneal fractures. The ideal treatment method is however still debated and largely based on individual case factors and surgeon experience. Aim of this study was thus to compare the treatment characteristics and radiographic correction potential of a locking nail system with a sinus tarsi approach to plate fixation via an extended lateral approach. MATERIAL AND METHODS We retrospectively reviewed 39 cases of patients with calcaneal fractures that received primary fracture treatment for displaced intra-articular calcaneal fractures between July 2017 and March 2020. Patient characteristics, time to surgery, time to discharge, OR time and the correction achieved were analyzed and comparative statistics performed. RESULTS In total 19 patients treated with the locking nail and 20 patients treated with plate fixation were analyzed. Patient age and fracture severity according to the Sanders classification were comparable between the groups. Overall surgical time, as well as the achieved reduction was equal between both groups. Time to surgery, as well as time from surgery to discharge was significantly shorter in the locking nail group. 2 additional soft tissue procedures were necessary in the extended lateral approach group. DISCUSSION AND CONCLUSIONS The results with the locking calcaneus nail and sinus tarsi approach suggest, that similar treatment results can be achieved as with plate osteosynthesis and an extended lateral approach. Soft tissue management, as well as pre- and postoperative timing and discharge management can be improved with the nail. Further controlled trials comparing the longterm outcome between the treatment options are needed. Key words: calcaneus fracture, sinus tarsi approach, calcaneal nail, C-Nail. Cited by 1 article 21. Performance Increases in Pair Skating and Ice Dance at International Championships and Olympic Games Int J Environ Res Public Health. 2022 Sep 19;19(18):11806. doi: 10.3390/ijerph191811806. Authors Thomas Rauer 1 , Hans-Christoph Pape 1 , Zoé Stehlin 2 , Sandro Heining 1 , Matthias Knobe 3 , Tim Pohlemann 4 , Bergita Ganse 4 5 Affiliations 1 Department of Trauma Surgery, University Hospital Zurich, 8091 Zurich, Switzerland. 2 Faculty of Medicine, University of Zurich, 8032 Zurich, Switzerland. 3 Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Luzern, Switzerland. 4 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany. 5 Werner Siemens Foundation Endowed Chair of Innovative Implant Development, Saarland University, 66421 Homburg, Germany. PMID: 36142074 PMCID: PMC9517212 DOI: 10.3390/ijerph191811806 Abstract In pair skating and ice dance, performance seems to have increased at international competitions, which is potentially associated with changes in athlete age. We hypothesized increasing age, numbers of total points and more complex jumps of the best elite couples at international championships in recent years. Corresponding data were assessed via the results databases of the European and World Championships, as well as the Winter Olympics since 2005. Linear regression statistics were conducted, and significance was assessed via one-way ANOVAs. There were no significant changes in age. Increases in total points were found in both disciplines (World and European Championships both p < 0.001 for both disciplines, Olympics pair skating p = 0.003, ice dance n/a). Significant increases were found in the number of double and triple twist jumps at the European Championships (Double p = 0.046, triple p = 0.041), but not at the World Championships or the Olympics. At the World Championships, single solo jumps decreased ( p = 0.031) in favor of triple jumps, which increased ( p = 0.020), without a similar effect at the European Championships or Olympics. In conclusion, increases in total points and more complex jumps were observed at international championships without associated changes in age. Attention should be given to possible changes in the incidence of acute and overuse injuries following this development. Keywords: age; competition; elite athlete; figure skating; performance; trauma; winter sports. Conflict of interest statement The authors declare no conflict of interest. 36 references 2 figures Full text links 22. Minimal-invasive anterior approach to the hip provides a better surgery-related and early postoperative functional outcome than conventional lateral approach after hip hemiarthroplasty following femoral neck fractures Arch Orthop Trauma Surg. 2023 Jun;143(6):3173-3181. doi: 10.1007/s00402-022-04602-2. Epub 2022 Sep 2. Authors M Orth 1 , D Osche 2 , P Mörsdorf 2 , J H Holstein 2 3 , M F Rollmann 2 4 , T Fritz 2 , T Pohlemann 2 , A Pizanis 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland Univesity, Kirrberger Strasse 1, D-66421, Homburg, Saarland, Germany. marcel.orth@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland Univesity, Kirrberger Strasse 1, D-66421, Homburg, Saarland, Germany. 3 Ethianum Clinic, Heidelberg, Germany. 4 BG Klinik Tuebingen on behalf of the Eberhard-Karls-University Tuebingen, Tuebingen, Germany. PMID: 36053291 PMCID: PMC10192169 DOI: 10.1007/s00402-022-04602-2 Abstract Introduction: Femoral neck fractures (FNF) are one of the most frequent fractures among elderly patients and commonly require surgical treatment. Bipolar hip hemiarthroplasty (BHHA) is mostly performed in these cases. Material and methods: In the present retrospective study geriatric patients with FNF (n = 100) treated either by anterior minimal-invasive surgery (AMIS; n = 50) or lateral conventional surgery (LCS; n = 50) were characterized (age at the time of surgery, sex, health status/ASA score, walking distance and need for walking aids before the injury) and intraoperative parameters (duration of surgery, blood loss, complications), as well as postoperative functional performance early (duration of in-patient stay, radiological leg length discrepancy, ability to full weight-bearing, mobilization with walking aids) and 12 months (radiological signs of sintering, clinical parameters, complication rate) after surgery were analyzed. Results: Patients in the AMIS group demonstrated a reduced blood loss intraoperatively, while the duration of surgery and complication rates did not differ between the two groups. Further, more patients in the AMIS group achieved full weight-bearing of the injured leg and were able to walk with a rollator or less support during their in-patient stay. Of interest, patients in the AMIS group achieved this level of mobility earlier than those of the LCS group, although their walking distance before the acute injury was reduced. Moreover, patients of the AMIS group showed equal leg lengths postoperatively more often than patients of the LCS group. No significant differences in functional and surgery-related performance could be observed between AMIS and LCS group at 12 months postoperatively. Conclusions: In conclusion, geriatric patients treated by AMIS experience less surgery-related strain and recover faster in the early postoperative phase compared to LCS after displaced FNF. Hence, AMIS should be recommended for BHHA in these vulnerable patients. Keywords: AMIS; Femoral neck fracture; Hemiarthroplasty; Hip; Lateral approach. © 2022. The Author(s). Conflict of interest statement The authors have no relevant financial or non-financial interests to disclose. Cited by 1 article 19 references 1 figure Full text links 23. Sacroiliac Screw Placement with Ease: CT-Guided Pelvic Fracture Osteosynthesis in the Elderly Medicina (Kaunas). 2022 Jun 15;58(6):809. doi: 10.3390/medicina58060809. Authors Hannah Kress 1 , Roman Klein 1 , Tim Pohlemann 2 , Christoph Georg Wölfl 1 Affiliations 1 Klinik für Orthopädie, Unfallchirurgie und Sporttraumatologie, Marienhaus Klinikum Hetzelstift, 67434 Neustadt an der Weinstraße, Germany. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Saarland University Medical Center, 66421 Homburg, Germany. PMID: 35744073 PMCID: PMC9227275 DOI: 10.3390/medicina58060809 Abstract Background and Objectives : The number of geriatric patients presenting with fragility fractures of the pelvis is increasing due to ageing Western societies. There are nonoperative and several operative treatment approaches. Many of which cause prolonged hospitalisation, so patients become bedridden and lose mobility and independence. This retrospective study evaluates the postoperative outcome of a computed tomography-guided (CT-guided) minimally invasive approach of sacroiliac screw osteosynthesis. The particular focus is to demonstrate its ease of use, feasibility with the equipment of virtually every hospital and beneficial outcomes to the patients. Materials and Methods : 28 patients (3 men, 25 women, age 80.5 ± 6.54 years) with fragility fractures of the pelvis types II-IV presenting between August 2015 and September 2021 were retrospectively reviewed. The operation was performed using the CT of the radiology department for intraoperative visualization of screw placement. Patients only received screw osteosynthesis of the posterior pelvic ring and cannulated screws underwent cement augmentation. Outcomes measured included demographic data, fracture type, postoperative parameters and complications encountered. The quality of life (QoL) was assessed using the German version of the EQ-5D-3L. Results : The average operation time was 32.4 ± 9.6 min for the unilateral and 50.7 ± 17.4 for the bilateral procedure. There was no significant difference between surgeons operating ( p = 0.12). The postoperative CT scans were used to evaluate the outcome and showed only one case of penetration (by 1 mm) of the ventral cortex, which did not require operative revision. No case of major complication was reported. Following surgery, patients were discharged after a median of 4 days (Interquartile range 3-7.5). 53.4% of the patients were discharged home or to rehabilitation. The average score on the visual analogue scale of the EQ-5D-3L evaluating the overall wellbeing was 55.6 (Interquartile range (IQR) 0-60). Conclusions : This study shows that the operative method is safe to use in daily practice, is readily available and causes few complications. It permits immediate postoperative mobilization and adequate pain control. Independence and good quality of life are preserved. Keywords: fracture; osteoporosis; pelvis; spine. Conflict of interest statement The authors declare no conflict of interest. 23 references 4 figures Full text links 24. Dose-dependent dominance: How cell densities design stromal cell functions during soft tissue healing Cell Biochem Funct. 2022 Jul;40(5):439-450. doi: 10.1002/cbf.3705. Epub 2022 Jun 15. Authors Philipp Kuhn 1 , Monika Bubel 1 , Martina Jennewein 1 , Silke Guthörl 1 , Tim Pohlemann 1 , Martin Oberringer 1 Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Homburg, Germany. PMID: 35707856 DOI: 10.1002/cbf.3705 Abstract Regular soft tissue healing relies on the well-organized interaction of different stromal cell types with endothelial cells. However, spatiotemporal conditions might provoke high densities of one special stromal cell type, potentially leading to impaired healing. Detailed knowledge of the functions of rivaling stromal cell types aiming for tissue contraction and stabilization as well as vascular support is mandatory. By the application of an in vitro approach comprising the evaluation of cell proliferation, cell morphology, myofibroblastoid differentiation, and cytokine release, we verified a density-dependent modulation of these functions among juvenile and adult fibroblasts, pericytes, and adipose-derived stem cells during their interaction with microvascular endothelial cells in cocultures. Results indicate that juvenile fibroblasts rather support angiogenesis via paracrine regulation at the early stage of healing, a role potentially compromised in adult fibroblasts. In contrast, pericytes showed a more versatile character aiming at angiogenesis, vessel stabilization, and tissue contraction. Such a universal character was even more pronounced among adipose-derived stem cells. The explicit knowledge of the characteristic functions of stromal cell types is a prerequisite for the development of new analytical and therapeutic approaches for impaired soft tissue healing. The present study delivers new considerations concerning the roles of rivaling stromal cell types within a granulation tissue, pointing to extraordinary properties of pericytes and adipose-derived stem cells. Keywords: adipose-derived stem cell; endothelial cell; fibroblast; pericyte; stromal cell; tissue repair; wound healing. © 2022 The Authors. Cell Biochemistry and Function published by John Wiley & Sons Ltd. 35 references Full text links 25. Weight-Bearing Restrictions after Acetabular Fracture, Necessity or False Hope? A Brief Observational Study Acta Chir Orthop Traumatol Cech. 2022;89(2):146-149. Authors B J Braun 1 , T Histing 1 , M F R Rollmann 1 , M M Menger 1 , D Osche 2 , M Orth 2 , T Pohlemann 2 , S C Herath 1 Affiliations 1 University Hospital Tuebingen; on behalf of the Eberhard-Karls-University Tuebingen, Faculty of Medicine; BG Hospital Tuebingen, Germany. 2 Saarland University Hospital; Department of Trauma, Hand and Reconstructive Surgery, Homburg, Germany. PMID: 35621406 Abstract PURPOSE OF THE STUDY Most common postoperative treatment recommendations after acetabulum fractures suggest at least 6 weeks of postoperative partial or non weight-bearing. To protect the osteosynthetic construct this surgically set weight-bearing limit is trained by physical therapy. Aim of our analysis was to determine the free field patient compliance to these weight-bearing restrictions and observe their influence on the early postoperative radiographic imaging. MATERIAL AND METHODS Patients after surgical treatment of an acetabulum fracture were included in our analysis. Every patient was instructed to maintain a 20 kg weight-bearing limit for 6 weeks. Postoperative weight-bearing was continuously monitored during this time with a pressure measuring insole. Maximum weight-bearing per day was recorded and maintenance of reduction assessed after this time. RESULTS In total 10 patients were included into the study. Only 1 patient stayed within the weight-bearing limit during the analysis. Maximum weight-bearing as high as 110 kg was recorded. All patients maintained postoperative reduction at the 6 week timepoint. DISCUSSION AND CONCLUSIONS Despite regular physical therapy training compliance to the generally accepted weight-bearing limits was low. Regardless of the non-compliance the radiographic outcome remained unchanged. Further analysis on the use of permissive weightbearing aftercare regimes are warranted. Key words: weight-bearing, acetabulum fracture, compliance. Cited by 1 article 26. Concepts and clinical aspects of active implants for the treatment of bone fractures Acta Biomater. 2022 Jul 1:146:1-9. doi: 10.1016/j.actbio.2022.05.001. Epub 2022 May 7. Authors Bergita Ganse 1 , Marcel Orth 2 , Michael Roland 3 , Stefan Diebels 3 , Paul Motzki 4 , Stefan Seelecke 4 , Susanne-Marie Kirsch 4 , Felix Welsch 4 , Annchristin Andres 3 , Kerstin Wickert 3 , Benedikt J Braun 5 , Tim Pohlemann 2 Affiliations 1 Werner Siemens-Endowed Chair for Innovative Implant Development (Fracture Healing), Clinics and Institutes of Surgery, Saarland University, Homburg, Germany; Department of Trauma, Hand and Reconstructive Surgery, Clinics and Institutes of Surgery, Saarland University, Homburg, Germany. Electronic address: bergita.ganse@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Clinics and Institutes of Surgery, Saarland University, Homburg, Germany. 3 Chair of Applied Mechanics, Saarland University, Saarbrücken, Germany. 4 ZeMA - Center for Mechatronics and Automation Technology, Intelligent Material Systems Laboratory, Saarland University, Saarbrücken, Germany. 5 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center, Tübingen, Germany. PMID: 35537678 DOI: 10.1016/j.actbio.2022.05.001 Free article Abstract Nonunion is a complication of long bone fractures that leads to disability, morbidity and high costs. Early detection is difficult and treatment through external stimulation and revision surgery is often a lengthy process. Therefore, alternative diagnostic and therapeutic options are currently being explored, including the use of external and internal sensors. Apart from monitoring fracture stiffness and displacement directly at the fracture site, it would be desirable if an implant could also vary its stiffness and apply an intervention to promote healing, if needed. This could be achieved either by a predetermined protocol, by remote control, or even by processing data and triggering the intervention itself (self-regulated 'intelligent' or 'smart' implant). So-called active or smart materials like shape memory alloys (SMA) have opened up opportunities to build active implants. For example, implants could stimulate fracture healing by active shortening and lengthening via SMA actuator wires; by emitting pulses, waves, or electromagnetic fields. However, it remains undefined which modes of application, forces, frequencies, force directions, time durations and periods, or other stimuli such implants should ideally deliver for the best result. The present paper reviews the literature on active implants and interventions for nonunion, discusses possible mechanisms of active implants and points out where further research and development are needed to build an active implant that applies the most ideal intervention. STATEMENT OF SIGNIFICANCE: Early detection of delays during fracture healing and timely intervention are difficult due to limitations of the current diagnostic strategies. New diagnostic options are under evaluation, including the use of external and internal sensors. In addition, it would be desirable if an implant could actively facilitate healing ('Intelligent' or 'smart' implant). Implants could stimulate fracture healing via active shortening and lengthening; by emitting pulses, waves, or electromagnetic fields. No such implants exist to date, but new composite materials and alloys have opened up opportunities to build such active implants, and several groups across the globe are currently working on their development. The present paper is the first review on this topic to date. Keywords: Fracture healing; Shape memory alloy; Smart implant; Surgery; Trauma. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. Conflict of interest statement Declaration of Competing Interest TP is president elect and board member of the AO Foundation, Switzerland, and extended board member of the German Society of Orthopedic Trauma Surgery (DGU), the German Society of Orthopedic Surgery and Traumatology (DGOU), and the German Society of Surgery (DGCH). TP is also the speaker of the medical advisory board of the German Ministry of Defense. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Cited by 4 articles Full text links 27. Development of an ischemic fracture healing model in mice Acta Orthop. 2022 Apr 25:93:466-471. doi: 10.2340/17453674.2022.2529. Authors Maximilian M Menger 1 , Janine Stutz 2 , Sabrina Ehnert 3 , Andreas K Nussler 4 , Mika F Rollmann 5 , Steven C Herath 6 , Benedikt J Braun 7 , Tim Pohlemann 8 , Michael D Menger 9 , Tina Histing 10 Affiliations 1 Institute for Clinical & Experimental Surgery, Saarland University, Homburg/Saar; Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen. maximilian.menger@uks.eu. 2 Institute for Clinical & Experimental Surgery, Saarland University, Homburg/Saar; Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg/Saar. janine.stutz@uks.eu. 3 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen; Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tübingen, Tübingen, Germany. sabrina.ehnert@gmail.com. 4 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen; Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tübingen, Tübingen, Germany. Andreas.Nuessler@med.uni-tuebingen.de. 5 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen. mrollman@bgu-tuebingen.de. 6 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen. sherath@bgu-tuebingen.de. 7 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen. bbraun@bgu-tuebingen.de. 8 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg/Saar. tim.pohlemann@uks.eu. 9 Institute for Clinical & Experimental Surgery, Saarland University, Homburg/Saar. michael.menger@uks.eu. 10 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen. thisting@bgu-tuebingen.de. PMID: 35478260 PMCID: PMC9047454 DOI: 10.2340/17453674.2022.2529 Abstract Background and purpose: In fracture healing, ischemia caused by vascular injuries, chronic vascular diseases, and metabolic comorbidities is one of the major risk factors for delayed union and non-union formation. To gain novel insights into the molecular and cellular pathology of ischemic fracture healing, appropriate animal models are needed. Murine models are of particular interest, as they allow to study the molecular aspects of fracture healing due to the availability of both a large number of murine antibodies and gene-targeted animals. Thus, we present the development of an ischemic fracture healing model in mice. Material and methods: After inducing a mild ischemia by double ligature of the deep femoral artery in CD-1 mice, the ipsilateral femur was fractured by a 3-point bending device and stabilized by screw osteosynthesis. In control animals, the femur was fractured and stabilized without the induction of ischemia. The femora were analyzed at 2 and 5 weeks after fracture healing by means of radiology, biomechanics, histology, and histomorphometry. Results: The surgically induced ischemia delayed and impaired the process of fracture healing. This was indicated by a lower Goldberg score, decreased bending stiffness, and reduced bone callus formation in the ischemic animals when compared with the controls. Interpretation: We introduce a novel ischemic femoral fracture healing model in mice, which is characterized by delayed bone healing. In future, the use of this model may allow both the elucidation of the molecular aspects of ischemic fracture healing and the study of novel treatment strategies. 27 references 4 figures Full text links 28. COVID-19: a catalyst for the digitization of surgical teaching at a German University Hospital BMC Med Educ. 2022 Apr 22;22(1):308. doi: 10.1186/s12909-022-03362-2. Authors Milan Anton Wolf 1 2 , Antonius Pizanis 3 , Gerrit Fischer 4 , Frank Langer 5 , Philipp Scherber 6 , Janine Stutz 3 , Marcel Orth 3 , Tim Pohlemann 3 , Tobias Fritz 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. Milan.wolf@uks.eu. 2 Department of Orthopaedics and Orthopaedic Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. Milan.wolf@uks.eu. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. 4 Department of Neurosurgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. 5 Department of Thoracic and Cardiac Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. 6 Department of General Surgery, Visceral, Vascular and Pediatric Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. PMID: 35459175 PMCID: PMC9030685 DOI: 10.1186/s12909-022-03362-2 Abstract Background: The summer semester 2020, had to be restructured due to the SARS-CoV-2 pandemic and the associated contact restrictions. Here, for the first time, the established lectures in lecture halls and small group seminars could not be conducted in presence as usual. A possible tool for the implementation of medical teaching, offers the use of eLearning, online webinars and learning platforms. At present it is unclear how the SARS-CoV-2 pandemic will affect surgical teaching, how digitization will be accepted by students, and how virtual teaching can be expanded in the future. Methods: The teaching, which was previously delivered purely through face-to-face lectures, was completely converted to digital media. For this purpose, all lectures were recorded and were available to students on demand. The seminars were held as a twice a week occurring online webinar. The block internship was also conducted as a daily online webinar and concluded with an online exam at the end. At the end of the semester, a survey of the students was carried out, which was answered by n = 192 students with an anonymized questionnaire. The questionnaire inquires about the previous and current experience with eLearning, as well as the possibility of a further development towards a purely digital university. Results: There were n = 192 students in the study population. For 88%, the conversion of classes to web-based lectures represented their first eLearning experience. For 77% of all students, the digitization of teaching led to a change in the way they prepare for class. 73% of the participating students are of the opinion that eLearning lectures should continue to be offered. 54% of the students felt that eLearning lectures made more sense than face-to-face lectures. A purely virtual university could be imagined by 41% of the students. Conclusion: The conversion of teaching represented the first contact with eLearning for most students. Overall, the eLearning offering was experienced as positive. Due to the new teaching structure, the way of learning had already changed during the semester. Based on the new eLearning content, the already existing formats can be further expanded in the future. Nevertheless, it turned out that the practical-surgical contents and skills cannot be adequately represented by purely online offers; for this, the development of hybrid practice-oriented teaching concepts is necessary. Keywords: Covid-19; Digitalization; Surgical education; Webinar; eLearning. © 2022. The Author(s). Conflict of interest statement The authors declare that they have no competing interests. Cited by 1 article 32 references 2 figures Full text links 29. Experiences in the Use of Motorized Intramedullary Nails after Complex Injuries to the Extremities Z Orthop Unfall. 2023 Jun;161(3):271-279. doi: 10.1055/a-1640-0935. Epub 2022 Feb 1. [Article in English, German] Authors Marcel Orth 1 , Philipp Mörsdorf 1 , Tobias Fritz 1 , Benedikt J Braun 2 , Vakhtang Pirpilashvili 1 , Janine Stutz 1 , Nils Veith 1 , Tim Pohlemann 1 , Antonius Pizanis 1 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg, Deutschland. 2 Klinik für Unfall- und Wiederherstellungschirurgie, Universitätsklinikum Tübingen, Tübingen, Deutschland. PMID: 35104903 DOI: 10.1055/a-1640-0935 Abstract in English, German The treatment of complex injuries of the extremities after comminuted fractures or non-unions is a challenging area in the field of trauma surgery. Internal, motorized implants nowadays enable a patient-oriented and progressive treatment of these cases. The present article aims to present modern treatment strategies of complex injuries of the extremities, support the use of novel, motorized intramedullary nails and provide experiences for the handling with lengthening nails or transport nails. For this purpose, the preoperative planning including selection of patients, presentation of internal lengthening and transport systems and the most important factors during preparation of the surgery are described. Moreover, critical steps during the implantation of motorized nails and also during potential follow-up interventions are highlighted and the postoperative protocol including precise recommendations for the transport und consolidation phase are provided. Finally, the experiences are illustrated by presentation of the four different cases. The use of internal, motorized implants represents the latest step in the treatment of complex injuries of the extremities. These implants improve the quality of life and the authors recommend its use. However, these implants require a high expertise and adaption of established treatment protocols in these challenging trauma cases. Follow-up analyses with a considerably large number of cases are necessary and the research on implants to solve persisting problems in the area of complex injuries of the extremities has to be pursued intensively. Die Behandlung komplexer Extremitätenverletzungen infolge von Trümmerfrakturen oder Pseudarthrosen stellt eine besondere Herausforderung in der Unfallchirurgie dar. Rein interne, motorisierte Implantatsysteme ermöglichen heutzutage eine patientenorientierte und fortschrittliche Behandlung solcher Fälle. Der vorliegende Beitrag soll moderne Behandlungskonzepte komplexer Extremitätenverletzungen vorstellen, Unterstützung bei der Anwendung neuartiger, motorisierter Marknägel liefern und Erfahrungen beim Umgang mit Verlängerungs- und Transportnägeln darstellen. Hierzu wird zunächst die präoperative Planung inkl. Patientenselektion, Vorstellung interner Verlängerungs- und Transportsysteme und der wichtigsten Faktoren für die OP-Vorbereitung erläutert. Im Anschluss werden intraoperative Besonderheiten bei der Implantation motorisierter Marknägel sowie bei möglichen Folgeeingriffen dargestellt und das postoperative Prozedere mit konkreten Empfehlungen zur Transport- und Konsolidierungsphase beschrieben. Abschließend werden die Erfahrungen durch 4 Anwendungsbeispiele veranschaulicht. Der Einsatz interner, motorisierter Implantate stellt den derzeit letzten Schritt in der Behandlung komplexer Extremitätenverletzungen dar. Sie verbessern die Lebensqualität betroffener Patienten und ihre Anwendung wird seitens der Autoren befürwortet. Doch erfordern diese neuen Implantate ein hohes Maß an Expertise und eine Anpassung etablierter Behandlungsstrategien bei diesen ohnehin anspruchsvollen unfallchirurgischen Krankheitsbildern. Weitere Untersuchungen mit großen Fallzahlen sollten künftig erhoben und die Implantatforschung zur Lösung fortbestehender Probleme in der Behandlung komplexer Extremitätenverletzungen intensiv fortgesetzt werden. Thieme. All rights reserved. Conflict of interest statement Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht. Full text links 30. Local Application of Mineral-Coated Microparticles Loaded With VEGF and BMP-2 Induces the Healing of Murine Atrophic Non-Unions Front Bioeng Biotechnol. 2022 Jan 11:9:809397. doi: 10.3389/fbioe.2021.809397. eCollection 2021. Authors M Orth 1 2 , T Fritz 1 , J Stutz 1 2 , C Scheuer 2 , B Ganse 1 3 , Y Bullinger 1 , J S Lee 4 , W L Murphy 4 , M W Laschke 2 , M D Menger 2 , T Pohlemann 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany. 3 Werner Siemens Endowed Chair of Innovative Implant Development (Fracture Healing), Saarland University, Homburg, Germany. 4 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States. PMID: 35087807 PMCID: PMC8787303 DOI: 10.3389/fbioe.2021.809397 Abstract Deficient angiogenesis and disturbed osteogenesis are key factors for the development of nonunions. Mineral-coated microparticles (MCM) represent a sophisticated carrier system for the delivery of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP)-2. In this study, we investigated whether a combination of VEGF- and BMP-2-loaded MCM (MCM + VB) with a ratio of 1:2 improves bone repair in non-unions. For this purpose, we applied MCM + VB or unloaded MCM in a murine non-union model and studied the process of bone healing by means of radiological, biomechanical, histomorphometric, immunohistochemical and Western blot techniques after 14 and 70 days. MCM-free non-unions served as controls. Bone defects treated with MCM + VB exhibited osseous bridging, an improved biomechanical stiffness, an increased bone volume within the callus including ongoing mineralization, increased vascularization, and a histologically larger total periosteal callus area consisting predominantly of osseous tissue when compared to defects of the other groups. Western blot analyses on day 14 revealed a higher expression of osteoprotegerin (OPG) and vice versa reduced expression of receptor activator of NF-κB ligand (RANKL) in bone defects treated with MCM + VB. On day 70, these defects exhibited an increased expression of erythropoietin (EPO), EPO-receptor and BMP-4. These findings indicate that the use of MCM for spatiotemporal controlled delivery of VEGF and BMP-2 shows great potential to improve bone healing in atrophic non-unions by promoting angiogenesis and osteogenesis as well as reducing early osteoclast activity. Keywords: BMP-2; VEGF; bone healing; fracture; mineral-coated microparticles; non-union. Copyright © 2022 Orth, Fritz, Stutz, Scheuer, Ganse, Bullinger, Lee, Murphy, Laschke, Menger and Pohlemann. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 1 article 51 references 7 figures Full text links 31. Individualized Determination of the Mechanical Fracture Environment After Tibial Exchange Nailing-A Simulation-Based Feasibility Study Front Surg. 2021 Sep 29:8:749209. doi: 10.3389/fsurg.2021.749209. eCollection 2021. Authors Benedikt J Braun 1 , Marcel Orth 2 , Stefan Diebels 3 , Kerstin Wickert 3 , Annchristin Andres 3 , Joshua Gawlitza 4 , Arno Bücker 5 , Tim Pohlemann 2 , Michael Roland 3 Affiliations 1 University Hospital Tuebingen on Behalf of the Eberhard-Karls-University Tuebingen, Faculty of Medicine, BG Hospital Tuebingen, Tuebingen, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 3 Department of Applied Mechanics, Saarland University, Saarbruecken, Germany. 4 Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany. 5 Clinic of Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, Germany. PMID: 34660686 PMCID: PMC8511819 DOI: 10.3389/fsurg.2021.749209 Abstract Non-union rate after tibial fractures remains high. Apart from largely uncontrollable biologic, injury, and patient-specific factors, the mechanical fracture environment is a key determinant of healing. Our aim was to establish a patient-specific simulation workflow to determine the mechanical fracture environment and allow for an estimation of its healing potential. In a referred patient with failed nail-osteosynthesis after tibial-shaft fracture exchange nailing was performed. Post-operative CT-scans were used to construct a three-dimensional model of the treatment situation in an image processing and computer-aided design system. Resulting forces, computed in a simulation-driven workflow based on patient monitoring and motion capturing were used to simulate the mechanical fracture environment before and after exchange nailing. Implant stresses for the initial and revision situation, as well as interfragmentary movement, resulting hydrostatic, and octahedral shear strain were calculated and compared to the clinical course. The simulation model was able to adequately predict hardware stresses in the initial situation where mechanical implant failure occurred. Furthermore, hydrostatic and octahedral shear strain of the revision situation were calculated to be within published healing boundaries-accordingly the fracture healed uneventfully. Our workflow is able to determine the mechanical environment of a fracture fixation, calculate implant stresses, interfragmentary movement, and the resulting strain. Critical mechanical boundary conditions for fracture healing can be determined in relation to individual loading parameters. Based on this individualized treatment recommendations during the early post-operative phase in lower leg fractures are possible in order to prevent implant failure and non-union development. Keywords: fracture healing; individualized simulation; non-union; simulation; tibia. Copyright © 2021 Braun, Orth, Diebels, Wickert, Andres, Gawlitza, Bücker, Pohlemann and Roland. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 4 articles 35 references 5 figures Full text links 32. Acceleration of Longitudinal Track and Field Performance Declines in Athletes Who Still Compete at the Age of 100 Years Front Physiol. 2021 Sep 28:12:730995. doi: 10.3389/fphys.2021.730995. eCollection 2021. Authors Bergita Ganse 1 2 , Anne Kristin Braczynski 3 4 , Christoph Hoog Antink 5 , Matthias Knobe 6 , Tim Pohlemann 2 , Hans Degens 7 8 Affiliations 1 Division of Surgery, Werner Siemens Foundation Endowed Chair of Innovative Implant Development, Saarland University, Homburg, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 3 Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany. 4 Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 5 KISMED - AI Systems in Medicine, Electrical Engineering and Information Technology, TU Darmstadt, Darmstadt, Germany. 6 Department of Orthopaedic and Trauma Surgery, Lucerne Cantonal Hospital, Lucerne, Switzerland. 7 Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, United Kingdom. 8 Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania. PMID: 34650443 PMCID: PMC8505806 DOI: 10.3389/fphys.2021.730995 Abstract While physical performance decline rates accelerate after around the age of 70 years, longitudinal athletic performance trends in athletes older than 95 years are unknown. We hypothesized a further accelerated decline in human performance in athletes who still perform at the age of 100 years. To investigate this, longitudinal data of all athletes with results at or over the age of 100 years were collected from the "World Master Rankings" data base spanning 2006-2019 (138 results from 42 athletes; 5 women, 37 men; maximum 105 years) and compared to previously published longitudinal data from 80- to 96-year-old athletes from Sweden (1,134 results from 374 athletes). Regression statistics were used to compare performance decline rates between disciplines and age groups. On average, the individual decline rate of the centenarian group was 2.53 times as steep (100 m: 8.22x; long jump: 0.82x; shot put: 1.61x; discus throw: 1.04x; javelin throw: 0.98x) as that seen in non-centenarians. The steepest increase in decline was found in the 100-m sprint ( t -test: p < 0.05, no sign. difference in the other disciplines). The pooled regression statistics of the centenarians are: 100 m: R = 0.57, p = 0.004; long jump: R = 0.90, p < 0.001; shot put: R = 0.65, p < 0.001; discus throw: R = 0.73, p < 0.001; javelin throw: R = 0.68, p < 0.001. This first longitudinal dataset of performance decline rates of athletes who still compete at 100 years and older in five athletics disciplines shows that there is no performance plateau after the age of 90, but rather a further acceleration of the performance decline. Keywords: aging; centenarian; javelin throw; long jump; longevity; master athletics; oldest-old; physical activity. Copyright © 2021 Ganse, Braczynski, Hoog Antink, Knobe, Pohlemann and Degens. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cited by 1 article 25 references 1 figure Full text links 33. The effect of an infra-acetabular screw for anatomically shaped three-dimensional plate or standard plate designs in acetabulum fractures: a biomechanical analysis Eur J Trauma Emerg Surg. 2022 Oct;48(5):3757-3764. doi: 10.1007/s00068-021-01805-x. Epub 2021 Oct 7. Authors I Graul 1 2 , I Marintschev 1 , A Pizanis 3 , S C Herath 3 4 , T Pohlemann 3 , T Fritz 5 Affiliations 1 Jena University Hospital, Department of Trauma, Hand and Reconstructive Surgery, Friedrich Schiller University Jena, Erlanger Allee 101, 07740, Jena, Germany. 2 Department of Orthopedics, Campus Eisenberg, University of Jena, Eisenberg, Germany. 3 Department for Trauma, Hand- and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. 4 BG Trauma Center, Eberhard Karls Universitaet Tuebingen, Tuebingen, Germany. 5 Department for Trauma, Hand- and Reconstructive Surgery, Saarland University Medical Center, Kirrbergerstr. 100, 66421, Homburg, Germany. Tobias.fritz@uks.eu. PMID: 34618166 PMCID: PMC9532306 DOI: 10.1007/s00068-021-01805-x Abstract Background: Various plate shapes and implant configurations are used for stabilization of acetabulum fractures via anterior approaches. Little is known about the biomechanical stability of a two-dimensionally shaped "conventional" plate ("J-Plate"-JP) in comparison to three-dimensionally shaped plate configurations (3DP). In addition, the augmentary effect of an infra-acetabular lag-screw (IACS) fixation for anterior column and posterior hemi-transverse acetabulum fractures has not been clarified in comparison of JP and 3DP constructs. This study analyzed the difference between the biomechanical stability of JP compared to 3DP and the role of an IACS in a standardized acetabular fracture model in a single-leg stance loading configuration. Methods: In an artificial bone substitute pelvis model (Synbone © Malans, Switzerland), a typical and standardized fracture pattern (anterior column and posterior hemi-transverse) was created with osteotomy jigs. After anatomic reduction the stabilization was performed using JP or 3DP. Eight pelvises per group were axially loaded in a single-leg stance model up to 400 N. After the load cycle, an additional infra-acetabular screw was placed and the measurement repeated. Fragment displacement was recorded by an optical tracking system (Optitrack Prime 13®, Corvallis, USA). Results: In the pure placement, 3DP provided significantly superior stability when compared to JP. Augmentation of JP by IACS increased the stability significantly, up to the level of 3DP alone, whereas augmentation of the 3DP did not result in further increase of overall stability. Conclusion: The anatomically shaped plate alone provides a superior biomechanical stability in fixation of an anterior column and posterior hemi-transverse fracture model. In a JP fixation the augmentation by IACS provides similar strength as the anatomically shaped 3DP. By use of the anatomically shaped 3DP the need of a clinically risky application of IACS might be avoidable. Level of evidence: IV, Experimental study. Keywords: Acetabular fracture; Anatomically shaped plate; Biomechanics; Infra-acetabular screw; Suprapectineal. © 2021. The Author(s). Conflict of interest statement The authors state no conflict of interest for this study. Cited by 5 articles 36 references 5 figures Full text links 34. Macrophage-activating lipoprotein (MALP)-2 impairs the healing of partial tendon injuries in mice Ann Anat. 2022 Jan:239:151818. doi: 10.1016/j.aanat.2021.151818. Epub 2021 Aug 13. Authors Tobias Fritz 1 , Julia Schäfer 2 , Claudia Scheuer 3 , Janine Stutz 2 , Tina Histing 4 , Tim Pohlemann 2 , Michael D Menger 3 , Matthias W Laschke 3 , Moritz Klein 2 , Marcel Orth 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, 66421 Homburg, Germany. Electronic address: tobias.fritz@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, 66421 Homburg, Germany. 3 Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany. 4 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, 66421 Homburg, Germany; BG Trauma Center, Eberhard Karls Universitaet Tuebingen, Tuebingen, Germany. PMID: 34391911 DOI: 10.1016/j.aanat.2021.151818 Abstract Tendon injuries are accounted for up to 50% of musculoskeletal injuries and often result in poor outcomes. Inflammation is a major hallmark of tendon regeneration. Therefore, we analyzed in this study whether the topical application of the pro-inflammatory mediator macrophage-activating lipoprotein (MALP)-2 improves the healing of partial tendon injuries. C57BL/6 mice underwent a partial tenotomy of the flexor digitorum longus tendon of the left hind limb, which was treated with a solution containing either 0.5 µg MALP-2 or vehicle (control). Repetitive gait analyses were performed prior to the surgical intervention as well as postoperatively on days 1, 3, 7, 14 and 36. The structural stability of the tendons was biomechanically tested on day 7 and 36. In addition, Western blot analyses were performed on isolated tendons that were treated in vitro with MALP-2 or vehicle. In both groups, partial tenotomy resulted in a pathological gait pattern during the initial postoperative phase. On day 7, the gait pattern normalized in vehicle-treated animals, but not in MALP-2-treated mice. Moreover, the tendons of MALP-2-treated mice exhibited a significantly reduced biomechanical stiffness after 7 and 36 days when compared to controls. Western blot analyses revealed a significantly higher expression of heme oxygenase (HO)-1 and lower expression of cyclin D in MALP-2-treated tendons. These findings indicate that MALP-2 delays the healing of injured tendons most likely due to increased intracellular stress and suppressed cell proliferation in this naturally bradytrophic tissue. Hence, the application of MALP-2 cannot be recommended for the treatment of tendon injuries. Keywords: Catwalk XT; Gait analysis; Inflammation; MALP-2; Tendon healing; Tendon injury. Copyright © 2021 Elsevier GmbH. All rights reserved. Conflict of interest statement Conflict of interest All authors declare no conflict of interest. Cited by 1 article Full text links 35. [Case-based learning can improve the teaching quality in trauma surgery education : A survey analysis among medical students] Unfallchirurg. 2022 Mar;125(3):219-226. doi: 10.1007/s00113-021-01009-3. Epub 2021 Jun 8. [Article in German] Authors Friedemann Strobel 1 2 , Tina Histing 1 , Tim Pohlemann 1 , Antonius Pizanis 1 , Benedikt Johannes Braun 1 , Marcel Orth 1 , Tobias Fritz 3 Affiliations 1 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66421, Homburg/Saar, Deutschland. 2 Klinik für Anästhesiologie und operative Intensivmedizin, Kliniken Köln-Merheim, Ostmerheimer Str. 200, 51109, Köln, Deutschland. 3 Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66421, Homburg/Saar, Deutschland. tobias.fritz@uks.eu. PMID: 34100962 PMCID: PMC8881268 DOI: 10.1007/s00113-021-01009-3 Abstract in English, German Background: Medical education has always been challenging for students and teachers. Of growing importance is the promotion of knowledge of correlations and knowledge transfer from theoretical aspects into clinical practice. In order to achieve this aim, student-centered teaching concepts are increasingly being employed in the literature. Objective: Can a trauma surgery practical seminar be improved by a case-based teaching concept? Material and methods: For this purpose, standardized case studies and corresponding teaching materials, such as classification aids and treatment strategies, were made available to the students and lecturers. Using a two-staged evaluation the effects of the modified teaching design could be recorded and statistically analyzed. Results: The seminar was considered to be relevant for the examinations. The teaching by the lecturers was found to be more competent and appeared more motivated. Overall, the seminar was rated better by the students. Conclusion: A case-based teaching concept can significantly improve the education in trauma surgery, when correctly and specifically implemented. Zusammenfassung: HINTERGRUND: Medizinische Lehre ist seit jeher eine Herausforderung für Studierende und Dozenten. Die Förderung des Zusammenhangswissens und ein Wissenstransfer von der Theorie auf die Praxis gewinnen in den letzten Jahren an Bedeutung. Um dieses Ziel zu erreichen, werden zunehmend studierendenzentrierte Lehrkonzepte in der Literatur eingesetzt. Fragestellung: Kann durch ein fallbasiertes Lehrkonzept das unfallchirurgische Seminar verbessert werden? Material und methoden: Den Studierenden und Dozenten wurden standardisierte Fallbeispiele und dazugehörige Unterrichtsmaterialien wie Klassifikationshilfen und Versorgungsstrategien zur Verfügung gestellt. Durch eine zweizeitige Evaluation konnten die Auswirkungen dieser Modifikationen des Lehrdesigns erfasst und statistisch ausgewertet werden. Ergebnisse: Das Seminar wurde als prüfungsrelevanter empfunden. Die Lehre durch die Dozenten wurde als kompetenter und motivierter empfunden. Insgesamt wurde das Seminar durch die Studierenden besser bewertet. Schlussfolgerungen: Ein fallbasiertes Lehrkonzept kann daher, richtig und gezielt eingesetzt, die unfallchirurgische Lehre signifikant verbessern. Keywords: Case-based learning; Student-centered teaching format; Surgical teaching; Teaching; Trauma surgery seminar. © 2021. The Author(s). Cited by 3 articles 28 references 3 figures Full text links 36. Amlodipine accelerates bone healing in a stable closed femoral fracture model in mice Eur Cell Mater. 2021 May 24:41:592-602. doi: 10.22203/eCM.v041a38. Authors M M Menger 1 , B Merscher , C Scheuer , B J Braun , S C Herath , M F Rollmann , D Stenger , T Später , T Pohlemann , M D Menger , T Histing Affiliation 1 Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany. mmenger@bgu-tuebingen.de. PMID: 34027631 DOI: 10.22203/eCM.v041a38 Free article Abstract Calcium channel blockers (CCBs), which are widely used in the treatment of hypertension, have been shown to influence bone metabolism. However, there is little information on whether CCBs also influence the process of fracture healing. Therefore, the effect of the CCB amlodipine on bone healing was studied in a stable closed fracture model in mice using intramedullary screw fixation. Bone healing was investigated by radiology, biomechanics, histomorphometry and Western blot analysis 2 and 5 weeks after fracture healing. Animals were treated daily (post operatively) per os using a gavage with amlodipine low dose (1 mg/ kg body weight, n = 20), amlodipine high dose (3 mg/kg body weight, n = 20) or vehicle (NaCl) (control, n = 20) serving as a negative control. At 2 and 5 weeks, histomorphometric analysis revealed a significantly larger amount of bone tissue within the callus of amlodipine low-dose- and high-dose-treated animals when compared to controls. This was associated with a smaller amount of cartilaginous and fibrous tissue, indicating an acceleration of fracture healing. Biomechanics showed a slightly, but not significantly, higher bending stiffness in amlodipine low-dose- and high-dose-treated animals. Western blot analysis revealed a significantly increased expression of bone morphogenetic protein (BMP)-2 and vascular endothelial growth factor (VEGF). Moreover, the analysis showed a 5-fold higher expression of osteoprotegerin (OPG) and a 10-fold elevated expression of the receptor activator of NF-κB ligand (RANKL), indicating an increased bone turnover. These findings demonstrated that amlodipine accelerated fracture healing by stimulating bone formation, callus remodelling and osteoclast activity. Cited by 4 articles Full text links 37. Flow cytometric quantification of apoptotic and proliferating cells applying an improved method for dissociation of spheroids Cell Biol Int. 2021 Aug;45(8):1633-1643. doi: 10.1002/cbin.11618. Epub 2021 May 11. Authors Wolfgang Metzger 1 , Barbara Rösch 1 , Daniela Sossong 1 , Monika Bubel 1 , Tim Pohlemann 1 Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. PMID: 33913594 DOI: 10.1002/cbin.11618 Abstract Spheroids are a promising tool for many cell culture applications, but their microscopic analysis is limited. Flow cytometry on a single cell basis, which requires a gentle but also efficient dissociation of spheroids, could be an alternative analysis. Mono-culture and coculture spheroids consisting of human fibroblasts and human endothelial cells were generated by the liquid overlay technique and were dissociated using AccuMax as a dissociation agent combined with gentle mechanical forces. This study aimed to quantify the number of apoptotic and proliferative cells. We were able to dissociate spheroids of differing size, age, and cellular composition in a single-step dissociation protocol within 10 min. The number of single cells was higher than 95% and in most cases, the viability of the cells after dissociation was higher than 85%. Coculture spheroids exhibited a higher sensitivity as shown by lower viability, higher amount of cellular debris, and a higher amount of apoptotic cells. Considerable expression of the proliferation marker Ki67 could only be seen in 1-day-old spheroids but was already downregulated on Day 3. In summary, our dissociation protocol enabled a fast and gentle dissociation of spheroids for the subsequent flow cytometric analysis. The chosen cell type had a strong influence on cell viability and apoptosis. Initially high rates of proliferative cells decreased rapidly and reached values of healthy tissue 3 days after generation of the spheroids. In conclusion, the flow cytometry of dissociated spheroids could be a promising analytical tool, which could be ideally combined with microscopic techniques. Keywords: Ki67; activated caspase 3; dissociation; flow cytometry; live-dead-assay; spheroids. © 2021 The Authors. Cell Biology International published by John Wiley & Sons Ltd on behalf of International Federation of Cell Biology. Cited by 1 article 33 references Full text links 38. Clinical feasibility of fracture healing assessment through continuous monitoring of implant load J Biomech. 2021 Feb 12:116:110188. doi: 10.1016/j.jbiomech.2020.110188. Epub 2020 Dec 24. Authors Manuela Ernst 1 , Heiko Baumgartner 2 , Stefan Döbele 2 , Dankward Höntzsch 2 , Tim Pohlemann 3 , Markus Windolf 4 Affiliations 1 AO Research Institute Davos, Davos, Switzerland. Electronic address: manuela.ernst@aofoundation.org. 2 BG Trauma Center Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 4 AO Research Institute Davos, Davos, Switzerland. PMID: 33444926 DOI: 10.1016/j.jbiomech.2020.110188 Abstract Current fracture fixation follow-up is based on subjective radiological and clinical examination. Efforts to objectify the procedure have been undertaken since decades. Assessment of implant load as an indirect predictor of callus maturity has so far failed to enter clinical routine due to limited practicability, technical obstacles and its snap-shot nature. We recently introduced the concept of continuous implant load monitoring to aid in diagnosing fracture healing progression. This study aimed at investigating the feasibility of the system in a clinical context. Ten patients treated with Taylor-Spatial-Frame external fixators following pathological tibia fractures were equipped with a Fracture Monitor device attached to a fixator-strut and were monitored until hardware removal. Two patients were excluded due to technical issues. Implant load and fracture activity was continuously and autonomously measured for 139 ± 89 days (mean ± SD). Data was wirelessly collected with consumer smartphones. Relative implant load initially rose for 34.1 ± 22.2 days and finally declined to a level of 45.0 ± 33.8% of the maximum implant load. In five patients the load dropped below 50% of the maximum load. These patients underwent hardware removal according to the clinical assessment. In three patients, whose external fixators were exchanged to internal fixation at the end of the study, implant load did not drop below the 50% margin. The continuous measurement principle allows resolving implant load progression and appears indicative for the bone healing status. Data can be acquired in a homecare setting and is believed to provide valuable information to support timely healing assessment and enable patient specific after-care. Keywords: Fracture healing; Fracture monitoring; Healing assessment; Implant load; Nonunion. Copyright © 2020 Elsevier Ltd. All rights reserved. Conflict of interest statement Declaration of Competing Interest The authors are not compensated and there are no other institutional subsidies, corporate affiliations or funding sources supporting this work unless clearly documented and disclosed. This study was performed with the assistance of the AO Technical Commission. Cited by 6 articles Full text links 39. Pantoprazole impairs fracture healing in aged mice Sci Rep. 2020 Dec 23;10(1):22376. doi: 10.1038/s41598-020-79605-3. Authors Maximilian M Menger 1 2 , Philipp Bremer 3 , Claudia Scheuer 3 , Mika F Rollmann 4 , Benedikt J Braun 4 , Steven C Herath 4 , Marcel Orth 5 , Thomas Später 3 , Tim Pohlemann 5 , Michael D Menger 3 , Tina Histing 3 4 Affiliations 1 Institute for Clinical & Experimental Surgery, Saarland University, 66421, Homburg/Saar, Germany. maximilian.menger@uks.eu. 2 Department of Trauma and Reconstructive Surgery, BG Trauma Center Tuebingen, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany. maximilian.menger@uks.eu. 3 Institute for Clinical & Experimental Surgery, Saarland University, 66421, Homburg/Saar, Germany. 4 Department of Trauma and Reconstructive Surgery, BG Trauma Center Tuebingen, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. PMID: 33361800 PMCID: PMC7758334 DOI: 10.1038/s41598-020-79605-3 Abstract Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs markedly differ in the elderly compared to the young, we herein studied the effect of the PPI pantoprazole on bone healing in aged mice using a murine fracture model. Bone healing was analyzed by biomechanical, histomorphometric, radiological and protein biochemical analyses. The biomechanical analysis revealed a significantly reduced bending stiffness in pantoprazole-treated animals when compared to controls. This was associated with a decreased amount of bone tissue within the callus, a reduced trabecular thickness and a higher amount of fibrous tissue. Furthermore, the number of osteoclasts in pantoprazole-treated animals was significantly increased at 2 weeks and decreased at 5 weeks after fracture, indicating an acceleration of bone turnover. Western blot analysis showed a lower expression of the bone morphogenetic protein-4 (BMP-4), whereas the expression of the pro-angiogenic parameters was higher when compared to controls. Thus, pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation. Conflict of interest statement The authors declare no competing interests. Cited by 7 articles 63 references 8 figures Full text links 40. Development of a dynamic fall risk profile in elderly nursing home residents: A free field gait analysis based study Arch Gerontol Geriatr. 2021 Mar-Apr:93:104294. doi: 10.1016/j.archger.2020.104294. Epub 2020 Nov 11. Authors Eduard Witiko Unger 1 , Tina Histing 2 , Mika Frieda Rollmann 2 , Marcel Orth 1 , Esther Herath 3 , Maximilian Menger 2 , Steven Christian Herath 2 , Bernd Grimm 4 , Tim Pohlemann 1 , Benedikt Johannes Braun 5 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany. 2 Department of Trauma and Reconstructive Surgery, University Hospital Tuebingen, Eberhard-Karls-University Tuebingen, Faculty of Medicine, BG Hospital Tübingen, Germany. 3 Department of Gastroenterology and Endocrinology, Saarland University Hospital, Germany. 4 Luxembourg Institute of Health, Luxembourg. 5 Department of Trauma and Reconstructive Surgery, University Hospital Tuebingen, Eberhard-Karls-University Tuebingen, Faculty of Medicine, BG Hospital Tübingen, Germany. Electronic address: bbraun@bgu-tuebingen.de. PMID: 33217640 DOI: 10.1016/j.archger.2020.104294 Abstract Falls in nursing home residents are associated with a significant individual and socioeconomic burden of disease. To trigger and tailor individual intervention programs, solid early detection measures of residents at risk are needed. Aim of this study was thus to test the capability of a free field gait analysis insole to determine its usefulness in determining fall risk. In an observational study gait data of 22 nursing home residents over the age of 75 years was collected over one week with a measuring insole. Clinical scores were performed at baseline (POMA; DGI, TUG). For 6 months before and after the insole measurement, the fall events per resident were recorded. Correlation analysis as well as receiver operating characteristic curve analysis were performed. The average resident age was 88.2 years (range 78-99), 15 had at least one fall event. There was no significant correlation between clinical assessment and fall risk. Moderate correlations between different temporospatial parameters and fall risk were seen. Pressure distribution during gait was markedly changed in fallers. Differences between fallers and non-fallers as well as cut off values for increased fall risk in the ROC analysis could be determined. The introduced measurement protocol suggests that patients at risk for falling can be detected without any additional office visits. Based on the introduced protocol in a limited patient setting, further large scale studies should now determine the effect of prevention measures triggered by gait analysis, the specific risk reduction and the associated personal and socioeconomic advantages. Keywords: Dynamic gait analysis; Elderly; Fall risk. Copyright © 2020 Elsevier B.V. All rights reserved. Cited by 1 article Full text links 41. Anterior approaches to the acetabulum: which one to choose? EFORT Open Rev. 2020 Oct 26;5(10):707-712. doi: 10.1302/2058-5241.5.190061. eCollection 2020 Oct. Authors Tim Pohlemann 1 , Steven C Herath 1 , Benedikt J Braun 1 , Mika F Rollmann 1 , Tina Histing 1 , Antonius Pizanis 1 Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. PMID: 33204514 PMCID: PMC7608571 DOI: 10.1302/2058-5241.5.190061 Abstract Surgical treatment of acetabular fractures remains challenging even for experienced surgeons.Whilst the ilioinguinal and the Kocher-Langenbeck approach remain the standard procedures to expose the anterior or posterior aspects of the acetabulum, some modified anterior approaches for the stabilization of the acetabulum have been introduced.This article will provide an overview of approaches to the anterior aspect of the acetabulum and explain the efforts that have been made to improve the surgeon's options for certain fracture modifications, such as fractures with separation of the quadrilateral surface. Cite this article: EFORT Open Rev 2020;5:707-712. DOI: 10.1302/2058-5241.5.190061. Keywords: acetabular fracture; approach; osteosynthesis. © 2020 The author(s). Conflict of interest statement ICMJE Conflict of interest statement: TP reports unrestricted research grants from AO Foundation, Werner, Siemens Stiftung, outside the submitted work. The other authors declare no conflict of interest relevant to this work. Cited by 6 articles 11 references 3 figures Full text links 42. Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers Exp Ther Med. 2020 Nov;20(5):28. doi: 10.3892/etm.2020.9156. Epub 2020 Aug 31. Authors Denis Höfer 1 , Christina Körbel 2 , Matthias W Laschke 2 , Nils T Veith 3 , Tim Pohlemann 3 , Reinhard Kappl 4 , Thomas Tschernig 1 Affiliations 1 Department of Anatomy and Cell Biology, Saarland University, D-66421 Homburg/Saar, Germany. 2 Department of Clinical and Experimental Surgery, Saarland University, D-66421 Homburg/Saar, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, D-66421 Homburg/Saar, Germany. 4 Department of Biophysics, Saarland University, D-66421 Homburg/Saar, Germany. PMID: 32952619 PMCID: PMC7480121 DOI: 10.3892/etm.2020.9156 Abstract Experimental chest trauma or blunt thoracic trauma using a blast wave mechanism is well established in animal models. The aim of the present study was to establish a complementary, murine experimental chest trauma model precisely defined by physical data and calculations. For this purpose, a device was developed using a dropped weight and physical properties, including velocity, energy and impact, were calculated. The device allowed for the maximum depth of impression to be measured. The device was first tested using blocks of modelling clay and was then applied to mouse cadavers. X-ray and dissection were performed to check for bone fractures and organ injuries following blunt chest traumas of increasing impact. Lesions and hemorrhages were observed in mouse cadavers which sustained a force equivalent to the energy of ~1 J. Keywords: blunt chest trauma; depth of impression; mouse model. Copyright: © HöFer et al. 9 references 3 figures Full text links 43. A novel press-fit minimally-invasive symphysiodesis technique J Exp Orthop. 2020 Sep 17;7(1):67. doi: 10.1186/s40634-020-00284-0. Authors Sascha J Hopp 1 2 , Antonius Pizanis 1 , Jeremy Briem 1 , Jill Hahner 1 , Laura Mettelsiefen 1 , Steven C Herath 1 , Tina Histing 1 , Tim Pohlemann 1 , Tobias Fritz 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Saarland, Kirrbergerstr 1, 66421, Homburg/Saar, Germany. 2 Groin Pain and Core Injury Center, Lutrina Clinic, Karl-Marx-Straße 33, 67655, Kaiserslautern, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Saarland, Kirrbergerstr 1, 66421, Homburg/Saar, Germany. tobias.fritz@uks.eu. PMID: 32940814 PMCID: PMC7498525 DOI: 10.1186/s40634-020-00284-0 Abstract Objective: Instability of the pubic symphysis often results in a poor outcome and reduced mobility of the patient. In some cases, an arthrodesis of the pubic symphysis is required. Until today, there is no data published how many of these procedures are performed annually and there is also no data about the outcome after this extensive surgery. Methods: We developed a novel surgical technique to address the arthrodesis of the pubic symphysis in a minimally invasive approach. Therefore, we used for this purpose modified instruments and performed the transplantation of a cylindrical bone substitute into the pubic symphysis, without an extensive approach or dissecting the anterior or posterior symphyseal ligaments. Results: Using this novel technique, a minimally invasive symphysiodesis was achieved in radiological findings, after the procedure. Conclusion: Thus, this actually minimally invasive surgical technique seems to be a promising advancement for the arthrodesis of the pubic symphysis. Keywords: Arthrodesis Symphysis; Non-union Symphysis; Pelvis; Pubic Symphysis; Symphysiodesis. Conflict of interest statement There is no conflict of interest. The instruments for this article have been developed in collaboration with and provided by KARL STORZ, Tuttlingen, Germany. This study has not been funded. Cited by 1 article 15 references 3 figures Full text links 44. Vascularization Strategies in the Prevention of Nonunion Formation Tissue Eng Part B Rev. 2021 Apr;27(2):107-132. doi: 10.1089/ten.TEB.2020.0111. Epub 2020 Aug 26. Authors Maximilian M Menger 1 , Matthias W Laschke 2 , Marcel Orth 1 , Tim Pohlemann 1 , Michael D Menger 2 , Tina Histing 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Institute for Clinical & Experimental Surgery, Saarland University, Homburg, Germany. PMID: 32635857 DOI: 10.1089/ten.TEB.2020.0111 Abstract Delayed healing and nonunion formation are major challenges in orthopedic surgery, which require the development of novel treatment strategies. Vascularization is considered one of the major prerequisites for successful bone healing, providing an adequate nutrient supply and allowing the infiltration of progenitor cells to the fracture site. Hence, during the last decade, a considerable number of studies have focused on the evaluation of vascularization strategies to prevent or to treat nonunion formation. These involve (1) biophysical applications, (2) systemic pharmacological interventions, and (3) tissue engineering, including sophisticated scaffold materials, local growth factor delivery systems, cell-based techniques, and surgical vascularization approaches. Accumulating evidence indicates that in nonunions, these strategies are indeed capable of improving the process of bone healing. The major challenge for the future will now be the translation of these strategies into clinical practice to make them accessible for the majority of patients. If this succeeds, these vascularization strategies may markedly reduce the incidence of nonunion formation. Impact statement Delayed healing and nonunion formation are a major clinical problem in orthopedic surgery. This review provides an overview of vascularization strategies for the prevention and treatment of nonunions. The successful translation of these strategies in clinical practice is of major importance to achieve adequate bone healing. Keywords: VEGF; angiogenesis; bone formation; bone healing; cell therapy; delayed healing; nonunion; scaffold; tissue engineering; vascularization. Cited by 8 articles Full text links 45. Azetabulumfrakturen – Zugänge und Implantate im Wandel Z Orthop Unfall. 2020 Jun;158(3):353-363. doi: 10.1055/a-0900-4533. Epub 2020 Jun 17. [Article in German] Authors Tina Histing , Steven C Herath , Antonius Pizanis , Tim Pohlemann PMID: 32557473 DOI: 10.1055/a-0900-4533 No abstract available Conflict of interest statement Die Autoren geben an, dass kein Interessenkonflikt besteht. Full text links 46. Flexor tendon grafts for pulley reconstruction - Morphological aspects Ann Anat. 2020 Sep:231:151550. doi: 10.1016/j.aanat.2020.151550. Epub 2020 Jun 5. Authors Tobias Fritz 1 , Pascal Ducommun 2 , Tim Pohlemann 3 , Maurizio Calcagni 4 , Thomas Tschernig 5 , Michael D Menger 6 , Wolfgang Metzger 3 , Florian S Frueh 7 Affiliations 1 Institute for Clinic al and Experimental Surgery, Saarland University, Homburg/Saar, Germany; Department for Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg/Saar, Germany. 2 Department of Hand and Plastic Surgery, Cantonal Hospital of Lucerne, Lucerne, Switzerland. 3 Department for Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg/Saar, Germany. 4 Department of Plastic Surgery and Hand Surgery, University Hospital Zürich, University of Zürich, Zürich, Switzerland. 5 Saarland University Medical Center, Institute of Anatomy and Cell Biology, Homburg/Saar, Germany. 6 Institute for Clinic al and Experimental Surgery, Saarland University, Homburg/Saar, Germany. 7 Institute for Clinic al and Experimental Surgery, Saarland University, Homburg/Saar, Germany; Department of Plastic Surgery and Hand Surgery, University Hospital Zürich, University of Zürich, Zürich, Switzerland. Electronic address: florian.frueh@usz.ch. PMID: 32512200 DOI: 10.1016/j.aanat.2020.151550 Free article Abstract Background: Pulleys are crucial to convert flexor tendon excursion into angular motion at the metacarpophalangeal and interphalangeal joints. Loss of pulley function can lead to significant impairment of hand function and may require surgical reconstruction. This reconstruction can be achieved using different flexor tendons grafts, such as the intrasynovial flexor digitorum superficialis (FDS) or the extrasynovial palmaris longus (PL). However, there is limited knowledge on the micromorphology of human pulleys and the suitability of flexor tendon grafts for their reconstruction remains elusive. Methods: In the present cadaver study A2 and A4 pulleys were compared with FDS and PL tendons by means of scanning electron microscopy (SEM), histology and immunohistochemistry. Surface morphology, core structure and vascularization of the specimens were analyzed. Results: SEM imaging of the gliding surfaces revealed morphological differences between tendons and pulleys. Moreover, the core structure of FDS samples was characterized by bundles of individual collagen fibrils whereas PL tendons exhibited a less hierarchical microstructure. In contrast, pulleys consisted of lamellar sheets of densely packed collagen fibrils. Finally, immunohistochemical analyses revealed that the flexor tendons and pulleys contain similar numbers of CD31 + microvessels, indicating a comparable tissue vascularization. Conclusion: This study provides novel SEM and immunohistochemical insights into the micromorphology of human pulleys and flexor tendon grafts. Intrasynovial flexor tendons may be particularly suitable for pulley reconstruction and preserving the paratenon may be crucial for graft revascularization. Keywords: Flexor digitorum superficialis; Flexor tendon graft; Hand surgery; Palmaris longus; Pulley reconstruction; Pulley vascularization. Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved. Cited by 1 article Full text links 47. How effective are different models of pelvic binders: results of a study using a Pelvic Emergency Simulator Eur J Trauma Emerg Surg. 2022 Apr;48(2):847-855. doi: 10.1007/s00068-020-01406-0. Epub 2020 May 26. Authors Uwe Schweigkofler # 1 , Dennis Wincheringer # 2 , Jörg Holstein 3 , Tobias Fritz 4 , Reinhard Hoffmann 5 , Tim Pohlemann 4 , Steven C Herath 4 Affiliations 1 Department of Orthopedic and Trauma Surgery, Berufsgenossenschaftliche Unfallklinik Frankfurt, Friedberger Landstraße 430, 60389, Frankfurt, Germany. Uwe.schweigkofler@bgu-frankfurt.de. 2 Orthopaedicum Wiesbaden, Friedrichstraße 29, 65185, Wiesbaden, Germany. 3 ETHIANUM Heidelberg, Voßstr. 6, 69115, Heidelberg, Germany. 4 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg, Germany. 5 Department of Orthopedic and Trauma Surgery, Berufsgenossenschaftliche Unfallklinik Frankfurt, Friedberger Landstraße 430, 60389, Frankfurt, Germany. # Contributed equally. PMID: 32458045 DOI: 10.1007/s00068-020-01406-0 Abstract Background: The application of pelvic binders in the preclinical and early clinical phase is advisable to avoid or treat C-problems in unstable and potential bleeding pelvic ring fractures, even if the clinical effectivity is not completely proved. The use for pathologies in the posterior pelvic ring is still debatable. Questions/purposes: We determined if there is a difference in achievable compression in the dorsal pelvic ring depending on position and pelvic binder model. Can this effect be tested with a simplified artificial model? Methods: We simulated a Tile type C fracture within the established pelvic emergency trainer and measured in a test series the effectivity of reduction with a non-invasive stabilization technique using 3 different pelvic binders. Results: Any therapeutic effect of a pelvic binder with compression to the posterior pelvic ring requires at first a reduction maneuver. While the compression effect in the symphysis depends only on positioning of the binder, in the posterior pelvic ring, the result varies with the used model. The achievable pressure in the SI joint with a pelvic binder is only 20-25% (33.5-47 N) compared to the C-Clamp values (156 N). Conclusions: The use of pelvic binders for non-invasive pelvic ring stabilization, even with a posterior pathology, could be proven in a simplified fracture model. A proper fracture reduction and an adequate device positioning influence the effectiveness. Clinical relevance: The use of an emergency pelvic trainer even for a non-invasive maneuver is advisable. Keywords: Pelvic binder; Pelvic emergency trainer; Pelvic ring fracture. © 2020. Springer-Verlag GmbH Germany, part of Springer Nature. Cited by 4 articles 24 references Full text links 48. A novel internal fixation method for open book injuries of the pubic symphysis- A biomechanical analysis Clin Biomech (Bristol, Avon). 2020 Jul:77:105009. doi: 10.1016/j.clinbiomech.2020.105009. Epub 2020 May 5. Authors Tobias Fritz 1 , Laura Mettelsiefen 2 , Friedemann Strobel 2 , Benedikt J Braun 3 , Steven C Herath 4 , Sascha J Hopp 5 , Tina Histing 6 , Tim Pohlemann 7 , Antonius Pizanis 8 Affiliations 1 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: tobias.fritz@uks.eu. 2 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. 3 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: benedikt.braun@uks.eu. 4 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: steven.herath@uks.eu. 5 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany; Lutrina Hospital, Kaiserslautern, Karl-Marx-Straße 33, 67655 Kaiserslautern, Germany. Electronic address: sascha.hopp@uks.eu. 6 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: tina.histing@uks.eu. 7 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: tim.pohlemann@uks.eu. 8 Saarland University Medical Center, Department for Trauma, Hand and Reconstructive Surgery, Kirrbergerstr. 1, 66421, Homburg, Saar, Germany. Electronic address: antonius.pizanis@uks.eu. PMID: 32454345 DOI: 10.1016/j.clinbiomech.2020.105009 Abstract Background: Pelvic fractures in adults are common injuries and account for up to 3.64% of all fractures. Usually, the treatment of open book injuries (Types B1.1 and B1.2 AO-Classification) is open reduction and plate stabilization using dynamic compression plates, with or without interlocking screws. These implants seem to enhance the outcome of such injuries, but also variety of complications occurs. To reduce complications and achieve appropriate reduction and stabilization, this study compared established stabilization techniques to a novel minimally invasive internal fixation method using an internal fixator system that is already being utilized for spinal fractures. Methods: This study was performed on 32 composite pelvises in a bilateral stance biomechanical model. The pelvises were variously stabilized with an internal fixator, a 4.5 mm dynamic compression plate and a 3.5 mm symphyseal locking dynamic compression plate. The contact area and loading forces were assessed by a sensor film inside the symphyseal gap. Findings: This study showed significantly greater reduction and loading capabilities of the internal fixator compared to the other implants (p < 0.05). There was also significantly greater contact area with the use of an internal fixator compared to the other implants (p < 0.05). The 3.5 mm interlocking plate showed significantly greater contact area compared to the 4.5 mm plate (p < 0.05). Interpretation: The internal fixator that is already proven in spinal surgery is biomechanically superior to conventional implants used in pelvic surgery. The contact area analysis furthermore showed a more physiological loading pattern, which can improve ligamentous healing in a clinical context. Keywords: Compression forces symphysis; Internal fixator; Open Book injury; Symphysis. Copyright © 2020 Elsevier Ltd. All rights reserved. Conflict of interest statement Declaration of competing interest The authors state that there is no conflict of interest and do not work as consultants or have patent applications related to this article. Cited by 7 articles Full text links 49. Long-term results of reconstructing the joints' articular surface in the knee and ankle with the surgical diamond instrumentation (SDI) Eur J Trauma Emerg Surg. 2021 Oct;47(5):1627-1634. doi: 10.1007/s00068-020-01318-z. Epub 2020 Feb 21. Authors Mika Frieda Rollmann 1 , Steven Christian Herath 2 , Tina Histing 2 , Benedikt Johannes Braun 2 , Julia Schmalenbach 2 , Yvette Draenert 3 , Klaus Draenert 3 , Tim Pohlemann 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg, Saar, Germany. mika.rollmann@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg, Saar, Germany. 3 Center of Orthopaedic Research, Gabriel-Max-Str. 3, 81545, München, Germany. PMID: 32086544 DOI: 10.1007/s00068-020-01318-z Abstract Purpose: The surgical diamond instrumentation (SDI), a precise wet-grinding technology, promised contact healing of press-fit inserted bone and even hyaline cartilage, lacks medium- and long-term results. This retrospective study was conducted to identify risk factors associated with the failure of the technique and the subjective patient outcome. Methods: All patients treated for cartilage defects of the knee or ankle joint using the SDI technology between 2000 and 2012 with a follow-up > 1 year were included. Patients with general joint diseases or joint-related procedures, except for corrective osteotomies, were excluded. A standardized questionnaire (EQ-5D) and a questionnaire-based patient-reported outcome survey were used. Descriptive statistics were applied. A multivariate analysis examining risk factors for joint failure was performed. A p value < 0.05 was considered to indicate significant differences. Results: 87 patients with autologous osteochondral transplantation (68 knee, 19 ankle) were included. The median age was 53 years (IQR 37.5-63.0 years) for knee and 36 years (IQR 27.5-54.0 years) for ankle joints. 57.9% of knee and 55.6% of ankle patients were female. Nine patients (8 knee, 1 ankle) had received arthroplasty. 93.3% of knee and 83.3% of ankle patients had an excellent function or minor disabilities. 73.3% of knee and 64.7% of ankle patients did not require pain medication. The mean EQ-5D score was 0.84 for knee and 0.77 for ankle. Patients with higher age were more likely to receive arthroplasty (p = 0.022). Conclusions: The SDI technique provides promising results with excellent joint survival rates and satisfying patient-reported outcomes. Failure of the technique might be associated with higher age. Keywords: Autologous resurfacing; Cartilage repair; Quality of life; Reconstruction of joints; Surgical diamond instrumentation. © 2020. Springer-Verlag GmbH Germany, part of Springer Nature. 32 references Full text links 50. Interacting adipose-derived stem cells and microvascular endothelial cells provide a beneficial milieu for soft tissue healing Mol Biol Rep. 2020 Jan;47(1):111-122. doi: 10.1007/s11033-019-05112-y. Epub 2019 Oct 3. Authors Sophie Bachmann 1 , Martina Jennewein 1 , Monika Bubel 1 , Silke Guthörl 1 , Tim Pohlemann 1 , Martin Oberringer 2 Affiliations 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. 2 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. martin.oberringer@uks.eu. PMID: 31583562 DOI: 10.1007/s11033-019-05112-y Abstract There is growing evidence suggesting that healing of chronic soft tissue wounds profits from the presence of adipose-derived stem cells (ADSC). Among the large spectrum of mechanisms by which ADSC might act, especially the interaction with the microvascular endothelial cell, a main player during angiogenesis, is of special interest. In the present 2D model on the basis of endothelial cell ADSC co-cultures, we focused on the identification of characteristics of both cell types in response to a typical condition in acute and chronic wounds: hypoxia. Parameters like proliferation capacity, migration, myofibroblastoid differentiation of ADSC and the quantification of important paracrine factors related to angiogenesis and inflammation were used to correlate our experimental model with the in vivo situation of soft tissue healing. ADSC were not negatively affected by hypoxia in terms of proliferation, referring to their excellent hypoxia tolerance. Myofibroblastoid differentiation among ADSC was enhanced by hypoxia in mono- but not in co-culture. Furthermore, co-cultures were able to migrate under hypoxia. These effects might be caused to some extent by the distinct milieu created by interacting ADSC and endothelial cells, which was characterized by modulated levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1 and vascular endothelial growth factor. The identification of these cell characteristics in the present 2D in vitro model provide new insights into the process of human soft tissue healing, and underpin a beneficial role of ADSC by regulating inflammation and angiogenesis. Keywords: Adipose-derived stem cell; Angiogenesis; Co-culture; Hypoxia; Inflammation; Microvascular endothelial cell; Myofibroblastoid differentiation; Soft tissue healing. Cited by 14 articles 36 references Full text links 51. Stabilization of a Type B1.1 Injury in a Morbidly Obese Patient Using an Internal Fixator in a Minimally Invasive Technique: A Case Report JBJS Case Connect. 2019 Jul-Sep;9(3):e0075. doi: 10.2106/JBJS.CC.18.00075. Authors Tobias Fritz 1 , Benedikt J Braun 1 , Nils T Veith 1 , Sascha J Hopp 1 2 , Laura Mettelsiefen 1 , Friedemann Strobel 1 , Tim Pohlemann 1 , Antonius Pizanis 1 Affiliations 1 Department of Trauma, Hand and Reconstrutive Surgery, Saarland University Hospital, Homburg, Germany. 2 Lutrina Clinic, Kaiserslautern, Germany. PMID: 31469666 DOI: 10.2106/JBJS.CC.18.00075 Abstract Case: In this case report, we present a novel stabilization technique of the pubic symphysis using an internal spinal fixator in a 78-year-old morbidly obese woman having a pelvic disruption type B1.1 (AO classification). We treated the disruption using an internal fixator to reduce the extent of the incision and soft-tissue damage. Conclusions: The use of an internal fixator, known from percutaneous spinal fixation, for the stabilization of the pubic symphysis in cases of disruption ("open book" injuries) may be an alternative to the standard plate fixation as a novel minimally invasive stabilization technique. Cited by 4 articles 22 references Full text links 52. Controlling fibroblast adhesion and proliferation by 1D Al 2 O 3 nanostructures IET Nanobiotechnol. 2019 Aug;13(6):621-625. doi: 10.1049/iet-nbt.2018.5088. Authors Oral Cenk Aktas 1 , Wolfgang Metzger 2 , Lisa Mees 2 , Marina Miro Martinez 3 , Ayman Haidar 4 , Martin Oberringer 2 , Gunther Wennemuth 5 , Norbert Pütz 6 , Muhammad Zubair Ghori 7 , Tim Pohlemann 2 , Michael Veith 3 Affiliations 1 Department of Paediatric Cardiology, Saarland University, 66421 Homburg, Germany. oca@tf.uni-kiel.de. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany. 3 INM-Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany. 4 Department of Paediatric Cardiology, Saarland University, 66421 Homburg, Germany. 5 University Clinic Essen, Department of Anatomy, 45147 Essen, Germany. 6 Department of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany. 7 Institute for Materials Science, Christian-Albrechts-University of Kiel, 24143 Kiel, Germany. PMID: 31432796 PMCID: PMC8675958 DOI: 10.1049/iet-nbt.2018.5088 Abstract The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast-surface interaction. In the present study, one-dimensional aluminium oxide (1D Al 2 O 3 ) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well-defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al 2 O 3 nanostructures on the substratum. 21 references 7 figures Full text links 53. Profiling microRNA expression in murine bone healing and non-union formation: Role of miR-140 during the early stage of bone healing PLoS One. 2019 Jul 19;14(7):e0218395. doi: 10.1371/journal.pone.0218395. eCollection 2019. Authors Marcel Orth 1 2 , Claudia Scheuer 2 , Christina Backes 3 , Andreas Keller 3 , Mika F Rollmann 1 , Benedikt J Braun 1 , Nicole Ludwig 4 , Eckart Meese 4 , Tim Pohlemann 1 , Matthias W Laschke 2 , Michael D Menger 2 , Tina Histing 1 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany. 3 Department of Clinical Bioinformatics, Saarland University, Saarbrücken, Germany. 4 Department of Human Genetics, Saarland University, Homburg, Germany. PMID: 31323027 PMCID: PMC6641081 DOI: 10.1371/journal.pone.0218395 Abstract Although cellular and molecular mechanisms during the course of bone healing have been thoroughly investigated, the regulation of gene expression by microRNA during bone regeneration is still poorly understood. We hypothesized that nonunion formation is associated with different microRNA expression patterns and that target proteins of these microRNAs are differently expressed in callus tissue of nonunions compared to physiologically healing bones. In a well-established femoral osteotomy model in CD-1 mice osteotomies were induced which result either in healing or in nonunion formation. MicroRNA and target protein expression was evaluated by microarray, quantitative real-time polymerase chain reaction (qrt-PCR) and Western blot. Microarray analyses demonstrated 44 microRNAs to be relevant for nonunion formation compared to physiological bone healing. In nonunions qrt-PCR could validate a higher expression of microRNA-140-3p and microRNA-140-5p. This was associated with a reduced expression of Dnpep and stromal cell-derived factor (SDF)-1α, which are both known to be target proteins of microRNA-140 and also to be involved in the process of bone healing. These data suggest that an increased expression of microRNA-140-3p and microRNA-140-5p markedly contributes to the development of nonunions, most probably by affecting bone morphogenetic protein (BMP)-2 function during the early stage of healing due to a reduced SDF-1α expression. Conflict of interest statement The authors have declared that no competing interests exist. Cited by 2 articles 35 references 4 figures Full text links 54. Increased therapy demand and impending loss of previous residence status after proximal femur fractures can be determined by continuous gait analysis - A clinical feasibility study Injury. 2019 Jul;50(7):1329-1332. doi: 10.1016/j.injury.2019.05.007. Epub 2019 May 18. Authors Benedikt J Braun 1 , David Osche 2 , Mika Rollmann 2 , Marcel Orth 2 , Philipp Mörsdorf 2 , Tina Histing 2 , Tim Pohlemann 2 , Steven C Herath 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421 Homburg, Germany. Electronic address: benedikt.braun@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421 Homburg, Germany. PMID: 31178148 DOI: 10.1016/j.injury.2019.05.007 Abstract Proximal femur fractures account for increased healthcare costs whenever patients are unable to return to their previous state of residence. Studies suggest that patients benefit from early weight-bearing, yet compliance to weight-bearing regimes is poorly investigated. Aim of the study was thus to show the clinical feasibility of a new measurement tool able to determine continuous weight-bearing behavior after intramedullary nail osteosynthesis of intertrochanteric femur fractures, assess the influence of weight-bearing on clinical outcome and determine rehabilitation demand based on early postoperative gait performance. In an observational study, gait data of 22 patients with intertrochanteric femur fractures were evaluated. During the inpatient stay patients were continuously monitored with a gait analysis insole. Primary outcome was the amount of weight-bearing reached. Short-term functional outcome, as well as return to the previous state of living were evaluated in relation to weight-bearing and activity during the inpatient stay. With the presented technique continuous gait data of all patients during postoperative mobilization could be obtained. Only 13 patients reached full weight-bearing. The technique was feasible to determine correlations between weight-bearing and outcome, as well as between gait activity and outcome. Significant gait differences between patients able to return to their previous state of living and those who could not were seen. Dynamic insole measurements are feasible to continuously determine the postoperative gait performance. Their postoperative use showed, that the continuous compliance to permissive weight-bearing after intertrochanteric fractures is low. The presented measurement technique has the potential to identify patients at risk for reduced outcome and impending loss of previous residence status. Further studies will have to investigate the effects of technology assisted "patient at risk" identification and adapted therapy on clinical outcome. Keywords: Aftercare; Elderly; Hip fractures; Weight-bearing. Copyright © 2019. Published by Elsevier Ltd. Cited by 2 articles Full text links 55. Autologous Transplantation of Press-fit Bone Cylinders in the Treatment of Pelvic Nonunion Orthop Surg. 2019 Jun;11(3):516-523. doi: 10.1111/os.12463. Epub 2019 May 3. Authors Steven C Herath 1 , Benedikt J Braun 1 , Mika F Rollmann 1 , Philipp Mörsdorf 1 , Jörg H Holstein 1 , Tim Pohlemann 1 Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. PMID: 31050213 PMCID: PMC6595114 DOI: 10.1111/os.12463 Abstract The present study describes method for autologous bone transplantation to an area of nonunion at the pelvic ring in a way that ensures the best possible bone-to-bone interface ("press-fit") and provides optimal preconditions for the ingrowth of the bone graft. We modified a technique that has been used to transplant press-fit bone-baseplate-cartilage cylinders for the repair of joint cartilage defects. The technique allows for precise harvesting of bone cylinders with a diamond-coated and fluid-cooled instrument. At the site where the graft shall be inserted, a cylindrical hole is created with a corresponding hollow diamond-coated trephine. This ensures an optimal press-fit implantation of the graft. The new surgical technique has been applied in four patients with nonunion of the pelvic ring. No intraoperative or postoperative complications occurred. In three patients, the procedure led to a reduction of pain and a higher level of mobility as well as a timely radiographic union (imaging not available for another patient). Our technique offers a valuable new treatment option for pelvic nonunion. The current article serves as a proof of concept. Future comparative studies will have to determine its value in detail. Keywords: Bone graft; Nonunion; Pelvic ring fracture; Press-fit cylinder; Treatment. © 2019 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd. Cited by 3 articles 32 references 8 figures Full text links 56. Erythropoietin does not improve fracture healing in aged mice Exp Gerontol. 2019 Jul 15:122:1-9. doi: 10.1016/j.exger.2019.04.005. Epub 2019 Apr 16. Authors M Orth 1 , J Baudach 2 , C Scheuer 3 , D Osche 2 , N T Veith 4 , B J Braun 4 , M F Rollmann 4 , S C Herath 4 , T Pohlemann 4 , M D Menger 3 , T Histing 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany; Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Germany. Electronic address: marcel.orth@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany; Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Germany. 3 Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Germany. 4 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany. PMID: 30998964 DOI: 10.1016/j.exger.2019.04.005 Abstract Fracture healing in the elderly is associated with a declined healing potential caused by multiple factors including a delay of vascularization. Erythropoietin (EPO) has been demonstrated to improve vascularization and fracture healing in adult mice. We, therefore, hypothesized that EPO in aged mice also improves fracture healing. For this purpose, EPO was given daily in a femoral fracture model in aged mice and compared to vehicle-treated controls using radiological, biomechanical, histomorphometric and Western blot techniques. Blood analyses revealed significantly higher concentrations of hemoglobin and a higher hematocrit in EPO-treated animals at 14 and 35 days after fracture. Micro-computed tomography (μCT) indicated that the fraction of bone volume/tissue volume within the callus did not differ between the two groups. However, μCT showed a 3-fold increased tissue mineral density (TMD) in the callus of EPO-treated animals compared to controls. The callus TMD of the EPO-treated animals was also 2-fold higher when compared to the TMD of the unfractured contralateral femur. Interestingly, biomechanical analyses revealed a reduced bending stiffness in femurs of EPO-treated animals at day 35. The histomorphometrically analyzed callus size and callus composition did not show significant differences between the study groups. However, Western blot analyses exhibited an increased expression of osteoprotegerin (OPG), but in particular of receptor activator of NF-κB ligand (RANKL) in the callus of the EPO-treated animals. Further histological analyses of the callus tissue showed that this was associated with an increased number of newly formed blood vessels and a higher number of tartrate-resistant acid phosphatase (TRAP) + cells. Conclusion: In fracture healing of aged mice EPO treatment increases callus TMD as well as OPG and RANKL expression, indicating an accelerated bone turnover when compared to controls. However, EPO does not improve fracture healing in aged mice. The process of fracture healing may be altered by EPO due to a deterioration of the microcirculation caused by the worsened rheological properties of the blood and due to an increased bone fragility caused by the accelerated bone turnover. Thus, EPO may not be used to improve fracture healing in the elderly. Keywords: Aged mice; Bone healing; Bone turnover; EPO; Fracture healing; Tissue mineral density. Copyright © 2019 Elsevier Inc. All rights reserved. Cited by 4 articles Full text links 57. VEGF-loaded mineral-coated microparticles improve bone repair and are associated with increased expression of epo and RUNX-2 in murine non-unions J Orthop Res. 2019 Apr;37(4):821-831. doi: 10.1002/jor.24267. Epub 2019 Mar 28. Authors Marcel Orth 1 2 , Amira K Shenar 1 2 , Claudia Scheuer 2 , Benedikt J Braun 1 , Steven C Herath 1 , Jörg H Holstein 1 2 , Tina Histing 1 2 , Xiaohua Yu 3 , William L Murphy 3 , Tim Pohlemann 1 , Matthias W Laschke 2 , Michael D Menger 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany. 3 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin. PMID: 30835895 DOI: 10.1002/jor.24267 Free article Abstract A poor vascular supply of the fracture gap is a key factor for the development of atrophic non-unions. Mineral-coated microparticles (MCM) represent a sophisticated carrier system for the delivery of vascular endothelial growth factor (VEGF). Hence, we investigated whether VEGF-loaded MCM improve bone repair in non-unions. For this purpose, we analyzed binding and release kinetics of MCM for VEGF in vitro. Moreover, we applied VEGF-loaded or -unloaded MCM in a murine non-union model in vivo and studied the process of bone healing by means of biomechanical, radiological, histomorphometric, and Western blot techniques. MCM-free non-unions served as controls. The binding efficiency of MCM for VEGF was 46 ± 3% and the release profile revealed an initial minor burst release followed by a sustained release over a 50-day study period, thus, mimicking the physiological expression profile of VEGF during bone healing. In vivo, bone defects treated with VEGF-loaded MCM exhibited a higher bending stiffness, a higher fraction of bone volume/tissue volume and a larger callus area on days 14 and 70 when compared to the other groups. Western blot analyses on day 14 revealed a higher expression of VEGF, erythropoietin (EPO), and runt-related transcription factor 2, but not of EPO-receptor in bone defects treated with VEGF-loaded MCM. These findings demonstrate that the use of MCM for VEGF delivery shows great potential due to the ability to maintain protein stability and functionality in vivo. Moreover, the application of VEGF-loaded MCM represent a promising strategy for the treatment of non-unions. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. Keywords: VEGF; bone healing; mineral coated microparticles; non-union. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Cited by 12 articles Full text links 58. Cement augmentation of the proximal humerus internal locking system in elderly patients: a multicenter randomized controlled trial Arch Orthop Trauma Surg. 2019 Jul;139(7):927-942. doi: 10.1007/s00402-019-03142-6. Epub 2019 Feb 25. Authors Clemens Hengg 1 , Stefaan Nijs 2 , Tim Klopfer 3 , Martin Jaeger 4 , Andreas Platz 5 , Tim Pohlemann 6 , Reto Babst 7 , Jochen Franke 8 , Franz Kralinger 9 10 Affiliations 1 Department for Trauma Surgery, A.ö. Landeskrankenhaus - Universitätskliniken Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. 2 Department of Traumatology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium. 3 Department for Traumatology and Reconstructive Surgery, BG Trauma Center, Eberhard Karls University Tübingen, Schnarrenbergstrasse 95, 72076, Tübingen, Germany. 4 Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany. 5 Department of Traumatology, City Hospital Triemli Zurich, Birmensdorferstrasse 497, 8063, Zurich, Switzerland. 6 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Bldng. 57, 66421, Homburg, Germany. 7 Department of Orthopedics and Traumatology, Cantonal Hospital Lucerne, Spitalstrasse, 6000, Lucerne 16, Switzerland. 8 Clinic for Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Strasse 13, 67071, Ludwigshafen, Germany. 9 Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria. franz.kralinger@meduniwien.ac.at. 10 Trauma and Sports Department, Teaching Hospital Medical University of Vienna, Wilhelminenspital, Montlearstr. 37, 1160, Vienna, Austria. franz.kralinger@meduniwien.ac.at. PMID: 30805708 PMCID: PMC6570671 DOI: 10.1007/s00402-019-03142-6 Abstract Introduction: Cement augmentation of the proximal humerus internal locking system (PHILOS) screws might reduce complication rates in osteoporotic bones. This study compared the risk of mechanical failure during the first year after PHILOS™ treatment of proximal humerus fractures (PHF) without (control group) and with (augmented group) screw augmentation. Secondary objectives were to report shoulder functions, quality of life (QoL), adverse events (AEs), and reoperation rates. Materials and methods: This multicenter randomized trial enrolled patients aged ≥ 65 years with displaced/unstable PHF from eight European centers. Randomization was performed during surgery through sealed opaque envelopes. Mechanical failures were assessed by two independent reviewers via radiographs, shoulder function by Quick DASH, SPADI, and Constant Murley scores, and QoL by EQ-5D. Follow-ups were planned at postoperative 6 weeks, 3, 6, and 12 months. Results: The preliminary analysis of 6-week radiographs of the first 59 enrolled patients suggested a mechanical failure rate lower than expected and the difference between groups was too small to be detected by the planned sample size of 144. The trial was prematurely terminated after 67 patients had been enrolled: 34 (27 eligible) in the control group and 33 (29 eligible) in the augmented group. Follow-ups were performed as planned. Nine patients had mechanical failures and the failure rates (95% CI) were: augmented group, 16.1% (5.5; 33.7); control group, 14.8% (4.2; 33.7); the relative risk (95% CI) for the augmented group was 1.09 (0.32; 3.65) compared to the control group (p = 1.000). No statistically significant differences in shoulder function, QoL, and AEs were observed between study groups at 1 year. Nine patients (15.8%) underwent a revision. Conclusions: Due to premature termination, the study was underpowered. A larger study will be necessary to determine if cement augmentation lowers the risk of mechanical failure rate. Keywords: Augmentation; Multicenter randomized trial; Osteoporosis; PHILOS; Proximal humerus fracture; Proximal humerus internal locking system. Conflict of interest statement Franz Kralinger is a consultant with DePuySynthes but did not receive personal benefits for the current study. Tim Pohlemann was the chairman of the AO TK-System during the time of study. Martin Jaeger is a member of the AO UEEG. Cited by 21 articles 54 references 2 figures Full text links 59. Geriatric Acetabular Surgery: Letournel's Contraindications Then and Now-Data From the German Pelvic Registry J Orthop Trauma. 2019 Feb:33 Suppl 2:S8-S13. doi: 10.1097/BOT.0000000000001406. Authors Steven C Herath 1 , Hendrik Pott 1 , Mika F R Rollmann 1 , Benedikt J Braun 1 , Jörg H Holstein 1 , Andreas Höch 2 , Fabian M Stuby 3 , Tim Pohlemann 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Department of Orthopaedics, Trauma and Plastic Surgery, University of Leipzig, Leipzig, Germany. 3 BG Trauma Center, Murnau, Germany. PMID: 30688853 DOI: 10.1097/BOT.0000000000001406 Abstract Objective: In his original series of 129 surgically treated acetabular fractures, Letournel did not operate on patients older than 60 years. Almost 30 years later, he still emphasized that no patients with reduced bone quality should be operated on. The aim of the study was to analyze epidemiologic characteristics and treatment modes for today's cohort of elderly patients with acetabular fractures. Design: Retrospective analysis. Setting: Multicenter registry/Level I trauma center. Patients: Three thousand seven hundred ninety-three patients who had sustained a fracture of the acetabulum. Intervention: Operative and nonoperative treatment of acetabular fractures. Main outcome measurements: Epidemiologic characteristics, treatment mode, in-hospital mortality, rate of secondary hip arthroplasty, and quality of life indicated by EQ-5D score. Results: For the multicenter registry, more than 50% of all patients with acetabular fractures had an age of 60 years or over. The age peak was found at 75-80 years. Fifty percent of the elderly patients were treated surgically. The in-hospital mortality was significantly higher in elderly patients than patients younger than 60 years. In our Level I trauma center, surgical treatment by open reduction and internal fixation did not influence in-hospital mortality or quality of life of elderly patients with acetabular fractures. Conclusions: Today, elderly persons represent the dominant cohort among patients with fractures of the acetabulum. Fifty-five years after the publication of Letournel's original case series, data indicate that currently, surgical treatment is a common and necessary option in the therapy of acetabular fractures in elderly patients. Level of evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence. Cited by 16 articles Full text links 60. Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing J Med Chem. 2019 Feb 14;62(3):1362-1372. doi: 10.1021/acs.jmedchem.8b01493. Epub 2019 Jan 15. Authors Ahmed S Abdelsamie 1 2 , Steven Herath , Yannik Biskupek , Carsten Börger 3 , Lorenz Siebenbürger 3 , Mohamed Salah 4 , Claudia Scheuer , Sandrine Marchais-Oberwinkler 5 , Martin Frotscher 4 , Tim Pohlemann , Michael D Menger , Rolf W Hartmann 4 6 , Matthias W Laschke , Chris J van Koppen 1 4 Affiliations 1 ElexoPharm GmbH , Im Stadtwald, Building A1.2 , 66123 Saarbrücken , Germany. 2 Chemistry of Natural and Microbial Products Department , National Research Centre , Dokki, 12622 Cairo , Egypt. 3 PharmBioTec GmbH , 66123 Saarbrücken , Germany. 4 Department of Pharmaceutical and Medicinal Chemistry , Saarland University , 66123 Saarbrücken , Germany. 5 Institute of Pharmaceutical Chemistry , Philipps-University , 35032 Marburg , Germany. 6 Department of Drug Design and Optimization , Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) , 66123 Saarbrücken , Germany. PMID: 30645111 DOI: 10.1021/acs.jmedchem.8b01493 Abstract Current therapies of steroid hormone-dependent diseases predominantly alter steroid hormone concentrations (or their actions) in plasma, in target and nontarget tissues alike, rather than in target organs only. Targeted therapy through the inhibition of steroidogenic enzymes may pose an attractive alternative with much less side effects. Here, we describe the design of a nanomolar potent 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitor (compound 15) and successful targeted intracrine therapy in a mouse bone fracture model. Blockade of 17β-HSD2 in bone is thought to increase intracellular estradiol (E2) and testosterone (T), which thereby inhibits bone resorption by osteoclasts and stimulates bone formation by osteoblasts, respectively. Administration of compound 15 in the mouse fracture model strongly increases the mechanical stability of the healing fractured bone because of a larger periosteal callus with newly formed bone without changing the plasma E2 and T concentrations. Steroidogenic 17β-HSD2 inhibition thus enables targeted intracrine therapy. Cited by 1 article Full text links 61. In-hospital mortality of pelvic ring fractures in older adults now and then: A pelvic registry study Geriatr Gerontol Int. 2019 Jan;19(1):24-29. doi: 10.1111/ggi.13558. Epub 2018 Dec 26. Authors Mika F Rollmann 1 , Steven C Herath 1 , Benedikt J Braun 1 , Joerg H Holstein 1 , Tim Pohlemann 1 , Michael D Menger 2 , Tina Histing 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Institute for Clinical & Experimental Surgery, Saarland University, Homburg, Germany. PMID: 30586683 DOI: 10.1111/ggi.13558 Abstract Aim: With the predicted demographic change, the treatment of geriatric patients will become a major issue for health systems worldwide. The majority of pelvic ring fractures occur in older adults, and their treatment might be associated with a distinct mortality. Herein, we analyzed the data of 5665 patients with pelvic ring fractures aged ≥60 years included in the German Pelvic Trauma Registry from 1991 to 2013. Methods: The data were collected prospectively, multicentrically in hospitals participating in the German Pelvic Trauma Registry. Demographic data were retrospectively analyzed, stratified for age, sex, type of injury, mode of therapy, injury severity score (ISS) and mortality. Results: The overall mortality decreased over the 22-year study period from 9.3% to 3.8% (P < 0.05), whereas the median ISS significantly increased. During the observation period, mortality was higher in patients with type B and, particularly, type C fractures when compared with patients with type A fractures. Mortality rates of patients aged >80 years did not significantly differ from those aged >60 or >70 years. Male patients showed a significantly higher mortality compared with female patients, as well as a significantly higher median ISS. The mortality rate of patients with surgically-treated type C fractures decreased over the study period from 35.7% to 6.9% (P < 0.05). Conclusions: Over the past two decades, the mortality of older patients after pelvic ring fractures has significantly decreased. The higher overall mortality rate of male patients might mainly be accounted for by the relatively higher fraction of type C fractures and a higher ISS. Geriatr Gerontol Int 2019; 19: 24-29. Keywords: German Pelvic Trauma Registry; mortality of pelvic ring fractures; pelvic ring fractures. © 2018 Japan Geriatrics Society. Cited by 6 articles Full text links 62. Marble-derived microcalcite improves bone healing in mice osteotomy Biomed Mater. 2018 Dec 7;14(2):025001. doi: 10.1088/1748-605X/aaee54. Authors Marcel Orth 1 , Takhirjan Shadmanov , Claudia Scheuer , Benedikt J Braun , Tobias Fritz , Jörg H Holstein , Tina Histing , Matthias W Laschke , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany. PMID: 30524063 DOI: 10.1088/1748-605X/aaee54 Abstract Approximately 10% of all fractures result in delayed healing or non-unions. Bone healing can be improved by the application of osteoconductive and osteoinductive biomaterials. Microcalcite (MCA) as a naturally available calcium carbonate-based biomaterial derived from marble may have the potential to improve bone healing. Herein, we studied for the first time, if MCA in combination with platelet-rich plasma (PRP) can be used as a bone graft material for bone healing in vivo. For this purpose, osteotomies were induced in CD-1 mice (n = 60). Animals received into the osteotomy gap either MCA-loaded PRP (MCA + PRP; n = 20), PRP alone (PRP; n = 20) or no application (NONE; n = 20). Bone healing was evaluated at two and five weeks after osteotomy by micro-computed tomography (μCT), histomorphometric, immunohistochemical and Western Blot analyses. μCT of MCA + PRP femurs revealed more bone volume and an increased polar moment of inertia, indicating a higher biomechanical stability when compared to PRP and NONE femurs. Histomorphometry revealed an increased total callus area after two weeks and a reduced callus tissue area after five weeks in MCA + PRP and PRP animals compared to NONE animals, indicating an accelerated process of bone healing and remodeling over the study period. Moreover, histomorphometric analyses demonstrated an increased fraction of osseous tissue within the callus in MCA + PRP femurs when compared to PRP and NONE femurs. Immunohistochemical analyses showed increased numbers of Ki67 + cells in callus tissue of MCA + PRP femurs. Of interest, Western Blotting revealed a significantly reduced expression of BMP-4 in MCA + PRP animals, while the expression of BMP-2 did not reveal any significant differences between the groups. This indicates a modified balance between angiogenesis and osteogenesis due to MCA. In conclusion, the application of MCA with PRP improved bone healing in a murine osteotomy model and, thus, might be a promising novel bone graft material which may be of interest for clinical fracture treatment. Cited by 2 articles Full text links 63. Should I Stay or Should I Go? A Prospective, Blinded Study Comparing the Diagnostic Capability of Dynamic and Stationary Pedobarography in Plantar Fasciitis J Foot Ankle Surg. 2018 Nov-Dec;57(6):1181-1185. doi: 10.1053/j.jfas.2018.06.015. Authors Benedikt J Braun 1 , Christine Huss 2 , Sina Heimueller 3 , Moritz Klein 4 , Steven C Herath 4 , Christian Ruebe 5 , Tim Pohlemann 6 , Marcus Niewald 7 Affiliations 1 Surgeon, Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Hamburg, Germany. Electronic address: benedikt.braun@uks.eu. 2 Medical Student, Department of Radiotherapy and Radiation Oncology, Saarland University Hospital, Hamburg, Germany. 3 Medical Student, Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Hamburg, Germany. 4 Surgeon, Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Hamburg, Germany. 5 Professor and Radiation Oncologist, Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Hamburg, Germany. 6 Professor and Surgeon, Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Hamburg, Germany. 7 Professor and Radiation Oncologist, Department of Radiotherapy and Radiation Oncology, Saarland University Hospital, Hamburg, Germany. PMID: 30368429 DOI: 10.1053/j.jfas.2018.06.015 Abstract The aim of this study was to determine the diagnostic capability of a dynamic gait analysis insole and compare its ability to detect clinical correlations to a common stationary analysis tool. Twenty-five patients with chronic plantar fasciitis were included in this prospective, blinded, diagnostic study. Conventional, stationary gait analysis on a force plate on an even surface and continuous dynamic pedobarography on a standardized course consisting of different gait tasks were performed and correlated to the disease severity. Mean patient age was 53.6 (range 41 to 68) years, with a mean pain level of 6.1 (range 4 to 10) on the Visual Analogue Scale and a calcaneodynia score of 48.7 (range 33 to 66). Significant correlations were seen between several dynamic gait values and clinical scoring: cadence (r s = 0.56, p = .004), stance time (r s = -0.6, p = .002), center-of-pressure velocity (r s = 0.44, p = .046), and double support time (r s = 0.42, p = .042). No significant correlations were seen between any force plate gait analysis values and clinical scoring. In this study setting, dynamic gait analysis was able to identify clinically relevant correlations to plantar fasciitis disease severity that standard force plate measurements could not. Keywords: gait; gait analysis; heel pain; insole; plantar fasciopathy. Copyright © 2018 the American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved. Full text links 64. Predictors for secondary hip osteoarthritis after acetabular fractures-a pelvic registry study Int Orthop. 2019 Sep;43(9):2167-2173. doi: 10.1007/s00264-018-4169-3. Epub 2018 Sep 29. Authors Mika F Rollmann 1 , Jörg H Holstein 2 , Tim Pohlemann 2 , Steven C Herath 2 , Tina Histing 2 , Benedikt J Braun 2 , Hagen Schmal 3 , Guy Putzeys 4 , Ivan Marintschev 5 , Emin Aghayev 6 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. mika.rollmann@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. 3 Department of Orthopaedics and Traumatology, Odense University Hospital, University of Southern Denmark, Søndre Blvd. 29, 5000, Odense C, Denmark. 4 Department of Orthopaedic and Trauma Surgery, AZ Groeninge, B. Vercruysselaan 5, 8500, Kortrijk, Belgium. 5 Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich-Schiller-University, Am Klinikum 1, 07747, Jena, Germany. 6 Spine Centre Division, Department of Research and Development, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland. PMID: 30267245 DOI: 10.1007/s00264-018-4169-3 Abstract Purpose: Secondary hip osteoarthritis after acetabular fractures requiring total arthroplasty (THA) poses a huge burden on the affected patients as well as health systems. The present study aimed to assess risk factors associated with THA after acetabular fractures based on the data from the German Pelvic Trauma Registry. Methods: Retrospective analysis of 678 acetabular fracture cases without concomitant pelvic ring fracture treated and followed-up between January 2004 and May 2015 at six large trauma centres. Multivariate Cox regression analysis was performed assessing the association of patient/treatment characteristics with THA likelihood at an average follow-up of 2.7 years (range 0.4-9.5 years; SD 1.8 years). Results: Overall, the rate of secondary osteoarthritis was 19.8%. The likelihood for THA increased with 6% per age year (95% CI 1.04-1.09) and with 21% per millimetre subluxation (95%CI 1.09-1.33). This likelihood was 3.54 (95% CI 1.77-7.08) and 3.68 times (95% CI 1.87-7.47) higher if the posterior wall was involved and a contusion and/or impaction of the femoral head was present. Other covariates (sex, ISS, trauma type, AO/OTA and Letournel classification, initial displacement, surgical approach, intra-articular fragments, contusion and/or impaction to the acetabulum, reduction, intervention type, duration of surgery, soft tissue damage, residual fracture step/gap, and prevention of heterotopic ossifications) were not significantly associated (p > 0.15). Conclusions: Twenty percent of patients with acetabular fractures require THA. The associated risk factors are patient age, femoral head lesion/subluxation, and involvement of the posterior wall. The identified risk factors support previous research and should be minded when treatment of acetabular fractures is planned. Keywords: Acetabular fracture; Cox regression model; German pelvic trauma registry; Secondary hip osteoarthritis. Cited by 18 articles 27 references Full text links 65. Effects of locally applied adipose tissue-derived microvascular fragments by thermoresponsive hydrogel on bone healing Acta Biomater. 2018 Sep 1:77:201-211. doi: 10.1016/j.actbio.2018.07.029. Epub 2018 Jul 17. Authors M Orth 1 , M A B Altmeyer 2 , C Scheuer 3 , B J Braun 2 , J H Holstein 2 , D Eglin 4 , M D'Este 4 , T Histing 2 , M W Laschke 3 , T Pohlemann 5 , M D Menger 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany. Electronic address: marcel.orth@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany. 3 Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany. 4 AO Research Institute Davos, Davos, Switzerland. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany. PMID: 30030175 DOI: 10.1016/j.actbio.2018.07.029 Abstract Insufficient vascularization is a major cause for the development of non-unions. To overcome this problem, adipose tissue-derived microvascular fragments (MVF) may serve as vascularization units. However, their application into bone defects needs a carrier system. Herein, we analyzed whether this is achieved by a thermoresponsive hydrogel (TRH). MVF were isolated from CD-1 mice and cultivated after incorporation into TRH, while non-incorporated MVF served as controls. Viability of MVF was assessed immunohistochemically over a 7-day period. Moreover, osteotomies were induced in femurs of CD-1 mice. The osteotomy gaps were filled with MVF-loaded TRH (TRH + MVF), unloaded TRH (TRH) or no material (control). Bone healing was evaluated 14 and 35 days postoperatively. MVF incorporated into TRH exhibited less apoptotic cells and showed a stable vessel morphology compared to controls. Micro-computed tomography revealed a reduced bone volume in TRH + MVF femurs. Histomorphometry showed less bone and more fibrous tissue after 35 days in TRH + MVF femurs compared to controls. Accordingly, TRH + MVF femurs exhibited a lower osseous bridging score and a reduced bending stiffness. Histology and Western blot analysis revealed an increased vascularization and CD31 expression, whereas vascular endothelial growth factor (VEGF) expression was reduced in TRH + MVF femurs. Furthermore, the callus of TRH + MVF femurs showed increased receptor activator of NF-κB ligand expression and higher numbers of osteoclasts. These findings indicate that TRH is an appropriate carrier system for MVF. Application of TRH + MVF increases the vascularization of bone defects. However, this impairs bone healing, most likely due to lower VEGF expression during the early course of bone healing. Statement of significance: In the present study we analyzed for the first time the in vivo performance of a thermoresponsive hydrogel (TRH) as a delivery system for bioactive microvascular fragments (MVF). We found that TRH represents an appropriate carrier for MVF as vascularization units and maintains their viability. Application of MVF-loaded TRH impaired bone formation in an established murine model of bone healing, although vascularization was improved. This unexpected outcome was most likely due to a reduced VEGF expression in the early phase bone healing. Keywords: Bone healing; Microvascular fragments; Thermoresponsive hydrogel; VEGF; Vascularization. Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. Cited by 14 articles Full text links 66. Evaluation of strategies for the treatment of type B and C pelvic fractures: results from the German Pelvic Injury Register Bone Joint J. 2018 Jul;100-B(7):973-983. doi: 10.1302/0301-620X.100B7.BJJ-2017-1377.R1. Authors H Schmal 1 , L Froberg 2 , M S Larsen 3 , N P Südkamp 4 , T Pohlemann 5 , E Aghayev 6 , K Goodwin Burri 7 Affiliations 1 Department of Orthopaedics and Traumatology, Odense University Hospital, and Department of Clinical Research, University of Southern Denmark, Odense, Denmark and Department of Orthopaedics and Trauma Surgery, Medical Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany. 2 Department of Orthopaedics and Traumatology, Odense University Hospital and Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 3 Department of Orthopaedics and Traumatology, Odense University Hospital, Odense, Denmark and Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 4 Department of Orthopaedics and Trauma Surgery, Medical Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 6 Spine Centre Division, Department of Research and Development, Schulthess Klinik, Zurich, Switzerland. 7 Swiss Medical Registries and Data Linkage (SwissRDL), Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. PMID: 29954203 DOI: 10.1302/0301-620X.100B7.BJJ-2017-1377.R1 Free article Abstract Aims: The best method of treating unstable pelvic fractures that involve the obturator ring is still a matter for debate. This study compared three methods of treatment: nonoperative, isolated posterior fixation and combined anteroposterior stabilization. Patients and methods: The study used data from the German Pelvic Trauma Registry and compared patients undergoing conservative management (n = 2394), surgical treatment (n = 1345) and transpubic surgery, including posterior stabilization (n = 730) with isolated posterior osteosynthesis (n = 405) in non-complex Type B and C fractures that only involved the obturator ring anteriorly. Calculated odds ratios were adjusted for potential confounders. Outcome criteria were intraoperative and general short-term complications, the incidence of nerve injuries, and mortality. Results: Operative stabilization reduced mortality by 36% (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.42 to 0.98) but the incidence of complications was twice as high (OR 2.04, 95% CI 1.57 to 2.64). Mortality and the incidence of neurological deficits at discharge were no different after isolated posterior or combined anteroposterior fixation. However, the odds of both surgical (98%, OR 1.98, 95%CI 1.22 to 3.22) and general complications (43%, OR 1.43, 95% CI 1.02 to 2.00) were higher in the group with the more extensive surgery. Conclusion: Operative stabilization is recommended for non-complex unstable pelvic fractures. The need for anterior fixation of obturator ring fractures should, however, be considered critically. Cite this article: Bone Joint J 2018;100-B:973-83. Keywords: Anterior pelvic ring; Fixation; Logistic regression; Models; Osteosynthesis; Pelvic fracture; Registry; Treatment; Unstable. Cited by 11 articles Full text links 67. C-arm fluoroscopy in orthopaedic surgical practice Eur J Orthop Surg Traumatol. 2018 Dec;28(8):1563-1568. doi: 10.1007/s00590-018-2234-7. Epub 2018 May 23. Authors Ishaq Ojodu 1 , Ayodele Ogunsemoyin 2 , Sascha Hopp 3 4 , Tim Pohlemann 4 , Oluwole Ige 5 , Oluwaseun Akinola 2 Affiliations 1 Department of Surgery, University of Medical Sciences, Ondo City, Ondo State, Nigeria. deleojodu@yahoo.com. 2 Department of Radiology, University of Medical Sciences, Ondo City, Ondo State, Nigeria. 3 Lutrina Clinic Kaiserslautern, Centre for Knee Surgery, Orthopaedics and Sports Traumatology, Groin Pain and Core Muscle Injury Centre, Karl-Marx-Strasse 33, 67655, Kaiserslautern, Germany. 4 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421, Homburg, Saar, Germany. 5 Department of Surgery, University of Medical Sciences, Ondo City, Ondo State, Nigeria. PMID: 29796825 DOI: 10.1007/s00590-018-2234-7 Abstract The use of C-arm fluoroscopy in intraoperative orthopaedic procedures has become an important tool in modern orthopaedic surgical practice. It enhances the technical proficiency of the surgeon in addition to reducing the morbidity and length of hospital stay of the patient. Despite the documented benefits of this device, there has been a growing concern about the increased radiation exposure to the surgical team. We therefore present the review of the literature on the usefulness of C-arm fluoroscopy, pitfalls in application of the machine as well as the harmful radiation effects and precautionary measures that need to be observed when using the C-arm fluoroscopy in orthopaedic surgical procedures. Keywords: C-arm; Exposure; Fluoroscopy; Orthopaedic; Practice; Radiation. Cited by 11 articles 44 references Full text links 68. A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions J Vis Exp. 2018 Mar 22:(133):57255. doi: 10.3791/57255. Authors Tina Histing 1 , Philipp Bremer 2 , Mika F Rollmann 2 , Steven Herath 2 , Moritz Klein 2 , Tim Pohlemann 2 , Michael D Menger 3 , Tobias Fritz 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University; tina.histing@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University. 3 Institute for Clinical & Experimental Surgery, Saarland University. PMID: 29630050 PMCID: PMC5933239 DOI: 10.3791/57255 Abstract Bone healing models are necessary to analyze the complex mechanisms of fracture healing to improve clinical fracture treatment. During the last decade, an increased use of mouse models in orthopedic research was noted, most probably because mouse models offer a large number of genetically-modified strains and special antibodies for the analysis of molecular mechanisms of fracture healing. To control the biomechanical conditions, well-characterized osteosynthesis techniques are mandatory, also in mice. Here, we report on the design and use of a closed bone healing model to stabilize femur fractures in mice. The intramedullary screw, made of medical-grade stainless steel, provides through fracture compression an axial and rotational stability compared to the mostly used simple intramedullary pins, which show a complete lack of axial and rotational stability. The stability achieved by the intramedullary screw allows the analysis of endochondral healing. A large amount of callus tissue, received after stabilization with the screw, offers ideal conditions to harvest tissue for biochemical and molecular analyses. A further advantage of the use of the screw is the fact that the screw can be inserted into the femur with a minimally invasive technique without inducing damage to the soft tissue. In conclusion, the screw is a unique implant that can ideally be used in closed fracture healing models offering standardized biomechanical conditions. Cited by 3 articles 18 references 7 figures Full text links 69. Novel pathomorphologic classification of capsulo-articular lesions of the pubic symphysis in athletes to predict treatment and outcome Arch Orthop Trauma Surg. 2018 May;138(5):687-697. doi: 10.1007/s00402-018-2893-1. Epub 2018 Feb 7. Authors Sascha Hopp 1 2 , Ishaq Ojodu 3 4 , Atul Jain 3 5 , Tobias Fritz 3 , Tim Pohlemann 3 , Jens Kelm 6 Affiliations 1 Lutrina Clinic Kaiserslautern, Centre for Knee Surgery, Orthopaedics and Sports Traumatology, Groin Pain and Core Muscle Injury Centre, Karl-Marx-Strasse 33, 67655, Kaiserslautern, Germany. hopp@lutrinaklinik.de. 2 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg, Saar, Germany. hopp@lutrinaklinik.de. 3 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg, Saar, Germany. 4 Ondo State Trauma Centre, Ondo, Nigeria. 5 Department of Orthopaedics, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India. 6 Chirurgisch-Orthopädisches Zentrum, Illingen, Germany. PMID: 29417208 DOI: 10.1007/s00402-018-2893-1 Abstract Introduction: Radiographic abnormalities of the symphysis as well as the formation of accessory clefts, indicating injury at the rectus-adductor aponeurosis, reportedly relate to longstanding groin pain in athletes. However, yet, no systematic classification for clinical and scientific purposes exists. We aimed to (1) create a radiographic classification based on symphysography; (2) test intra- and interobserver reliability; (3) characterise clinical significance of the morphologic patterns by evaluating success of injection therapy. Patients and methods: We retrospectively reviewed symphysography, AP radiographs, and MRI of the pelvis from 70 consecutive competitive athletes, with chronic groin pain. Symphysographs were evaluated for intra- and interobserver variance using cohen's kappa statistics. Morphologic studies of the different contrast distribution patterns and their clinical and radiological correlation with symptom relief were investigated. All patients were followed up to evaluate immediate and long-term response to the initial therapeutic injection with steroid. Results: Four reproducible symphysographic patterns were identified: type 0, no changes; type 1, symphyseal disk degeneration; types 2a with unilateral clefts, bilateral clefts (2b), suprapubic clefts (2c); and type 3, with expanded or multidirectional clefts. Analysis revealed excellent intra (0.94)-and interobserver (0.90) reliability. Our findings showed that 78.6% of our patients had significant short-term improvement enabling early resumption of physiotherapy, only in types 1 and 2 (p = 0.001), while type 0 and 3 did not respond. At follow-up, only 21.8% had permanent pain relief. Regarding the detection of pathologic clefts with symphysography, sensitivity (88%) and specifity (77%) were superior to that of MRI. Conclusions: A reproducible symphysography-based classification of distinct morphologic patterns is proposed. It serves as a predictive tool for response to injection therapy in a select group of pathologic lesions. Complete recovery after injection can only be expected in a lesser percentage, as this might indicate surgical treatment for long-term non-responders. Keywords: Athletic pubalgia; Classification; Groin pain; Pubic symphysis; Symphysography. Cited by 4 articles Full text links 70. The role of adipose-derived stem cells in a self-organizing 3D model with regard to human soft tissue healing Mol Cell Biochem. 2018 Aug;445(1-2):195-210. doi: 10.1007/s11010-017-3265-9. Epub 2018 Jan 5. Authors Martin Oberringer 1 , Monika Bubel 2 , Martina Jennewein 2 , Silke Guthörl 2 , Tamara Morsch 2 , Sophie Bachmann 2 , Wolfgang Metzger 2 , Tim Pohlemann 2 Affiliations 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. martin.oberringer@uks.eu. 2 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. PMID: 29305678 DOI: 10.1007/s11010-017-3265-9 Abstract The clinical phenomenon of inadequate soft tissue healing still remains an important issue. The occurrence of chronic wounds is correlated to the life span, which is still increasing in western countries. Tissue engineering products containing adipose-derived stem cells are discussed as a promising therapeutic approach. Several studies confirmed the value of these cells for soft tissue healing improvement, suggesting a paracrine as well as a direct effect on vessel repair and angiogenesis. In an attempt to figure out specific effects of adipose-derived stem cells on dermal microvascular endothelial cells with respect to the different phases of soft tissue healing, we designed a 3D in vitro model on the basis of spheroids. Basic parameters like spheroid volume, cell numbers, and rate of apoptotic cells were determined in dependence on culture time, on different oxygen conditions and using mono- as well as co-cultures of both cell types. Furthermore we focused on gene expression and protein levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1, and vascular endothelial growth factor, which are discussed against the background of therapies for chronic wounds. The visualization of α-smooth muscle actin allowed the estimation of the function of adipose-derived stem cells as stabilizer for dermal microvascular endothelial cells. The results of the present 3D model underscore a paracrine effect of adipose-derived stem cells on microvessel repair during early hypoxic conditions, whereas a stabilizing effect occurs during a later phase of soft tissue healing, simultaneously to reoxygenation. Keywords: Adipose-derived stem cell; Co-culture; Hypoxia; Microvascular endothelial cell; Soft tissue healing; Wound. Cited by 14 articles 33 references Full text links 71. Long-term pathological gait pattern changes after talus fractures - dynamic measurements with a new insole Int Orthop. 2018 May;42(5):1075-1082. doi: 10.1007/s00264-017-3720-y. Epub 2018 Jan 2. Authors Benedikt J Braun 1 , Patrick Pelz 2 , Nils T Veith 2 , Mika Rollmann 2 , Moritz Klein 2 , Steven C Herath 2 , Jörg H Holstein 2 , Tim Pohlemann 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421, Homburg, Germany. benedikt.braun@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421, Homburg, Germany. PMID: 29297103 DOI: 10.1007/s00264-017-3720-y Abstract Purpose: The aim of the current study was to describe long-term gait changes after talus fractures, identify patterns associated with poor outcome and discuss possible treatment options based on dynamic gait analysis. Methods: Twenty-seven patients were followed-up clinically and via gait analysis after talus fracture osteosynthesis. Continuous dynamic pedobarography with a gait analysis insole was performed on a standardized parcours consisting of different gait tasks and matched to the outcome. Results: Mean follow-up was 78.3 months (range 21-150), mean AOFAS and Olerud-Molander scores 66 (range 20-100) and 54 (range 15-100). Significant correlations between fracture classification and osteoarthritis (Hawkins: r s = 0.67 / Marti-Weber: r s = 0.5) as well as several gait differences between injured and healthy foot with correlations to outcome were seen: decreased step load-integral/maximum-load; associations between centre-of-pressure displacement and outcome as well as between temporospatial measures and outcome. Overall, pressure-distribution was lateralized in patients with subtalar joint injury (Δ: 0.5765 N/cm 2 , p = 0.0475). Conclusions: Talus fractures lead to chronic gait changes and restricted function. Dynamic pedobarography can identify patterns associated with poor results. The observed gait patterns suggest that changes can be addressed by physical therapy and customized orthoses to improve overall outcome. The presented insole and measurement protocol are immediately feasible as a diagnostic and rehabilitation aid. Keywords: Fracture; Gait analysis; Pedobarography; Talus. Cited by 6 articles 37 references Full text links 72. Accidental Thumb Injection With an Epinephrine Autoinjector Dtsch Arztebl Int. 2017 Nov 24;114(47):804. doi: 10.3238/arztebl.2017.0804. Authors Tobias Fritz , Tim Pohlemann , Moritz Klein PMID: 29229045 PMCID: PMC5736864 DOI: 10.3238/arztebl.2017.0804 No abstract available 1 figure Full text links 73. Dissociation of mono- and co-culture spheroids into single cells for subsequent flow cytometric analysis Ann Anat. 2018 Mar:216:1-8. doi: 10.1016/j.aanat.2017.10.002. Epub 2017 Nov 21. Authors Ute Grässer 1 , Monika Bubel 2 , Daniela Sossong 3 , Martin Oberringer 4 , Tim Pohlemann 5 , Wolfgang Metzger 6 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: u.graesser@web.de. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: monika.bubel@uks.eu. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: daniela.sossong@uks.eu. 4 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: martin.oberringer@uks.eu. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: tim.pohlemann@uks.eu. 6 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: johann-wolfgang.metzger@uks.eu. PMID: 29162481 DOI: 10.1016/j.aanat.2017.10.002 Abstract Background: Spheroids are considered to reflect the natural organization of cells better than 2D cell cultures, but their analysis by flow cytometry requires dissociation into single cells. Methods: We established protocols for dissociation of mono- and co-culture spheroids consisting of human fibroblasts and human endothelial cells. Cell recovery rate and viability after dissociation were evaluated with hemocytometer and by flow cytometry. The diameter of cells and the amount of cell aggregates were quantified by Casy ® -technology and the cellular composition was analyzed by flow cytometry. Results: Optimal dissociation conditions with low cell aggregation were determined by size, cultivation time and cellular composition of the spheroids. Smaller spheroids (10,000 cells) could be dissociated with Accutase ® , whereas larger spheroids (50,000 cells) required more stringent dissociation conditions. The size of the cells decreased with increasing cultivation time. Cell recovery rate was dependent upon cellular composition and spheroid size. The highest cell recovery rate was found for co-culture spheroids. The highest cell viability was detected for dissociated fibroblast spheroids. A quantitative analysis of the cellular composition of dissociated co-culture spheroids was possible. Discussion: Spheroids can be successfully dissociated into singular cells for subsequent flow cytometric analysis. Dissociation conditions as well as cell recovery rate and cell viability depend on size, cultivation time and cellular composition of the spheroids. The observed decrease in cell size in spheroids over time might be responsible for the well-known time-dependent decrease in spheroid size. Keywords: Cell recovery rate; Cell viability; Co-culture; Dissociation; Endothelial cells; Fibroblasts; Spheroids. Copyright © 2017 Elsevier GmbH. All rights reserved. Cited by 11 articles Full text links 74. Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients J Invest Dermatol. 2018 Feb;138(2):413-422. doi: 10.1016/j.jid.2017.08.032. Epub 2017 Sep 9. Authors Fabio Sabino 1 , Fabian E Egli 2 , Simonas Savickas 2 , Jörg Holstein 3 , Daniela Kaspar 4 , Mika Rollmann 3 , Jayachandran N Kizhakkedathu 5 , Tim Pohlemann 3 , Hans Smola 4 , Ulrich Auf dem Keller 6 Affiliations 1 ETH Zurich, Department of Biology, Institute of Molecular Health Sciences, Zurich, Switzerland; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. 2 ETH Zurich, Department of Biology, Institute of Molecular Health Sciences, Zurich, Switzerland. 3 Department of Trauma, Hand, and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. 4 Paul Hartmann AG, Heidenheim, Germany. 5 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Chemistry, Centre for Blood Research, 4.401 Life Sciences Institute, Vancouver, British Columbia, Canada. 6 ETH Zurich, Department of Biology, Institute of Molecular Health Sciences, Zurich, Switzerland; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: ulrich.aufdemkeller@biol.ethz.ch. PMID: 28899681 DOI: 10.1016/j.jid.2017.08.032 Free article Abstract Impaired cutaneous wound healing is a major complication in elderly people and patients suffering from diabetes, the rate of which is rising in industrialized countries. Heterogeneity of clinical manifestations hampers effective molecular diagnostics and decisions for appropriate therapeutic regimens. Using a customized positional quantitative proteomics workflow, we have established a time-resolved proteome and N-terminome resource from wound exudates in a clinically relevant pig wound model that we exploited as a robust template to interpret a heterogeneous dataset from patients undergoing the same wound treatment. With zyxin, IQGA1, and HtrA1, this analysis and validation by targeted proteomics identified differential abundances and proteolytic processing of proteins of epidermal and dermal origin as prospective biomarker candidates for assessment of critical turning points in wound progression. Thus, we show the possibility of using a fine-tuned animal wound model to bridge the translational gap as a prerequisite for future extended clinical studies with large cohorts of individuals affected by healing impairments. Data are available via ProteomeXchange with identifier PXD006674. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved. Cited by 8 articles Full text links 75. Mechanical and biological characterization of alkaline substituted orthophosphate bone substitutes containing meta- and diphosphates Biomed Mater. 2017 Sep 25;12(5):055007. doi: 10.1088/1748-605X/aa7e80. Authors Moritz Klein 1 , Matthias W Laschke , Jörg H Holstein , Tina Histing , Tim Pohlemann , Michael D Menger , Patric Garcia Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Str. 1, D-66421 Homburg/Saar, Germany. PMID: 28691695 DOI: 10.1088/1748-605X/aa7e80 Abstract Despite the growing knowledge on the mechanisms of fracture healing, bone defects often do not heal in a timely manner. Clinically, tricalcium phosphate (TCP) bone substitutes are used to fill bone defects and promote bone healing. However, the degradation rate of these implants is often too slow for sufficient bone replacement. The use of calcium phosphate material with the crystalline phase Ca 10 [K/Na](PO 4 ) 7 containing different amounts of di- and metaphosphates may overcome this problem, because these materials show an accelerated degradation. Therefore, we generated alkaline substituted Ca-P scaffolds with different amounts of ortho-, di- and metaphosphates. The degradation of these materials was analyzed in TRIS-HCl buffer solution in vitro. Moreover, we measured the compressive strength and porosity of the scaffolds by micro-CT analysis. The biocompatibility of the scaffolds was evaluated in vivo in the mouse dorsal skinfold chamber by means of intravital fluorescence microscopy and histology. We found that higher amounts of incorporated di- and metaphosphates increase the degradation rate and compressive strength of the scaffolds without inducing a stronger leukocytic inflammatory host tissue reaction after implantation. Histological analyses confirmed the good biocompatibility of the scaffolds containing di- and metaphosphates. In summary, this study demonstrates that the compressive strength and degradation rate of Ca-P scaffolds can be improved by incorporation of di- and metaphosphates without affecting their good biocompatibility. Hence, this material modification may be particularly beneficial for the treatment of metaphyseal bone defects in weight bearing locations. Full text links 76. Helping prometheus: liver protection in acute hemorrhagic shock Ann Transl Med. 2017 May;5(10):206. doi: 10.21037/atm.2017.03.109. Authors Nils T Veith 1 , Tina Histing 1 , Michael D Menger 2 , Tim Pohlemann 1 , Thomas Tschernig 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. 2 Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. 3 Institute of Anatomy, Saarland University, D-66421 Homburg/Saar, Germany. PMID: 28603721 PMCID: PMC5451618 DOI: 10.21037/atm.2017.03.109 Abstract Acute hemorrhagic hypovolemic shock is caused by a significant high blood loss and leads to hemodynamic instability. The decrease in intravascular volume results in cellular hypoxia and finally in damage to organs such as the liver and the kidney. The liver plays a decisive role in the development or prevention of multiple organ failure after hemorrhagic shock. Despite the large number of experimental studies, the knowledge of pathophysiological mechanisms in the liver after hemorrhagic shock is incomplete. The aim of this mini review was to provide an overview of the pathophysiological changes in liver function after acute hemorrhagic shock and to address treatment options to improve liver perfusion. Keywords: Adrenomedullin; experimental treatment; hemorrhagic shock; intravital microscopy; liver perfusion. Conflict of interest statement Conflicts of Interest: The authors have no conflicts of interest to declare. Cited by 10 articles 48 references Full text links 77. Polytrauma in the elderly: a review EFORT Open Rev. 2017 Mar 13;1(5):146-151. doi: 10.1302/2058-5241.1.160002. eCollection 2016 May. Authors Benedikt Johannes Braun 1 , Jörg Holstein 1 , Tobias Fritz 1 , Nils Thomas Veith 1 , Steven Herath 1 , Philipp Mörsdorf 1 , Tim Pohlemann 1 Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. PMID: 28461941 PMCID: PMC5367536 DOI: 10.1302/2058-5241.1.160002 Abstract Although the field of geriatric trauma is - ironically - young, care for the elderly trauma patient is increasingly recognised as an important challenge, considering the worldwide trend towards increasing longevity.Increasing age is associated with physiological changes and resulting comorbidities that present multiple challenges to the treating physician.Even though polytrauma is less likely with increasing age, lower-energy trauma can also result in life-threatening injuries due to the reduced physiological reserve.Mechanisms of injury and resulting injury patterns are markedly changed in the elderly population and new management strategies are needed. From initial triage to long-term rehabilitation, these patients require care that differs from the everyday standard.In the current review, the special requirements of this increasing patient population are reviewed and management options discussed. With the increase in orthogeriatrics as a speciality, the current status quo will almost certainly shift towards a more tailored treatment approach for the elderly patient. Further research expanding our current knowledge is needed to reduce the high morbidity and mortality rate. Cite this article: Braun BJ, Holstein J, Fritz T, Veith NT, Herath S, Mörsdorf P, Pohlemann T. Polytrauma in the elderly: a review. EFORT Open Rev 2016;1:146-151. DOI: 10.1302/2058-5241.1.160002. Keywords: comorbidities; elderly; orthogeriatrics; polytrauma. Conflict of interest statement Conflict of Interest: None declared. Cited by 17 articles 36 references 2 figures Full text links 78. Weight-bearing recommendations after operative fracture treatment-fact or fiction? Gait results with and feasibility of a dynamic, continuous pedobarography insole Int Orthop. 2017 Aug;41(8):1507-1512. doi: 10.1007/s00264-017-3481-7. Epub 2017 Apr 19. Authors Benedikt J Braun 1 , Nils T Veith 2 , Mika Rollmann 2 , Marcel Orth 2 , Tobias Fritz 2 , Steven C Herath 2 , Jörg H Holstein 2 , Tim Pohlemann 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421, Homburg, Germany. benedikt.braun@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Building 57, Kirrbergerstr. 1, 66421, Homburg, Germany. PMID: 28421239 DOI: 10.1007/s00264-017-3481-7 Abstract Purpose: Rehabilitation after lower-extremity fractures is based on the physicians' recommendation for non-, partial-, or full weight-bearing. Clinical studies rely on this assumption, but continuous compliance or objective loading rates are unknown. The purpose of this study was to determine the compliance to weight-bearing recommendations by introducing a novel, pedobarography system continuously registering postoperative ground forces into ankle, tibial shaft and proximal femur fracture aftercare and test its feasibility for this purpose. Methods: In this prospective, observational study, a continuously measuring pedobarography insole was placed in the patients shoe during the immediate post-operative aftercare after ankle, tibial shaft and intertrochanteric femur fractures. Weight-bearing was ordered as per the institutional standard and controlled by physical therapy. The insole was retrieved after a maximum of six weeks (28 days [range 5-42 days]). Non-compliance was defined as a failure to maintain, or reach the ordered weight-bearing within 30%. Results: Overall 30 patients were included in the study. Fourteen (47%) of the patients were compliant to the weight-bearing recommendations. Within two weeks after surgery patients deviated from the recommendation by over 50%. Sex, age and weight did not influence the performance (p > 0.05). Ankle fracture patients (partial weight-bearing) showed a significantly increased deviation from the recommendation (p = 0.01). Conclusions: Our study results show that, despite physical therapy training, weight-bearing compliance to recommended limits was low. Adherence to the partial weight-bearing task was further decreased over time. Uncontrolled weight-bearing recommendations should thus be viewed with caution and carefully considered as fiction. The presented insole is feasible to determine weight bearing continuously, could immediately help define real-time patient behaviour and establish realistic, individual weight-bearing recommendations. Keywords: Compliance; Gait analysis; Pedobarography; Weight-bearing. Cited by 31 articles 30 references Full text links 79. Pelvic ring fractures in the elderly now and then - a pelvic registry study Arch Gerontol Geriatr. 2017 Jul:71:83-88. doi: 10.1016/j.archger.2017.03.007. Epub 2017 Mar 19. Authors Mika F Rollmann 1 , Steven C Herath 2 , Florian Kirchhoff 2 , Benedikt J Braun 2 , Joerg H Holstein 2 , Tim Pohlemann 2 , Michael D Menger 3 , Tina Histing 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg/Saar, Germany. Electronic address: mika.rollmann@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg/Saar, Germany. 3 Institute for Clinical & Experimental Surgery, Saarland University, Homburg/Saar, Germany. PMID: 28384504 DOI: 10.1016/j.archger.2017.03.007 Abstract Objectives: To analyze the changes in demographic data stratified for age, sex and type of injury of elderly patients suffering from pelvic ring fractures over a 22-year observation period. Design/setting: Data has been collected prospectively, multi-centrically in hospitals participating in the German Pelvic Trauma Registry. Patients: We analyzed the data of 5665 patients with an age ≥60years included in the German Pelvic Trauma Registry from 1991 to 2013. Key results: Over the 22-year study period the frequency of type A fractures decreased significantly from 84.8% to 43.9%, while type C and, in particular, type B fractures significantly increased from 7.0% and 8.2% to 14.3% and 41.8%. In patients between 60 and 70 years of age the frequency of type B and C fractures was higher compared to patients >70years. The proportion of female patients, who represent the majority of the cohort (75%), was stable over the entire observation period. Interestingly, type A fractures were found more frequently in females, while type B and C fractures were found more frequently in males. Conclusions: With the predicted demographic change and a shift toward more severe injury patterns (type B and C pelvic fractures) in the elderly population, trauma departments will need to develop specific surgical concepts for geriatric patients with pelvic ring fractures. Keywords: Elderly; Gender; Geriatric medicine; Pelvic ring fractures. Copyright © 2017 Elsevier B.V. All rights reserved. Cited by 14 articles Full text links 80. Introduction of a computer-based method for automated planning of reduction paths under consideration of simulated muscular forces Int J Comput Assist Radiol Surg. 2017 Aug;12(8):1369-1381. doi: 10.1007/s11548-017-1562-0. Epub 2017 Mar 20. Authors Jan Buschbaum 1 , Rainer Fremd 2 , Tim Pohlemann 3 , Alexander Kristen 3 Affiliations 1 Fachbereich Angewandte Ingenieurwissenschaften, Hochschule Kaiserslautern - University of Applied Sciences, Schoenstraße 11, 67659, Kaiserslautern, Germany. jan.buschbaum@hs-kl.de. 2 Fachbereich Angewandte Ingenieurwissenschaften, Hochschule Kaiserslautern - University of Applied Sciences, Schoenstraße 11, 67659, Kaiserslautern, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrbergerstraße, 66421, Homburg/Saar, Germany. PMID: 28321805 DOI: 10.1007/s11548-017-1562-0 Abstract Purpose: Reduction is a crucial step in the surgical treatment of bone fractures. Finding an optimal path for restoring anatomical alignment is considered technically demanding because collisions as well as high forces caused by surrounding soft tissues can avoid desired reduction movements. The repetition of reduction movements leads to a trial-and-error process which causes a prolonged duration of surgery. By planning an appropriate reduction path-an optimal sequence of target-directed movements-these problems should be overcome. For this purpose, a computer-based method has been developed. Methods: Using the example of simple femoral shaft fractures, 3D models are generated out of CT images. A reposition algorithm aligns both fragments by reconstructing their broken edges. According to the criteria of a deduced planning strategy, a modified A*-algorithm searches collision-free route of minimal force from the dislocated into the computed target position. Muscular forces are considered using a musculoskeletal reduction model (OpenSim model), and bone collisions are detected by an appropriate method. Results: Five femoral SYNBONE models were broken into different fracture classification types and were automatically reduced from ten randomly selected displaced positions. Highest mean translational and rotational error for achieving target alignment is [Formula: see text] and [Formula: see text]. Mean value and standard deviation of occurring forces are [Formula: see text] for M. tensor fasciae latae and [Formula: see text] for M. semitendinosus over all trials. These pathways are precise, collision-free, required forces are minimized, and thus regarded as optimal paths. Conclusions: A novel method for planning reduction paths under consideration of collisions and muscular forces is introduced. The results deliver additional knowledge for an appropriate tactical reduction procedure and can provide a basis for further navigated or robotic-assisted developments. Keywords: Automated path planning; Computer-assisted fracture reduction; Femoral fractures; Guided surgery; Reduction paths. Cited by 6 articles 15 references Full text links 81. Clinical outcome after alternative treatment of scaphoid fractures and nonunions Eur J Trauma Emerg Surg. 2018 Feb;44(1):113-118. doi: 10.1007/s00068-017-0773-y. Epub 2017 Feb 27. Authors A L Sander 1 2 , K Sommer 3 , D Schäf 3 , C Braun 4 , I Marzi 3 , T Pohlemann 5 , J Frank 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Johann Wolfgang Goethe-University, Frankfurt/Main, Germany. AnnaLena.Sander@kgu.de. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. AnnaLena.Sander@kgu.de. 3 Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Johann Wolfgang Goethe-University, Frankfurt/Main, Germany. 4 Department of Trauma, Hand and Reconstructive Surgery, St.-Antonius-Hospital, Kleve, Germany. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Medical Center, Homburg, Germany. PMID: 28243717 DOI: 10.1007/s00068-017-0773-y Abstract Purpose: Achieving stable fixation of scaphoid fractures and nonunions continues to be a challenge. Compression screw fixation has been the current standard surgical procedure. However, in some cases, bone healing cannot be achieved and requires further revision. Recent series reintroduced volar plating as valid option for stable fixation. The aim of the study was to review clinical outcome of alternative scaphoid treatment. Methods: From 2011 to 2014, nine patients with scaphoid fracture were treated by Headless Compression Screw (HCS) and seven patients with scaphoid nonunion by HCS or volar mini condylar plate with bone graft. The average age was 34.4 years and the average time to follow-up was 19.3 months. From 1996 to 1998, 38 patients with scaphoid nonunion were treated using compression screw (S-group) or volar mini condylar plate (P-group) with bone graft. The average age was 39.6 years and the average time to follow-up was 26.2 months. Results: The union rate was 100%. For scaphoid fractures, the mean Modified Mayo Wrist Score (MMWS) was 94.1 and the DASH score 7.4. From 2011 to 2014, the MMWS was 87.9 and the DASH score 7 in scaphoid nonunions. In the period between 1996 and 1998, the MMWS was 67.2 in the P-group and 58.6 in the S-group, and the DASH score 16.8 and 28.2. Conclusions: Our study demonstrated that appropriate application of the HCS was able to produce very satisfactory results in scaphoid fractures and nonunions. In our opinion, however, the method of scaphoid plate osteosynthesis can achieve a higher degree of stability, particularly rotational stability, in case of multifragmentary avascular scaphoid nonunions. Keywords: 1,2-ICSRA; Compression screw; Mini condylar plate; Scaphoid fracture; Scaphoid nonunion. Cited by 5 articles 36 references Full text links 82. [A new continuous gait analysis system for ankle fracture aftercare] Unfallchirurg. 2018 Apr;121(4):293-299. doi: 10.1007/s00113-017-0332-3. [Article in German] Authors B J Braun 1 , N T Veith 2 , S C Herath 2 , R Hell 2 , M Rollmann 2 , M Orth 2 , J H Holstein 2 , T Pohlemann 2 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str., 66421, Homburg, Deutschland. benedikt.braun@uks.eu. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str., 66421, Homburg, Deutschland. PMID: 28235983 DOI: 10.1007/s00113-017-0332-3 Abstract Background: Correct aftercare following lower extremity fractures remains a controversial issue. Reliable, clinically applicable weight-bearing recommendations have not yet been defined. The aim of the current study was to establish a new gait analysis insole during physical therapy aftercare of ankle fractures to test patients' continuous, long-term compliance to partial weight-bearing restrictions and investigate whether patients can estimate their weight-bearing compliance. Materials and methods: The postoperative gait of 14 patients after operative treatment of Weber B-type ankle fractures was monitored continuously for six weeks (OpenGO, Moticon GmbH, Munich). All patients were instructed and trained by physical therapists on how to maintain partial weight-bearing for this time. Discontinuous (three, six and twelve weeks) clinical (patient questionnaire, visual analogue pain score [VAS]) and radiographic controls were performed. Results: Despite the set weight-bearing limits, individual ranges for overall weight-bearing (range 5-107% of the contralateral side) and patient activity (range 0-366 min/day) could be shown. A good correlation between weight-bearing and pain was seen (r s = -0.68; p = <0.0001). Patients significantly underestimated their weight-bearing time over the set limit (2.3 ± 1.4 min/day vs. real: 12.6 ± 5.9 min/day; p < 0.01). Conclusions: Standardized aftercare protocols and repeated training alone cannot ensure compliance to postoperative partial weight-bearing. Patients unconsciously increased weight-bearing based on their pain level. This study shows that new, individual and possibly technology-assisted weight-bearing regimes are needed. The introduced measuring device is feasible to monitor and steer patient weight-bearing during future studies. Keywords: Aftercare; Ankle; Fracture; Gait analysis; Pedobarography. Cited by 2 articles 31 references Full text links 83. Evaluation of cell-surface interaction using a 3D spheroid cell culture model on artificial extracellular matrices Mater Sci Eng C Mater Biol Appl. 2017 Apr 1:73:310-318. doi: 10.1016/j.msec.2016.12.087. Epub 2016 Dec 20. Authors Wolfgang Metzger 1 , Sandra Rother 2 , Tim Pohlemann 3 , Stephanie Möller 4 , Matthias Schnabelrauch 4 , Vera Hintze 2 , Dieter Scharnweber 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. Electronic address: johann-wolfgang.metzger@uks.eu. 2 Institute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Straße 27, 01069 Dresden, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany. 4 Biomaterials Department, INNOVENT e. V., Prüssingstraße 27 B, 07745 Jena, Germany. PMID: 28183614 DOI: 10.1016/j.msec.2016.12.087 Abstract Since decades, cell-surface interactions are studied in 2D cell culture approaches, but cells organized in 3D (spheroids) reflect the normal situation of cells in tissues much better due to intense cell-cell-contacts. Accordingly, this study aimed to prove, if spheroids could be used to study cell-surface interaction. Spheroids consisting of fibroblasts and/or osteoblasts were seeded on artificial extracellular matrices. Here, non-sulfated hyaluronan as a biological relevant compound of the extracellular matrix was chemically sulfated to different extents and co-fibrillised with collagen. The changes of the spheroid diameters and the migration distance of outgrown cells after seeding on the matrices were used as parameters to evaluate cell-surface interaction quantitatively. Fibroblast-based spheroids reacted in the initial phase of adhesion with different spheroid sizes on the contact with the matrices. In contrast, the reaction of osteoblasts was more pronounced at later time points exhibiting a decrease of the size of the spheroids with increasing sulfation degree of the matrix. The migration of the cells was impaired by increasing sulfation degree, which might be caused by an increased expression of focal adhesion relevant proteins. In summary, spheroids can be used in cell-surface interaction studies and additional analytical tools could be implemented. Keywords: Cell-surface interaction; Glycosaminoglycans; Spheroid; Sulfated hyaluronan. Copyright © 2016 Elsevier B.V. All rights reserved. Cited by 6 articles Full text links 84. [Surgery in the elderly] Chirurg. 2017 Feb;88(2):93-94. doi: 10.1007/s00104-016-0350-7. [Article in German] Author T Pohlemann 1 Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66421, Homburg/Saar, Deutschland. tim.pohlemann@uks.eu. PMID: 28180914 DOI: 10.1007/s00104-016-0350-7 No abstract available Cited by 1 article Full text links 85. BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions Eur Cell Mater. 2017 Jan 2:33:1-12. doi: 10.22203/eCM.v033a01. Authors M Orth 1 , N J Kruse , B J Braun , C Scheuer , J H Holstein , A Khalil , X Yu , W L Murphy , T Pohlemann , M W Laschke , M D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Strasse 1, D-66421 Homburg/Saar, Germany.marcel.orth@uks.eu. PMID: 28054333 DOI: 10.22203/eCM.v033a01 Free article Abstract Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in vitro to bind growth factors electrostatically and enable a tuneable sustained release. Herein, we studied whether MCM can be used in vivo to apply Bone Morphogenetic Protein-2 (BMP-2) to improve bone repair of atrophic non-unions. For this purpose, atrophic non-unions were induced in femurs of CD-1 mice (n = 48). Animals either received BMP-2-coated MCM (MCM + BMP; n = 16), uncoated MCM (MCM; n = 16) or no MCM (NONE; n = 16). Bone healing was evaluated 2 and 10 weeks postoperatively by micro-computed tomographic (µCT), biomechanical, histomorphometric and immunohistochemical analyses. µCT revealed more bone volume with more highly mineralised bone in MCM + BMP femurs. Femurs of MCM + BMP animals showed a significantly higher bending stiffness compared to other groups. Histomorphometry further demonstrated that the callus of MCM + BMP femurs was larger and contained more bone and less fibrous tissue. After 10 weeks, 7 of 8 MCM + BMP femurs presented with complete osseous bridging, whereas NONE femurs exhibited a non-union rate of 100 %. Of interest, immunohistochemistry could not detect macrophages within the callus, indicating a good biocompatibility of MCM. In conclusion, the local application of BMP-2-coated MCM improved bone healing in a challenging murine non-union model and, thus, should be of clinical interest in the treatment of non-unions. Cited by 14 articles Full text links 86. [Periprosthetic acetabular fractures in geriatric patients] Chirurg. 2017 Feb;88(2):105-109. doi: 10.1007/s00104-016-0340-9. [Article in German] Authors S C Herath 1 , M F R Rollmann 2 , T Histing 2 , J H Holstein 2 , T Pohlemann 2 Affiliations 1 Klink für Unfall-, Hand und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 100, 66421, Homburg/Saar, Deutschland. Steven.Herath@uks.eu. 2 Klink für Unfall-, Hand und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 100, 66421, Homburg/Saar, Deutschland. PMID: 28054110 DOI: 10.1007/s00104-016-0340-9 Abstract Periprosthetic acetabular fractures in geriatric patients are rare injuries; however, the incidence is increasing because of the current demographic developments. For diagnosis of periprosthetic acetabular fractures, conventional X‑ray images are regularly complemented by computed tomography (CT). For exclusion of loosening of the prosthesis more advanced techniques, such as single photon emission CT (SPECT/CT) are applied. In addition to classification of periprosthetic acetabular fractures by the traditional system of Letournel there are several other classification systems, which take into account the etiology of the fracture and the stability of the prosthesis. While, under certain circumstances conservative treatment of periprosthetic acetabular fractures is possible, operative treatment often requires extensive surgical procedures to restore the stability of the acetabulum as a support for the cup of the prosthesis. Besides the traditional techniques of acetabular osteosynthesis, special revision systems, augmentations and allografts are used for the reconstruction of periprosthetic acetabular fractures. To determine a therapeutic regimen patient-specific preconditions as well as fracture pattern and type of prosthesis need to be taken into account. In the literature there are several algorithms, which are aimed at supporting the attending physician in making the correct decision for the treatment of periprosthetic acetabular fractures. In cases of periprosthetic acetabular fractures even experienced surgeons are faced with great challenges. Thus, treatment should be carried out in specialized centers. Keywords: Acetabulum; Hip; Periprosthetic fracture; Prosthesis; Treatment. Cited by 1 article 33 references Full text links 87. Challenges in geriatric trauma care Innov Surg Sci. 2016 Dec 22;1(2):47-48. doi: 10.1515/iss-2016-0201. eCollection 2016 Dec. Authors Tim Pohlemann 1 , Tina Histing 2 Affiliations 1 Direktor der Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Strasse 1, D-66421 Homburg/Saar, Germany. 2 Universität des Saarlandes, Klinik für Unfall,- Hand- und Wiederherstellungschirurgie, 66421 Homburg/Saar, Germany. PMID: 31579718 PMCID: PMC6753990 DOI: 10.1515/iss-2016-0201 No abstract available Cited by 3 articles Full text links 88. An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice J Vis Exp. 2016 Nov 13:(117):54472. doi: 10.3791/54472. Authors Tina Histing 1 , Michael D Menger 2 , Tim Pohlemann 3 , Romano Matthys 4 , Tobias Fritz 3 , Patric Garcia 3 , Moritz Klein 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University; tina.histing@uks.eu. 2 Institute for Clinical & Experimental Surgery, Saarland University. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University. 4 RISystem AG. PMID: 27911364 PMCID: PMC5226229 DOI: 10.3791/54472 Abstract Bone healing models are essential to the development of new therapeutic strategies for clinical fracture treatment. Furthermore, mouse models are becoming more commonly used in trauma research. They offer a large number of mutant strains and antibodies for the analysis of the molecular mechanisms behind the highly differentiated process of bone healing. To control the biomechanical environment, standardized and well-characterized osteosynthesis techniques are mandatory in mice. Here, we report on the design and use of an intramedullary nail to stabilize open femur osteotomies in mice. The nail, made of medical-grade stainless steel, provides high axial and rotational stiffness. The implant further allows the creation of defined, constant osteotomy gap sizes from 0.00 mm to 2.00 mm. Intramedullary locking nail stabilization of femur osteotomies with gap sizes of 0.00 mm and 0.25 mm result in adequate bone healing through endochondral and intramembranous ossification. Stabilization of femur osteotomies with a gap size of 2.00 mm results in atrophic non-union. Thus, the intramedullary locking nail can be used in healing and non-healing models. A further advantage of the use of the nail compared to other open bone healing models is the possibility to adequately fix bone substitutes and scaffolds in order to study the process of osseous integration. A disadvantage of the use of the intramedullary nail is the more invasive surgical procedure, inherent to all open procedures compared to closed models. A further disadvantage may be the induction of some damage to the intramedullary cavity, inherent to all intramedullary stabilization techniques compared to extramedullary stabilization procedures. Cited by 6 articles 18 references 1 figure Full text links 89. Predictive value of clinical scoring and simplified gait analysis for acetabulum fractures J Surg Res. 2016 Dec;206(2):405-410. doi: 10.1016/j.jss.2016.08.061. Epub 2016 Aug 23. Authors Benedikt J Braun 1 , Julian Wrona 2 , Nils T Veith 2 , Mika Rollman 2 , Marcel Orth 2 , Steven C Herath 2 , Jörg H Holstein 2 , Tim Pohlemann 2 Affiliations 1 Department for Trauma, Hand, and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. Electronic address: benedikt.braun@uks.eu. 2 Department for Trauma, Hand, and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. PMID: 27884336 DOI: 10.1016/j.jss.2016.08.061 Abstract Background: Fractures of the acetabulum show a high, long-term complication rate. The aim of the present study was to determine the predictive value of clinical scoring and standardized, simplified gait analysis on the outcome after these fractures. Methods: Forty-one patients with acetabular fractures treated between 2008 and 2013 and available, standardized video recorded aftercare were identified from a prospective database. A visual gait score was used to determine the patients walking abilities 6-m postoperatively. Clinical (Merle d'Aubigne and Postel score, visual analogue scale pain, EQ5d) and radiological scoring (Kellgren-Lawrence score, postoperative computed tomography, and Matta classification) were used to perform correlation and multivariate regression analysis. Results: The average patient age was 48 y (range, 15-82 y), six female patients were included in the study. Mean follow-up was 1.6 y (range, 1-2 y). Moderate correlation between the gait score and outcome (versus EQ5d: r s = 0.477; versus Merle d'Aubigne: r s = 0.444; versus Kellgren-Lawrence: r s = -0.533), as well as high correlation between the Merle d'Aubigne score and outcome were seen (versus EQ5d: r s = 0.575; versus Merle d'Aubigne: r s = 0.776; versus Kellgren-Lawrence: r s = -0.419). Using a multivariate regression model, the 6 m gait score (B = -0.299; P < 0.05) and early osteoarthritis development (B = 1.026; P < 0.05) were determined as predictors of final osteoarthritis. A good fit of the regression model was seen (R 2 = 904). Conclusions: Easy and available clinical scoring (gait score/Merle d'Aubigne) can predict short-term radiological and functional outcome after acetabular fractures with sufficient accuracy. Decisions on further treatment and interventions could be based on simplified gait analysis. Keywords: Acetabular fracture; Clinical scoring; Gait analysis. Copyright © 2016 Elsevier Inc. All rights reserved. Cited by 2 articles Full text links 90. Blood loss in pelvic ring fractures: CT-based estimation Ann Transl Med. 2016 Oct;4(19):366. doi: 10.21037/atm.2016.08.39. Authors Nils T Veith 1 , Moritz Klein 1 , Daniel Köhler 1 , Thomas Tschernig 2 , Jörg Holstein 1 , Philipp Mörsdorf 1 , Tim Pohlemann 1 , Benedikt J Braun 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland's University Hospital, Homburg, Germany. 2 Department of Anatomy and Cell Biology, Saarland's University, Homburg, Germany. PMID: 27826569 PMCID: PMC5075860 DOI: 10.21037/atm.2016.08.39 Abstract Background: The main cause of mortality after pelvic ring fractures is the acute haemorrhagic shock. The aim of the study was to estimate blood loss using CT and to correlate estimated blood loss to the mortality. Methods: A retrospective analysis of 42 patients with AO/OTA C-type pelvic ring fractures was performed. In total 29 AO/OTA C1-type, 4 C2-type and 9 C3-type fractures were analysed. A CT-volumetric analysis was developed to estimate the early blood loss in the different compartments. The results were correlated to the mortality of the patients. Results: Significant increases in interstitial free blood volume (392±502.8 vs . 888±663; P<0.05) and total blood loss (476±535 vs . 1,005±649; P<0.05) were seen when comparing C1 to C3-type fractures. Early blood loss significantly correlated to mortality. No significant difference was seen between all groups with respect to systolic blood pressure, haemoglobin concentration and the Injury Severity Score (ISS). Conclusions: In pelvic ring fractures the CT-estimated blood loss correlates to mortality. Keywords: Pelvic ring fractures; blood loss; haemorrhagic shock; volumetric CT. Conflict of interest statement The authors have no conflicts of interest to declare. Cited by 2 articles 10 references 2 figures Full text links 91. [Traumatic hip dislocation in a 6-year-old male child: Seldom but demanding] Unfallchirurg. 2017 Apr;120(4):350-354. doi: 10.1007/s00113-016-0268-z. [Article in German] Authors P Mörsdorf 1 , A Lauer 2 , T Histing 1 , T Pohlemann 1 , M Burkhardt 3 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Homburg/Saar, Deutschland. 2 Abteilung für Chirurgie, Segment Unfallchirurgie und Orthopädie, Handchirurgie, Evangelisches Stadtkrankenhaus Saarbrücken, Saarland Kliniken, Großherzog-Friedrich-Str. 44, 66111, Saarbrücken, Deutschland. 3 Abteilung für Chirurgie, Segment Unfallchirurgie und Orthopädie, Handchirurgie, Evangelisches Stadtkrankenhaus Saarbrücken, Saarland Kliniken, Großherzog-Friedrich-Str. 44, 66111, Saarbrücken, Deutschland. mac.burkhardt@t-online.de. PMID: 27770168 DOI: 10.1007/s00113-016-0268-z Abstract Traumatic hip dislocations in children are not frequent but constitute true emergencies. They require urgent reduction because of the risk of consecutive avascular necrosis of the femoral head. We report a 6-year-old boy with traumatic posterior hip dislocation on a vacation abroad. After closed reduction the day of the accident, a hip spica cast was applied and the patient was transferred home. Once home, X‑ray and CT diagnostics were completed by MRI. In future, long-term clinical and radiological investigations for avascular necrosis and growth disorders, as well as thoroughly informing the parents, should be mandatory. Keywords: Childhood; Problems and complications; Traumatic hip dislocation; Treatment. Cited by 2 articles 9 references Full text links 92. Does the implant make the difference ? - Prospective comparison of two different proximal femur nails Acta Orthop Belg. 2016 Aug;82(2):319-331. Authors S Hopp , R Wirbel , I Ojodu , A Pizanis , T Pohlemann , J Fleischer PMID: 27682295 Abstract The aim of this study was to compare two proximal femur nails with regard to the complication rate and midterm clinical outcome : the InterTAN nail (ITN) versus the third generation gamma nail (GN). 78 patients older than 60 years with an unstable intertrochanteric femoral fracture (AO/OTA 31 A2/A3) were randomised over a 20 month period into either ITN (n = 39) or GN (n = 39). The outcomes of interest were the perioperative implant-related complications and the functional status (Harris Hip Score) at 6 months postoperatively. In 14 of the ITN and in two of the GN procedures the surgeons rated the implant as cumbersome (p = 0.002). Functional outcome and complication rate did not differ between both groups. The mechanical failure correlated with the positioning of the lag screw independent on the used implant. The surgeon's technique (closed reduction, positioning of lag screw) and not implant configuration, is of crucial importance in achieving successful outcome. Cited by 14 articles 93. [Salvage procedure for painful proximalisation of the 1st metacarpal after trapeziectomy using the Mini TightRope®] Handchir Mikrochir Plast Chir. 2016 Aug;48(5):300-5. doi: 10.1055/s-0042-113774. Epub 2016 Aug 31. [Article in German] Authors B J Braun 1 , N T Veith 1 , F S Frueh 2 , M Klein 1 , W Knopp 1 , T Pohlemann 1 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg. 2 Institut für Klinisch-Experimentelle Chirurgie, Universität des Saarlandes, Homburg. PMID: 27580444 DOI: 10.1055/s-0042-113774 Abstract Purpose: This study analyses our results after revision surgery for failed trapezectomy and suspension arthroplasty with painful proximalisation of the 1(st) metacarpal using the Mini TightRope(®). Patients and methods: In a prospective observational study, 5 patients (4 women and 1 man) with an average age of 62 years were treated with the Mini TightRope(®) for revision of a failed Epping arthroplasty with painful proximalisation of the first ray. The mean time between initial surgery and revision was 23.1 (12.5-31.5) months; the mean follow-up was 25±7.7 (12-32) months. The pain level (visual analogue scale - VAS), pinch grip, and qDASH score were evaluated preoperatively and postoperatively. In addition, the Conolly score was used postoperatively. Directly after surgery and at the last follow-up exam, the degree of proximalisation of the first metacarpal was measured radiologically. Results: At the last follow-up, there was significant mean pain relief during everyday stress, from 5.2 preoperatively to 1.6 (p<0.01) postoperatively, and a significant increase in pinch grip, from 0.5 kg to 3 kg (p<0.01). qDASH improved significantly, from 54 to 20 (p<0.001). The Conolly score showed 2 good and 3 fair results. Renewed proximalisation could not be entirely prevented, but was limited to an average of 2 mm. Conclusion: Mini TightRope(®) revision surgery after failed trapezectomy and suspension arthroplasty showes good results with significant pain reduction and gain of function. Renewed proximalisation of the first ray cannot be completely avoided. © Georg Thieme Verlag KG Stuttgart · New York. Comment in Stellungnahme. Braun BJ. Handchir Mikrochir Plast Chir. 2017 Feb;49(1):67-68. doi: 10.1055/s-0036-1597213. Epub 2017 Apr 19. PMID: 28423450German.No abstract available. [Salvage Procedure after Trapeziectomy using Mini TightRope®]. Funk EM. Handchir Mikrochir Plast Chir. 2017 Feb;49(1):67. doi: 10.1055/s-0042-119724. Epub 2017 Apr 19. PMID: 28423451German.No abstract available. Cited by 2 articles Full text links 94. Penetrating Thoracic Trauma Patients with Gross Physiological Derangement: A Responsibility for the General Surgeon in the Absence of Trauma or Cardiothoracic Surgeon? World J Surg. 2017 Jan;41(1):170-175. doi: 10.1007/s00268-016-3703-y. Authors Dietrich Doll 1 2 , Markus Eichler 2 , Pantelis Vassiliu 3 , Kenneth Boffard 4 , Tim Pohlemann 5 , Elias Degiannis 1 4 Affiliations 1 Department of Surgery, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand Medical School, Johannesburg, Republic of South Africa. 2 Department of Surgery, St.-Marien-Hospital Vechta, Academic Teaching Hospital of the MHH, Marienstr. 6, 49377, Vechta, Germany. 3 Department of Surgery, 4th Surgical Clinic, "Attikon" University Hospital, 15 Anexartisias str, 12461, Haidari, Athens, Greece. pant_greek@hotmail.com. 4 Department of Surgery, Netcare Milpark Academic Trauma Centre, University of the Witwatersrand Medical School, Johannesburg, Republic of South Africa. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Str. 100, 66421, Homburg/Saar, Germany. PMID: 27553197 DOI: 10.1007/s00268-016-3703-y Abstract Background: Penetrating trauma is becoming increasingly common in parts of the world where previously it was rare. At the same time, general surgeons and surgical trainees are becoming more specialized, and less comfortable operating within areas beyond their zone of specialization. Objective: The purpose of this manuscript is to assess the technical difficulties encountered in operating on patients who have sustained penetrating trauma, and to prove to general surgeons that the technical skills and techniques required are no different to those required for abdominal surgery, and do not require additional dexterity. Methods: This prospective study was conducted in an Academic Trauma unit over a 3-year period. All patients who were operated upon for penetrating thoracic trauma were included in the study. The pre-operative management, techniques of surgical repair and the outcome were assessed. Results: One hundred and forty-five patients were included in the study over a 3-year period. There were 97 patients with stab wounds, 47 with gunshot wounds and 1 patient with an injury from an angle grinder. Mortality was six times greater in those patients with gunshot wounds, than those with stab wounds. Several patients had multiple thoracic organ injuries. There were 57 patients who were operated upon for thoracic vessel injury. There was a 3.5 % mortality overall. Eighty-eight patients sustained pulmonary injury with a 7 % mortality, and they were managed mainly by simply repair, tractotomy or stapled partial non-anatomical lobectomy. Of the 39 patients with cardiac trauma, there was 17 % mortality, and all cases were managed by simple repair. There were 5 patients with an oesophageal injury of whom 3 died (mortality of 60 %). Twenty-four patients had thoraco-abdominal injuries with 30 % mortality. Conclusion: Most of the injuries in the chest can be managed by simple procedures to control life-threatening bleeding. The techniques required are similar to those taught to and are practiced comfortably by general surgeons used to work in the abdominal cavity. We encourage the general surgeon who receives a grossly unstable patient with penetrating thoracic trauma to operate, instead of adding risk to the patient's physiology by a transfer to cardio-thoracic or dedicated trauma units. Cited by 3 articles 15 references Full text links 95. Surgical treatment of pelvic ring fractures in the elderly now and then: a pelvic registry study Aging Clin Exp Res. 2017 Aug;29(4):639-646. doi: 10.1007/s40520-016-0612-8. Epub 2016 Aug 19. Authors Mika F Rollmann 1 , Steven C Herath 2 , Joerg H Holstein 2 , Tim Pohlemann 2 , Michael D Menger 3 , Tina Histing 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. mika.rollmann@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. 3 Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg/Saar, Germany. PMID: 27540742 DOI: 10.1007/s40520-016-0612-8 Abstract Background: With the demographic change, the treatment of elderly patients has become a major issue for health systems worldwide. Aims: The aim of this study was to analyze the change in the rate of surgical treatment of pelvic ring fractures in patients with an age of ≥60 years over a 22-year period depending on fracture type, age and sex. Methods: Data of 5665 patients with an age of ≥60 years, who were treated for pelvic ring fractures from 1991 to 2013 in one of 31 hospitals participating in the German Pelvic Trauma Registry, were included. The registry is divided into four time periods: t 1 = 1991-1993, t 2 = 1997-2000, t 3 = 2001-2008 and t 4 = 2009-2013. Data had been collected prospectively and was analyzed retrospectively, stratified for age and sex of the patients as well as type of fracture and mode of therapy (surgical vs. conservative). Results: There was a significant increase (p < 0.05) in the overall rate of surgical treatment. Nonetheless, during all time periods patients with an age of >70 years were significantly less frequently surgically treated compared to 60- to 70-year-olds. Regardless of the fracture type, the rate of surgical treatment was significantly higher (p < 0.05) in male compared to female patients during t 1 . While this difference persisted for type A and type B fractures, the frequency of surgical treatment of type C fractures approximated in males and females. Conclusions: The present data indicate that the rate of surgical treatment of pelvic ring fractures in elderly patients has significantly increased over the 22-year period. Nonetheless, older patients (>70 years) as well as female patients are still less frequently surgically treated. Keywords: Conservative; Elderly; Gender; Pelvic fractures; Surgery; Treatment. Cited by 3 articles Full text links 96. [Midterm Results for Quality of Life After Surgical Treatment of Moore Type V Fractures of the Tibial Plateau] Z Orthop Unfall. 2016 Oct;154(5):513-520. doi: 10.1055/s-0042-106905. Epub 2016 Jul 1. [Article in German] Authors R Wirbel 1 , A Weber 1 , J Heinzmann 2 , C Meyer 3 , T Pohlemann 2 Affiliations 1 Unfall-, Hand- und Wiederherstellungschirurgie, Verbundkrankenhaus Bernkastel-Wittlich, Wittlich. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätskliniken des Saarlandes, Homburg/Saar. 3 Zentrum für Orthopädie und Unfallchirurgie, Klinikum Saarbrücken. PMID: 27366953 DOI: 10.1055/s-0042-106905 Abstract Background: Dislocation fractures of the tibial plateau often lead to functional restrictions and subjective complaints from the patients. Besides functional and radiological results, criteria to determine the quality of life are of increasing importance. Intermediate term restriction in quality of life was evaluated and correlated with objective radiological results in patients with Moore type V dislocation fracture of the tibial plateau. Patients and Methods: From 2003 to 2012, a multicentre retrospective cohort study in three hospitals was used to register 36 patients with 38 Moore type V dislocation fractures of the tibial plateau. The injury mechanism, the surgical treatment (one step or two step surgery, single or double plate fixation) the complication rate, the radiological result (Kellgren/Lawrence osteoarthritis score, loss of reduction, secondary deviation of the axis) after a mean follow-up of 37 months, and the quality of life (pain and function by NRS, IKDC form, EQ 5D score) after a mean follow-up of 68 months (range, 15-128 months), were analysed. Results: The mean age of the 27 men and the 9 women was 50.8 years. There were 30 cases of high impact injury. An external fixator was used for primary fracture stabilisation in 24 knees; definitive internal fixation was performed in a second step. Internal fixation using a single plate was used in 12 knees, and double plate fixation in 25 knees; one patient was treated definitively with an external fixator. Early complications (3 × infection, 2 × compartment syndrome, 4 × implant failure) were seen in 21.1 % of patients; all could be cured surgically. The function of the affected knee joint gave a mean NRS of 4.53; the IKDC score was 50.46, and the EQ 5D 7.47. Only two patients (5 %) were free of pain, 27 (75 %) reported mild to moderate pain, and 7 patients (20 %) reported severe pain. Four patients are retired or have applied for a pension. Altogether, the quality of life was calculated as being 44 % of the initial value before the injury. Four patients required an endoprosthetic replacement at an early stage, after an average of 6 months. Signs of osteoarthritis (Kellgren/Lawrence > I) were seen in 32 of the remaining 33 fractures; 19 of these exhibited distinct signs of osteoarthritis (Kellgren/Lawrence III, IV). Loss of reduction (≥ 2 mm) was seen in 13 (34.2 %) and deviation of axis (> 10°) in 3 patients (7.8 %). There was no relation to the surgical strategy. However, there was a correlation between the subjective assessments of the quality of life and the radiological results. Conclusion: Moore type V dislocation fractures of the tibial plateau are severe knee injuries resulting in a distinct reduction in quality of life in the intermediate term. There is a correlation between the subjective assessments and the objective radiological results. Therefore, the congruency of the articular surface and the axis have to be reconstructed as precisely as possible when repairing fractures of the tibial plateau. Georg Thieme Verlag KG Stuttgart · New York. Cited by 1 article Full text links 97. [Talus Fractures - an Update] Zentralbl Chir. 2017 Apr;142(2):189-193. doi: 10.1055/s-0042-107950. Epub 2016 Jun 23. [Article in German] Authors N Veith 1 , B Braun 1 , M Hell 1 , M T Klein 1 , T Tschernig 2 , P Mörsdorf 1 , J H Holstein 1 , T Pohlemann 1 Affiliations 1 Universitätsklinikum des Saarlandes, Klinik für Unfall-Hand und Wiederherstellungschirurgie, Homburg, Deutschland. 2 Universität des Saarlandes, Medizinische Fakultät, Institut für Anatomie und Zellbiologie, Homburg, Deutschland. PMID: 27337117 DOI: 10.1055/s-0042-107950 Abstract Background: Talus fractures are rare and often result from axial trauma. As most of the talus surface is covered by cartilage, the blood supply is limited. Thus talus fractures are seen as one of the most severe fractures and often lead to significant long-term complications. Several studies suggest that the initial fracture classification can lead to correct treatment and that this can influence the long-term outcome. The aim of the current study was to investigate the importance of the initial fracture classification in respect to the radiological outcome in a large patient cohort. Patients and Methods: Over a span of 12 years, 61 patients with talus fractures were treated at our institution. Overall 45 patients were available for a retrospective analysis. Correlation analysis was performed between the initial fracture severity and the radiological outcome. Results: The average follow-up was 17.3 months (range 6-68). Significant correlations were found between the Marti-Weber Classification and Bargon Score (r s = 0.78; p < 0.0001), as well as between the Hawkins Classification and the Bargon Score (r s = 0.80; p < 0.0001). Conclusions: Precise prediction of the expected radiological outcome of talar neck and body fractures is possible through the initial fracture classification alone. Computed tomography is the accepted standard to determine the exact diagnosis and extent of injury. Georg Thieme Verlag KG Stuttgart · New York. Full text links 98. [Influence of the pelvic trauma registry of the DGU on treatment of pelvic ring fractures] Unfallchirurg. 2016 Jun;119(6):475-81. doi: 10.1007/s00113-016-0168-2. [Article in German] Authors J H Holstein 1 , F M Stuby 2 , S C Herath 3 , U Culemann 4 , E Aghayev 5 , T Pohlemann 3 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstraße 100, 66421, Homburg/Saar, Deutschland. joerg.holstein@uks.eu. 2 Abteilung für Unfall- und Wiederherstellungschirurgie, BG Klinik Tübingen, Schnarrenbergstrasse 95, 72076, Tübingen, Deutschland. 3 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstraße 100, 66421, Homburg/Saar, Deutschland. 4 Klinik für Unfallchirurgie, Allgemeines Krankenhaus Celle, Siemensplatz 4, 29223, Celle, Deutschland. 5 Institut für Evaluative Forschung in der Medizin, Universität Bern, Stauffacherstraße 78, 3014, Bern, Schweiz. PMID: 27169851 DOI: 10.1007/s00113-016-0168-2 Free article Abstract Fractures of the pelvic ring are comparatively rare with an incidence of 2-8 % of all fractures depending on the study in question. The severity of pelvic ring fractures can be very different ranging from simple and mostly "harmless" type A fractures up to life-threatening complex type C fractures. Although it was previously postulated that high-energy trauma was necessary to induce a pelvic ring fracture, over the past decades it became more and more evident, not least from data in the pelvic trauma registry of the German Society for Trauma Surgery (DGU), that low-energy minor trauma can also cause pelvic ring fractures of osteoporotic bone and in a rapidly increasing population of geriatric patients insufficiency fractures of the pelvic ring are nowadays observed with no preceding trauma.Even in large trauma centers the number of patients with pelvic ring fractures is mostly insufficient to perform valid and sufficiently powerful monocentric studies on epidemiological, diagnostic or therapeutic issues. For this reason, in 1991 the first and still the only registry worldwide for the documentation and evaluation of pelvic ring fractures was introduced by the Working Group Pelvis (AG Becken) of the DGU. Originally, the main objectives of the documentation were epidemiological and diagnostic issues; however, in the course of time it developed into an increasingly expanding dataset with comprehensive parameters on injury patterns, operative and conservative therapy regimens and short-term and long-term outcome of patients. Originally starting with 10 institutions, in the meantime more than 30 hospitals in Germany and other European countries participate in the documentation of data. In the third phase of the registry alone, which was started in 2004, data from approximately 15,000 patients with pelvic ring and acetabular fractures were documented. In addition to the scientific impact of the pelvic trauma registry, which is reflected in the numerous national and international publications, the dramatically changing epidemiology of pelvic ring fractures, further developments in diagnostics and the changes in operative procedures over time could be demonstrated. Last but not least the now well-established diagnostic and therapeutic algorithms for pelvic ring fractures, which could be derived from the information collated in registry studies, reflect the clinical impact of the registry. Keywords: Diagnostics algorithms; Epidemiology; Pelvic fracture; Registry; Therapy algorithms. Cited by 8 articles 20 references Full text links 99. Obesity does not affect the healing of femur fractures in mice Injury. 2016 Jul;47(7):1435-44. doi: 10.1016/j.injury.2016.04.030. Epub 2016 Apr 23. Authors T Histing 1 , A Andonyan 2 , M Klein 2 , C Scheuer 3 , D Stenger 2 , J H Holstein 2 , N T Veith 2 , T Pohlemann 2 , M D Menger 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. Electronic address: tina.histing@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. 3 Institute for Clinical & Experimental Surgery, University of Saarland, Homburg/Saar, Germany. PMID: 27156834 DOI: 10.1016/j.injury.2016.04.030 Abstract Obesity is reported to be both protective and deleterious to bone. Lipotoxicity and inflammation might be responsible for bone loss through inhibition of osteoblasts and activation of osteoclasts. However, little is known whether obesity affects the process of fracture healing. Therefore, we studied the effect of high fat diet-induced (HFD) obesity on callus formation and bone remodelling in a closed femur fracture model in mice. Thirty-one mice were fed a diet containing 60kJ% fat (HFD) for a total of 20 weeks before fracture and during the entire postoperative observation period. Control mice (n=31) received a standard diet containing 10kJ% fat. Healing was analyzed using micro-CT, biomechanical, histomorphometrical, immunohistochemical, serum and protein biochemical analysis at 2 and 4 weeks after fracture. HFD-fed mice showed a higher body weight and increased serum concentrations of leptin and interleukin-6 compared to controls. Within the callus tissue Western blot analyses revealed a higher expression of transcription factor peroxisome proliferator-activated receptor y (PPARy) and a reduced expression of runt-related transcription factor 2 (RUNX2) and bone morphogenetic protein (BMP)-4. However, obesity did not affect the expression of BMP-2 and did not influence the receptor activator of nuclear factor κB (RANK)/RANK ligand/osteoprotegerin (OPG) pathway during fracture healing. Although the bones of HFD-fed animals showed an increased number of adipocytes within the bone marrow, HFD did not increase callus adiposity. In addition, radiological and histomorphometric analysis could also not detect significant differences in bone formation between HFD-fed animals and controls. Accordingly, HFD did not affect bending stiffness after 2 and 4 weeks of healing. These findings indicate that obesity does not affect femur fracture healing in mice. Keywords: Bone formation; Bone remodelling; Callus adiposity; Fracture healing; Obesity. Copyright © 2016 Elsevier Ltd. All rights reserved. Cited by 9 articles Full text links 100. Two- and three-dimensional co-culture models of soft tissue healing: pericyte-endothelial cell interaction Cell Tissue Res. 2016 Aug;365(2):279-93. doi: 10.1007/s00441-016-2391-0. Epub 2016 Mar 30. Authors Martina Jennewein 1 , Monika Bubel 1 , Silke Guthörl 1 , Wolfgang Metzger 1 , Martin Weigert 1 , Tim Pohlemann 1 , Martin Oberringer 2 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Building 57, 66421, Homburg, Germany. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Building 57, 66421, Homburg, Germany. martin.oberringer@uks.eu. PMID: 27026609 DOI: 10.1007/s00441-016-2391-0 Abstract The demographic change in western countries towards an older population is being shadowed by an increased appearance of chronic diseases influencing soft tissue healing in a negative manner. Although various promising therapeutic approaches are available for treating chronic wounds, no in vitro model exists that successfully allows the analysis of interacting cells and of the effect of therapeutic drugs within a wound. Granulation tissue assures wound stability, neo-angiogenesis and revascularization finally leading to functional soft tissue repair. As one of the first steps in developing a model for human granulation tissue, we examined microvascular endothelial cells and pericytes in conventional 2D and in 3D spheroid co-cultures. We determined which parameters could be used in a standardized manner and whether the cultures were responsive to hypoxia and to erythropoietin supplementation. The read-out parameters of cell migration, cell density, rate of apoptotic cells, spatial cell distribution in the spheroid and spheroid volume were shown to be excellent analytic measures. In addition, quantification of hypoxia-related genes identified a total of 13 genes that were up-regulated in spheroids after hypoxia. As these parameters delivered reliable results in the present approach and as the general morphological distribution of pericytes and endothelial cells within the spheroid occurred in a typical manner, we believe that this basic in vitro model will serve for the future study of diverse aspects of soft tissue healing. Keywords: Granulation tissue; Hypoxia; Microvascular endothelial cells; Pericytes; Wound healing. Cited by 1 article Full text links 101. Effect of Stabilization on the Healing Process of Femur Fractures in Aged Mice J Invest Surg. 2016 Aug;29(4):202-8. doi: 10.3109/08941939.2015.1127448. Epub 2016 Feb 18. Authors T Histing 1 , K Heerschop 1 , M Klein 1 , C Scheuer 2 , D Stenger 1 , S C Herath 1 , T Pohlemann 1 , M D Menger 2 Affiliations 1 a Department of Trauma, Hand and Reconstructive Surgery , Saarland University , D-66421 Homburg/Saar, Germany. 2 b Institute for Clinical & Experimental Surgery , Saarland University , Homburg/Saar, Germany. PMID: 26891453 DOI: 10.3109/08941939.2015.1127448 Abstract Background: The influence of mechanical stability on fracture healing has previously been studied in adult mice, but is poorly understood in aged animals. Therefore, we herein studied the effect of stabilization on the healing process of femur fractures in aged mice. Methods: Twenty-four 18-month-old CD-1 mice were stabilized after midshaft fracture of the femur with an intramedullary screw. In another 24 18-month-old mice, the femur fractures were left unstabilized. Bone healing was studied by radiological, biomechanical, histomorphometric, and protein expression analyses. Results: After 2 and 5 weeks of healing, the callus of nonstabilized fractures compared to stabilized fractures was significantly larger, containing a significantly smaller amount of osseous tissue and a higher amount of cartilaginous tissue. This was associated with a significantly lower biomechanical stiffness during the early phase of healing. However, during the late phase of fracture healing both nonstabilized and stabilized fractures showed a biomechanical stiffness of ∼40%. Of interest, Western blot analyses of callus tissue demonstrated that the expression of proteins related to angiogenesis, bone formation and remodeling, i.e. VEGF, CYR61, BMP-2, BMP-4, Col-2, Col-10, RANKL, OPG, did not differ between nonstabilized and stabilized fractures. Conclusion: Nonstabilized fractures in aged mice show delayed healing and remodeling. This is not caused by an altered protein expression in the callus but rather by the excessive interfragmentary movements. Keywords: aging; bone remodeling; fracture; mechanical stability; nonstabilization; stabilization. Cited by 3 articles Full text links 102. Osteogenic differentiation of immature osteoblasts: Interplay of cell culture media and supplements Biotech Histochem. 2016;91(3):161-9. doi: 10.3109/10520295.2015.1110254. Epub 2016 Jan 21. Authors A Brauer 1 , T Pohlemann 1 , W Metzger 1 Affiliation 1 a Department of Trauma , Hand and Reconstructive Surgery, Saarland University , Homburg , Germany. PMID: 26795823 DOI: 10.3109/10520295.2015.1110254 Abstract Differentiation of immature osteoblasts to mature osteoblasts in vitro initially was induced by supplementing the medium with β-gylcerophosphate and dexamethasone. Later, ascorbic acid, vitamin D3, vitamin K3 and TGFβ1 were used in varying concentrations as supplements to generate a mature osteoblast phenotype. We tested the effects of several combinations of cell culture media, seeding protocols and osteogenic supplements on osteogenic differentiation of human primary osteoblasts. Osteogenic differentiation was analyzed by staining alkaline phosphatase (ALP) with 5-bromo-4-chloro-3-indolyl-phosphate/nitro blue tetrazolium (BCIP/NBT) and by von Kossa staining of deposited calcium phosphate. The combinations of culture media and supplements significantly influenced osteogenic differentiation, but the seeding protocol did not. Staining of ALP and calcium phosphate could be achieved only if our own mix of osteogenic supplements was used in combination with Dulbecco's modified Eagle medium or if a commercial mix of osteogenic supplements was used in combination with osteoblast growth medium. Especially for von Kossa, we observed great variations in the staining intensity. Because osteogenic differentiation is a complex process, the origin of the osteoblasts, cell culture media and osteogenic supplements should be established by preliminary experiments to achieve optimal differentiation. Staining of ALP or deposited calcium phosphate should be supplemented with qRT-PCR studies to learn more about the influence of specific supplements on osteogenic markers. Keywords: alkaline; cell culture; culture media; human; osteoblasts; osteogenic differentiation; osteogenic supplements; phosphatase; von Kossa staining. Cited by 18 articles Full text links 103. [Saw Injuries to the Hand - Epidemiological Aspects] Zentralbl Chir. 2017 Apr;142(2):194-198. doi: 10.1055/s-0041-107435. Epub 2015 Dec 17. [Article in German] Authors N T Veith 1 , B Braun 1 , T Fritz 1 , T Pohlemann 1 , T Tschernig 2 , R Ziegler 1 , P Mörsdorf 1 , W Knopp 1 Affiliations 1 Universitätsklinikum des Saarlandes, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Homburg, Deutschland. 2 Universität des Saarlandes, Institut für Anatomie und Zellbiologie, Homburg, Deutschland. PMID: 26679716 DOI: 10.1055/s-0041-107435 Abstract Background: No current studies regarding saw injuries have been published in German literature for quite some time. Despite awareness measures and safety instructions, saw accidents along with crush injuries are the most common causes of severe hand injuries. Approximately 12,000 circular saw injuries occur in Germany each year. Since professional providers have increased prices due to the rising energy costs and a wide range of different home appliance saws are available, increasing use has been made of portable circular saws in the do-it-yourself market sector. Patients and methods: At our hospital, we evaluated the data of 51 male patients with saw injuries. The present study investigated factors that may contribute to accidents involving saws. Results: 80 % of the accidents occurred at home, usually on weekends or after work. 51 % of the accidents happened while patients cut firewood. In 84 % of the cases, an electric table saw was used. The majority of severe hand injuries were sustained with lower priced saws. Injuries occurred most frequently between 11 a. m. and 2 p. m., primarily with injuries to bones, tendons, blood vessels and nerves. Replantable amputations or partial amputations occured rarely. In 37 % of the patients, anatomical reconstruction using osteosynthesis and/or microsurgical techniques was performed successfully. Conclusions: Saw injuries to the hand are sustained almost exclusively by men. Serious injuries from low-priced table saws and due to the lack of protective covering are predominant. Preventive measures and mandatory training could reduce the number of saw injuries in the years to come. The results obtained by us largely confirm the data from previous publications. Georg Thieme Verlag KG Stuttgart · New York. Cited by 1 article Full text links 104. A novel tool for continuous fracture aftercare - Clinical feasibility and first results of a new telemetric gait analysis insole Injury. 2016 Feb;47(2):490-4. doi: 10.1016/j.injury.2015.11.004. Epub 2015 Nov 12. Authors Benedikt J Braun 1 , Eva Bushuven 2 , Rebecca Hell 3 , Nils T Veith 3 , Jan Buschbaum 3 , Joerg H Holstein 3 , Tim Pohlemann 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany. Electronic address: benedikt.braun@uks.eu. 2 Department of Diagnostic and Interventional Radiology, Saarland University Hospital, Germany. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany. PMID: 26626806 DOI: 10.1016/j.injury.2015.11.004 Abstract Weight bearing after lower extremity fractures still remains a highly controversial issue. Even in ankle fractures, the most common lower extremity injury no standard aftercare protocol has been established. Average non weight bearing times range from 0 to 7 weeks, with standardised, radiological healing controls at fixed time intervals. Recent literature calls for patient-adapted aftercare protocols based on individual fracture and load scenarios. We show the clinical feasibility and first results of a new, insole embedded gait analysis tool for continuous monitoring of gait, load and activity. Ten patients were monitored with a new, independent gait analysis insole for up to 3 months postoperatively. Strict 20 kg partial weight bearing was ordered for 6 weeks. Overall activity, load spectrum, ground reaction forces, clinical scoring and general health data were recorded and correlated. Statistical analysis with power analysis, t-test and Spearman correlation was performed. Only one patient completely adhered to the set weight bearing limit. Average time in minutes over the limit was 374 min. Based on the parameters load, activity, gait time over 20 kg weight bearing and maximum ground reaction force high and low performers were defined after 3 weeks. Significant difference in time to painless full weight bearing between high and low performers was shown. Correlation analysis revealed a significant correlation between weight bearing and clinical scoring as well as pain (American Orthopaedic Foot and Ankle Society (AOFAS) Score rs=0.74; Olerud-Molander Score rs=0.93; VAS pain rs=-0.95). Early, continuous gait analysis is able to define aftercare performers with significant differences in time to full painless weight bearing where clinical or radiographic controls could not. Patient compliance to standardised weight bearing limits and protocols is low. Highly individual rehabilitation patterns were seen in all patients. Aftercare protocols should be adjusted to real-time patient conditions, rather than fixed intervals and limits. With a real-time measuring device high performers could be identified and influenced towards optimal healing conditions early, while low performers are recognised and missing healing influences could be corrected according to patient condition. Keywords: Aftercare performance; Ankle fracture; Continuous fracture monitoring; Gait analysis. Copyright © 2015 Elsevier Ltd. All rights reserved. Cited by 19 articles Full text links 105. Characterization of the healing process in non-stabilized and stabilized femur fractures in mice Arch Orthop Trauma Surg. 2016 Feb;136(2):203-11. doi: 10.1007/s00402-015-2367-7. Epub 2015 Nov 24. Authors T Histing 1 , K Heerschop 2 , M Klein 2 , C Scheuer 3 , D Stenger 2 , J H Holstein 2 , T Pohlemann 2 , M D Menger 3 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. tina.histing@uks.eu. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg/Saar, Germany. 3 Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg/Saar, Germany. PMID: 26602903 DOI: 10.1007/s00402-015-2367-7 Abstract Background: Although a variety of suitable fracture models for mice exist, in many studies bone healing was still analyzed without fracture stabilization. Because there is little information whether the healing of non-stabilized fractures differs from that of stabilized fractures, we herein studied the healing process of non-stabilized compared to stabilized femur fractures. Materials and methods: Twenty-one CD-1 mice were stabilized after midshaft fracture of the femur with an intramedullary screw allowing micromovements and endochondral healing. In another 22 mice the femur fractures were left unstabilized. Bone healing was studied by radiological, biomechanical, histomorphometric and protein expression analyses. Results: Non-stabilized femur fractures revealed a significantly lower biomechanical stiffness compared to stabilized fractures. During the early phase of fracture healing non-stabilized fractures demonstrated a significantly lower amount of osseous tissue and a higher amount of cartilage tissue. During the late phase of fracture healing both non-stabilized and stabilized fractures showed almost 100 % osseous callus tissue. However, in stabilized fractures remodeling was almost completed with lamellar bone while non-stabilized fractures still showed large callus with great amounts of woven bone, indicating a delay in bone remodeling. Of interest, western blot analyses of callus tissue demonstrated in non-stabilized fractures a significantly reduced expression of vascular endothelial growth factor and a slightly lowered expression of bone morphogenetic protein-2 and collagen-10. Conclusion: Non-stabilized femur fractures in mice show a marked delay in bone healing compared to stabilized fractures. Therefore, non-stabilized fracture models may not be used to analyze the mechanisms of normal bone healing. Keywords: Bone remodeling; Fracture; Mice; Non-stabilization; Stabilization. Cited by 6 articles Full text links 106. Validation and reliability testing of a new, fully integrated gait analysis insole J Foot Ankle Res. 2015 Sep 22:8:54. doi: 10.1186/s13047-015-0111-8. eCollection 2015. Authors Benedikt Johannes Braun 1 , Nils Thomas Veith 1 , Rebecca Hell 1 , Stefan Döbele 2 , Michael Roland 3 , Mika Rollmann 1 , Jörg Holstein 1 , Tim Pohlemann 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrbergerstr. 1, 66421 Homburg, Germany. 2 BG Trauma Center, Department of Trauma Surgery, Eberhard Karls University Tübingen, Tübingen, Germany. 3 Saarland University, Chair of Applied Mechanics, Saarbruecken, Germany. PMID: 26396594 PMCID: PMC4578601 DOI: 10.1186/s13047-015-0111-8 Abstract Background: A new tool (OpenGo, Moticon GmbH) was introduced to continuously measure kinetic and temporospatial gait parameters independently through an insole over up to 4 weeks. The goal of this study was to investigate the validity and reliability of this new insole system in a group of healthy individuals. Methods: Gait data were collected from 12 healthy individuals on a treadmill at two different speeds. In total, six trials of three minutes each were performed by every participant. Validation was performed with the FDM-S System (Zebris). Complete sensor data were used for a within test reliability analysis of over 10000 steps. Intraclass correlation was calculated for different gait parameters and analysis of variance performed. Results: Intraclass correlation for the validation was >0.796 for temporospatial and kinetic gait parameters. No statistical difference was seen between the insole and force plate measurements (difference between means: 36.3 ± 27.19 N; p = 0.19 and 0.027 ± 0.028 s; p = 0.36). Intraclass correlation for the reliability was >0.994 for all parameters measured. Conclusion: The system is feasible for clinical trials that require step by step as well as grouped analysis of gait over a long period of time. Comparable validity and reliability to a stationary analysis tool has been shown. Keywords: Gait analysis; Integrated insole system; Reliability; Validation. Cited by 38 articles 30 references 4 figures Full text links 107. Fracture healing redefined Med Hypotheses. 2015 Dec;85(6):940-3. doi: 10.1016/j.mehy.2015.09.006. Epub 2015 Sep 5. Authors B J Braun 1 , M Rollmann 2 , N Veith 2 , T Pohlemann 2 Affiliations 1 Department of Trauma-, Hand-, Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. Electronic address: benedikt.braun@uks.eu. 2 Department of Trauma-, Hand-, Reconstructive Surgery, Saarland University Hospital, Homburg, Germany. PMID: 26364044 DOI: 10.1016/j.mehy.2015.09.006 Abstract It is well established that local mechanical conditions and interfragmentary movement are important factors for successful bone healing and may vary dramatically with patient fracture-load and activity. Up until now however it was technically impossible to use these key influence parameters in the aftercare treatment process of human lower extremity fractures. We propose a theory that with state of the art sensor technology these biomechanical influences can not only be monitored in vivo, but also used for individualized therapy protocols. Local measurement systems for fracture healing are available but remain research tools, due to various technical issues. To investigate the biomechanical influences on healing right away surrogate sensor tools are needed. Various gait characteristics have been proposed as surrogate measures. Currently available sensor tools could be modified with the appropriate support structure to allow such measurements continuously over the course of a fracture healing. Interdisciplinary work between clinicians, software engineers with computer and biomechanical simulations is needed. Through such a sensor system human boundary conditions for fracture healing could not only be defined for the first time, but also used for a unique, extendible aftercare system. With this tool critical healing situations would be detected much earlier and could be prevented with easy activity modifications, reducing patient and socioeconomic burden of disease. The hypothesis, necessary tools and support structures are presented. Copyright © 2015 Elsevier Ltd. All rights reserved. Cited by 3 articles Full text links 108. Predictors of mortality for complex fractures of the pelvic ring in the elderly: a twelve-year review from a German level I trauma center Injury. 2015 Oct;46(10):1996-8. doi: 10.1016/j.injury.2015.07.034. Epub 2015 Aug 3. Authors Ishaq Ojodu 1 , Tim Pohlemann 2 , Sascha Hopp 2 , Mika F R Rollmann 2 , Joerg H Holstein 2 , Steven C Herath 3 Affiliations 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg/Saar, Germany; Department of Orthopedic and Trauma Surgery, Cedarcrest Hospital, 37 Oladipo Bateye Street, 23401 Lagos, Nigeria. 2 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg/Saar, Germany. 3 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg/Saar, Germany. Electronic address: steven.herath@uks.eu. PMID: 26275513 DOI: 10.1016/j.injury.2015.07.034 Abstract Study objective: To document mortality rate and predictors of mortality in elderly patients with complex pelvic fractures. Methods: We reviewed a total of 84 subjects whose ages were above 70 years with complex pelvic fractures, admitted to our hospital from January 2001 to December 2012. A multivariate linear regression model was used to determine the predictors of mortality in the study population. The median age of the patients was 80.4 years (range 70-94 years). 65 of 84 (77%) patients were females. There were 72 Tile Type B fractures (86%) and 12 Type C fractures (14%). The most common associated injuries were thoracic, extremity and head injuries, with incidence of 13 (15%), 11 (13%), and 9 (11%), respectively. Results: The mortality rate was 10% in our study population. The initial haemoglobin on admission (p<0.01), the presence of blood vessel injuries (p<0.01) and the number of PRBCs transfused within the first six hours after admission (p<0.01) independently predicted mortality in elderly patients with complex pelvic fractures. Conclusion: Although there is a downward trend in mortality in elderly patients with complex pelvic fractures, haemodynamic instability still has a significant impact on survival of those patients. Keywords: Elderly; Mortality; Pelvic fracture; Predictors. Copyright © 2015 Elsevier Ltd. All rights reserved. Comment in Regarding the predictors of mortality for complex fractures of the pelvic ring in the elderly. Živković V, Ille M, Nikolić S. Injury. 2016 Feb;47(2):509-10. doi: 10.1016/j.injury.2015.11.021. Epub 2015 Nov 23. PMID: 26653773No abstract available. Cited by 14 articles Full text links 109. Stimulation of angiogenesis by cilostazol accelerates fracture healing in mice J Orthop Res. 2015 Dec;33(12):1880-7. doi: 10.1002/jor.22967. Epub 2015 Jul 7. Authors Steven C Herath 1 , Thorsten Lion 1 , Moritz Klein 1 , David Stenger 1 , Claudia Scheuer 2 , Jörg H Holstein 1 , Philipp Mörsdorf 1 , Mika F R Rollmann 1 , Tim Pohlemann 1 , Michael D Menger 2 , Tina Histing 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Saarland, Germany. 2 Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Saarland, Germany. PMID: 26134894 DOI: 10.1002/jor.22967 Free article Abstract Cilostazol, a selective phosphodiesterase-3 inhibitor, is known to control cyclic adenosine monophosphate (c-AMP) and to stimulate angiogenesis through upregulation of pro-angiogenic factors. There is no information, however, whether cilostazol affects fracture healing. We, therefore, studied the effect of cilostazol on callus formation and biomechanics during fracture repair. Bone healing was analyzed in a murine femur fracture stabilized with an intramedullary screw. Radiological, biomechanical, histomorphometric, histochemical, and protein biochemical analyses were performed at 2 and 5 weeks after fracture. Twenty-five mice received 30 mg/kg body weight cilostazol p.o. daily. Controls (n=24) received equivalent amounts of vehicle. In cilostazol-treated animals radiological analysis at 2 weeks showed an improved healing with an accelerated osseous bridging compared to controls. This was associated with a significantly higher amount of bony tissue and a smaller amount of cartilage tissue within the callus. Western blot analysis showed a higher expression of cysteine-rich protein 61 (CYR61), bone morphogenetic protein (BMP)-4, and receptor activator of NF-kappaB ligand (RANKL). At 5 weeks, improved fracture healing after cilostazol treatment was indicated by biomechanical analyses, demonstrating a significant higher bending stiffness compared to controls. Thus, cilostazol improves fracture healing by accelerating both bone formation and callus remodeling. Keywords: BMP-4; CYR61; RANKL; cilostazol; fracture healing. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Cited by 6 articles Full text links 110. Response of endothelial cells and pericytes to hypoxia and erythropoietin in a co-culture assay dedicated to soft tissue repair Mol Cell Biochem. 2015 Sep;407(1-2):29-40. doi: 10.1007/s11010-015-2451-x. Epub 2015 May 31. Authors Gerrit Schneider 1 , Monika Bubel , Tim Pohlemann , Martin Oberringer Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Bldng. 57, 66421, Homburg, Germany. PMID: 26026617 DOI: 10.1007/s11010-015-2451-x Abstract The increasing mean life expectancy of the citizens of the western world countries leads to an increase of the age-related diseases, among them soft tissue defects exhibiting inadequate healing. In order to develop new therapeutic strategies to support disturbed soft tissue repair, there is a strong need of sophisticated in vitro assays. A new assay combining scratch wounding with co-cultures of primary human microvascular endothelial cells (HDMEC) and pericytes (HPC) focuses on basic characteristics of cell interaction against the background of soft tissue repair. The cell parameters proliferation, migration and differentiation, and the release of monocyte chemoattractant protein-1 (MCP-1) were analysed in response to hypoxia (pO2 < 5 mmHg) and to erythropoietin (EPO; 50 IU/ml), a glycoprotein hormone having shown promising effects in soft tissue repair. As basic characteristics of the assay, direct cell contact in co-culture led to a weakened proliferation of both cell types, an increase of the percentage of myofibroblast-like pericytes and to a higher release of MCP-1. Hypoxia caused a proliferation decrease of HPC in co-culture, which was slightly attenuated by EPO. Hypoxia also reduced the MCP-1 release of co-cultured cells, when EPO had been added. In addition, EPO had a rather positive effect on HPC migration under hypoxia. These in vitro results allow new insights into the interaction of pericytes with endothelial cells in the context of soft tissue repair. Cited by 5 articles 42 references Full text links 111. Seltene Kombinationsverletzung des Unterarmes nach Abstütztrauma Chirurg. 2016 Feb;87(2):162-4. doi: 10.1007/s00104-015-0025-9. [Article in German] Authors N T Veith 1 , W Knopp 2 , A Pizanis 2 , T Tschernig 3 , T Pohlemann 2 , P Mörsdorf 2 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Kirrberger Straße 1, 66421, Homburg/Saar, Deutschland. nils.veith@uks.eu. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Kirrberger Straße 1, 66421, Homburg/Saar, Deutschland. 3 Institut für Anatomie und Zellbiologie, Universität des Saarlandes, 66421, Homburg, Deutschland. PMID: 26016712 DOI: 10.1007/s00104-015-0025-9 No abstract available 7 references Full text links 112. [Penetrating injury of two body cavities with a 20 cm long dagger-like sliver after falling into a glass door] Unfallchirurg. 2015 Nov;118(11):982-6. doi: 10.1007/s00113-014-2719-8. [Article in German] Authors P Mörsdorf 1 , S C Herath 2 , H V Groesdonk 3 , S Hoersch 3 , T Pohlemann 2 , M Burkhardt 4 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland. philipp.moersdorf@uks.eu. 2 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland. 3 Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland. 4 Abteilung für Unfallchirurgie & Orthopädie, Evangelisches Stadtkrankenhaus Saarbrücken, Saarbrücken, Deutschland. PMID: 25747944 DOI: 10.1007/s00113-014-2719-8 Abstract In Germany the numbers of penetrating thoracic injuries are rare compared to Anglo-American countries; however, the number of cases has increased in recent years due to an increase in violent incidents. This article reports the case of a patient who suffered such a penetrating thoracic injury after a domestic accident. Operative treatment was performed according to the well-established standard treatment algorithms. Contrary to the initial assessment of the emergency doctor, substantially more severe injuries were found. Keywords: Accidental; Domestic accident; Penetrating injuries; Thoracic injuries; Treatment algorithm. 13 references Full text links 113. Comparison of healing process in open osteotomy model and open fracture model: Delayed healing of osteotomies after intramedullary screw fixation J Orthop Res. 2015 Jul;33(7):971-8. doi: 10.1002/jor.22861. Epub 2015 Apr 10. Authors Moritz Klein 1 , Andrea Stieger 1 , David Stenger 1 , Claudia Scheuer 2 , Jörg H Holstein 1 , Tim Pohlemann 1 , Michael D Menger 2 , Tina Histing 1 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, D-66421, Homburg/Saar, Germany. 2 Institute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany. PMID: 25732349 DOI: 10.1002/jor.22861 Free article Abstract Murine osteotomy and fracture models have become the standard to study molecular mechanisms of bone healing. Because there is little information whether the healing of osteotomies differs from that of fractures, we herein studied in mice the healing of femur osteotomies compared to femur fractures. Twenty CD-1 mice underwent a standardized open femur osteotomy. Another 20 mice received a standardized open femur fracture. Stabilization was performed by an intramedullary screw. Bone healing was studied by micro-CT, biomechanical, histomorphometric and protein expression analyses. Osteotomies revealed a significantly lower biomechanical stiffness compared to fractures. Micro-CT showed a reduced bone/tissue volume within the callus of the osteotomies. Histomorphometric analyses demonstrated also a significantly lower amount of osseous tissue in the callus of osteotomies (26% and 88% after 2 and 5 weeks) compared to fractures (50% and 100%). This was associated with a delayed remodeling. Western blot analyses demonstrated comparable BMP-2 and BMP-4 expression, but higher levels of collagen-2, CYR61 and VEGF after osteotomy. Therefore, we conclude that open femur osteotomies in mice show a markedly delayed healing when stabilized less rigidly with an intramedullary screw. This should be considered when choosing a model for studying the mechanisms of bone healing in mice. Keywords: CYR61; VEGF; bone healing; callus remodeling; mouse. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Cited by 11 articles Full text links 114. Posterior symphyseal spurs--an unusual differential diagnosis in athletes with groin pain Phys Sportsmed. 2015 May;43(2):150-4. doi: 10.1080/00913847.2015.1012038. Epub 2015 Feb 11. Authors Sascha Jörg Hopp 1 , Ishaq Ojodu , Tim Pohlemann , Jens Kelm Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Saarland , Homburg , Germany. PMID: 25673359 DOI: 10.1080/00913847.2015.1012038 Abstract We set out to highlight the significance of posterior symphyseal spurs as an unusual diagnostic possibility in athletes with chronic groin pain and to demonstrate that operative resection was successful in quickly and safely returning the patients to sporting activities. Five competitive nonprofessional male athletes, three soccer players, and two marathon runners (median age: 30 [26/33] years), who presented to us with significant groin and central pubic pain with duration of at least 12 months, and who had failed conservative or surgical interventions (symphyseal plating), were evaluated. Physical examination as well as pelvic radiographs confirmed the diagnosis of posterior symphyseal spurs. Four out of five athletes underwent complete resection of the spur. Size of spurs was 2.2 (1.3/2.9) cm (median) with four of them posterosuperiorly and one posterocentrally located. All of them had uneventful postoperative recovery period and were still pain-free at the latest follow up after 26.6 months (24/30). Median time-to-return to competitive sports level was 10 weeks (8/13). None of the patients developed pubic instability due to symphyseal spur resection. The results of considerable postoperative improvement in our patients highlight the significance of posterior symphyseal spurs as a diagnostic possibility in athletes with chronic groin pain. Keywords: Symphyseal spurs; athletes; groin pain; pubalgia; pubic symphysis; surgery. Cited by 1 article Full text links 115. Dynamic locking screw improves fixation strength in osteoporotic bone: an in vitro study on an artificial bone model Int Orthop. 2015 Apr;39(4):761-8. doi: 10.1007/s00264-014-2658-6. Epub 2015 Jan 28. Authors Tim Pohlemann 1 , Boyko Gueorguiev , Yash Agarwal , Dieter Wahl , Christoph Sprecher , Karsten Schwieger , Mark Lenz Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University Hospital Saarland, Saar, Germany, tim.pohlemann@uks.eu. PMID: 25623135 DOI: 10.1007/s00264-014-2658-6 Abstract Purpose: The novel dynamic locking screw (DLS) was developed to improve bone healing with locked-plate osteosynthesis by equalising construct stiffness at both cortices. Due to a theoretical damping effect, this modulated stiffness could be beneficial for fracture fixation in osteoporotic bone. Therefore, the mechanical behaviour of the DLS at the screw-bone interface was investigated in an artificial osteoporotic bone model and compared with conventional locking screws (LHS). Methods: Osteoporotic surrogate bones were plated with either a DLS or a LHS construct consisting of two screws and cyclically axially loaded (8,500 cycles, amplitude 420 N, increase 2 mN/cycle). Construct stiffness, relative movement, axial screw migration, proximal (P) and distal (D) screw pullout force and loosening at the bone interface were determined and statistically evaluated. Results: DLS constructs exhibited a higher screw pullout force of P 85 N [standard deviation (SD) 21] and D 93 N (SD 12) compared with LHS (P 62 N, SD 28, p = 0.1; D 57 N, SD 25, p < 0.01) and a significantly lower axial migration over cycles compared with LHS (p = 0.01). DLS constructs showed significantly lower axial construct stiffness (403 N/mm, SD 21, p < 0.01) and a significantly higher relative movement (1.1 mm, SD 0.05, p < 0.01) compared with LHS (529 N/mm, SD 27; 0.8 mm, SD 0.04). Conclusion: Based on the model data, the DLS principle might also improve in vivo plate fixation in osteoporotic bone, providing enhanced residual holding strength and reducing screw cutout. The influence of pin-sleeve abutment still needs to be investigated. Cited by 3 articles 31 references Full text links 116. [Purpura fulminans of the adult--a hematological emergency] Dtsch Med Wochenschr. 2014 Dec;139(50):2597-601. doi: 10.1055/s-0034-1387428. Epub 2014 Dec 3. [Article in German] Authors N T Veith 1 , T Tschernig 2 , B J Braun 1 , T Pohlemann 1 , G Aßmann 3 Affiliations 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie - Universität des Saarlandes, Homburg (Saar). 2 Institut für Anatomie und Zellbiologie - Universität des Saarlandes, Homburg (Saar). 3 Onkologie, Hämatologie, Klinische Immunologie und Rheumatologie - Universität des Saarlandes, Homburg (Saar). PMID: 25469695 DOI: 10.1055/s-0034-1387428 Abstract History and clinical findings: A 51-year-old female patient with history of longterm drug abuse, was admitted to our hospital with large, stocking-shaped areas of painful, non-displaceable confluent bruising reaching up to the groin. Investigations: The emergency laboratory tests showed leucopenia, thrombocytopenia and anemia as well as a distinct protein C deficiency. Diagnosis, treatment and course: Purpura fulminans was diagnosed and treated with an initial dose of protein C. The patient survived and the skin necrosis can be treated. Conclusion: Purpura fulminans is an internistic and dermatological emergency situation which can lead to shock through consumptive coagulopathy. The serious course of disease can be prevented by rapid treatment with protein C. © Georg Thieme Verlag KG Stuttgart · New York. Full text links 117. Evaluation of the effectiveness of the angular stable locking system in patients with distal tibial fractures treated with intramedullary nailing: a multicenter randomized controlled trial J Bone Joint Surg Am. 2014 Nov 19;96(22):1889-97. doi: 10.2106/JBJS.M.01355. Authors Dankward Höntzsch 1 , Klaus-Dieter Schaser 2 , Gunther O Hofmann 3 , Tim Pohlemann 4 , Einar Sturla Hem 5 , Erik Rothenbach 6 , Christian Krettek 7 , René Attal 8 Affiliations 1 Berufsgenossenschaftliche Unfallklinik Tübingen, Schnarrenbergstrasse 95, D-72076 Tübingen, Germany. 2 Centrum fur Muskuloskeletale Chirurgie, Campus Verchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany. 3 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Friedrich-Schiller-Universität Jena, Erlanger Allee 101, D-07740 Jena, Germany. 4 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Kirrberger Strasse, D-66421 Homburg/Saar, Germany. 5 Sykehuset I Vestfold HF Tønsberg, Halfdan Wilhelmsens allé 17, Postboks 2168, N-3103 Tønsberg, Norway. 6 Klinik und Poliklinik fur Unfallchirurgie, Universitätsmedizin Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany. 7 Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D-30625 Hannover, Germany. 8 Universitätsklinik für Unfallchirurgie und Sporttraumatologie, Medizinische Universität Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. E-mail address: rene.attal@uki.at. PMID: 25410507 DOI: 10.2106/JBJS.M.01355 Abstract Background: Angular stable locking of intramedullary nails has been shown to enhance fixation stability of tibial fractures in biomechanical and animal studies. The aim of our study was to assess whether use of the angular stable locking system or conventional locking resulted in earlier full weight-bearing with minimum pain for patients with a distal tibial fracture treated with an intramedullary nail. Methods: A prospective multicenter, randomized, patient-blinded trial was conducted with adults who had a distal tibial fracture. Patients' fractures were managed with an intramedullary nail locked with either an angular stable locking system or conventional locking screws. Outcomes were evaluated at six weeks, twelve weeks, six months, and one year after surgery. Time to full weight-bearing with minimum pain was calculated with use of daily entries from patient diaries. Secondary outcomes included pain at the fracture site under load, quality of life, gait analysis, mobility, radiographic findings, and adverse events. Results: One hundred and forty-two patients were randomly allocated to two treatment groups: seventy-five to the group receiving intramedullary nailing with the angular stable locking system and sixty-seven to the group receiving conventional intramedullary nailing. No clinically important differences were found for either the primary or secondary outcome parameters between the groups during the entire follow-up period. Conclusions: Use of an angular stable locking system with intramedullary nailing did not improve the outcome compared with conventional locking screws in the treatment of distal tibial fractures. Trial registration: ClinicalTrials.gov NCT00875992 . Copyright © 2014 by The Journal of Bone and Joint Surgery, Incorporated. Cited by 3 articles Full text links 118. Pelvic fracture in multiple trauma: are we still up-to-date with massive fluid resuscitation? Injury. 2014 Oct:45 Suppl 3:S70-5. doi: 10.1016/j.injury.2014.08.021. Authors Markus Burkhardt 1 , Alexander Kristen 2 , Ulf Culemann 3 , Daniel Koehler 4 , Tina Histing 5 , Joerg H Holstein 6 , Antonius Pizanis 7 , Tim Pohlemann 8 ; TraumaRegister DGU ; German Pelvic Injury Register Affiliations 1 Department of Trauma, Orthopaedic and Hand Surgery, Protestant City Hospital, Großherzog-Friedrich-Straße 44, 66111 Saarbrücken, Germany. Electronic address: mac.burkhardt@t-online.de. 2 Department of Trauma, Orthopaedic and Hand Surgery, Protestant City Hospital, Großherzog-Friedrich-Straße 44, 66111 Saarbrücken, Germany. Electronic address: alexander.kristen@me.com. 3 Department of Trauma Surgery, General Hospital Celle, Siemensplatz 4, 29223 Celle, Germany. Electronic address: ulf.culemann@akh-celle.de. 4 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421 Homburg/Saar, Germany. Electronic address: daniel.koehler@uks.eu. 5 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421 Homburg/Saar, Germany. Electronic address: tina.histing@uks.eu. 6 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421 Homburg/Saar, Germany. Electronic address: joerg.holstein@uks.eu. 7 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421 Homburg/Saar, Germany. Electronic address: antonius.pizanis@uks.eu. 8 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421 Homburg/Saar, Germany. Electronic address: tim.pohlemann@uks.eu. PMID: 25284239 DOI: 10.1016/j.injury.2014.08.021 Abstract Until today the mortality of complex pelvic trauma remains unacceptably high. On the one hand this could be attributed to a biological limit of the survivable trauma load, on the other hand side an ongoing inadequate treatment might be conceivable too. For the management of multiple trauma patients with life-threatening pelvic fractures, there is ongoing international debate on the adequate therapeutic strategy, e.g. arterial embolization or pelvic packing, as well as aggressive or restrained volume therapy. Whereas traditional pelvis-specific trauma algorithms still recommend massive fluid resuscitation, there is upcoming evidence that a restrained volume therapy in the preclinical setting may improve trauma outcomes. Less intravenous fluid administration may also reduce haemodilution and concomitant trauma-associated coagulopathy. After linking the data of the TraumaRegister DGU(®) and the German Pelvic Injury Register, for the first time, the initial fluid management for complex pelvic traumas as well as for different Tile/OTA types of pelvic ring fractures could be addressed. Unfortunately, the results could not answer the question of the adequate fluid resuscitation but confirmed the actuality of massive fluid resuscitation in the prehospital and emergency room setting. Low-volume resuscitation seems not yet accepted in practice in managing multiple trauma patients with pelvic fractures at least in Germany. Nevertheless, prevention of exsanguination and of complications like multiple organ dysfunction syndrome still poses a major challenge in the management of complex pelvic ring injuries. Even nowadays, fluid management for trauma, not only for pelvic fractures, remains a controversial area and further research is mandatory. Keywords: Coagulopathy; Fluid resuscitation; Haemorrhage; Management; Mortality; Pelvic fractures. Copyright © 2014 Elsevier Ltd. All rights reserved. Cited by 16 articles Full text links 119. [Fractures of the acetabulum: complications and joint replacement] Z Orthop Unfall. 2014 Aug;152(4):399-413. doi: 10.1055/s-0034-1382862. Epub 2014 Aug 21. [Article in German] Authors S C Herath 1 , J H Holstein 1 , A Pizanis 1 , T Pohlemann 1 Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes - UKS, Homburg/Saar. PMID: 25144852 DOI: 10.1055/s-0034-1382862 Abstract Acetabular fractures assume a special role amongst the fractures of the pelvis, because they involve a major weight-bearing joint. As those fractures mostly result from exposure to great force, and because of their location in an anatomically complex region, a high rate of complications has to be anticipated. Besides general and perioperative complications long-term consequences, especially post-traumatic arthrosis, are relevant problems when it comes to treating fractures of the acetabulum. The primary reconstruction of the acetabulum, as well as a possibly necessary prosthetic replacement of the hip joint, makes high demands on the diagnostic and operative capabilities of the attending physician. Exact knowledge of the specific risks and pitfalls for each type of fracture and for the specific surgical techniques is crucial for a successful treatment. Due to the much worse long-term outcome when compared to primary total hip replacement in patients with osteoarthritis, acetabular fractures should, regardless of the patient's age, whenever possible be treated by operative reconstruction. Georg Thieme Verlag KG Stuttgart · New York. Cited by 3 articles Full text links 120. Proper coding of the Abbreviated Injury Scale: can clinical parameters help as surrogates in estimating blood loss? Eur J Trauma Emerg Surg. 2014 Aug;40(4):473-9. doi: 10.1007/s00068-013-0335-x. Epub 2013 Oct 5. Authors M Burkhardt 1 , J H Holstein 2 , P Moersdorf 3 , A Kristen 4 , R Lefering 5 , T Pohlemann 6 , A Pizanis 7 ; TraumaRegister DGU Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. Mac.Burkhardt@t-online.de. 2 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. joerg.holstein@uks.eu. 3 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. philipp.moersdorf@uks.eu. 4 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. alexander.kristen@icloud.com. 5 Institute for Research in Operative Medicine (IFOM), Faculty of Health, University of Witten/Herdecke, Cologne Merheim Medical Centre, Ostmerheimer Straße 200, 51109, Cologne, Germany. Rolf.Lefering@uni-wh.de. 6 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. tim.pohlemann@uks.eu. 7 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 100, 66421, Homburg, Germany. antonius.pizanis@uks.eu. PMID: 26816243 DOI: 10.1007/s00068-013-0335-x Abstract Purpose: The Abbreviated Injury Scale (AIS) requires the estimation of the lost blood volume for some severity assignments. This study aimed to develop a rule of thumb for facilitating AIS coding by using objective clinical parameters as surrogate markers of blood loss. Methods: Using the example of pelvic ring fractures, a retrospective analysis of TraumaRegister DGU(®) data from 2002 to 2011 was performed. As potential surrogate markers of blood loss, we recorded the hemoglobin (Hb) level, systolic blood pressure (SBP), base excess (BE), Quick's value, units of packed red blood cells (PRBCs) transfused before intensive care unit (ICU) admission, and mortality within 24 h. Results: We identified 11,574 patients with pelvic ring fractures (Tile/OTA classification: 39 % type A, 40 % type B, 21 % type C). Type C fractures were 73.1 % AISpelvis 4 and 26.9 % AISpelvis 5. Type B fractures were 47 % AISpelvis 3, 47 % AISpelvis 4, and 6 % AISpelvis 5. In type C fractures, cut-off values of <7 g/dL Hb, <90 mmHg SBP, <-9 mmol/L BE, <35 % Quick's value, >15 units PRBCs, and death within 24 h had a positive predictive value of 47 % and a sensitivity of 62 % for AISpelvis 5. In type B fractures, these cut-off values had poor sensitivity (48 %) and positive predictive value (11 %) for AISpelvis 5. Conclusions: We failed to develop a rule of thumb for facilitating a proper future AIS coding using the example of pelvic ring fractures. The estimation of blood loss for severity assignment still remains a noteworthy weakness in the AIS coding of traumatic injuries. Keywords: Abbreviated Injury Scale (AIS); Coding; Estimated blood loss; Pelvic ring fracture; Rule of thumb. 10 references Full text links 121. Arthroscopic pubic symphysis debridement and adductor enthesis repair in athletes with athletic pubalgia: technical note and video illustration Arch Orthop Trauma Surg. 2014 Nov;134(11):1595-9. doi: 10.1007/s00402-014-2065-x. Epub 2014 Jul 24. Authors Sascha Hopp 1 , Masjudin Tumin , Peter Wilhelm , Tim Pohlemann , Jens Kelm Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg/Saar, Germany, sascha.hopp@uks.eu. PMID: 25055756 DOI: 10.1007/s00402-014-2065-x Abstract We elaborately describe our novel arthroscopic technique of the symphysis pubis in athletes with osteitis pubis and concomitant adductor enthesopathy who fail to conservative treatment modalities. The symphysis pubis is debrided arthroscopically and the degenerated origin of adductor tendon (enthesis) is excised and reattached. With our surgical procedure the stability of the symphysis pubis is successfully preserved and the adductor longus enthesopathy simultaneously addressed in the same setting. Cited by 2 articles Full text links 122. Analysis of cellular composition of co-culture spheroids Ann Anat. 2014 Sep;196(5):303-11. doi: 10.1016/j.aanat.2014.05.038. Epub 2014 Jun 10. Authors Natalie Dorst 1 , Martin Oberringer 2 , Ute Grässer 3 , Tim Pohlemann 4 , Wolfgang Metzger 5 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrberger Str., 66421 Homburg, Germany. Electronic address: ndl@gmx.net. 2 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrberger Str., 66421 Homburg, Germany. Electronic address: martin.oberringer@uks.eu. 3 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrberger Str., 66421 Homburg, Germany. Electronic address: ute.graesser@uks.eu. 4 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrberger Str., 66421 Homburg, Germany. Electronic address: tim.pohlemann@uks.eu. 5 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, Kirrberger Str., 66421 Homburg, Germany. Electronic address: johann-wolfgang.metzger@uks.eu. PMID: 24962944 DOI: 10.1016/j.aanat.2014.05.038 Abstract 3D spheroids and in particular co-culture spheroids reflect the natural organization of cells in tissues much better than 2D cell cultures as indicated by differences in cellular phyisology. However, most methods to analyze cells were established for 2D cultures and cannot easily be applied to spheroids. This study has aimed to demonstrate the possibility of quantification of the cellular composition of co-culture spheroids without previous dissociation into single cells. Prior to the generation of the spheroids, human endothelial cells, osteoblasts and fibroblasts were stained with fluoresent dyes for living cells. Co-culture spheroids of defined stoichiometric compositions were generated by the liquid overlay technique, cultivated for one, three or six days, respectively, and afterwards snap-frozen in liquid nitrogen. Cryo-sections of co-culture spheroids were analyzed by fluorescence microscopy and a newly established semi-automatic measuring routine. In order to compare the results, spheroids of one group were dissociated and the cellular composition was quantified by FACS-analysis. Staining efficiencies were higher than 95% as quantified in preliminary experiments with 2D cultures. Depending on the staining procedure, variations from uniform to punctate signals were detected. The size of all co-culture spheroids decreased over time and snap-freezing did not lead to shrinkage of the spheroids. We were able to detect organizational patterns of different cell types within the spheroids. It was possible to determine the cellular composition by quantitative microscopic analyses of cryo-sections as it could be confirmed by flow cytometric analyses. Depending on the experimental requirements, a combination of both methods might lead to valuable synergy. Keywords: Cellular composition; Co-culture spheroids; Dissociation; Endothelial cells; Fibroblasts; Fluorescence staining; Osteoblasts. Copyright © 2014 Elsevier GmbH. All rights reserved. Cited by 4 articles Full text links 123. Arthroscopic debridement of the pubic symphysis: an experimental study Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2568-75. doi: 10.1007/s00167-014-3105-3. Epub 2014 Jun 11. Authors Sascha Hopp 1 , Ulf Culemann , Ishaq Ojodu , Tim Pohlemann , Jens Kelm Affiliation 1 Department of Trauma Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstraße 1, 66421, Homburg, Saarland, Germany, sascha.hopp@uks.eu. PMID: 24912577 DOI: 10.1007/s00167-014-3105-3 Abstract Purpose: Open curettage of the symphysis has shown promising results in patients with recalcitrant osteitis pubis. However, this has been bedevilled with an extended intraoperative morbidity. Aim of this study was to come up with a novel arthroscopic debridement of the pubic symphysis and to bring to the fore the potential risks of soft tissue damage. Methods: This study was conducted on six human cadavers (mean age 83 years). CT scans were obtained for measurement of the symphyseal morphology. Consequent upon these measurements, four different potential arthroscopic portals were defined with the intention to gain adequate insight and to reach the whole joint space with instruments: one suprapubic portal and three anterior portals (antero-superior, antero-central and antero-inferior). Soft tissue, except for musculotendinous attachments and neurovascular structures, was dissected. A two-portal arthroscopic debridement under image intensifier control with resection of the symphyseal disc and abrasion of the subchondral bone were performed. Results: Considering the narrow joint space, small instruments/scope (4.5/2.7 mm) is recommended. Correct portal placement and debridement procedure can only be reliably performed under fluoroscopic imaging in two radiographic projections (outlet and inlet view) with a mean total fluoroscopic time of 15-20 s and a dose area product between 100 and 120 cGy cm(2). Two portals have proved beneficial: the suprapubic portal for instruments and the antero-central portal for the scope. Other portals had several limitations, e.g. potential instrumental conflict (anterior-superior) or damaging of neurovascular and other soft tissue structures (anterior-inferior). Conclusion: With well-defined arthroscopic portals and adherence to basic principles of arthroscopic surgery, debridement of the pubic symphysis can be performed reproducibly without compromising important anatomical structures. This less invasive arthroscopic debridement is a safely applicable procedure and therefore might be a reasonable alternative to open curettage. One may assume that this technique will lead to a shorter rehabilitation time and will provide a successful therapy especially in the treatment of professional athletes in the future. Cited by 4 articles 16 references 124. [Funktionsoberarzt. Pseudo-title or meaningful position?] Unfallchirurg. 2014 Jun;117(6):557-9. doi: 10.1007/s00113-014-2581-8. [Article in German] Authors T Histing 1 , M Burkhardt , M Rollmann , M D Menger , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Deutschland, tina.histing@uks.eu. PMID: 24903505 DOI: 10.1007/s00113-014-2581-8 Abstract The position of the Funktionsoberarzt ("functioning senior physician") is to date not specified. Nevertheless, in the majority of hospitals the position exists, although the function and responsibilities are not clearly defined. Frequently, it is thought that the position represents a consultant who works independently, but who is still supported by experienced colleagues to achieve the full qualification for a senior physician. In contrast, others indicate that the position represents a consultant who works as a senior physician with all responsibilities, but without an established post and without the corresponding reimbursement. A critical disadvantage of the position is that frequently the duties of both a resident and senior physician must be managed. Rotation between the two functions results in a higher workload, and the lack of identity and acceptance may lead to frustration. Therefore, we feel that the position is only meaningful if the Funktionsoberarzt works exclusively as a senior physician who is supported for complex surgeries and decisions by more experienced colleagues. In addition, the position should only be temporary and the time period for the position should be defined in advance. Full text links 125. Computer-assisted fracture reduction: a new approach for repositioning femoral fractures and planning reduction paths Int J Comput Assist Radiol Surg. 2015 Feb;10(2):149-59. doi: 10.1007/s11548-014-1011-2. Epub 2014 May 10. Authors Jan Buschbaum 1 , Rainer Fremd , Tim Pohlemann , Alexander Kristen Affiliation 1 Fachbereich Angewandte Ingenieurwissenschaften, Fachhochschule Kaiserslautern - University of Applied Sciences, Morlauterer Straße 31, 67657 , Kaiserslautern, Germany, jan.buschbaum@fh-kl.de. PMID: 24817061 DOI: 10.1007/s11548-014-1011-2 Abstract Purpose: Reduction is a crucial step in the surgical treatment of bone fractures to achieve anatomical alignment and facilitate healing. Surgical planning for treatment of simple femoral fractures requires suitable gentle reduction paths. A plan with optimal movement of fracture fragments from the initial to the desired target position should improve the reduction procedure. A virtual environment which repositions the fracture fragments automatically and provides the ability to plan reduction paths was developed and tested. Methods: Virtual 3D osseous fragments are created from CT scans. Based on the computed surface curvatures, strongly curved edges are selected and fracture lines are generated. After assignment of matching points, the lines are compared and the desired target position is calculated. Planning of reduction paths was achieved using a reference-coordinate-system for the computation of reduction parameters. The fracture is reduced by changing the reduction parameters step by step until the target position is reached. To test this system, nine different fractured SYNBONE models and one human fracture were reduced, based on CT scans with varying resolution. Results: The highest mean translational error is 1.2 ± 0.9 (mm), and the rotational error is 2.6 ± 2.8 (°), both of which are considered as clinically acceptable. The reduction paths can be planned manually or semi-automatically for each fracture. Conclusions: Automated fracture reduction was achieved using a system based on preoperative CT scans. The automated system provides a clinically feasible basis for planning optimal reduction paths that may be augmented by further computer- or robot-assisted applications. Cited by 13 articles 17 references Full text links 126. Induction of osteogenic differentiation by nanostructured alumina surfaces J Biomed Nanotechnol. 2014 May;10(5):831-45. doi: 10.1166/jbn.2014.1775. Authors Wolfgang Metzger , Benedikt Schwab , Marina M Miro , Sibylle Grad , Angharad Simpson , Michael Veith , Gunther Wennemuth , Vladimir Zaporojtchenko , Sophie Verrier , Jessica S Hayes , Monika Bubel , Tim Pohlemann , Martin Oberringer , Cenk Aktas PMID: 24734536 DOI: 10.1166/jbn.2014.1775 Abstract Permanent orthopedic implants are becoming increasingly important due to the demographic development. Their optimal osseointegration is key in obtaining good secondary stability. For anchorage dependent cells, topographic features of a surface play an essential role for cell adhesion, proliferation, differentiation and biomineralization. We studied the topographical effect of nanostructured alumina surfaces prepared by chemical vapor deposition on osteogenic differentiation and growth of human osteoblasts. Chemical vapor deposition of the single source precursor (tBuOAIH2)2 led to synthesis of one dimensional alumina nanostructures of high purity with a controlled stoichiometry. We fabricated different topographic features by altering the distribution density of deposited one dimensional nanostructures. Although the topography differed, all surfaces exhibited identical surface chemistry, which is the key requirement for systematically studying the effect of the topography on cells. Forty-eight hours after seeding, cell density and cell area were not affected by the nanotopography, whereas metabolic activity was reduced and formation of actin-fibres and focal adhesions was impaired compared to the uncoated control. Induction of osteogenic differentiation was demonstrated via up-regulation of alkaline phosphatase, bone sialoprotein, osteopontin and Runx2 at the mRNA level, demonstrating the potential of nanostructured surfaces to improve the osseointegration of permanent implants. Cited by 5 articles 127. [Complex pelvic traumas : data linkage of the German Pelvic Injury Register and the TraumaRegister DGU®] Unfallchirurg. 2015 Nov;118(11):957-62. doi: 10.1007/s00113-014-2565-8. [Article in German] Authors M Burkhardt 1 , U Nienaber 2 , J Krause 3 , A Pizanis 3 , P Moersdorf 3 , U Culemann 4 , E Aghayev 5 , T Paffrath 6 , T Pohlemann 3 , J H Holstein 3 ; Beckenregister DGU ; TraumaRegister DGU® Affiliations 1 Abteilung für Chirurgie, Schwerpunkt Unfallchirurgie und Orthopädie, Handchirurgie, Evangelisches Stadtkrankenhaus Saarbrücken, Großherzog-Friedrich-Straße 44, 66111, Saarbrücken, Deutschland. Mac.Burkhardt@t-online.de. 2 AUC - Akademie der Unfallchirurgie GmbH, München, Deutschland. 3 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland. 4 Klinik für Unfallchirurgie, Allgemeines Krankenhaus Celle, Celle, Deutschland. 5 Institut für Evaluative Forschung in der Medizin, Universität Bern, Bern, Schweiz. 6 Lehrstuhl für Orthopädie, Unfallchirurgie und Sporttraumatologie, Universitätsklinikum Witten/Herdecke, Klinikum Köln-Merheim, Köln, Deutschland. PMID: 24695812 DOI: 10.1007/s00113-014-2565-8 Free article Abstract Background: Complex pelvic traumas, i.e., pelvic fractures accompanied by pelvic soft tissue injuries, still have an unacceptably high mortality rate of about 18 %. Patients and methods: We retrospectively evaluated an intersection set of data from the TraumaRegister DGU® and the German Pelvic Injury Register from 2004-2009. Patients with complex and noncomplex pelvic traumas were compared regarding their vital parameters, emergency management, stay in the ICU, and outcome. Results: From a total of 344 patients with pelvic injuries, 21 % of patients had a complex and 79 % a noncomplex trauma. Complex traumas were significantly less likely to survive (16.7 % vs. 5.9 %). Whereas vital parameters and emergency treatment in the preclinical setting did not differ substantially, patients with complex traumas were more often in shock and showed acute traumatic coagulopathy on hospital arrival, which resulted in more fluid volumes and transfusions when compared to patients with noncomplex traumas. Furthermore, patients with complex traumas had more complications and longer ICU stays. Conclusion: Prevention of exsanguination and complications like multiple organ dysfunction syndrome still pose a major challenge in the management of complex pelvic traumas. Keywords: Emergency management; Mortality; Pelvic fracture; Pelvic trauma, complex; Registry. Cited by 9 articles 18 references Full text links 128. [Current treatment of pelvic ring fractures] Unfallchirurg. 2014 Feb;117(2):145-59; quiz 160-1. doi: 10.1007/s00113-014-2558-7. [Article in German] Authors U Culemann 1 , H J Oestern , T Pohlemann Affiliation 1 Klinik für Unfallchirurgie, Orthopädie und Neurotraumatologie, Allgemeines Krankenhaus Celle, 29223, Celle, Deutschland, ulf.culemann@akh-celle.de. PMID: 24549586 DOI: 10.1007/s00113-014-2558-7 Abstract Pelvic injuries are often associated with multiple injuries of other body regions, neurovascular and visceral lesions, as well as hemodynamic instability. The use of a standardized classification characterizing the severity and stability of pelvic fractures and the early stabilization of pelvic ring injuries in appreciation of damage control principles has helped to improve the number of survivors. This is particularly necessary due to the higher number of older patients. Complex pelvic trauma still represents a life-threatening situation for the patient, particularly in multiple traumatized patients. Standardized clinical investigations and modern concepts even in the preclinical therapy of complex pelvic fractures make a contribution to enhancement of treatment options. Because of the still problematic long-term results after surgery of instable pelvic fractures, the need for modern treatment concepts has to be adapted to the requirements. Cited by 9 articles 39 references Full text links 129. [Quality of life after multiple trauma] Chirurg. 2014 Mar;85(3):208, 210-4. doi: 10.1007/s00104-013-2601-1. [Article in German] Authors P Mörsdorf 1 , S C Becker , J H Holstein , M Burkhardt , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland, philipp.moersdorf@uks.eu. PMID: 24519611 DOI: 10.1007/s00104-013-2601-1 Abstract Background: Multiple trauma is an independent injury pattern which, because of its complexity, is responsible for 25 % of the costs for the treatment of all injured patients. Because of the often long-lasting physical impairment and the high incidence of residual permanent handicaps, it is apparent that multiple trauma can lead to a reduction in patient quality of life. Objectives: The aim of this study was to give an overview of the known data concerning the change in quality of life for multiple trauma patients. Furthermore, predictors for the reduction of quality of life after multiple trauma will be identified. Materials and methods: A MedLine search was performed to identify studies dealing with the outcome after multiple trauma. Results: In addition to functional outcome parameters, the term quality of life has become more important in recent years when it comes to evaluating the outcome following injury. While the mortality after multiple trauma could be significantly reduced over the years, there is no comparable effect on the quality of life. Predictors for a worse quality of life after multiple trauma are female gender, high age, low social status, concomitant head injuries and injury to the lower extremities. Conclusion: The fact that mortality after multiple trauma has decreased but not impairment of the quality of life makes it clear that in addition to the acute medical treatment, a follow-up treatment including not only physiotherapy but also psychotherapy is crucial for multiple trauma patients. Cited by 2 articles 22 references Full text links 130. [Primary cancellous bone formation around micro-chambered beads] Rev Esp Cir Ortop Traumatol. 2014 May-Jun;58(3):131-7. doi: 10.1016/j.recot.2013.11.003. Epub 2014 Feb 8. [Article in Spanish] Authors M E Draenert 1 , Y Draenert 2 , K Draenert 2 , T Pohlemann 3 , M Erler 4 Affiliations 1 Center of Orthopaedic Sciences, Munich, Alemania; Clinic for Restorative Dentistry and Periodontology, Ludwig Maximilian University, Munich, Alemania. Electronic address: mdraener@dent.med.uni-muenchen.de. 2 Center of Orthopaedic Sciences, Munich, Alemania. 3 Department of Trauma-, Hand-, and Reconstructive Surgery, Saarland University, Homburg, Alemania. 4 Departamento de Traumatología, Clínica Berka, Universidad de Madrid, Madrid, España. PMID: 24512804 DOI: 10.1016/j.recot.2013.11.003 Abstract Objectives: The question has been raised whether benign bone defects in patients can be treated with bone forming osteoconductive ceramics achieving primarily a cancellous bone scaffold, which is under load from the beginning. Material and methods: Ten reconstructions were performed in 9patients (6women and 3male), with a mean age of 49 (25-65)years, suffering a high variety of epi- and metaphyseal defects, four tibial fractures, two calcaneal fractures, one pathological phalangeal fracture, one chondroma of the distal femur and two open-wedge osteotomies were filled with micro-chambered ceramic beads of 4 and 6mm in diameter. The mean follow up was 22 (7- 8)months. X-rays and CT-scans formed the basis for the evaluation of the reconstruction of the cancellous bone scaffolds. Results: All cancellous structures were rebuilt, if completely filled with bone-forming elements. If the filling was incomplete, no physiological cancellous bone scaffold resulted. The β-TCP micro-chambered beads were completely reabsorbed or sandwich-like incorporated at the time of evaluation. The HA micro-chambered beads revealed a contrast enhancement and were integrated in the osseous construction of the bone scaffold. Conclusion: Primary cancellous bone formation can be achieved with osteoconductive ceramic micro-chambered beads and can be combined with any osteosynthesis for stable fixation. Keywords: Bone defect; Bone substitute; Cancellous bone; Defecto óseo; Fractura; Fracture; Hueso esponjoso; Open wedge osteotomy; Osteotomía de apertura; Sustitutivo óseo. Copyright © 2013 SECOT. Published by Elsevier Espana. All rights reserved. Full text links 131. Generation of co-culture spheroids as vascularisation units for bone tissue engineering Eur Cell Mater. 2013 Nov 6:26:222-33. doi: 10.22203/ecm.v026a16. Authors R Walser 1 , W Metzger , A Görg , T Pohlemann , M D Menger , M W Laschke Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building 57, 66421 Homburg, Germany.johann-wolfgang.metzger@uks.eu. PMID: 24197544 DOI: 10.22203/ecm.v026a16 Free article Abstract Cell spheroids represent attractive building units for bone tissue engineering, because they provide a three-dimensional environment with intensive direct cell-cell contacts. Moreover, they allow for co-culture of both osteoblasts and vessel-forming cells, which may markedly increase their survival and vascularisation after transplantation. To test this hypothesis, we generated co-culture spheroids by aggregating different combinations of primary human osteoblasts (HOB), human dermal microvascular endothelial cells (HDMEC) and normal human dermal fibroblasts (NHDF) using the liquid overlay technique. Mono-culture spheroids consisting either of HOB or HDMEC served as controls. After in vitro characterisation, the different spheroids were transplanted into dorsal skinfold chambers of CD1 nu/nu mice to study in vivo their viability and vascularisation over a 2-week observation period by means of repetitive intravital fluorescence microscopy and immunohistochemistry. In vitro, co-culture spheroids containing HDMEC rapidly formed dense tubular vessel-like networks within 72 h and exhibited a significantly decreased rate of apoptotic cell death when compared to mono-culture HDMEC spheroids. After transplantation, these networks interconnected to the host microvasculature by external inosculation. Of interest, this process was most pronounced in HOB-HDMEC spheroids and could not further be improved by the addition of NHDF. Accordingly, HOB-HDMEC spheroids were larger when compared to the other spheroid types. These findings indicate that HOB-HDMEC spheroids exhibit excellent properties to preserve viability and to promote proliferation and vascularisation. Therefore, they may be used as functional vascularisation units in bone tissue engineering for the seeding of scaffolds or for the vitalisation of non-healing large bone defects. Cited by 32 articles Full text links 132. Intra- and postoperative complications of navigated and conventional techniques in percutaneous iliosacral screw fixation after pelvic fractures: Results from the German Pelvic Trauma Registry Injury. 2013 Dec;44(12):1765-72. doi: 10.1016/j.injury.2013.08.008. Epub 2013 Aug 15. Authors Jörn Zwingmann 1 , Norbert P Südkamp , Benjamin König , Ulf Culemann , Tim Pohlemann , Emin Aghayev , Hagen Schmal Affiliation 1 Department of Orthopaedic and Trauma Surgery, University of Freiburg Medical Center, Hugstetter Strasse 55, 79106 Freiburg, Germany. Electronic address: joern.zwingmann@uniklinik-freiburg.de. PMID: 24001785 DOI: 10.1016/j.injury.2013.08.008 Abstract Background: Percutaneous iliosacral screw placement following pelvic trauma is a very demanding technique involving a high rate of screw malpositions possibly associated with the risk of neurological damage or inadequate stability. In the conventional technique, the screw's correct entry point and the small target corridor for the iliosacral screw may be difficult to visualise using an image intensifier. 2D and 3D navigation techniques may therefore be helpful tools. The aim of this multicentre study was to evaluate the intra- and postoperative complications after percutaneous screw implantation by classifying the fractures using data from a prospective pelvic trauma registry. The a priori hypothesis was that the navigation techniques have lower rates of intraoperative and postoperative complications. Methods: This study is based on data from the prospective pelvic trauma registry introduced by the German Society of Traumatology and the German Section of the AO/ASIF International in 1991. The registry provides data on all patients with pelvic fractures treated between July 2008 and June 2011 at any one of the 23 Level I trauma centres contributing to the registry. Results: A total of 2615 patients were identified. Out of these a further analysis was performed in 597 patients suffering injuries of the SI joint (187×with surgical interventions) and 597 patients with sacral fractures (334×with surgical interventions). The rate of intraoperative complications was not significantly different, with 10/114 patients undergoing navigated techniques (8.8%) and 14/239 patients in the conventional group (5.9%) for percutaneous screw implantation (p=0.4242). Postoperative complications were analysed in 30/114 patients in the navigated group (26.3%) and in 70/239 patients (29.3%) in the conventional group (p=0.6542). Patients who underwent no surgery had with 66/197 cases (33.5%) a relatively high rate of complications during their hospital stay. The rate of surgically-treated fractures was higher in the group with more unstable Type-C fractures, but the fracture classification had no significant influence on the rate of complications. Discussion: In this prospective multicentre study, the 2D/3D navigation techniques revealed similar results for the rate of intraoperative and postoperative complications compared to the conventional technique. The rate of neurological complications was significantly higher in the navigated group. Keywords: German Pelvic Trauma Registry; Iliosacral screw; Navigation; Pelvic fracture; SI screw. Copyright © 2013 Elsevier Ltd. All rights reserved. Cited by 24 articles Full text links 133. [Current treatment of pelvic ring fractures] Chirurg. 2013 Sep;84(9):809-26. doi: 10.1007/s00104-012-2391-x. [Article in German] Authors U Culemann 1 , H J Oestern , T Pohlemann Affiliation 1 Klinik für Unfallchirurgie, Orthopädie und Neurotraumatologie, Allgemeines Krankenhaus Celle, 29223, Celle, Deutschland, ulf.culemann@akh-celle.de. PMID: 23989168 DOI: 10.1007/s00104-012-2391-x Abstract Pelvic injuries are often associated with multiple injuries of other body regions, neurovascular and visceral lesions, as well as hemodynamic instability. The use of a standardized classification characterizing the severity and stability of pelvic fractures and the early stabilization of pelvic ring injuries in appreciation of damage control principles has helped to improve the number of survivors. This is particularly necessary due to the higher number of older patients.Complex pelvic trauma still represents a life-threatening situation for the patient, particularly in multiple traumatized patients. Standardized clinical investigations and modern concepts even in the preclinical therapy of complex pelvic fractures make a contribution to enhancement of treatment options. Because of the still problematic long-term results after surgery of instable pelvic fractures, the need for modern treatment concepts has to be adapted to the requirements. Cited by 1 article 39 references Full text links 134. The posterior two-portal approach for reconstruction of scapula fractures: results of 39 patients Injury. 2013 Nov;44(11):1630-5. doi: 10.1016/j.injury.2013.07.020. Epub 2013 Aug 6. Authors A Pizanis 1 , G Tosounidis , C Braun , T Pohlemann , R J Wirbel Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital of Saarland, Homburg/Saar, Germany. Electronic address: antonius.pizanis@uks.eu. PMID: 23972388 DOI: 10.1016/j.injury.2013.07.020 Abstract The purpose of this study was to describe the so-called posterior two-portal approach to the scapula in detail and to investigate the clinical outcome of patients with displaced glenoid and scapular neck fractures who were surgically treated using this approach. From February 1992 to August 2008, 39 patients (30 men and nine women; mean age: 53 years) with scapular fractures underwent surgical fixation at our institution. Thirty-three patients had glenoid fractures and six had unstable scapular neck fractures. All patients were treated via the two-portal approach. The reduction was evaluated radiographically, and the clinical results were analysed using the Constant score. The mean follow-up period was 78 months (range: 6-168). In 24 of the 33 glenoid fractures, the reduction was anatomical. The mean Constant score was 82.3 (range: 35-100) points. In one case, an early postoperative wound infection was cured by local revision, and one patient developed posttraumatic osteoarthritis of the acromioclavicular joint after 2 years. Only one patient developed specific glenohumeral degeneration after non-anatomical reduction. The posterior two-portal approach allows for a good visualisation of the posterior scapular neck and the glenoid area, facilitating the reduction and safe internal fixation of dislocated scapular neck and glenoid fractures. Keywords: Scapula fracture; Scapula surgery; Surgical approach. Copyright © 2013 Elsevier Ltd. All rights reserved. Cited by 4 articles Full text links 135. Compression and contact area of anterior strut grafts in spinal instrumentation: a biomechanical study BMC Musculoskelet Disord. 2013 Aug 26:14:254. doi: 10.1186/1471-2474-14-254. Authors Antonius Pizanis 1 , Jörg H Holstein , Felix Vossen , Markus Burkhardt , Tim Pohlemann Affiliation 1 Department for Trauma-, Hand- and Reconstructive Surgery, University Medical Centre of the Saarland, Homburg, Saar, D 66421, Germany. antonius.pizanis@uks.eu. PMID: 23971712 PMCID: PMC3766234 DOI: 10.1186/1471-2474-14-254 Abstract Background: Anterior bone grafts are used as struts to reconstruct the anterior column of the spine in kyphosis or following injury. An incomplete fusion can lead to later correction losses and compromise further healing. Despite the different stabilizing techniques that have evolved, from posterior or anterior fixating implants to combined anterior/posterior instrumentation, graft pseudarthrosis rates remain an important concern. Furthermore, the need for additional anterior implant fixation is still controversial. In this bench-top study, we focused on the graft-bone interface under various conditions, using two simulated spinal injury models and common surgical fixation techniques to investigate the effect of implant-mediated compression and contact on the anterior graft. Methods: Calf spines were stabilised with posterior internal fixators. The wooden blocks as substitutes for strut grafts were impacted using a "pressfit" technique and pressure-sensitive films placed at the interface between the vertebral bone and the graft to record the compression force and the contact area with various stabilization techniques. Compression was achieved either with posterior internal fixator alone or with an additional anterior implant. The importance of concomitant ligament damage was also considered using two simulated injury models: pure compression Magerl/AO fracture type A or rotation/translation fracture type C models. Results: In type A injury models, 1 mm-oversized grafts for impaction grafting provided good compression and fair contact areas that were both markedly increased by the use of additional compressing anterior rods or by shortening the posterior fixator construct. Anterior instrumentation by itself had similar effects. For type C injuries, dramatic differences were observed between the techniques, as there was a net decrease in compression and an inadequate contact on the graft occurred in this model. Under these circumstances, both compression and the contact area on graft could only be maintained at high levels with the use of additional anterior rods. Conclusions: Under experimental conditions, we observed that ligamentous injury following type C fracture has a negative influence on the compression and contact area of anterior interbody bone grafts when only an internal fixator is used for stabilization. Because of the loss of tension banding effects in type C injuries, an additional anterior compressing implant can be beneficial to restore both compression to and contact on the strut graft. Cited by 1 article 42 references 4 figures Full text links 136. [Practical courses for students can not only improve the teaching quality but can also increase the attractiveness of orthopaedic and trauma surgery] Z Orthop Unfall. 2013 Aug;151(4):389-93. doi: 10.1055/s-0033-1350747. Epub 2013 Aug 20. [Article in German] Authors T Histing 1 , J Jung , D Wincheringer , J Ludwig , A Pizanis , T Pohlemann , M D Menger Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universität des Saarlandes, Homburg/Saar. tina.histing@uks.eu PMID: 23963986 DOI: 10.1055/s-0033-1350747 Abstract Background: Students often complain about a lack of teaching of practical skills. This may be a cause for the low attractiveness of surgical disciplines. We therefore established a practical course to improve teaching quality to inspire the students for orthopedic and trauma surgery. Methods: The platforms of the course included the teaching and acquisition of suture techniques, arthroscopy and osteosynthesis techniques. A total of 119 students participated in 9 courses and performed a detailed evaluation. Results: The main motivation to participate was (i) to acquire practical skills (93 %), (ii) to learn about orthopaedic and trauma surgery (66 %) and (iii) to facilitate decision-making for the occupational choice (21 %). 94 % judged the quality of the course as "excellent", and all 119 participants indicated that they would recommend the course to other students. 43 of 45 students, who had not yet decided on their occupational choice, indicated that the course stimulated them for a career in orthopaedic and trauma surgery. Conclusion: This course not only can improve the teaching quality but also can increase the attractiveness of muskuloskeletal surgery. Georg Thieme Verlag KG Stuttgart · New York. Full text links 137. Emergency stabilization of the pelvic ring: Clinical comparison between three different techniques Injury. 2013 Dec;44(12):1760-4. doi: 10.1016/j.injury.2013.07.009. Epub 2013 Aug 2. Authors A Pizanis 1 , T Pohlemann , M Burkhardt , E Aghayev , J H Holstein Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg, Germany. PMID: 23916903 DOI: 10.1016/j.injury.2013.07.009 Abstract Background: Emergency devices for pelvic ring stabilization include circumferential sheets, pelvic binders, and c-clamps. Our knowledge of the outcome of these techniques is currently based on limited information. Methods: Using the dataset of the German Pelvic Trauma Registry, demographic and injury-associated characteristics as well as the outcome of pelvic fracture patients after sheet, binder, and c-clamp treatment was compared. Outcome parameters included transfusion requirement of packed red blood cells, length of hospital stay, mortality, and incidence of lethal pelvic bleeding. Results: Two hundred seven of 6137 (3.4%) patients documented in the German Pelvic Trauma Registry between April 30th 2004 and January 19th 2012 were treated by sheets, binders, or c-clamps. In most cases, c-clamps (69%) were used, followed by sheets (16%), and binders (15%). The median age was significantly lower in patients treated with binders than in patients treated with sheets or c-clamps (26 vs. 47 vs. 42 years, p=0.01). Sheet wrapping was associated with a significantly higher incidence of lethal pelvic bleeding compared to binder or c-clamp stabilization (23% vs. 4% vs. 8%). No significant differences between the study groups were found in sex, fracture type, blood haemoglobin concentration, arterial blood pressure, Injury Severity Score, the incidence of additional pelvic packing and arterial embolization, need of red blood cell transfusion, length of hospitalisation, and mortality. Conclusions: The data suggest that emergency stabilization of the pelvic ring by binders and c-clamps is associated with a lower incidence of lethal pelvic bleeding compared to sheet wrapping. Level of evidence: Level III. Keywords: Bleeding control; C-clamp; Circumferential sheet; Pelvic binder; Pelvic fracture. Copyright © 2013 Elsevier Ltd. All rights reserved. Cited by 28 articles Full text links 138. Rodent animal models of delayed bone healing and non-union formation: a comprehensive review Eur Cell Mater. 2013 Jul 16:26:1-12; discussion 12-4. doi: 10.22203/ecm.v026a01. Authors P Garcia 1 , T Histing , J H Holstein , M Klein , M W Laschke , R Matthys , A Ignatius , B Wildemann , J Lienau , A Peters , B Willie , G Duda , L Claes , T Pohlemann , M D Menger Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, D-48308 Muenster, Germany. patric.garcia@ukmuenster.de PMID: 23857280 DOI: 10.22203/ecm.v026a01 Free article Abstract Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain a major clinical challenge. Animal models are needed to study the complex process of normal and impaired fracture healing and to develop new therapeutic strategies. Whereas in the past mainly large animals have been used to study normal and impaired fracture healing, nowadays rodent models are of increasing interest. New osteosynthesis techniques for rat and mice have been developed during the last years, which allowed for the first time stable osteosynthesis in these animals comparable to the standards in large animals and humans. Based on these new implants, different models in rat and mice have been established to study delayed healing and non-union formation. Although in humans the terms delayed union and non-union are well defined, in rodents definitions are lacking. However, especially in scientific studies clear definitions are necessary to develop a uniform scientific language and allow comparison of the results between different studies. In this consensus report, we define the basic terms "union", "delayed healing" and "non-union" in rodent animal models. Based on a review of the literature and our own experience, we further provide an overview on available models of delayed healing and non-union formation in rats and mice. We further summarise the value of different approaches to study normal and delayed fracture healing as well as non-union formation, and discuss different methods of data evaluation. Cited by 65 articles Full text links 139. Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay Naunyn Schmiedebergs Arch Pharmacol. 2013 Oct;386(10):853-63. doi: 10.1007/s00210-013-0890-z. Epub 2013 Jun 15. Authors Kathrin Aichele 1 , Monika Bubel , Gunther Deubel , Tim Pohlemann , Martin Oberringer Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Straße, Bldng. 57, 66421, Homburg, Germany. PMID: 23771413 DOI: 10.1007/s00210-013-0890-z Abstract Bromelain, a pineapple-derived enzyme mixture, is a widely used drug to improve tissue regeneration. Clinical and experimental data indicate a better outcome of soft tissue healing under the influence of bromelain. Proteolytic, anti-bacterial, anti-inflammatory, and anti-oedematogenic effects account for this improvement on the systemic level. It remains unknown, whether involved tissue cells are directly influenced by bromelain. In order to gain more insight into those mechanisms by which bromelain modulates tissue regeneration at the cellular level, we applied a well-established in vitro wound healing assay. Two main players of soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-cultures. Cell migration, proliferation, apoptosis, and the differentiation of fibroblasts to myofibroblasts as well as interleukin-6 were quantified in response to bromelain (36 × 10(-3) IU/ml) under normoxia and hypoxia. Bromelain attenuated endothelial cell and fibroblast proliferation in a moderate way. This proliferation decrease was not caused by apoptosis, rather, by driving cells into the resting state G0 of the cell cycle. Endothelial cell migration was not influenced by bromelain, whereas fibroblast migration was clearly slowed down, especially under hypoxia. Bromelain led to a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %), coincident with higher levels of interleukin-6. Myofibroblast differentiation, a clear sign of fibrotic development, can be attenuated by the application of bromelain in vitro. Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future. Cited by 9 articles 55 references Full text links 140. Treatment for displaced proximal humerus fractures: comparison of interlocking plate fixation versus minimal invasive techniques Eur J Orthop Surg Traumatol. 2014 Jul;24(5):707-14. doi: 10.1007/s00590-013-1235-9. Epub 2013 Jun 1. Authors Felix Bachelier 1 , Antonius Pizanis , Julia Schwitalla , Tim Pohlemann , Dieter Kohn , Reiner Wirbel Affiliation 1 Department of Orthopaedics, University Hospital of Saarland, 66421, Homburg, Germany. PMID: 23728442 DOI: 10.1007/s00590-013-1235-9 Abstract Background and purpose: The functional results and the complications following interlocking plate fixation of displaced proximal humerus fractures should be evaluated and compared with those following minimal invasive fixation techniques. Patients and methods: Fifty patients (30 women, 20 men, mean age 62.7 (18-91) years) were treated for a displaced proximal humerus fracture using an interlocking plate fixation (PHILOS®) between 2003 and 2004. The mean follow-up time was 12 (9-36) months. Functional and radiographic results (Constant-Murley and Neer scores) were analyzed and compared with an equivalent historical control group of 53 patients operated for the same fracture types using minimal invasive techniques (K-wires and/or cannulated screws) between 1995 and 1997. According to the OTA/AO classification, there were 15 type A, 18 type B, and 17 type C fractures in the plate fixation group, and 23, 25, and 5 of these types in the control group, respectively. Results: The mean Neer score was 85.9, the mean Constant-Murley score 84, whereas 82.4 and 75.4 for the control group, respectively. Good and excellent results were seen in 78%, whereas in 70% in the control group. The results were dependent upon the fracture's type, sex, and patient's age. Complications were seen in 9 patients, whereas in 16 patients in the control group. Interpretation: Using an interlocking plate, the indication of fixation of displaced proximal humerus fractures had been expanded to type C fractures. The implant failure rate can be reduced. The functional results achieved are better compared with those following minimal invasive techniques. Cited by 4 articles 26 references Full text links 141. Endostatin inhibits Callus remodeling during fracture healing in mice J Orthop Res. 2013 Oct;31(10):1579-84. doi: 10.1002/jor.22401. Epub 2013 May 30. Authors Joerg H Holstein 1 , Bianca Karabin-Kehl , Claudia Scheuer , Patric Garcia , Tina Histing , Christoph Meier , Emanuel Benninger , Michael D Menger , Tim Pohlemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse, 66421, Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 23720153 DOI: 10.1002/jor.22401 Free article Abstract Information on the impact of endogenous anti-angiogenic factors on bone repair is limited. The hypothesis of the present study was endostatin, an endogenous inhibitor of angiogenesis, disturbs fracture healing. We evaluated this hypothesis in a closed femoral fracture model studying two groups of mice, one that was treated by a daily injection of 10 µg recombinant endostatin subcutaneously (n = 38) and a second one that received the vehicle for control (n = 37). Histomorphometric analysis showed a significantly increased callus formation in endostatin-treated animals at 2 and 5 weeks post-fracture. This was associated with a significantly higher callus tissue fraction of cartilage and fibrous tissue at 2 weeks and a significantly higher fraction of bone at 5 weeks post-fracture. Biomechanical testing revealed a significantly higher torsional stiffness in the endostatin group at 2 weeks. For both groups, we could demonstrate the expression of the endostatin receptor unit integrin alpha5 in endothelial cells, osteoblasts, osteoclasts, and chondrocytes at 2 weeks. Immunohistochemical fluorescence staining of CD31 showed a lower number of blood vessels in endostatin-treated animals compared to controls. The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis. Keywords: angiogenesis; endostatin; fracture healing; integrin alpha5; mice. Copyright © 2013 Orthopaedic Research Society. Cited by 16 articles Full text links 142. Improvement of research quality in the fields of orthopaedics and trauma: a global perspective Int Orthop. 2013 Jul;37(7):1205-12. doi: 10.1007/s00264-013-1897-2. Epub 2013 May 21. Authors Hangama C Fayaz 1 , Norbert Haas , James Kellam , Suthorn Bavonratanavech , Javad Parvizi , George Dyer , Tim Pohlemann , Jörg Jerosch , Karl-Josef Prommersberger , Hans Christoph Pape , Malcolm Smith , Marc Vrahas , Carsten Perka , Klaus Siebenrock , Bassem Elhassan , Christopher Moran , Jesse B Jupiter Affiliation 1 Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. dr.hana.fayaz@hotmail.de PMID: 23689761 PMCID: PMC3685675 DOI: 10.1007/s00264-013-1897-2 Abstract The international orthopaedic community aims to achieve the best possible outcome for patient care by constantly modifying surgical techniques and expanding the surgeon's knowledge. These efforts require proper reflection within a setting that necessitates a higher quality standard for global orthopaedic publication. Furthermore, these techniques demand that surgeons acquire information at a rapid rate while enforcing higher standards in research performance. An international consensus exists on how to perform research and what rules should be considered when publishing a scientific paper. Despite this global agreement, in today's "Cross Check Era", too many authors do not give attention to the current standards of systematic research. Thus, the purpose of this paper is to describe these performance standards, the available choices for orthopaedic surgeons and the current learning curve for seasoned teams of researchers and orthopaedic surgeons with more than three decades of experience. These lead to provide an accessible overview of all important aspects of the topics that will significantly influence the research development as we arrive at an important globalisation era in orthopaedics and trauma-related research. Cited by 11 articles 39 references 1 figure Full text links 143. Osteitis pubis and adductor tendinopathy in athletes: a novel arthroscopic pubic symphysis curettage and adductor reattachment Arch Orthop Trauma Surg. 2013 Jul;133(7):1003-9. doi: 10.1007/s00402-013-1777-7. Epub 2013 May 21. Authors Sascha Jörg Hopp 1 , Ulf Culemann , Jens Kelm , Tim Pohlemann , Antonius Pizanis Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University of Saarland, Kirrbergerstrasse 1, 6421 Homburg/Saar, Germany. sascha.hopp@uks.eu PMID: 23689650 DOI: 10.1007/s00402-013-1777-7 Abstract Introduction: Various surgical treatment options have been described in athletes with degenerative osteitis pubis who fail to respond to conservative treatment modalities. Although adductor longus tendinopathy often represents an additional pain generator in chronic groin pain associated with osteitis pubis, this has not been acknowledged in the surgical literature, to our knowledge. We present the results of a novel surgical technique for combined degenerative lesions of the pubic symphysis joint and the adjacent adductor longus tendon in a series of athletes with osteitis pubis. Methods: During 2009 and 2010, five competitive non-professional soccer players with considerable groin and pubic pain were referred to our clinic, after conservative therapy over a period of at least 12 months had failed. According to our clinical protocol for patients with groin pain, physical examination, pelvic radiographs and arthrography of the pubic symphysis to detect microlesions of the adjacent adductor longus tendons were performed. The patients diagnosed with degenerative osteitis pubis and concomitant lesion of the adductor longus origin were indicated for surgery. Surgery consisted of resection of the degenerative soft and bone tissue and subsequent reattachment with suture anchors. With regard to stability of the symphysis pubis, a two-portal arthroscopic curettage of the degenerative fibrocartilaginous disc tissue was performed. The patients were followed prospectively at medium term with assessment of general pain level (VAS score) and sport activity with pain (NIPPS score) pre- and postoperatively. Results: All patients recovered to full activity sports after an average period of 14.4 weeks. VAS and NIPPS scores markedly improved and overall satisfaction with the postoperative result was high. One intraoperative bleeding occurred, needing revision surgery. None of the patients developed pubic instability due to pubic symphysis curettage in the sequel. Conclusions: This novel surgical technique combines successfully stability-preserving arthroscopic pubic symphysis curettage with adductor debridement and reattachment in well-selected cases of athletes suffering from degenerative osteitis pubis and concomitant adductor pathology, being refractory to conservative treatment. Diligent preoperative evaluation of the specific pathology will lead to successful outcome. Cited by 12 articles Full text links 144. Trauma registry record linkage: methodological approach to benefit from complementary data using the example of the German Pelvic Injury Register and the TraumaRegister DGU(®) BMC Med Res Methodol. 2013 Mar 5:13:30. doi: 10.1186/1471-2288-13-30. Authors Markus Burkhardt 1 , Ulrike Nienaber , Joerg H Holstein , Ulf Culemann , Bertil Bouillon , Emin Aghayev , Thomas Paffrath , Marc Maegele , Tim Pohlemann , Rolf Lefering ; TraumaRegister DGU(®) ; Pelvic Injury Register of the German Trauma Society Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstrasse 100, 66421, Homburg/Saar, Germany. markus.burkhardt@uks.eu PMID: 23496832 PMCID: PMC3607975 DOI: 10.1186/1471-2288-13-30 Abstract Background: In Germany, hospitals can deliver data from patients with pelvic fractures selectively or twofold to two different trauma registries, i.e. the German Pelvic Injury Register (PIR) and the TraumaRegister DGU(®) (TR). Both registers are anonymous and differ in composition and content. We describe the methodological approach of linking these registries and reidentifying twofold documented patients. The aim of the approach is to create an intersection set that benefit from complementary data of each registry, respectively. Furthermore, the concordance of data entry of some clinical variables entered in both registries was evaluated. Methods: PIR (4,323 patients) and TR (34,134 patients) data from 2004-2009 were linked together by using a specific match code including code of the trauma department, dates of admission and discharge, patient's age, and sex. Data entry concordance was evaluated using haemoglobin and blood pressure levels at emergency department arrival, Injury Severity Score (ISS), and mortality. Results: Altogether, 420 patients were identified as documented in both data sets. Linkage rates for the intersection set were 15.7% for PIR and 44.4% for TR. Initial fluid management for different Tile/OTA types of pelvic ring fractures and the patient's posttraumatic course, including intensive care unit data, were now available for the PIR population. TR is benefiting from clinical use of the Tile/OTA classification and from correlation with the distinct entity "complex pelvic injury." Data entry verification showed high concordance for the ISS and mortality, whereas initial haemoglobin and blood pressure data showed significant differences, reflecting inconsistency at the data entry level. Conclusions: Individually, the PIR and the TR reflect a valid source for documenting injured patients, although the data reflect the emphasis of the particular registry. Linking the two registries enabled new insights into care of multiple-trauma patients with pelvic fractures even when linkage rates were poor. Future considerations and development of the registries should be done in close bilateral consultation with the aim of benefiting from complementary data and improving data concordance. It is also conceivable to integrate individual modules, e.g. a pelvic fracture module, into the TR likewise a modular system in the future. Cited by 7 articles 28 references 2 figures Full text links 145. [Anterior approaches to the pelvic ring] Unfallchirurg. 2013 Mar;116(3):198-204. doi: 10.1007/s00113-012-2329-2. [Article in German] Authors S C Becker 1 , J H Holstein , A Pizanis , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg. PMID: 23478896 DOI: 10.1007/s00113-012-2329-2 Abstract Anterior approaches for the stabilization of anterior and also posterior B and C type instability of the pelvic ring were the standard procedures before minimally invasive percutaneous methods supported by image intensifiers or navigation devices were established. Anterior approaches are currently still of high relevance for difficult or impossible closed reductions in multiple trauma surgery where the patient must remain in a supine position. They are also used for stabilization of an increasing number of osteoporotic fractures in the elderly which are no longer only treated in specialized pelvic trauma centres. The anterior as well as the posterior part of the pelvic ring can be stabilized via various anterior approaches. A Pfannenstiel incision is appropriate for plating of ruptures of the pubic symphysis and can be extended to a modified Stoppa approach if necessary. Fractures of the iliac wings can be approached either laterally or less traumatically, via an anterolateral approach. The latter equates the lateral window of the ilioinguinal approach to the acetabulum, allows visualization of the entire sacroiliac joint and therefore stabilization of not only iliosacral luxation but also luxated fractures with a small iliac fragment. By a combination of the different approaches it is possible to simultaneously stabilize ventral and dorsal instabilities in type C fractures of the pelvic ring with a minimal amount of iatrogenic soft tissue trauma. Although the described anterior approaches are considered as simple exact knowledge of the endangered structures and general risks for each approach are essential for a safe exposure of the anatomical region addressed. Cited by 5 articles 17 references Full text links 146. Reduced myofibroblast differentiation on femtosecond laser treated 316LS stainless steel Mater Sci Eng C Mater Biol Appl. 2013 Mar 1;33(2):901-8. doi: 10.1016/j.msec.2012.11.018. Epub 2012 Nov 21. Authors Martin Oberringer 1 , Erhan Akman 2 , Juseok Lee 3 , Wolfgang Metzger 1 , Cagri Kaan Akkan 3 , Elif Kacar 2 , Arif Demir 4 , Hashim Abdul-Khaliq 5 , Norbert Pütz 6 , Gunther Wennemuth 6 , Tim Pohlemann 1 , Michael Veith 3 , Cenk Aktas 7 Affiliations 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. 2 Laser Technologies Research and Application Center (LATARUM), Kocaeli University, Yeniköy/Kocaeli, Turkey. 3 CVD/Biosurfaces Division, INM - Leibniz Institute for New Materials, Saarbrücken, Germany. 4 Laser Technologies Research and Application Center (LATARUM), Kocaeli University, Yeniköy/Kocaeli, Turkey; BEAM Ar-Ge Optic, Laser and Spectroscopy, KOU Technopark, Kocaeli, 41275, Turkey. 5 Clinic for Pediatric Cardiology, Saarland University Hospital, Homburg, Germany. 6 Department of Anatomy and Cell Biology, Saarland University, Homburg, Germany. 7 CVD/Biosurfaces Division, INM - Leibniz Institute for New Materials, Saarbrücken, Germany. Electronic address: cenk.aktas@inm-gmbh.de. PMID: 25427504 DOI: 10.1016/j.msec.2012.11.018 Abstract In-stent restenosis is a common complication after stent surgery which leads to a dangerous wall narrowing of a blood vessel. Laser assisted patterning is one of the effective methods to modify the stent surface to control cell-surface interactions which play a major role in the restenosis. In this current study, 316 LS stainless steel substrates are structured by focusing a femtosecond laser beam down to a spot size of 50 μm. By altering the laser induced spot density three distinct surfaces (low density (LD), medium density (MD) and high density (HD)) were prepared. While such surfaces are composed of primary microstructures, due to fast melting and re-solidification by ultra-short laser pulses, nanofeatures are also observed as secondary structures. Following a detailed surface characterization (chemical and physical properties of the surface), we used a well-established co-culture assay of human microvascular endothelial cells and human fibroblasts to check the cell compatibility of the prepared surfaces. The surfaces were analyzed in terms of cell adherence, proliferation, cell morphology and the differentiation of the fibroblast into the myofibroblast, which is a process indicating a general fibrotic shift within a certain tissue. It is observed that myofibroblast proliferation decreases significantly on laser treated samples in comparison to non-treated ones. On the other hand endothelial cell proliferation is not affected by the surface topography which is composed of micro- and nanostructures. Such surfaces may be used to modify stent surfaces for prevention or at least reduction of restenosis. Copyright © 2012 Elsevier B.V. All rights reserved. Cited by 3 articles Full text links 147. What are predictors for patients' quality of life after pelvic ring fractures? Clin Orthop Relat Res. 2013 Sep;471(9):2841-5. doi: 10.1007/s11999-013-2840-y. Authors Joerg H Holstein 1 , Antonius Pizanis , Daniel Köhler , Tim Pohlemann ; Working Group Quality of Life After Pelvic Fractures Collaborators Working Group Quality of Life After Pelvic Fractures : Emin Aghayev , Marcus Burkhardt , Ulf Culemann , Ivan Marintschev , Thomas Fuchs , Hagen Schmal Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg, Germany. joerg.holstein@uks.eu PMID: 23408176 PMCID: PMC3734423 DOI: 10.1007/s11999-013-2840-y Abstract Background: Data from literature on predictors for patients' quality of life after pelvic ring fractures are conflicting and based on small study populations. Questions/purposes: We therefore evaluated predictors for health-related quality of life in patients with pelvic ring injuries at a minimum of 1 year postfracture. Methods: We surveyed 172 patients of the German Pelvic Trauma Registry admitted to four medical centers between February 3, 2004, and May 11, 2011. The median age of the followup cohort was 47 years (range, 8-88 years); 69 of 172 (40%) patients were female. Patients were characterized by a median Injury Severity Score of 17. There were 31 Tile Type A fractures (18%), 77 Type B fractures (45%), and 64 Type C fractures (37%). The incidence of complex fractures and multiple traumas was 34 of 172 (20%) and 116 of 172 (67%), respectively. One hundred twenty-five (73%) patients were treated operatively. We obtained the EQ-5D™ score to assess patients' health-related quality of life. For the analysis of predictors for quality of life, a multivariate linear regression model was built. The median followup was 3 years (range, 1-6 years). Results: The median EQ-5D™ score was 0.78 (interquartile limits, 0.63 and 1.00). Age, complex trauma, and surgery independently predicted the EQ-5D™ score. Conclusions: We conclude patients with higher age, complex trauma, and surgery had a higher likelihood for a reduced quality of life after pelvic ring injuries. Cited by 14 articles 29 references Full text links 148. Delayed fracture healing in aged senescence-accelerated P6 mice J Invest Surg. 2013 Feb;26(1):30-5. doi: 10.3109/08941939.2012.687435. Epub 2012 Dec 28. Authors Tina Histing 1 , Swantje Kuntz , David Stenger , Claudia Scheuer , Patric Garcia , Joerg H Holstein , Moritz Klein , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 23273143 DOI: 10.3109/08941939.2012.687435 Abstract Background: Osteoporosis is characterized by poor bone quality. However, it is still controversially discussed whether osteoporosis compromises fracture healing. Herein, we studied whether the course of healing of a femur fracture is affected by osteoporosis or age. Methods: Using the senescence-accelerated osteoporotic mouse, strain P6 (SAMP6), and a closed femur fracture model, we studied the process of fracture healing in 5- and 10-month-old animals, including biomechanical, histomorphometric, and protein biochemical analysis. Results: In five-month-old osteoporotic SAMP6 mice, bending stiffness, callus size, and callus tissue distribution as well as the concentrations of the bone formation marker osteocalcin and the bone resorption markers tartrate-resistant acid phosphatase form 5b (TRAP) and deoxypyridinoline (DPD) did not differ from that of non-osteoporotic, senescence-resistant, strain 1 (SAMR1) controls. In contrast, femur fractures in 10-month-old SAMP6 mice showed a significantly reduced bending stiffness and an increased callus size compared to fractures in age-matched SAMR1 controls. This indicates a delayed fracture healing in advanced age SAMP6 mice. The delay of fracture healing was associated with higher concentrations of TRAP and DPD. Significant differences in osteocalcin concentrations were not found between SAMP6 animals and SAMR1 controls. Conclusion: In conclusion, the present study indicates that fracture healing in osteoporotic SAMP6 mice is not affected in five-month-old animals, but delayed in animals with an age of 10 months. This is most probably due to the increased osteoclast activity in advanced age SAMP6 animals. Cited by 13 articles Full text links 149. Expansion and differentiation of human primary osteoblasts in two- and three-dimensional culture Biotech Histochem. 2013 Feb;88(2):86-102. doi: 10.3109/10520295.2012.741262. Epub 2012 Dec 4. Authors W Metzger 1 , L Schimmelpfennig , B Schwab , D Sossong , N Dorst , M Bubel , A Görg , N Pütz , G Wennemuth , T Pohlemann , M Oberringer Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Building. 57, 66421 Homburg, Germany. johann-wolfgang.metzger@uks.eu PMID: 23210615 DOI: 10.3109/10520295.2012.741262 Abstract Despite the regenerative capability of bone, treatment of large defects often requires bone grafts. The challenge for bone grafting is to establish rapid and sufficient vascularization. Three-dimensional (3D) multicellular spheroids consisting of the relevant cell types can be used as "mini tissues" to study the complexity of angiogenesis. We investigated two-dimensional (2D) expansion, differentiation and characterization of primary osteoblasts as steps toward the establishment of 3D multicellular spheroids. Supplementation of cell culture medium with vitamin D(3) induces the osteocalcin expression of osteoblasts. An increased osteocalcin concentration of 10.8 ± 0.58 ng/ml could be measured after 19 days in supplemented medium. Vitamin D(3) has no influence on the expression of alkaline phosphatase or the deposition of calcium. Expression of these additional osteogenic markers requires addition of a cocktail of osteogenic factors that, conversely, have no influence on the expression of osteocalcin. Supplementation of the cell culture medium with both vitamin D(3) and a cocktail of osteogenic factors is recommended to produce an osteoblast phenotype that secretes osteocalcin, expresses alkaline phosphatase and deposits calcium. In such a supplemented medium, a mean osteocalcin concentration of 11.63 ± 4.85 ng/ml was secreted by the osteoblasts. Distinguishing osteoblasts and fibroblasts remains a challenge. Neither differentiated nor undifferentiated osteoblasts can be distinguished from fibroblasts by the expression of CD90, ED-A-fibronectin or α-smooth muscle actin; however, these cell types exhibit clear differences in their growth characteristics. Osteoblasts can be arranged as 3D spheroids by coating the bottom of the cell culture device with agarose. The cellular composition of 3D multicellular spheroids can be evaluated quantitatively using vital fluorescence labeling techniques. Spheroids are a promising tool for studying angiogenic and osteogenic phenomena in vivo and in vitro. Cited by 4 articles Full text links 150. Excess dietary methionine does not affect fracture healing in mice Med Sci Monit. 2012 Dec;18(12):BR469-74. doi: 10.12659/msm.883590. Authors Joerg H Holstein 1 , Julia Schmalenbach , Markus Herrmann , Ilona Ölkü , Patric Garcia , Tina Histing , Wolfgang Herrmann , Michael D Menger , Tim Pohlemann , Lutz Claes Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 23197225 PMCID: PMC3560796 DOI: 10.12659/msm.883590 Abstract Background: An elevated serum concentration of homocysteine (hyperhomocysteinemia) has been shown to disturb fracture healing. As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair. Material/methods: We analyzed bone repair in 2 groups of mice. One group was fed a methionine-rich diet (n=13), and the second group received an equicaloric control diet without methionine supplementation (n=12). Using a closed femoral fracture model, bone repair was analyzed by histomorphometry and biomechanical testing at 4 weeks after fracture. Blood was sampled to measure serum concentrations of homocysteine, the bone formation marker osteocalcin, and the bone resorption marker collagen I C-terminal crosslaps Results: Serum concentrations of homocysteine were significantly higher in the methionine group than in the control group, while serum markers of bone turnover did not differ significantly between the 2 groups. Histomorphometry revealed no significant differences in size and tissue composition of the callus between animals fed the methionine-enriched diet and those receiving the control diet. Accordingly, animals of the 2 groups showed a comparable bending stiffness of the healing bones. Conclusions: We conclude that excess methionine intake causes hyperhomocysteinemia, but does not affect fracture healing in mice. Cited by 1 article 32 references 5 figures Full text links 151. [The pelvis] Unfallchirurg. 2012 Nov;115(11):956-7. doi: 10.1007/s00113-012-2311-z. [Article in German] Author T Pohlemann 1 Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Straße 166421 Homburgtim. pohlemann@uks.eu PMID: 23143031 DOI: 10.1007/s00113-012-2311-z No abstract available Full text links 152. Reduction and fixation capabilities of different plate designs for pubic symphysis disruption: a biomechanical comparison Injury. 2013 Feb;44(2):183-8. doi: 10.1016/j.injury.2012.09.023. Epub 2012 Oct 12. Authors Antonius Pizanis 1 , Patric Garcia , Maike Santelmann , Ulf Culemann , Tim Pohlemann Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital of Saarland, D-66424 Homburg/Saar, Germany. antonius.pizanis@uks.eu PMID: 23068141 DOI: 10.1016/j.injury.2012.09.023 Abstract Background: Typical stabilisation of pelvic open book injuries consists in plate fixation of the symphysis, leading to many different plate designs and procedures that have evolved. However, implant loosening and development of chronic instability are still evident and represent major complications after plate fixation of the symphysis. The aim of this study was to analyse reduction and fixation capabilities of different classical plate techniques with dynamic compression (DC), prebending or modern interlocking screws. Methods: Compression injuries (OTA B1.1) were simulated on synthetic composite pelvises. Sensor films placed in the disrupted symphysis allowed assessment of reduction and compression forces, as well as contact characteristics by implants at defined time points under static non loaded conditions. The commercially available steel plates used in our study differed in curved design, prebending and DC- or locking screw capabilities, as narrow large fragment (4.5) or small fragment plates (3.5). Results: DC procedure clearly increased the compressive force in the symphysis and improved the reduction by enhanced contact areas. These effects were preserved to the end of the experiments only when the plates were prebended (10°). Anatomically contoured and prebended 3.5 plates had a similar effect, but the contact area was even more pronounced. Best results were observed using the "3.5 symphyseal plate" with DC-effect medially and locking screws laterally. Purely interlocking screw plates by themselves allowed an optimal contact area, yet failed to preserve the initial compressive reduction force. Conclusions: The experimental results suggest a biomechanical advantage in using prebended plates for symphysis fixation compared to non-bended plates. Best results with regard to compression and increased contact area can be achieved by anatomically contoured plates with combined DC and locking screw capabilities. These findings are of special interest in pelvic surgery for choosing the right implant in severe displacements, obese patients and symphysiodesis techniques. Copyright © 2012 Elsevier Ltd. All rights reserved. Cited by 8 articles Full text links 153. Soft tissue fibroblasts from well healing and chronic human wounds show different rates of myofibroblasts in vitro Mol Biol Rep. 2013 Feb;40(2):1721-33. doi: 10.1007/s11033-012-2223-6. Epub 2012 Oct 14. Authors Florian Schwarz 1 , Martina Jennewein , Monika Bubel , Joerg H Holstein , Tim Pohlemann , Martin Oberringer Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Bldng. 57, 66421, Homburg, Germany. PMID: 23065295 DOI: 10.1007/s11033-012-2223-6 Abstract Due to an increasing life expectancy in western countries, chronic wound treatment will be an emerging challenge in the next decades. Because therapies are improving slowly appropriate diagnostic tools enabling the early prediction of the healing success remain to be developed. We used a well-established in vitro assay in combination with the analysis of 27 cytokines to discriminate between fibroblasts from chronic (n = 6) and well healing (n = 8) human wounds. Proliferation and migration of the cells as well as their response to hypoxia and their behaviour in co-culture with microvascular endothelial cells were analyzed. Myofibroblast differentiation, a time-limited essential process of regular wound healing, was also quantified. Besides weaker proliferation and migration significantly higher rates of myofibroblasts were detected in chronic wounds. With respect to the cytokine release, there was a clear trend within the group of chronic wound fibroblasts, which were releasing interferon-γ, monocyte chemotactic protein-1, granulocyte-macrophage colony stimulating factor and basic fibroblast growth factor in higher amounts than fibroblasts from healing wounds. Although the overall response of both groups of fibroblasts to hypoxia and to the contact with endothelial cells was similar, especially chronic wound fibroblasts seemed to benefit from the endothelial interaction during hypoxia and displayed better migration characteristics. The study shows (1) that the assay can identify specific features of fibroblasts derived from different human wounds and (2) that wound fibroblasts are varying in their response to the chosen parameters. Thus, current therapeutic approaches and individual healing prediction might benefit from this assay. Cited by 11 articles 67 references Full text links 154. Acute management and outcome of multiple trauma patients with pelvic disruptions Crit Care. 2012 Aug 22;16(4):R163. doi: 10.1186/cc11487. Authors Markus Burkhardt , Ulrike Nienaber , Antonius Pizanis , Marc Maegele , Ulf Culemann , Bertil Bouillon , Sascha Flohé , Tim Pohlemann , Thomas Paffrath ; TraumaRegister DGU ; German Pelvic Injury Register of the Deutsche Gesellschaft für Unfallchirurgie PMID: 22913820 PMCID: PMC3580753 DOI: 10.1186/cc11487 Abstract Introduction: Data on prehospital and trauma-room fluid management of multiple trauma patients with pelvic disruptions are rarely reported. Present trauma algorithms recommend early hemorrhage control and massive fluid resuscitation. By matching the German Pelvic Injury Register (PIR) with the TraumaRegister DGU (TR) for the first time, we attempt to assess the initial fluid management for different Tile/OTA types of pelvic-ring fractures. Special attention was given to the patient's posttraumatic course, particularly intensive care unit (ICU) data and patient outcome. Methods: A specific match code was applied to identify certain patients with pelvic disruptions from both PIR and TR anonymous trauma databases, admitted between 2004 and 2009. From the resulting intersection set, a retrospective analysis was done of prehospital and trauma-room data, length of ICU stay, days of ventilation, incidence of multiple organ dysfunction syndrome (MODS), sepsis, and mortality. Results: In total, 402 patients were identified. Mean ISS was 25.9 points, and the mean of patients with ISS ≥ 16 was 85.6%. The fracture distribution was as follows: 19.7% type A, 29.4% type B, 36.6% type C, and 14.3% isolated acetabular and/or sacrum fractures. The type B/C, compared with type A fractures, were related to constantly worse vital signs that necessitated a higher volume of fluid and blood administration in the prehospital and/or the trauma-room setting. This group of B/C fractures were also related to a significantly higher presence of concomitant injuries and related to increased ISS. This was related to increased ventilation and ICU stay, increased rate of MODS, sepsis, and increased rate of mortality, at least for the type C fractures. Approximately 80% of the dead had sustained type B/C fractures. Conclusions: The present study confirms the actuality of traditional trauma algorithms with initial massive fluid resuscitation in the recent therapy of multiple trauma patients with pelvic disruptions. Low-volume resuscitation seems not yet to be accepted in practice in managing this special patient entity. Mechanically unstable pelvic-ring fractures type B/C (according to the Tile/OTA classification) form a distinct entity that must be considered notably in future trauma algorithms. Cited by 21 articles 38 references 2 figures Full text links 155. Management of hemodynamic unstable patients "in extremis" with pelvic ring fractures Acta Chir Orthop Traumatol Cech. 2012;79(3):193-202. Authors A Gänsslen 1 , F Hildebrand , T Pohlemann Affiliation 1 Klinik für Unfallchirurgie, Orthopädie und Handchirurgie, Klinikum der Stadt Wolfsburg, Wolfsburg, Germany. PMID: 22840950 Abstract The hemodynamic status in patients with pelvic ring injuries is a major prognostic factor of an immediate mortality risk. Especially, patients "in extremis" are of high risk to die. This patient group is characterized by absent vital signs or being in severe shock with initial systolic blood pressure .70 mm Hg and/or requiring mechanical resuscitation or catecholamines despite >12 blood transfusions within the first two hours after admission. The sources of pelvic bleeding is in approximately 80-90% of venous origin and relevant arterial bleeding accounts for 10-20%. Important parts of the initial treatment treatment concept include mechanical pelvic ring stabilization combined with hemorrhage control concepts. Mechanical stabilization is performed non-invasively by pelvic binder application or invasively by classical anterior pelvic fixation or posterior pelvic C-clamp, depending on the local available resources. In patients "in extremis" the concept of direct extraperitoneal pelvic packing is recommended, whereas in moderately unstable patients or in patients where persistant hemodynamic instability occurs despite shock therapy and mechanical stabilization and pelvic packing, arterial injury is ruled out by angiography followed by selected embolization of pelvic vessels. Cited by 12 articles 156. Angioembolization for pelvic hemorrhage control: results from the German pelvic injury register J Trauma Acute Care Surg. 2012 Sep;73(3):679-84. doi: 10.1097/TA.0b013e318253b5ba. Authors Oliver Hauschild 1 , Emin Aghayev , Johanna von Heyden , Peter C Strohm , Ulf Culemann , Tim Pohlemann , Norbert P Suedkamp , Hagen Schmal Affiliation 1 Department for Orthopedic Surgery and Traumatology, Freiburg University Medical Center, Freiburg, Germany. PMID: 22710767 DOI: 10.1097/TA.0b013e318253b5ba Abstract Background: Hemorrhage from pelvic vessels is a potentially lethal complication of pelvic fractures. There is ongoing controversy on the ideal treatment strategy for patients with pelvic hemorrhage. The aim of the study was to analyze the role of angiography and subsequent embolization in patients with pelvic fractures and computed tomography scan-proven vascular injuries. Methods: The data from the prospective multicenter German pelvic injury registry were analyzed. Of 5,040 patients with pelvic fractures, 152 patients with associated vascular injuries were identified. Patients undergoing angioembolization (n = 17) were compared with those undergoing conventional measures for hemorrhage control (n = 135) with regard to demographic and physiologic parameters, fracture type distribution, and treatment measures. Outcome measures were mortality, requirement for blood transfusions, complications, and hospital length of stay. Results: Embolization and nonembolization groups were comparable with regard to age, sex, Injury Severity Score, Hannover Polytrauma Score, initial hemoglobin levels, blood pressure, fracture distribution, and conventional measures. Blood transfusion requirement was significantly prolonged in the embolization group. This resulted in a higher adult respiratory distress syndrome incidence and a tendency toward increased multiple organ failure rate in this group. There was no significant difference in overall mortality rate when compared with the nonembolization group (17.6% vs. 32.6%, respectively; p = 0.27). None of the patients undergoing embolization died from exsanguination when compared with 20.6% in the nonembolization group (p = 0.038). Conclusion: Angioembolization alongside with conventional measures is an effective complementary means for hemorrhage control in patients sustaining pelvic fracture-related vascular lesions. It might prove even more effective when performed early enough to avoid prolonged blood transfusion requirement. Further studies without the mentioned limitations of the study are desired. Level of evidence: Therapeutic study, level IV. Cited by 30 articles Full text links 157. Screw- versus plate-fixation strength of acetabular anterior column fractures: a biomechanical study J Trauma Acute Care Surg. 2012 Jun;72(6):1664-70. doi: 10.1097/TA.0b013e3182463b45. Authors Florian Gras 1 , Ivan Marintschev , Christoph E Schwarz , Gunther O Hofmann , Tim Pohlemann , Ulf Culemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Friedrich Schiller University, Jena, Germany. marc.gras@med.uni-jena.de PMID: 22695438 DOI: 10.1097/TA.0b013e3182463b45 Abstract Background: The standard for operative treatment of acetabular fractures is open reduction and plate fixation. Recently, screw fixation-only methods through less invasive approaches are reported, but biomechanical data are missing. Questions posed in this study are (1) is the static fixation strength of different screw types equivalent to the standard plate fixation for anterior column fractures of the acetabulum? and (2) does the placement of an additional screw in the infra-acetabular corridor increase the fixation strength independent of the used implant? Methods: Three groups of different screws (group II, titanium; group III, stainless steel; and group IV, biodegradable Poly-L-Lactid) were compared with the standard plate fixation (group I) in Synbone pelves with custom-made anterior column fractures. Six pelvises per group were axial loaded with six cycles of 800 N, twice with and without an additional placed infra-acetabular screw. Results: The fixation strength of titanium screws was equivalent to the standard plate fixation. The stainless steel and Poly-L-Lactid screw fixation strengths were equivalent to each other but inferior to the aforementioned. The additional placement of an infra-acetabular screw significantly increased the fracture fixation strength, independent of the used implant. Conclusion: Screw fixation is a promising alternative approach for the stabilization of noncomminuted acetabular fractures of the anterior column with equivalent fixation strength to the standard plate fixation. The additional placement of an infra-acetabular screw significantly increases the fracture fixation independent of the used implant and should be considered for acetabular fractures with separation of both columns. Level of evidence: Therapeutic study, level IV. Copyright © 2012 by Lippincott Williams & Wilkins. Cited by 27 articles Full text links 158. A new model to analyze metaphyseal bone healing in mice J Surg Res. 2012 Dec;178(2):715-21. doi: 10.1016/j.jss.2012.04.007. Epub 2012 Apr 27. Authors Tina Histing 1 , Moritz Klein , Andrea Stieger , David Stenger , Roland Steck , Romano Matthys , Joerg H Holstein , Patric Garcia , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 22560849 DOI: 10.1016/j.jss.2012.04.007 Abstract Background: Despite the increasing clinical problems with metaphyseal fractures, most experimental studies investigate the healing of diaphyseal fractures. Although the mouse would be the preferable species to study the molecular and genetic aspects of metaphyseal fracture healing, a murine model does not exist yet. Using a special locking plate system, we herein introduce a new model, which allows the analysis of metaphyseal bone healing in mice. Methods: In 24 CD-1 mice the distal metaphysis of the femur was osteotomized. After stabilization with the locking plate, bone repair was analyzed radiologically, biomechanically, and histologically after 2 (n=12) and 5 wk (n=12). Additionally, the stiffness of the bone-implant construct was tested biomechanically ex vivo. Results: The torsional stiffness of the bone-implant construct was low compared with nonfractured control femora (0.23 ± 0.1 Nmm/°versus 1.78 ± 0.15 Nmm/°, P<0.05). The cause of failure was a pullout of the distal screw. At 2 wk after stabilization, radiological analysis showed that most bones were partly bridged. At 5 wk, all bones showed radiological union. Accordingly, biomechanical analyses revealed a significantly higher torsional stiffness after 5 wk compared with that after 2 wk. Successful healing was indicated by a torsional stiffness of 90% of the contralateral control femora. Histological analyses showed new woven bone bridging the osteotomy without external callus formation and in absence of any cartilaginous tissue, indicating intramembranous healing. Conclusion: With the model introduced herein we report, for the first time, successful metaphyseal bone repair in mice. The model may be used to obtain deeper insights into the molecular mechanisms of metaphyseal fracture healing. Copyright © 2012 Elsevier Inc. All rights reserved. Cited by 8 articles Full text links 159. Pantoprazole, a proton pump inhibitor, delays fracture healing in mice Calcif Tissue Int. 2012 Jun;90(6):507-14. doi: 10.1007/s00223-012-9601-x. Epub 2012 Apr 24. Authors T Histing 1 , D Stenger , C Scheuer , W Metzger , P Garcia , J H Holstein , M Klein , T Pohlemann , M D Menger Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, 66421, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 22527206 DOI: 10.1007/s00223-012-9601-x Abstract Proton pump inhibitors (PPIs), which are widely used in the treatment of dyspeptic problems, have been shown to reduce osteoclast activity. There is no information, however, on whether PPIs affect fracture healing. We therefore studied the effect of the PPI pantoprazole on callus formation and biomechanics during fracture repair. Bone healing was analyzed in a murine fracture model using radiological, biomechanical, histomorphometric, and protein biochemical analyses at 2 and 5 weeks after fracture. Twenty-one mice received 100 mg/kg body weight pantoprazole i.p. daily. Controls (n = 21) received equivalent amounts of vehicle. In pantoprazole-treated animals biomechanical analysis revealed a significantly reduced bending stiffness at 5 weeks after fracture compared to controls. This was associated with a significantly lower amount of bony tissue within the callus and higher amounts of cartilaginous and fibrous tissue. Western blot analysis showed reduced expression of the bone formation markers bone morphogenetic protein (BMP)-2, BMP-4, and cysteine-rich protein (CYR61). In addition, significantly lower expression of proliferating cell nuclear antigen indicated reduced cell proliferation after pantoprazole treatment. Of interest, the reduced expression of bone formation markers was associated with a significantly diminished expression of RANKL, indicating osteoclast inhibition. Pantoprazole delays fracture healing by affecting both bone formation and bone remodeling. Cited by 27 articles Full text links 160. Balloon tibioplasty: a useful tool for reduction of tibial plateau depression fractures J Orthop Trauma. 2012 Jul;26(7):e88-93. doi: 10.1097/BOT.0b013e31823a8dc8. Authors Antonius Pizanis 1 , Patric Garcia , Tim Pohlemann , Markus Burkhardt Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. antonius.pizanis@uks.eu PMID: 22430523 DOI: 10.1097/BOT.0b013e31823a8dc8 Abstract Reduction of the articular surface in displaced tibial plateau fractures is still challenging and may result in joint incongruence, leading to posttraumatic arthrosis. Conventional techniques use bone tamps and similar instruments, which can increase the surgical trauma due to their size. "Balloon tibioplasty" is a novel minimally invasive technique for the reduction of depressed tibial plateau fractures. We successfully applied an inflatable balloon, commercially available from kyphoplasty, to elevate the depressed articular fragments. This technique allowed for reduction of the depressed tibial plateau fragment without classic fenestration of the tibia, thereby minimizing surgical trauma. Furthermore, under fluoroscopic control, optimal centering of the expanding tibioplasty balloon allows a widespread and continuously increasing reduction force to the fracture area. After fluoroscopy or arthroscopic confirmation of reduction of the articular surface, the cavity resulting from tibioplasty was filled with ceramic bone cement through small incisions and fractures were fixed with a small fragment locking T-plate (3.5 mm). Balloon tibioplasty was applied in 5 patients with displaced tibial plateau fractures (OTA type B2/3). No intra- or postoperative complications were observed. This new technique may be a useful tool to facilitate the reduction of select depressed tibial fractures in the future. Cited by 20 articles Full text links 161. The treatment of patients with severe and multiple traumatic injuries Dtsch Arztebl Int. 2012 Feb;109(6):102-8. doi: 10.3238/arztebl.2012.0102. Epub 2012 Feb 10. Authors Edmund A M Neugebauer 1 , Christian Waydhas , Sven Lendemans , Dieter Rixen , Michaela Eikermann , Tim Pohlemann Affiliation 1 Institut für Forschung in der Operativen Medizin, Universität Witten/Herdecke, Germany. edmund.neugebauer@uni-wh.de PMID: 22396708 PMCID: PMC3295210 DOI: 10.3238/arztebl.2012.0102 Abstract Background: The care of severely and multiply injured patients is an interdisciplinary challenge. The only existing German-language guideline up to now has been the S1-guideline issued in 2002 by the German Society for Trauma Surgery (Deutsche Gesellschaft für Unfallchirurgie, DGU). In this article, we present a new, comprehensive, evidence and consensus based S3-guideline for the treatment of severely and multiply injured patients in the pre-hospital and early in-hospital phases which has been developed with the aim of structural and procedural quality optimization. Its implementation should lower these patients' mortality and improve their quality of life. Methods: The guideline was developed by a panel consisting of 18 delegates from 11 specialty societies under the lead of the DGU, with designated coordinators for each of three phases of treatment: the pre-hospital phase, the emergency-room phase, and the emergency surgery phase. The key questions to be answered were determined by vote, and then the relevant literature (in English and German, 1995-2010) was systematically searched and evaluated. Key recommendations with explanatory texts were formulated and agreed upon in a nominal group process (NGP) with five consensus conferences and three further Delphi rounds. Results: 264 recommendations were issued: 66 for the pre-hospital phase, 102 for the emergency-room phase, and 96 for the emergency surgery phase. The three phases were subcategorized according to organizational and anatomical considerations. Topics of major emphasis were, in the pre-hospital phase, the establishment and implementation of correct priorities for treatment; in the emergency-room phase, the creation of clear structures and processes; and, in the emergency surgery phase, the avoidance of secondary injury (i.e., the principle of damage control). Conclusion: This guideline can only improve outcomes if it is implemented in routine practice. Aside from the guideline itself, the DGU trauma network (www.dgu-traumanetzwerk.de) has issued a set of directions as an aid to its implementation. Comment in Correspondence (letter to the editor): Team Leadership in the emergency room. Nöldge-Schomburg G, Van Aken H, Böttiger BW. Dtsch Arztebl Int. 2012 Oct;109(41):680; author reply 680. doi: 10.3238/arztebl.2012.0680a. Epub 2012 Oct 12. PMID: 23264809Free PMC article.No abstract available. Cited by 20 articles 22 references 1 figure Full text links 162. How to ensure the survival of the surgeon-scientist? The Homburg Program Langenbecks Arch Surg. 2012 Apr;397(4):619-22. doi: 10.1007/s00423-012-0925-9. Epub 2012 Feb 24. Authors Michael D Menger 1 , Martin K Schilling , Hans-Joachim Schäfers , Tim Pohlemann , Matthias W Laschke Affiliation 1 Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany. michael.menger@uks.eu PMID: 22362055 DOI: 10.1007/s00423-012-0925-9 Abstract Background: Academic surgery requires competence in research, teaching, and patient care. Because of the increasing complexity of both surgical research and clinical surgery, and additional skills necessary for adequate patient care, including economics, management, and organization, it becomes more and more difficult to provide an attractive education for surgeon-scientists. This has resulted in a dramatic decline in the number of surgeon-scientists in the past and alarms us to systematically restructure our research training system. Discussion: We herein introduce a program involving the clinical departments of surgery, trauma surgery, and cardiac-thoracic surgery as well as a surgical research institution. The program allows the clinical departments to sharpen their overall research profile and facilitates the establishment of competent working groups, guaranteeing long-term research activities on a high scientific level. The program involves both surgical residents and medical students, who will represent our future generation of academic surgeons, ensuring the survival of the surgeon-scientist. Cited by 13 articles 10 references Full text links 163. What are predictors of mortality in patients with pelvic fractures? Clin Orthop Relat Res. 2012 Aug;470(8):2090-7. doi: 10.1007/s11999-012-2276-9. Authors Joerg H Holstein 1 , Ulf Culemann , Tim Pohlemann ; Working Group Mortality in Pelvic Fracture Patients Collaborators Working Group Mortality in Pelvic Fracture Patients : Georgios Tosounidis , Markus Burkhardt , Emin Aghayev , Jörg Böhme , Hagen Schmal Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg, Germany. joerg.holstein@uks.eu PMID: 22354608 PMCID: PMC3392378 DOI: 10.1007/s11999-012-2276-9 Abstract Background: Our knowledge of factors influencing mortality of patients with pelvic ring injuries and the impact of associated injuries is currently based on limited information. Questions/purposes: We identified the (1) causes and time of death, (2) demography, and (3) pattern and severity of injuries in patients with pelvic ring fractures who did not survive. Methods: We prospectively collected data on 5340 patients listed in the German Pelvic Trauma Registry between April 30, 2004 and July 29, 2011; 3034 of 5340 (57%) patients were female. Demographic data and parameters indicating the type and severity of injury were recorded for patients who died in hospital (nonsurvivors) and compared with data of patients who survived (survivors). The median followup was 13 days (range, 0-1117 days). Results: A total of 238 (4%) patients died a median of 2 days after trauma. The main cause of death was massive bleeding (34%), predominantly from the pelvic region (62% of all patients who died because of massive bleeding). Fifty-six percent of nonsurvivors and 43% of survivors were male. Nonsurvivors were characterized by a higher incidence of complex pelvic injuries (32% versus 8%), less isolated pelvic ring fractures (13% versus 49%), lower initial blood hemoglobin concentration (6.7 ± 2.9 versus 9.8 ± 3.0 g/dL) and systolic arterial blood pressure (77 ± 27 versus 106 ± 24 mmHg), and higher injury severity score (ISS) (35 ± 16 versus 15 ± 12). Conclusion: Patients with pelvic fractures who did not survive were characterized by male gender, severe multiple trauma, and major hemorrhage. Level of evidence: Level III, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. Cited by 55 articles 46 references 6 figures Full text links 164. Increased exercise after stable closed fracture fixation does not affect fracture healing in mice J Biomech. 2012 Apr 30;45(7):1299-304. doi: 10.1016/j.jbiomech.2012.01.028. Epub 2012 Feb 14. Authors J H Holstein 1 , S C Becker , M Fiedler , C Scheuer , P Garcia , T Histing , M Klein , M D Menger , T Pohlemann Affiliation 1 Department of Trauma, Hand & Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 22336197 DOI: 10.1016/j.jbiomech.2012.01.028 Abstract Purpose: The aim of the present study was to evaluate the systemic biological effect of increased exercise on bone repair after stable fracture fixation. Methods: Two groups of SKH-1h mice were studied. Animals of the first group (n=36) were housed in cages supplied with a running wheel, while mice of the second group (n=37) were housed in standard cages for control. Using a closed femur fracture model, bone repair was analysed by histomorphometry and biomechanical testing at 2 and 5 weeks. At 2 weeks, we additionally evaluated the expression of the proliferation marker PCNA (proliferating cell nuclear antigen) and the angiogenic and osteogenic growth factor VEGF (vascular endothelial growth factor). To standardise the mechanical conditions in the fracture gap, we used an intramedullary compression screw for stable fracture fixation. Results: Each mouse of the exercise group run a mean total distance of 23.5 km after 2 weeks and 104.3 km after 5 weeks. Histomorphometric analysis of the size and tissue composition of the callus could not reveal significant differences between mice undergoing exercise and controls. Accordingly, biomechanical testing showed a comparable torsional stiffness, peak rotation angle, and load at failure of the healing bones in the two groups. The expression of PCNA and VEGF did also not differ between mice of the exercise group and controls. Conclusion: We conclude that increased exercise does not affect bone repair after stable fracture fixation. Copyright © 2012 Elsevier Ltd. All rights reserved. Cited by 3 articles Full text links 165. Initial experience using a pelvic emergency simulator to train reduction in blood loss Clin Orthop Relat Res. 2012 Aug;470(8):2098-103. doi: 10.1007/s11999-012-2272-0. Authors Tim Pohlemann 1 , Ulf Culemann , Joerg H Holstein Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg, Germany. tim.pohlemann@uks.eu PMID: 22311726 PMCID: PMC3392375 DOI: 10.1007/s11999-012-2272-0 Abstract Background: Because the average exposure of surgeons to pelvic injuries with life-threatening hemorrhage is decreasing, training opportunities are necessary to prepare surgeons for the rare but highly demanding emergency situations. We have developed a novel pelvic emergency simulator to train surgeons in controlling blood loss. Questions/purposes: We (1) described the design and use of the simulator; and (2) determined whether the simulator correctly identified proper and improper mechanical stabilization and bleeding control. Methods: The device contained two tube systems. The tubes of the first system were passed through the disrupted sacroiliac joint and the symphysis. By reduction (manual traction on the leg) and compression (application of the C-clamp) of the disrupted pelvis, the tubes were pinched by the synthetic bones leading to a stop of simulated blood flow through the tubes of the first system. The tubes of the second system ended in a foam representing the presacral and paravesical venous plexus. By correct preperitoneal packing, the flow into the foam was stopped. Simulated bleeding was monitored by quantifying flow out of a fluid reservoir and flow into fluid samplers. Results: The pelvic emergency simulator has been used for eight training sessions since 2002. Bleeding control by packing was achieved after 6 ± 3 minutes. Total simulated blood loss during the training session was 1296 ± 892 mL. Conclusions: Our data suggest the simulator can be used as a tool to train surgeons to reduce blood loss in severe pelvic ring injuries. Cited by 2 articles 33 references 3 figures Full text links 166. Biomechanical comparison of different acetabular plate systems and constructs--the role of an infra-acetabular screw placement and use of locking plates Injury. 2012 Apr;43(4):470-4. doi: 10.1016/j.injury.2011.11.009. Epub 2012 Jan 18. Authors Ivan Marintschev 1 , Florian Gras , Christoph E Schwarz , Tim Pohlemann , Gunther O Hofmann , Ulf Culemann Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Jena, Friedrich-Schiller-University, Jena, Erlanger Allee 101, Jena, Germany. PMID: 22261082 DOI: 10.1016/j.injury.2011.11.009 Abstract Introduction: The aim of this study was the direct comparison of the static fixation strength of two common plate systems: MPS (Matta Pelvic System) and LPPS (Low Profile Plate System). Furthermore the role of a modified screw placement with addressing the infra-acetabular corridor and the use of locking screws were evaluated. Materials and methods: Custom made anterior column fractures in artificial SYNBONE pelves were fixed with different acetabular plates (group I: MPS, group II: LPPS none locking and group III: LPPS locking). Each pelvis was tested twice, with the additionally placed infra-acetabular lag screw [+] first, followed by a repeated measurement without the infra-acetabular screw [-]. Six pelves per group were tested under static loading with six cycles up to 800N, each. The fracture displacement was measured in the weight bearing dome using an ultrasound based Zebris-3D-Motion Analyzer. Results: The MPS-plate had a less fixation strength compared to the LPPS-plate (mean±SD of maximum fracture displacement [mm] in group I vs. group II=0.63±0.02 vs. 0.37±0.02, p<0.05). The locking feature did not increase the fracture fixation strength (mean±SD of maximum fracture displacement [mm] in group II vs. group III: 0.37±0.02 vs. 0.37±0.03; ns). The infra-acetabular screw significantly reduces the maximum fracture displacement in all groups, independent of the plate systems ([Delta%] in group I=50; group II=63 and group III=40; p<0.05 each). Conclusion: The LPPS-plate performed superior fixation strength for anterior column fractures compared to the MPS-plate. The locking plate modality did not reduce the maximum fracture displacement, whereas the additional infra-acetabular screw placement actually doubles the fracture fixation strength independent of the used plate system. Copyright © 2011 Elsevier Ltd. All rights reserved. Cited by 33 articles Full text links 167. Temporal and spatial vascularization patterns of unions and nonunions: role of vascular endothelial growth factor and bone morphogenetic proteins J Bone Joint Surg Am. 2012 Jan 4;94(1):49-58. doi: 10.2106/JBJS.J.00795. Authors P Garcia 1 , A Pieruschka , M Klein , A Tami , T Histing , J H Holstein , C Scheuer , T Pohlemann , M D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Collaborative Research Center, AO Foundation, University of Saarland, D-66421 Homburg/Saar, Germany. patric.garcia@uks.eu PMID: 22218382 DOI: 10.2106/JBJS.J.00795 Abstract Background: Failure of fracture-healing with nonunion is a major clinical problem. Angiogenesis is closely linked to bone regeneration, but the role of angiogenesis in nonunion formation remains unclear. Because established nonunions are well vascularized, we hypothesized that lack of vascular endothelial growth factor (VEGF) expression and vascularization during the early time course of fracture-healing determine nonunion formation. Methods: In seventy-two CD-1 mice, a femoral osteotomy with a gap size of 1.80 mm (nonunion group) or a gap size of 0.25 mm (union group) was created and stabilized by a pin-clip technique. Healing was analyzed after three, seven, fourteen, twenty-one, twenty-eight, and seventy days by micro-computed tomography and histomorphometry. Vascularization was determined in different healing zones by immunohistochemical staining of PECAM-1 (platelet-endothelial cell adhesion molecule). Additional animals were analyzed after seven, fourteen, and twenty-one days with Western blot analysis of VEGF, bone morphogenetic protein (BMP)-2, and BMP-4 expression. Results: Micro-computed tomography and histomorphometry showed complete bone-bridging in the union group, whereas animals in the nonunion group showed atrophic nonunion formation. Vascularization increased from day 3 to day 7 in both groups, with a subsequent decrease after fourteen days. However, overall vascularization did not differ between unions and nonunions over time. It is of interest that vascularization within the endosteal healing zone was even higher in nonunions than in unions after fourteen days. Expression of VEGF was significantly higher in nonunions, while expression of BMP-2 and 4 and proliferating cell nuclear antigen were found significantly reduced compared with unions. Conclusions: Because vascularization during the early time course of fracture-healing was not impaired despite the failure of bone-healing in nonunions, we rejected our hypothesis and accepted the null hypothesis that nonunion formation is not due to failure of VEGF-mediated angiogenesis. Failure of fracture-healing was associated with a decreased expression of BMP-2 and 4 and a disturbed ratio of angiogenic to osteogenic growth factors, which may be responsible for nonunion. Clinical relevance: Because the intrinsic angiogenic response during nonunion formation was sufficient for adequate vascularization, treatment strategies for nonunions should focus on the stimulation of osteogenesis rather than on the stimulation of angiogenesis. Cited by 36 articles Full text links 168. Effects of pelvic volume changes on retroperitoneal and intra-abdominal pressure in the injured pelvic ring: a cadaveric model J Trauma. 2011 Sep;71(3):585-90; discussion 590. doi: 10.1097/TA.0b013e318224cd62. Authors Daniel Köhler 1 , Richard Martin Sellei , Aaron Sop , Ivan S Tarkin , Roman Pfeifer , Robert Leo Garrison , Tim Pohlemann , Hans Christoph Pape Affiliation 1 Department of Traumatology, Hand- and Reconstructive Surgery, UKS, Homburg, Germany. PMID: 21908997 DOI: 10.1097/TA.0b013e318224cd62 Abstract Background: Pelvic ring injuries can be associated with severe blood loss and hemodynamic instability. The increase in pelvic volume in disrupted pelvic ring injuries is thought to cause accumulation of large volumes of blood in the retroperitoneal cavity. Extra abdominal compression for reduction of the pelvic ring may affect intrapelvic pressure. We examined the effects of pelvic volume changes on retroperitoneal pressures (RPP) and intra-abdominal pressures (IAPs) in the intact and unstable pelvic ring. Methods: In a cadaver study, unembalmed human torsos were used. Infusion lines were placed adjacent to the sacroiliac joint in the retroperitoneum and in the abdominal cavity. IAP and RPP measurements were performed with sequential infusion of crystalloid solution in 1,000 mL increments. Measurements were performed in the intact pelvic ring and after induction of unilateral and bilateral instability by disruption of the pubic symphysis, the sacroiliac joints, the sacrotuberous ligaments, and sacrospinous ligaments. Results: After infusion of 4,000 mL of saline, we observed a pressure increase in the retroperitoneal cavity (RPP) of 19.64 mm Hg ± 6.43 mm Hg in the intact pelvis, 5.22 mm Hg ± 1.74 mm Hg in unilateral instability, and 2.78 mm Hg ± 0.57 mm Hg in bilateral instability. The RPP response in the case of instability decreased significantly (p = 0.019). The IAP showed a change of 4.63 mm Hg ± 2.64 mm Hg in the intact pelvis, 3.88 mm Hg ± 1.84 mm Hg in unilateral instability, and 2.30 mm Hg ± 0.36 mm Hg in bilateral instability. Further infusion revealed a close association between RAPs and IAPs. Conclusions: In the intact pelvis, RPP rises rapidly with increasing volume. The results seem to support the idea that disrupted pelvic ring fractures may lead to a significant volume uptake that is reversed during reduction. Cited by 4 articles Full text links 169. Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice Bone. 2011 Nov;49(5):1037-45. doi: 10.1016/j.bone.2011.08.004. Epub 2011 Aug 9. Authors J H Holstein 1 , M Orth , C Scheuer , A Tami , S C Becker , P Garcia , T Histing , P Mörsdorf , M Klein , T Pohlemann , M D Menger Affiliation 1 Department of Trauma, Hand & Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 21851867 DOI: 10.1016/j.bone.2011.08.004 Abstract The glycoprotein erythropoietin (EPO) has been demonstrated to stimulate fracture healing. The aim of the present study was to investigate the effect of EPO treatment on bone repair in a femoral segmental defect model. Bone repair was analyzed in mice which were treated by EPO (500IE/kg/d intraperitoneally; n=38) and in mice which received the vehicle for control (n=40). Two and 10 weeks after creating a 1.8mm femoral segmental defect, bone repair was studied by micro-CT, histology, and Western blot analysis. At 10 weeks, micro-CT and histomorphometric analyses showed a significantly higher bridging rate of the bone defects in EPO-treated animals than in controls. This was associated by a significantly higher bone volume within the segmental defects of the EPO-treated animals. At 2 weeks, Western blot analyses revealed a significantly higher expression of vascular endothelial growth factor (VEGF) in EPO-treated animals compared to controls. Accordingly, the number of blood vessels was significantly increased in the EPO group at 2 weeks. At 10 weeks, we found a significantly higher expression of proliferating cell nuclear antigen (PCNA) in EPO-treated animals when compared to controls. Western blot analyses showed no significant differences between the groups in the expression of the endothelial and inducible nitric oxide synthases (eNOS and iNOS) and the angiopoietin receptor Tie-2. Immunohistochemistry confirmed the results of the Western blot analyses, demonstrating a significantly higher number of VEGF- and PCNA-positive cells in EPO-treated animals than in controls at 2 and 10 weeks, respectively. We conclude that EPO is capable of stimulating bone formation, cell proliferation and VEGF-mediated angiogenesis in a femoral segmental defect model. Copyright © 2011 Elsevier Inc. All rights reserved. Cited by 51 articles Full text links 170. [Acetabular fractures in the elderly. Outcome of open reduction and internal fixation] Unfallchirurg. 2011 Aug;114(8):655-62. doi: 10.1007/s00113-011-2021-y. [Article in German] Authors G Tosounidis 1 , U Culemann , M Bauer , J H Holstein , P Garcia , R Kurowski , A Pizanis , E Aghayev , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstraße 1, 66421, Homburg/Saar, Deutschland. georgios.tosounidis@uks.eu PMID: 21800136 DOI: 10.1007/s00113-011-2021-y Abstract The aim of this study was to analyze the clinical outcome and incidence of hip arthritis in elderly patients with acetabular fractures. Because of poor bone quality in the elderly, even a low-energy trauma may lead to an acetabular fracture. An anatomical reconstruction of the acetabulum is necessary to achieve sufficient stability also for a potential hip arthroplasty. So far, there is very limited information on the outcome of acetabular fractures in the elderly. During a period of 6 years (2001-2006), 48 patients older than 60 years were admitted to our department with an acetabular fracture. Thirty-nine patients were treated operatively and nine patients non-operatively. Twenty-nine operatively treated patients were followed up. Nineteen of them were assessed using EQ-5D, SF-12 and Merle d'Aubigné questionnaires in addition to their clinical examination. Ten other surgical patients were only examined using the questionnaires. Of the 29 patients that were followed up, 5 underwent total hip arthroplasty due to secondary post-traumatic hip arthritis after open reduction and internal fixation (ORIF). The range of motion of the operated hip was comparable to that of the non-operated contralateral side. However, the internal rotation was found to be slightly decreased at the operated side when compared to the non-operated contralateral side. Merle d'Aubigné score and physical and mental SF-12 score components as well as quality of life were better in patients treated with ORIF compared to those patients that were treated by secondary hip arthroplasty. Regarding the different treatment strategies (ORIF vs primary hip arthroplasty vs non-operative treatment) of acetabular fractures in the elderly, data from the literature are conflicting. Our results indicate that ORIF represents a good treatment option for acetabular fractures in the elderly. In patients that did not develop secondary hip arthritis, a good clinical outcome and quality of life was documented. Cited by 5 articles 26 references Full text links 171. Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting Bone. 2011 Oct;49(4):591-9. doi: 10.1016/j.bone.2011.07.007. Epub 2011 Jul 19. Authors T Histing 1 , P Garcia , J H Holstein , M Klein , R Matthys , R Nuetzi , R Steck , M W Laschke , T Wehner , R Bindl , S Recknagel , E K Stuermer , B Vollmar , B Wildemann , J Lienau , B Willie , A Peters , A Ignatius , T Pohlemann , L Claes , M D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 21782988 DOI: 10.1016/j.bone.2011.07.007 Abstract Small animal fracture models have gained increasing interest in fracture healing studies. To achieve standardized and defined study conditions, various variables must be carefully controlled when designing fracture healing experiments in mice or rats. The strain, age and sex of the animals may influence the process of fracture healing. Furthermore, the choice of the fracture fixation technique depends on the questions addressed, whereby intra- and extramedullary implants as well as open and closed surgical approaches may be considered. During the last few years, a variety of different, highly sophisticated implants for fracture fixation in small animals have been developed. Rigid fixation with locking plates or external fixators results in predominantly intramembranous healing in both mice and rats. Locking plates, external fixators, intramedullary screws, the locking nail and the pin-clip device allow different degrees of stability resulting in various amounts of endochondral and intramembranous healing. The use of common pins that do not provide rotational and axial stability during fracture stabilization should be discouraged in the future. Analyses should include at least biomechanical and histological evaluations, even if the focus of the study is directed towards the elucidation of molecular mechanisms of fracture healing using the largely available spectrum of antibodies and gene-targeted animals to study molecular mechanisms of fracture healing. This review discusses distinct requirements for the experimental setups as well as the advantages and pitfalls of the different fixation techniques in rats and mice. Copyright © 2011 Elsevier Inc. All rights reserved. Cited by 72 articles Full text links 172. [Benchmarking of university trauma centers in Germany. Research and teaching] Unfallchirurg. 2011 Jul;114(7):639-44. doi: 10.1007/s00113-011-2057-z. [Article in German] Authors F Gebhard 1 , M Raschke , S Ruchholtz , R Meffert , I Marzi , T Pohlemann , N Südkamp , C Josten , H Zwipp Affiliation 1 Klinik für Unfallchirurgie, Hand-, Plastische und Wiederherstellungschirurgie, Universität Ulm, Steinhövelstraße 9, 89075, Ulm, Deutschland. PMID: 21691781 DOI: 10.1007/s00113-011-2057-z Abstract Benchmarking is a very popular business process and meanwhile is used in research as well. The aim of the present study is to elucidate key numbers of German university trauma departments regarding research and teaching. The data set is based upon the monthly reports given by the administration in each university. As a result the study shows that only well-known parameters such as fund-raising and impact factors can be used to benchmark university-based trauma centers. The German federal system does not allow a nationwide benchmarking. Cited by 2 articles Full text links 173. The liquid overlay technique is the key to formation of co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells Cytotherapy. 2011 Sep;13(8):1000-12. doi: 10.3109/14653249.2011.583233. Epub 2011 May 27. Authors Wolfgang Metzger 1 , Daniela Sossong , Annick Bächle , Norbert Pütz , Gunther Wennemuth , Tim Pohlemann , Martin Oberringer Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. johann-wolfgang.metzger@uks.eu PMID: 21619419 DOI: 10.3109/14653249.2011.583233 Abstract Background aims: The 3-dimensional (3-D) culture of various cell types reflects the in vivo situation more precisely than 2-dimensional (2-D) cell culture techniques. Spheroids as 3-D cell constructs have been used in tumor research for a long time. They have also been used to study angiogenic mechanisms, which are essential for the success of many tissue-engineering approaches. Several methods of forming spheroids are known, but there is a lack of systematic studies evaluating the performance of these techniques. Methods: We evaluated the performance of the hanging drop technique, carboxymethyl cellulose technique and liquid overlay technique to form both mono- and co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells. The performance of the three techniques was evaluated in terms of rate of yield and reproducibility. The size of the generated spheroids was determined systematically. Results: The liquid overlay technique was the most suitable for generating spheroids reproducibly. The rate of yield for this technique was between 60% and 100% for monoculture spheroids and 100% for co-culture spheroids. The size of the spheroids could be adjusted easily and precisely by varying the number of seeded cells organized in one spheroid. The formation of co-culture spheroids consisting of three different cell types was possible. Conclusions: Our results show that the most suitable technique for forming spheroids can vary from the chosen cell type, especially if primary cells are used. Co-culture spheroids consisting of three different cell types will be used to study angiogenic phenomena in further studies. Cited by 49 articles Full text links 174. Increased osteoblast and osteoclast activity in female senescence-accelerated, osteoporotic SAMP6 mice during fracture healing J Surg Res. 2012 Jun 15;175(2):271-7. doi: 10.1016/j.jss.2011.03.052. Epub 2011 Apr 19. Authors Tina Histing 1 , David Stenger , Swantje Kuntz , Claudia Scheuer , Andrea Tami , Patric Garcia , Joerg H Holstein , Moritz Klein , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 21571305 DOI: 10.1016/j.jss.2011.03.052 Abstract Background: Previous studies have shown that fracture healing depends on gender and that in females, ovariectomy-induced osteoporosis impairs the healing process. There is no information, however, whether the alteration of fracture healing in osteoporosis also depends on gender. Materials and methods: Therefore, we herein studied fracture healing in female and male senescence-accelerated osteoporotic mice, strain P6 (SAMP6), including biomechanical, histomorphometric, and protein biochemical analysis. Results: Bending stiffness was reduced in male and female SAMP6 mice compared with senescence-resistant strain 1 (SAMR1) controls. This was associated with elevated serum concentrations of tartrate-resistent acid phosphatase form 5b (TRAP) in both female and male SAMP6 mice. Callus size, however, was significantly larger in female SAMP6 mice compared with male SAMP6 mice and female SAMR1 controls. This indicates a delayed remodeling process in female SAMP6 mice. The delay of callus remodeling in female SAMP6 mice was associated with a significantly higher osteoprotegerin (OPG) callus tissue expression and increased serum concentrations of osteocalcin (OC) and deoxypyridinoline (DPD), indicating elevated osteoblast and osteoclast activities. Conclusion: The present study shows that remodeling during fracture healing in female, but not in male, SAMP6 mice is delayed, most probably due to an increased osteoblast and osteoclast activity. Copyright © 2012 Elsevier Inc. All rights reserved. Cited by 13 articles Full text links 175. High bone concentrations of homocysteine are associated with altered bone morphology in humans Br J Nutr. 2011 Aug;106(3):378-82. doi: 10.1017/S0007114511000304. Epub 2011 Apr 27. Authors Joerg H Holstein 1 , Markus Herrmann , Christina Splett , Wolfgang Herrmann , Patric Garcia , Tina Histing , Moritz Klein , Karsten Kurz , Thomas Siebel , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 21521540 DOI: 10.1017/S0007114511000304 Abstract Accumulation of homocysteine and S-adenosylhomocysteine in bone has been shown to be associated with reduced bone quality in rats. The aim of the present study was to investigate whether high bone concentrations of homocysteine and S-adenosylhomocysteine as well as a low methylation capacity are related to an impaired bone morphology in humans. Concentrations of homocysteine and its precursors S-adenosylhomocysteine and S-adenosylmethionine were measured in femoral bone samples of eighty-two males and females (age 71 (SD 8) years) who underwent elective hip arthroplasty. Cancellous bone structure was analysed by histomorphometry. In addition, blood was sampled to measure serum concentrations of homocysteine. Results of bone and serum analyses were grouped for individuals with high or low bone concentrations of homocysteine, S-adenosylhomocysteine and S-adenosylmethionine, as well as for individuals with a high or a low methylation capacity, which is indicated by a low or a high S-adenosylhomocysteine:S-adenosylmethionine ratio (n 41, each). Histomorphometry showed a higher trabecular separation and a lower trabecular thickness, trabecular number and trabecular area in individuals with high bone concentrations of homocysteine and S-adenosylhomocysteine compared with individuals with low bone concentrations of homocysteine and S-adenosylhomocysteine. There was no association between the S-adenosylhomocysteine:S-adenosylmethionine ratio and bone morphology. It was found that 48 % of bone homocysteine was bound to the collagen of the extracellular bone matrix. Blood analyses demonstrated a significant correlation between serum and bone homocysteine. The results of the present study indicate an association between altered bone morphology and elevated bone concentrations of homocysteine and S-adenosylhomocysteine, but not between altered bone morphology and methylation capacity. Cited by 9 articles Full text links 176. Survival trends and predictors of mortality in severe pelvic trauma: estimates from the German Pelvic Trauma Registry Initiative Injury. 2011 Oct;42(10):997-1002. doi: 10.1016/j.injury.2011.03.053. Epub 2011 Apr 22. Authors Tim Pohlemann 1 , Dirk Stengel , Georgios Tosounidis , Heinrich Reilmann , Fabian Stuby , Uli Stöckle , Andreas Seekamp , Hagen Schmal , Andreas Thannheimer , Francis Holmenschlager , Axel Gänsslen , Pol Maria Rommens , Thomas Fuchs , Friedel Baumgärtel , Ivan Marintschev , Gert Krischak , Stephan Wunder , Harald Tscherne , Ulf Culemann Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, Faculty of Medicine, Saarland University, Homburg, Saar, Germany. tim.pohlemann@uks.eu PMID: 21513936 DOI: 10.1016/j.injury.2011.03.053 Abstract Study objective: To determine longitudinal trends in mortality, and the contribution of specific injury characteristics and treatment modalities to the risk of a fatal outcome after severe and complex pelvic trauma. Methods: We studied 5048 patients with pelvic ring fractures enrolled in the German Pelvic Trauma Registry Initiative between 1991 and 1993, 1998 and 2000, and 2004 and 2006. Complete datasets were available for 5014 cases, including 508 complex injuries, defined as unstable fractures with severe peri-pelvic soft tissue and organ laceration. Multivariable mixed-effects logistic regression analysis was employed to evaluate the impact of demographic, injury- and treatment-associated variables on all-cause in-hospital mortality. Results: All-cause in-hospital mortality declined from 8% (39/466) in 1991 to 5% (33/638) in 2006. Controlling for age, Injury Severity Score, pelvic vessel injury, the need for emergency laparotomy, and application of a pelvic clamp, the odds ratio (OR) per annum was 0.94 (95% confidence interval [CI] 0.91-0.96). However, the risk of death did not decrease significantly in patients with complex injuries (OR 0.98, 95% CI 0.93-1.03). Raw mortality associated with this type of injury was 18% (95% CI 9-32%) in 2006. Conclusion: In contrast to an overall decline in trauma mortality, complex pelvic ring injuries remain associated with a significant risk of death. Awareness of this potentially life-threatening condition should be increased amongst trauma care professionals, and early management protocols need to be implemented to improve the survival prognosis. Copyright © 2011 Elsevier Ltd. All rights reserved. Cited by 40 articles Full text links 177. [Operative treatment of the peripelvic Morel-Lavallée lesion] Oper Orthop Traumatol. 2011 Feb;23(1):15-20. doi: 10.1007/s00064-010-0003-9. [Article in German] Authors D Köhler 1 , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstr. 1, 66421, Homburg/Saar, Deutschland. daniel.koehler@uks.eu PMID: 21327954 DOI: 10.1007/s00064-010-0003-9 Abstract Objective: Evacuation of hematoma, hemostasis, reduction of dead space by vacuum systems for minimization of secondary complications, such as full skin necrosis, deep infections, and secondary wound closure. Indications: Morel-Lavallée lesion (MLL), all larger epifascial hematomas. Contraindications: None. Surgical technique: Central longitudinal incision, detection of the extent of the hematoma, transection of the full length of the lesion, hemostasis, debridement, application of vacuum systems, secondary wound closure, or splitskin coverage. Postoperative management: Vacuum therapy must be continued until secretions are less than 30 ml/24 hours. Negative bacterial culture before wound closure is imperative. Daily change of wound dressings, frequent control of inflammation parameters. Weight bearing until consolidation of soft tissue. Results: Operative treatment of the MLL with vacuum systems is a relatively new concept, and results on larger collectives have not been published yet. A total of 8 patients in our hospital underwent vacuum therapy after sustaining a MLL, 5 of them with concomitant instability of the pelvic ring. Emergency stabilization and initiation of vacuum therapy were performed on the day of admission. Three patients had initially positive bacterial colonialization. Duration of vacuum therapy was 8.5 days (range 4-14 days). Dressings were changed every 2.6 days (range 1-4 days). While 6 wounds could be closed secondarily, 2 needed split skin coverage. Complications were not observed. Vacuum therapy facilitates wound management and helps reduce bacterial colonialization. It has also been proved to have a beneficial effect on qualitative and quantitative granulation. Cited by 5 articles 9 references Full text links 178. Exercise enhances angiogenesis during bone defect healing in mice J Orthop Res. 2011 Jul;29(7):1086-92. doi: 10.1002/jor.21352. Epub 2011 Jan 21. Authors Joerg H Holstein 1 , Steven C Becker , Martin Fiedler , Claudia Scheuer , Patric Garcia , Tina Histing , Moritz Klein , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 21259340 DOI: 10.1002/jor.21352 Free article Abstract The aim of the present study was to investigate the effect of exercise on angiogenesis during bone defect healing in mice. We evaluated angiogenesis during cranial bone defect healing by intravital fluorescence microscopy (IVM) at days 0-21. To characterize the type of bone repair, we performed additional histomorphometric analyses at days 3-15. IVM was conducted in mice, which were housed in cages supplied with running wheels (exercise group; n=7) and compared to IVM results of mice, which were housed in cages without running wheels (controls; n=7). In the exercise group, we additionally performed correlation analyses between results of the IVM and the running distance. IVM showed an accelerated decrease of bone defect area in the exercise group compared to the control group. This was associated with a significantly higher blood vessel diameter in animals undergoing exercise at days 9 and 12 and a significant correlation between running distance and blood vessel density at day 9 (r = 0.74). Histomorphometry showed osseous bridging of the defect at day 9. The newly woven bone was covered by a neo-periosteum containing those blood vessels, which were visible by IVM. We conclude that exercise accelerates bone defect healing and stimulates angiogenesis during bore repair. Copyright © 2011 Orthopaedic Research Society. Cited by 7 articles Full text links 179. Sildenafil accelerates fracture healing in mice J Orthop Res. 2011 Jun;29(6):867-73. doi: 10.1002/jor.21324. Epub 2011 Jan 18. Authors Tina Histing 1 , Kerstin Marciniak , Claudia Scheuer , Patric Garcia , Joerg H Holstein , Moritz Klein , Romano Matthys , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 21246617 DOI: 10.1002/jor.21324 Free article Abstract Sildenafil, a cyclic guanosine monophosphate (cGMP)-dependent phospodiesterase-5 inhibitor, has been shown to be a potent stimulator of angiogenesis through upregulation of pro-angiogenic factors and control of cGMP concentration. Herein, we determined whether sildenafil also influences angiogenic growth factor expression and bone formation during the process of fracture healing. Bone healing was studied in a murine closed femur fracture model using radiological, biomechanical, histomorphometric, and protein biochemical analysis at 2 and 5 weeks after fracture. Thirty mice received 5 mg/kg body weight sildenafil p.o. daily. Controls (n = 30) received equivalent amounts of vehicle. After 2 weeks of fracture healing sildenafil significantly increased osseous fracture bridging, as determined radiologically and histologically. This resulted in an increased biomechanical stiffness compared to controls. A smaller callus area with a slightly reduced amount of cartilaginous tissue indicated an accelerated healing process. After 5 weeks the differences were found blunted, demonstrating successful healing in both groups. Western blot analysis showed a significantly higher expression of the pro-angiogenic and osteogenic cysteine-rich protein (CYR) 61, confirming the increase of bone formation. We show for the first time that sildenafil treatment accelerates fracture healing by enhancing bone formation, most probably by a CYR61-associated pathway. Copyright © 2011 Orthopaedic Research Society. Cited by 22 articles Full text links 180. Changes in epidemiology and treatment of pelvic ring fractures in Germany: an analysis on data of German Pelvic Multicenter Study Groups I and III (DGU/AO) Acta Chir Orthop Traumatol Cech. 2010;77(6):450-6. Authors G Tosounidis 1 , J H Holstein , U Culemann , F Holmenschlager , F Stuby , T Pohlemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. PMID: 21223823 Abstract The diagnosis and treatment of pelvic ring injuries is demanding. Therefore, standardized classifications characterizing the stability and severity of pelvic ring fractures are essential to define clear algorithms for the treatment of these injuries. The first part of this article provides an overview of the etiology and classification of pelvic ring injuries. We recommend the AO classification to assess the stability of pelvic ring fractures. This classification includes 3 types of pelvic ring fractures: stable fractures (type A), fractures with only rotational instability (type B), and fractures with complete (rotational and translational) instability. To describe the severity of the injury, pelvic ring fractures can be classified as plain pelvic fractures, which include fractures with osteoligamentous instability, but without significant concomitant injuries to the soft tissue, versus complex pelvic fractures, which are combined with severe peripelvic soft tissue lesions.While plain pelvic fractures allow thorough clinical and radiological diagnostics, complex pelvic traumata represent a life threatening situation for the patient, which needs immediate emergency measures. In the second part of the this review we present current data of the German Pelvic Multicenter Study III (DGU/AO) on the epidemiology and treatment of pelvic ring injuries deriving from a study population of more than 3000 patients. In addition, we compare the present data with those of the German Pelvic Multicenter Study I and highlight changes in the epidemiology and treatment of pelvic ring fractures during the past decades. Taken together, we could observe an increasing number of elderly patients sustaining pelvic ring fractures.Regarding the treatment of pelvic ring fractures we found a rising use of external fixators and SI screws, while the number of laparotomies has markedly decreased. Cited by 27 articles 181. Infra-acetabular corridor--technical tip for an additional screw placement to increase the fixation strength of acetabular fractures J Trauma. 2011 Jan;70(1):244-6. doi: 10.1097/TA.0b013e3181f45f91. Authors Ulf Culemann 1 , Ivan Marintschev , Florian Gras , Tim Pohlemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. PMID: 21217495 DOI: 10.1097/TA.0b013e3181f45f91 No abstract available Cited by 28 articles Full text links 182. Intravital microscopic studies of angiogenesis during bone defect healing in mice calvaria Injury. 2011 Aug;42(8):765-71. doi: 10.1016/j.injury.2010.11.020. Epub 2010 Dec 14. Authors J H Holstein 1 , S C Becker , M Fiedler , P Garcia , T Histing , M Klein , M W Laschke , M Corsten , T Pohlemann , M D Menger Affiliation 1 Department of Trauma, Hand & Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. PMID: 21156316 DOI: 10.1016/j.injury.2010.11.020 Abstract Purpose: Due to the great availability of specific antibodies, gene-targeted animals and knockout strains, mouse models came into the focus of musculoskeletal research. Herein, we introduce a calvarian defect model in mice that allows the repetitive analysis of blood vessel formation during bone repair by intravital microscopy. Methods: The right parietal calvaria of 20 adult CD-1 mice were exposed by skin excision. Under continuous irrigation, a circular defect (Ø0.75 mm) was drilled into the calvarium without penetrating the inner cortical shell. A circular glass (Ø12 mm; thickness 0.15 mm) was fixed by two microscrews (M1; length 2mm) to cover the bone defect. Angiogenesis was analysed by intravital microscopy at days 0, 3, 6, 9, 12, 15, 18 and 21. In addition, bone repair was evaluated by histomorphometry at days 3, 6, 9 and 15. Immunohistochemical stainings for the angiogenic growth factor vascular endothelial growth factor (VEGF) and the cell proliferation marker proliferating cell nuclear antigen (PCNA) were performed to assess angiogenic and proliferative activity during healing of the calvarian defect. Results: Histomorphometry showed a typical pattern of intramembranous bone repair. Osseous bridging of the defect was observed at day 9. This was associated with the formation of a neo-periosteum, which covered the new woven bone and contained a dense network of newly formed blood vessels. At day 9, particularly cells of the neo-periosteum showed intense staining for VEGF, whilst PCNA-positive staining was found mainly in osteoblasts. At day 15, the major fraction of fibrous tissue was replaced by bone undergoing extensive remodelling. Intravital microscopy revealed an increase of vascular density between days 3 and 15. Blood vessel diameters showed an increase between days 3 and 9 and a subsequent decrease between days 9 and 21. Conclusions: The present calvarian defect model provides a powerful tool to evaluate the process of angiogenesis during intramembranous bone repair in mice. Copyright © 2010 Elsevier Ltd. All rights reserved. Cited by 8 articles Full text links 183. Operative treatment of the peripelvic Morel-Lavallée lesion Oper Orthop Traumatol. 2010 Dec 10. doi: 10.1007/s00064-010-9025-6. Online ahead of print. Authors Daniel Köhler 1 , Tim Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstr. 1, 66421, Homburg/ Saar, Germany, daniel.koehler@uks.eu. PMID: 21153523 DOI: 10.1007/s00064-010-9025-6 Abstract OBJECTIVE : Evacuation of haematoma, haemostasis, reduction of dead space by vacuum systems for minimisation of secondary complications as full skin necrosis and deep infections, secondary wound closure. INDICATIONS : Morel-Lavallée lesion (MLL). All larger epifascial haematomas. CONTRAINDICATIONS : None. SURGICAL TECHNIQUE : Central longitudinal incision, detection of the subcutanous extent of the haematoma, transection of the full length of the lesion, haemostasis, debridement, application of vacuum systems, secondary wound closure or splitskin coverage. POSTOPERATIVE MANAGEMENT : Vacuum therapy must be continued until secretions are less than 30 ml/24 h. Negative bacterial culture before wound closure is imperative. Daily change of wound dressings, frequent controls of inflammation parameters. Weight bearing until consolidation of soft tissue. RESULTS : Operative treatment of the MLL with vacuum systems is a relatively new concept and results on larger collectives have not been published yet. Eight patients in our hospital underwent vacuum therapy after sustaining a MLL, five of them with concomitant instability of the pelvic ring. Emergency stabilisation and initiation of vacuum therapy were performed on day of admission. Three patients had initially positive bacterial colonialisation. Duration of vacuum therapy was 8,5 days (4-14). Dressings were changed every 2,6 days (1-4). Six wounds could be closed secondarily, two needed split skin coverage. Complications were not observed. Vacuum therapy facilitates wound management and helps to reduce bacterial colonialisation. It has also been proved to have a beneficial effect on qualitative and quantitative granulation. Full text links 184. [Update Unfallchirurgie] Unfallchirurg. 2010 Dec;113(12):974-5. doi: 10.1007/s00113-010-1924-3. [Article in German] Author T Pohlemann 1 Affiliation 1 Klinik für Unfall-, Hand- und Wiederher- stellungschirurgie, Universitätsklinikum des Saarlandes Kirrberger Str. 1 66421 Homburg. tim.pohlemann@uks.eu PMID: 21153463 DOI: 10.1007/s00113-010-1924-3 No abstract available Full text links 185. Melatonin impairs fracture healing by suppressing RANKL-mediated bone remodeling J Surg Res. 2012 Mar;173(1):83-90. doi: 10.1016/j.jss.2010.08.036. Epub 2010 Sep 21. Authors Tina Histing 1 , Christina Anton , Claudia Scheuer , Patric Garcia , Joerg H Holstein , Moritz Klein , Romano Matthys , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. tina.histing@uks.eu PMID: 20888595 DOI: 10.1016/j.jss.2010.08.036 Abstract Background: Melatonin, the major pineal hormone, is known to regulate distinct physiologic processes. Previous studies have suggested that it supports skeletal growth and bone formation, most probably by inhibiting bone resorption. There is no information, however, whether melatonin affects fracture healing. We therefore studied in a mouse femur fracture model the influence of melatonin on callus formation and biomechanics during fracture healing. Methods and materials: Thirty CD-1 mice received 50 mg/kg body weight melatonin i.p. daily during the entire 2-wk or 5-wk observation period. Controls (n = 30) received equivalent amounts of vehicle. Bone healing was studied by radiological, biomechanical, histomorphometrical, and protein biochemical analyses at 2 and 5 wk after fracture. Results: Biomechanical analysis at 2 wk after fracture healing showed a significantly lower bending stiffness in melatonin-treated animals compared with controls. A slightly higher amount of cartilage tissue and a significantly larger callus size indicated a delayed remodeling process after melatonin treatment. Western blot analysis showed a significantly reduced expression of receptor activator of nuclear factor-κB ligand (RANKL) and collagen I after melatonin treatment. The reduced expression of RANKL was associated with a diminished number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts within the callus of the newly formed bone. Conclusions: Because bone resorption is an essential requirement for adequate remodeling during fracture healing, we conclude that melatonin impairs fracture healing by suppressing bone resorption through down-regulation of RANKL-mediated osteoclast activation. Copyright © 2012 Elsevier Inc. All rights reserved. Cited by 22 articles Full text links 186. In vivo gait analysis in a mouse femur fracture model J Biomech. 2010 Dec 1;43(16):3240-3. doi: 10.1016/j.jbiomech.2010.07.019. Epub 2010 Sep 15. Authors T Histing 1 , A Kristen , C Roth , J H Holstein , P Garcia , R Matthys , M D Menger , T Pohlemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. tina.histing@uks.eu PMID: 20832805 DOI: 10.1016/j.jbiomech.2010.07.019 Abstract Although the mouse has become a preferred species for molecular studies on fracture healing, gait analysis after fracture fixation and during bone healing has not yet been performed in mice. Herein, we introduce a novel technique for gait analysis in mice and report the change of motion pattern after fracture and fixation. A standardized femur fracture was stabilized by a common pin. The non-fractured tibia was additionally marked with a pin, allowing continuous analysis of the tibio-femoral angle by digital video-radiography. Dynamic gait analysis was performed at day fourteen after surgery in a radio-opaque running wheel. Fracture fixation resulted in a significantly reduced range and maximum of the tibio-femoral angle compared to non-fractured controls. This was associated with a significantly reduced stride length. Because stride frequency was slightly increased and, thus, stride time diminished, stride velocity was not significantly reduced compared to controls. Thus, our study demonstrates distinct alterations of the gait of mice at 2 weeks after femur fracture and stabilization. Our results support the need of gait analysis in fracture healing studies to assess the animals' well-being. Copyright © 2010 Elsevier Ltd. All rights reserved. Cited by 6 articles Full text links 187. Erythropoietin ameliorates the reduced migration of human fibroblasts during in vitro hypoxia J Physiol Biochem. 2011 Mar;67(1):1-13. doi: 10.1007/s13105-010-0043-5. Epub 2010 Sep 4. Authors Stephanie Breit 1 , Monika Bubel , Tim Pohlemann , Martin Oberringer Affiliation 1 Laboratory for Molecular and Cell Biology, Department of Trauma, Hand, and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Bldng. No. 57, 66421 Homburg, Germany. PMID: 20820978 DOI: 10.1007/s13105-010-0043-5 Abstract Erythropoietin promotes the formation of granulation tissue when administered to soft tissue wounds and it was shown to be most effective under tissue hypoxia. However, the action of erythropoietin on the cellular level is not well understood. In order to get a better insight into these processes, an in vitro wound healing assay was applied. Two main players of soft tissue healing-fibroblasts and microvascular endothelial cells-were used as mono- and co-cultures, subsequently inflicting in vitro wounds. Cell migration, proliferation, the differentiation of fibroblasts to myofibroblasts, and the release of vascular endothelial cell growth factor A and angiogenin were quantified in response to hypoxia and erythropoietin (5 IU/ml). Erythropoietin supplementation did neither affect proliferation nor migration of endothelial cells and fibroblasts under normoxia. Under hypoxia, the reduced fibroblast migration was ameliorated by erythropoietin. This effect coincided with an attenuated release of vascular endothelial growth factor A, whereas angiogenin release was unaffected by erythropoietin. The in vitro model applied in this study may represent an adequate approximation to certain aspects of the in vivo status of soft tissue regeneration and the results might serve to interpret the in vivo efficiency of erythropoietin at the cellular level: Erythropoietin has different impacts on the cells in normoxia and hypoxia. Its positive influence on fibroblast migration during hypoxia seems to support the strategies of applying erythropoietin in those chronic wounds, which exhibit fibroblastic dysfunction although good vascularisation is present. Cited by 5 articles 45 references Full text links 188. Adhesion of fibroblasts on micro- and nanostructured surfaces prepared by chemical vapor deposition and pulsed laser treatment Biofabrication. 2010 Sep;2(3):035001. doi: 10.1088/1758-5082/2/3/035001. Epub 2010 Jul 12. Authors M Veith 1 , O C Aktas , W Metzger , D Sossong , H Ullah Wazir , I Grobelsek , N Pütz , G Wennemuth , T Pohlemann , M Oberringer Affiliation 1 INM-Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany. Michael.Veith@inm-gmbh.de PMID: 20814089 DOI: 10.1088/1758-5082/2/3/035001 Abstract The development of micro- and nanostructured surfaces which improve the cell-substrate interaction is of great interest in today's implant applications. In this regard, Al/Al2O3 bi-phasic nanowires were synthesized by chemical vapor deposition of the molecular precursor (tBuOAlH2)2. Heat treatment of such bi-phasic nanowires with short laser pulses leads to micro- and nanostructured Al2O3 surfaces. Such surfaces were characterized by scanning electron microscopy (SEM), electron dispersive spectroscopy and x-ray photoelectron spectroscopy. Following the detailed material characterization, the prepared surfaces were tested for their cell compatibility using normal human dermal fibroblasts. While the cells cultivated on Al/Al2O3 bi-phasic nanowires showed an unusual morphology, cells cultivated on nanowires treated with one and two laser pulses exhibited morphologies similar to those observed on the control substrate. The highest cell density was observed on surfaces treated with one laser pulse. The interaction of the cells with the nano- and microstructures was investigated by SEM analysis in detail. Laser treatment of Al/Al2O3 bi-phasic nanowires is a fast and easy method to fabricate nano- and microstructured Al2O3-surfaces for studying cell-surface interactions. It is our goal to develop a biocompatible Al2O3-surface which could be used as a coating material for medical implants exhibiting a cell selective response because of its specific physical landscape and especially because it promotes the adhesion of osteoblasts while minimizing the adhesion of fibroblasts. Cited by 6 articles Full text links 189. Low dose erythropoietin stimulates bone healing in mice J Orthop Res. 2011 Feb;29(2):165-72. doi: 10.1002/jor.21219. Epub 2010 Aug 25. Authors P Garcia 1 , V Speidel , C Scheuer , M W Laschke , J H Holstein , T Histing , T Pohlemann , M D Menger Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. patric.garcia@uks.eu PMID: 20740668 DOI: 10.1002/jor.21219 Free article Abstract Beyond its classical role in regulation of erythropoiesis, erythropoietin (EPO) has been shown to exert protective and regenerative actions in a variety of non-hematopoietic tissues. However, little is known about potential actions in bone regeneration. To analyze fracture healing in mice, a femoral 0.25 mm osteotomy gap was stabilized with a pin-clip technique. Animals were treated with 500 U EPO/kg bw per day or with vehicle only. After 2 and 5 weeks, fracture healing was analyzed biomechanically, radiologically and histologically. Expression of PCNA and NFκB was examined by Western blot analysis. Vascularization was analyzed by immunohistochemical staining of PECAM-1. Circulating endothelial progenitor cells were measured by flow-cytometry. Herein, we demonstrate that EPO-treatment significantly accelerates bone healing in mice. This is indicated by a significantly greater biomechanical stiffness and a higher radiological density of the periosteal callus at 2 and 5 weeks after fracture and stabilization. Histological analysis demonstrated significantly more bone and less cartilage and fibrous tissue in the periosteal callus. Endosteal vascularization was significantly increased in EPO-treated animals when compared to controls. The number of circulating endothelial progenitor cells was significantly greater in EPO-treated animals. The herein shown acceleration of healing by EPO may represent a promising novel treatment strategy for fractures with delayed healing and non-union formation. Copyright © 2010 Orthopaedic Research Society. Cited by 37 articles Full text links 190. Identification of risk factors for neurological deficits in patients with pelvic fractures Orthopedics. 2010 Aug 11;33(8). doi: 10.3928/01477447-20100625-13. Authors Hagen Schmal 1 , Oliver Hauschild , Ulf Culemann , Tim Pohlemann , Fabian Stuby , Gert Krischak , Norbert P Südkamp Affiliation 1 Department of Orthopedics and Traumatology, University of Freiburg Medical Center, Freiburg, Germany. hagen.schmal@freenet.de PMID: 20704106 DOI: 10.3928/01477447-20100625-13 Abstract This multicenter register study was performed to define injury and fracture constellations that are at risk to develop pelvic associated neural lesions. Data of 3607 patients treated from 2004 to 2009 for pelvic fractures were evaluated for neurological deficits depending on Tile classification, pelvic injury configuration, and treatment.In 223 patients (6.5%), neurological lesions were diagnosed on the day of discharge from the hospital. The degree of instability of the pelvic fracture correlated with occurrence of nerve lesions. Rate of neurological dysfunction increased from 1.5% in type A fractures to 14.4% in type C fractures (P<.001). As the most endangered anatomical regions in pelvic fractures, the roots L5 (18.3%) and S1 (15.6%) and isolated peripheral nerves (19.2%) were identified. Patients sustaining complex pelvic trauma (7.85%) suffered from significantly more neurological dysfunctions (33.5%) compared to patients without peripelvic organ or soft tissue injuries (P<.001). Whereas stable type A3 sacral fractures were not associated with a different risk to develop neurological deficits (3.8%), unstable sacral fractures with the need for operative fixation showed an increased rate of accompanying nerve lesions (15.4%; P<.001). Twenty-one (11.5%) operative sacral stabilizations were supplemented with nerve root decompression (mainly S1). Neurological complications in the course of treatment were seen in 69 cases (1.9%).A high degree of instability, complex pelvic trauma, and unstable sacral fractures predispose for additional neurological deficits in patients with pelvic fractures. Copyright 2010, SLACK Incorporated. Cited by 7 articles Full text links 191. Reoxygenation attenuates the adhesion of neutrophils to microvascular endothelial cells Angiology. 2011 Feb;62(2):155-62. doi: 10.1177/0003319710375943. Epub 2010 Aug 5. Authors Katrin Schmitz 1 , Martina Jennewein , Tim Pohlemann , Andreas Seekamp , Martin Oberringer Affiliation 1 Department of Trauma and Reconstructive Surgery, Westpfalz-Klinikum Kaiserslautern, Kaiserslautern, Germany. PMID: 20688787 DOI: 10.1177/0003319710375943 Abstract In humans, the pathophysiological inflammation response subsequent to hypoxia and reoxygenation often leads to systemic inflammation and multiorgan failure. We applied a newly developed static interaction model using human polymorphonuclear neutrophils and microvascular endothelial cells to clarify the role of hypoxia and hypoxia/reoxygenation in vitro. Human dermal microvascular endothelial cell cultures (n = 7) were exposed to hypoxia and different reoxygenation periods and the adherence rate of neutrophils to the endothelial cells as well as to the protein matrix on the culture slide surface were determined by quantitative microscopy. Hypoxia clearly triggered neutrophil adhesion to human dermal microvascular endothelial cells whereas additional reoxygenation significantly decreased neutrophil adhesion. These in vitro findings suggest that systemic inflammation caused by increased neutrophil adherence to the microvascular endothelium is already initiated by hypoxia rather than by subsequent reoxygenation. Cited by 2 articles Full text links 192. Changes in the treatment of acetabular fractures over 15 years: Analysis of 1266 cases treated by the German Pelvic Multicentre Study Group (DAO/DGU) Injury. 2010 Aug;41(8):839-51. doi: 10.1016/j.injury.2010.04.010. Epub 2010 May 6. Authors Björn Gunnar Ochs 1 , Ivan Marintschev , Heike Hoyer , Bernd Rolauffs , Ulf Culemann , Tim Pohlemann , Fabian Maria Stuby Affiliation 1 BG Trauma Centre, Eberhard Karls University of Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany. PMID: 20451195 DOI: 10.1016/j.injury.2010.04.010 Abstract Epidemiological, clinical and radiological data of 1266 patients with a unilateral acetabular fracture of up to 29 hospitals was reviewed. Three time periods, 1991-1993 (Registry I; n=359), 1998-2000 (Registry II; n=503), and 2005-2006 (Registry III; n=404) were compared with regard to injury pattern and severity, fracture type, and chosen nonoperative vs. operative treatment to elucidate changes over time in the treatment of acetabular fractures. In the operatively treated group, time to operation, surgical approach, fracture fixation implants and fracture reduction quality were examined. 641 (50.6%) patients with isolated acetabular fractures, 410 (32.4%) multiple injured and 215 (17.0%) polytrauma patients with 642 (50.7%) simple and 624 (49.3%) associated acetabular fractures were evaluated. In the time period from 1991 to 2006, the rate of operative treatments increased nationwide to 77% (rho<0.001). The distribution of fracture types involving the anterior and posterior wall changed with age (rho<0.001). Across all registries, 583 (68.0%) operations were performed within 7 days, 212 (24.7%) operations between 7 and 14 days and 54 (6.3%) operations were performed later than 14 days after injury. An anatomical reduction (0-1mm displacement) was achieved in 551 (64%) acetabular fractures. The obtained reduction quality did not correlate with time to operation, was lower in associated than in simple fracture types, and also lower in patients with isolated acetabular fractures than in polytrauma patients. Most importantly, the fracture reduction quality did not improve over time despite a higher frequency of surgical interventions. The Kocher-Langenbeck approach was preferred in the nineties in nearly three quarters of all operative procedures. Currently, the Kocher-Langenbeck and the ilioinguinal approaches are used equally often. The fracture fixation did not change over time and is achieved in 51% with plates in combination with single screws. This multisurgeon series illustrates a nationwide performance in acetabular fracture management. Despite changes in the chosen approaches and an increased surgical frequency, the operative treatment of acetabular fractures of the last 15 years did not lead to an increased reduction quality. Therefore, the rarity and complexity of acetabular fractures demands further specific teaching by experienced acetabular surgeons, scientific research and clinical outcome evaluation. Copyright 2010 Elsevier Ltd. All rights reserved. Cited by 76 articles Full text links 193. Deficiencies of folate and vitamin B12 do not affect fracture healing in mice Bone. 2010 Jul;47(1):151-5. doi: 10.1016/j.bone.2010.04.592. Epub 2010 Apr 14. Authors J H Holstein 1 , M Herrmann , J Schmalenbach , R Obeid , I Olkü , M Klein , P Garcia , T Histing , T Pohlemann , M D Menger , W Herrmann , L Claes Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 20399291 DOI: 10.1016/j.bone.2010.04.592 Abstract Purpose: Recently, hyperhomocysteinemia has been shown to be associated with impaired fracture healing in mice. The main causes for hyperhomocysteinemia are deficiencies of folate and vitamin B12. However, there is no information on whether deficiencies of these B vitamins are affecting bone repair, too. Methods: We used two groups of mice to investigate the impact of folate and vitamin B12 deficiency on fracture healing: mice of the first group were fed a folate- and vitamin B12-deficient diet (n=14), while mice of the second group received an equicaloric control diet (n=13). Four weeks after stabilizing a closed femur fracture, bone repair was analyzed by histomorphometry and biomechanical testing. In addition, serum concentrations of homocysteine, folate, vitamin B12, the bone formation marker osteocalcin (OC), and the bone resorption marker collagen I C-terminal crosslaps (CTX) were measured. Results: Serum analyses revealed significantly decreased concentrations of folate and vitamin B12 in animals fed the folate- and vitamin B12-deficient diet when compared to controls. This was associated with a moderate hyperhomocysteinemia in folate- and vitamin B12-deficient mice, while no hyperhomocysteinemia was found in controls. Three-point bending tests showed no significant differences in callus stiffness between bones of folate- and vitamin B12-deficient animals and those of control animals. In accordance, the histomorphometric analysis demonstrated a comparable size and tissue composition of the callus, and also serum markers of bone turnover did not differ significantly between the two groups. Conclusions: We conclude that folate and vitamin B12 deficiency does not affect bone repair in mice. 2010 Elsevier Inc. All rights reserved. Cited by 7 articles Full text links 194. [Concept for treatment of pelvic ring injuries in elderly patients. A challenge] Unfallchirurg. 2010 Apr;113(4):258-71. doi: 10.1007/s00113-010-1762-3. [Article in German] Authors U Culemann 1 , A Scola , G Tosounidis , T Pohlemann , F Gebhard Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg/Saar, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland. ulf.culemann@uks.eu PMID: 20373068 DOI: 10.1007/s00113-010-1762-3 Abstract Whereas pelvic injuries in patients in their 20s and 30s are typically caused by high energy trauma, another group suffering this injury are elderly patients between the seventh and eighth decades of life. Due to osteoporosis and co-morbidities females are particularly affected by low energy trauma. After examining the medical history a physical examination of the pelvis is performed. This is followed by imaging with X-ray and CT scanning with 3D reconstruction if necessary. If there are concomitant injuries additional diagnostics are essential (e.g. sonography, MRI, retrograde ureterography, cystography and excretion urogram). The standard AO/ATO classification (Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association) has been well proven and does not depend on the age of the patient. Three different fracture types are differentiated, types A, B and C. This classification in combination with the description of the affected anatomical region (e.g. transsymphysis, transpubic, etc.) is sufficient in the daily clinical practice to decide on the necessary treatment. Often there are diagnostic difficulties in elderly patients (so-called differentiation of the A-B problem). In these patients a type A fracture is initially diagnosed and treated conservatively but due to persistent pain the imaging is repeated and an additional (insufficiency) fracture is found. With this new information the therapeutic regime has to be changed. The reconstruction of the pelvic ring is of major importance especially for elderly patients. This reduces the pain and the primary objective, an earliest possible rehabilitation without prolonged immobilization, can be achieved. In elderly patients external fixation with supra-acetabular screw positioning is an effective procedure and secondary insufficiency-instability (mostly dorsal) can be avoided. Whereas type A fractures can almost exclusively be treated non-surgically, types B and C fractures usually need surgery. As in young patients type B fractures are stabilized ventrally and C fractures dorsoventrally. In an emergency supra-acetabular external fixation and when required extraperitoneal tamponade has been established as the standard treatment for elderly patients in Germany. For the definitive surgical management standard procedures are used, but they often have to be modified depending on the bone structure. Cited by 27 articles 33 references Full text links 195. The LockingMouseNail--a new implant for standardized stable osteosynthesis in mice J Surg Res. 2011 Aug;169(2):220-6. doi: 10.1016/j.jss.2009.11.713. Epub 2009 Dec 10. Authors Patric Garcia 1 , Simon Herwerth , Romano Matthys , Joerg H Holstein , Tina Histing , Michael D Menger , Tim Pohlemann Affiliation 1 Department of Trauma-, Hand-, and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. chpgar@uniklinikum-saarland.de PMID: 20371084 DOI: 10.1016/j.jss.2009.11.713 Abstract Background: Mouse models are of increasing interest to study cellular and molecular mechanisms during fracture healing. However, unlike in large animals and in humans, stable fixation of fractures has been difficult due to the small size of the mouse. Methods: Based on μCT-scans of a mouse femur, we developed a new intramedullary implant system comparable to a human locking nail. We analyzed fracture healing with osteotomy gap sizes of 0.00, 0.25, and 2.00 mm, which were stabilized with the LockingMouseNail. Results: Femora with a gap size of 0.00 mm and 0.25 mm showed complete fracture healing after 5 wk. Femora showed a secondary bone healing pattern with induction of a small periosteal callus. In contrast, femora with a gap size of 2.00 mm showed sparse periosteal callus formation and a lack of bone bridging even after 10 wk, indicating atrophic non-union. Conclusion: The LockingMouseNail allows standardized fixation of mouse femur fractures and also stabilization of segmental defects. By introducing different gap sizes, the healing process can be influenced, ranging from normal fracture healing to atrophic non-union formation. Therefore, the model may ideally be suited to study molecular mechanisms of normal fracture healing, delayed healing, and non-union formation. It may additionally allow studying biological properties and effectiveness of different bone substitutes in stabilized segmental defects. Copyright © 2011 Elsevier Inc. All rights reserved. Cited by 15 articles Full text links 196. Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis Clin Chem Lab Med. 2010 Jun;48(6):821-7. doi: 10.1515/CCLM.2010.155. Authors Joerg H Holstein 1 , Markus Herrmann , Christina Splett , Wolfgang Herrmann , Patric Garcia , Tina Histing , Moritz Klein , Karsten Kurz , Thomas Siebel , Tim Pohlemann , Michael D Menger Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. joerg.holstein@uks.eu PMID: 20345232 DOI: 10.1515/CCLM.2010.155 Abstract Background: Recent clinical and animal studies suggest that increased serum homocysteine (HCY) concentrations may be a risk factor for osteoporosis. In vitro studies showed that increasing HCY concentrations stimulate the activity of human osteoclasts. However, there is no data demonstrating that circulating HCY is related to structural and biomechanical properties of human bones. This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA). Methods: Fasting blood samples and femoral heads were obtained from 94 males and females who underwent hip arthroplasty due to OA. Bones were assessed by dual energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry. Blood was collected for measurement of HCY, folate, vitamin B6, and vitamin B12. Subjects were classified as hyperhomocysteinemic (>12 micromol/L, n=47) and normohomocysteinemic (<12 micromol/L, n=47) according to their serum HCY concentrations. Results: Folate and vitamin B6, but not vitamin B12, were significantly lower in hyperhomocysteinemic subjects compared with controls. However, DXA, biomechanical testing, and histomorphometry did not reveal significant differences in bone quality between hyperhomocysteinemic subjects and controls. Conclusions: The results of the present study do not indicate a significant relationship between circulating HCY concentrations and morphological or biomechanical bone properties in humans with OA of the hip. Cited by 6 articles Full text links 197. [Complex pelvic trauma in elderly patients] Unfallchirurg. 2010 Apr;113(4):281-6. doi: 10.1007/s00113-010-1764-1. [Article in German] Authors G Tosounidis 1 , U Culemann , D Stengel , P Garcia , R Kurowski , J H Holstein , T Pohlemann Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg/Saar, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland. chgtos@uniklinik-saarland.de PMID: 20237750 DOI: 10.1007/s00113-010-1764-1 Abstract The definition of complex pelvic trauma has allowed a selection of those pelvic fracture patients with the highest mortality rate. The term complex pelvic trauma is used as a definition for pelvic fractures which are associated with serious soft tissue lesions in the pelvic region. These may include visceral and neurovascular, as well as extensive skin and muscle injuries. Haemodynamic instability particularly related to vascular injuries raises the mortality dramatically. Traumatic hemipelvectomy, which represents the worst case of a complex pelvic trauma, is associated with mortality rates of up to 60%. The pelvic study groups 1-3 of the German trauma association (DGU) and the Association for Osteosynthesis (AO) provide the worldwide largest database on pelvic injuries (group 1, 1991-1993: 1,722 patients from 10 hospitals; group 2, 1998-2002: 2,569 patients from 22 hospitals; and group 3, 2005-2007: 2,704 patients from 23 hospitals). Using this database this article reviews epidemiological data, therapy concepts, associated injuries as well as the incidence and mortality rates related to complex pelvic trauma over a 16-year time period. Special attention has been paid to complex trauma in the elderly (patients >60 years of age). An additional aim of this article is to analyze the correlation between different treatment modalities and the mortality rate of complex pelvic trauma and to investigate whether changes in the treatment of complex pelvic trauma have improved the outcome of these injuries. Taken together an increase in measures for an initial mechanical stabilization of the pelvic ring, such as the use of the pelvic C clamp, the external fixator or primary osteosynthesis was found over the 16-year observation period. In addition to stabilization of the pelvic ring, pelvic tamponade for mechanical haemostasis has been proven to be one of the most effective measures to control haemorrhaging. These treatment regimes did not differ between young patients and patients >60 years of age. Regarding the outcome of these treatment strategies only slight decreases in the mortality rate were found (pelvic study group 1: 21%; pelvic study group 2: 22%; pelvic study group 3: 18%). In all pelvic study groups the mortality rate in patients >60 years of age was found to be significantly higher than in individuals <60 years of age (pelvic study group 1: 57% versus 29.6%, pelvic study group 2: 33% versus 22.6%, pelvic study group 3: 41% versus 10.4%, p <0.05, respectively). Cited by 7 articles 14 references Full text links 198. Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system Br J Pharmacol. 2010 Apr;159(8):1672-80. doi: 10.1111/j.1476-5381.2010.00651.x. Epub 2010 Mar 5. Authors P Garcia 1 , S Schwenzer , J E Slotta , C Scheuer , A E Tami , J H Holstein , T Histing , M Burkhardt , T Pohlemann , M D Menger Affiliation 1 Department of Trauma-, Hand- and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany. chpgar@uniklinikum-saarland.de PMID: 20233225 PMCID: PMC2925490 DOI: 10.1111/j.1476-5381.2010.00651.x Abstract Background and purpose: The renin-angiotensin system (RAS) regulates blood pressure and electrolyte homeostasis. In addition, 'local' tissue-specific RAS have been identified, regulating regeneration, cell growth, apoptosis, inflammation and angiogenesis. Although components of the RAS are expressed in osteoblasts and osteoclasts, a local RAS in bone has not yet been described and there is no information on whether the RAS is involved in fracture healing. Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (ACE), during fracture healing. Experimental approach: In a murine femur fracture model, animals were treated with the ACE inhibitor perindopril or vehicle only. Fracture healing was analysed after 2, 5 and 10 weeks using X-ray, micro-CT, histomorphometry, immunohistochemistry, Western blotting and biomechanical testing. Key results: ACE was expressed in osteoblasts and hypertrophic chondrocytes in the periosteal callus during fracture healing, accompanied by expression of the angiotensin type-1 and type-2 receptors. Perindopril treatment reduced blood pressure and bone mineral density in unfractured femora. However, it improved periosteal callus formation, bone bridging of the fracture gap and torsional stiffness. ACE inhibition did not affect cell proliferation, but reduced apoptotic cell death. After 10 week treatment, a smaller callus diameter and bone volume after perindopril treatment indicated an advanced stage of bone remodelling. Conclusions: Our study provides evidence for a local RAS in bone that influenced the process of fracture healing. We show for the first time that inhibition of ACE is capable of accelerating bone healing and remodelling. Cited by 34 articles 51 references 4 figures Full text links 199. [Post-traumatic torticollis in a schoolchild: fracture, congenital anomaly or age-appropriate radiological findings of the atlas?] Unfallchirurg. 2010 Mar;113(3):230-4. doi: 10.1007/s00113-009-1696-9. [Article in German] Authors M Burkhardt 1 , P Garcia , P Fries , J Heinzmann , T Pohlemann , A Pizanis Affiliation 1 Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Deutschland. markus.burkhardt@uks.eu PMID: 20148240 DOI: 10.1007/s00113-009-1696-9 Abstract We describe the case of a 6-year-old girl with post-traumatic torticollis after falling on her head. The suspected fractures of the dens axis and/or atlas were ruled out after performing CT and MRI examinations as well as dynamic fluoroscopy. Radiological findings showed no further instability but there was a congenital non-fusion of the posterior arch and an age-appropriate non-fused anterior arch of the atlas. In addition to discoligamental injuries and fractures, congenital anomalies and normal variants of the immature anatomy of the cervical spine should also be considered in the diagnosis of the pediatric cervical spine after trauma. 7 references Full text links 200. Different stabilisation techniques for typical acetabular fractures in the elderly--a biomechanical assessment Injury. 2010 Apr;41(4):405-10. doi: 10.1016/j.injury.2009.12.001. Epub 2009 Dec 24. Authors U Culemann 1 , J H Holstein , D Köhler , C C Tzioupis , A Pizanis , G Tosounidis , M Burkhardt , T Pohlemann Affiliation 1 Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D-66421 Homburg/Saar, Germany. PMID: 20035936 DOI: 10.1016/j.injury.2009.12.001 Abstract Objectives: The tremendous increase of acetabular fractures in the elderly provides new challenges for their surgical treatment. The aim of this study was to evaluate the biomechanical properties of conventional and newly developed implants for the stabilisation of an anterior column combined with posterior hemitransverse fracture (ACPHTF), which represents the typical acetabular fracture in the elderly. Methods: Using a single-leg stance model we analysed four different implant systems for the stabilisation of ACPHTFs in synthetic and cadaveric pelvises. Applying an increasing axial load, fracture dislocation was analysed with a new multidirectional ultrasonic measuring system. Results of the different implant systems were compared by Scheffé post hoc test and one-way ANOVA. Results: In synthetic pelvises, the standard reconstruction plate fixed by 3 periarticular long screws and a new titanium fixator with multidirectional interlocking screws were associated with significantly less dislocation of the fractured quadrilateral plate of the acetabulum when compared to a standard reconstruction plate fixed by only one periarticular long screw and a locking reconstruction plate. No significant differences between the different osteosynthesis techniques could be observed in cadaver pelvises, probably due to a heterogeneous bone quality. Conclusions: We conclude that the plate fixation by positioning of periarticular long screws as well as the multidirectional positioning of interlocking screws account for the most sufficient fracture stabilisation of ACPHTFs under experimental conditions. Copyright (c) 2009 Elsevier Ltd. All rights reserved. Cited by 43 articles Full text links