Prof. Dr. Dr. h.c. Niels de Jonge

Honorarprofessor für das Fachgebiet Experimentalphysik

Head of Innovative Electron Microscopy at the INM Institute.

Nanometer-scale characterization of materials is essential for the advancement of modern nanotechnology and for the elucidation of functional mechanisms in biology. The Innovative Electron Microscopy (IEM) program area conducts interdisciplinary research at the interface of physics, electron microscopy (EM), cancer research, biophysics, materials science, and imaging. One of our major goals is to elucidate molecular mechanisms that lead to drug resistance in HER2 overexpressing cancer. This allows the identification of new predictive markers that can be used for personalized therapies. We are developing state-of-the-art techniques in in-situ electron microscopy for research on functional materials and biological samples under native conditions, mainly using liquid electron microscopes. Along with this, we are also exploring new ways for three-dimensional (3D) data acquisition using specialized software and machine learning. We have many years of experience in image processing and automated particle detection, as well as in the development of protocols for specific protein labeling using nanoparticles. A state-of-the-art transmission electron microscope (JEOL ARM200) is available to the program area. Various research collaborations exist with universities and industry.

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