Advanced Light Microscopy (ALM-CF)

To understand the secret of Ca2+ signalling in cardiomyocytes, we investigate the elementary Ca2+ release units (CRUs) in electrically stimulated Ca2+ transients of cardiomyocytes. We first isolate the elemental Ca2+ releases from these CRUs in cardiac Ca2+ transients using advanced methods and then quantify the effects of physiological or pathological conditions applied to these CRUs, e.g. slow Ca2+ signalling via IP3 receptors, adrenergic stimulation or in the state of cardiac hypertrophy or heart failure.