Junk, Lukas

Publikationen

15   L. Junk, V. M. Schmiedel, S. Guha, K. Fischel, P. Greb, K. Schwechel, V. Krisilia, L. van Geelen, K. Rumpel, P. Kaur, R. V. Krishna­murthy, S. Narayanan, C. Kofink, A. Mantoulidis, P. Biber, G. Gmaschitz, U. Kazmaier, A. Meinhart, J. Leodolter, D. Hoi, S. Junker, F. E. Morreale, T. Clausen, R. Kalscheuer, H. Weinstabl, G. Boehmelt, "Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria", Nature Commun. 2024, 15, 2005. DOI: 0.1038/s41467-024-46218-7

14   D. M. Hoi, S. Junker, L. Junk, K. Schwechel, K. Fischel, D. Podlesainski, P. M. E. Hawkins, L. van Geelen, F. Kaschani, J. Leodolter, F. E. Morreale, S. Kleine, S. Guha, K. Rumpel, V. M. Schmiedel, H. Weinstabl, A. Meinhart, R. J. Payne, M. Kaiser, M. Hartl, G. Boehmelt, U. Kazmaier, R. Kalscheuer, T. Clausen, "Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival", Cell 2023, 186, 2176-2192.https://doi.org/10.1016/j.cell.2023.04.009

13   L. Junk, V. M. Schmiedel, S. Guha, P. Greb, K. Fischel, K. Rumpel, P. Kaur, R. V. Krishnamurthy, S. Narayanan, C. Kofink, A. Mantoulidis, U. Kazmaier, A. Meinhart, J. Leodolter, D. M. Hoi, S. Junker, F. E. Morreale, T. Clausen, G. Boehmelt, H. Weinstabl, "BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria", ChemRxiv 2022. https://doi.org/10.26434/chemrxiv-2022-8hnrh

12   F. E. Morreale, S. Kleine, J. Leodolter, S. Junker, D. M. Hoi, S. Ovchinnikov, A. Okun, J. Kley, R. Kurzbauer, L. Junk, S. Guha, D. Podlesainski, U. Kazmaier, G. Boehmelt, H. Weinstabl, K. Rumpel, V. M. Schmiedel, M. Hartl, D. Haselbach, A. Meinhart, M. Kaiser, T. Clausen, "BacPROTACs mediate targeted protein degradation in bacteria", Cell 2022, 185, 2203-2205. DOI: 10.1016/j.cell.2022.05.009.

11   L. Junk, A. Ullrich, U. Kazmaier, "Synthesis of Modified Tryptophan Derivatives" in Targets in Heterocyclic Systems - Chemistry and Properties (Hrsg.: O. A. Attanasi, B. Gabriele, P. Merino, D. Spinelli), Italian Chemical Society, 2022, 25, 342-364.

10   A. Ullrich, L. Junk, U. Kazmaier, "Three Methods for the Solution Phase Synthesis of Cyclic Peptides" in Methods in Molecular Biology - Peptide Macrocycles (Hrsg.: M. B. Coppock , A. J. Winton), Humana, New York, NY, 2022, 2371, 43-61. https://doi.org/10.1007/978-1-0716-1689-5_4.

9   U. Kazmaier, L. Junk, "The Synthesis of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides that Demonstrate anti-Malaria and anti-Tuberculosis Activity", Mar. Drugs 2021, 19, 446. DOI: 10.3390/md19080446.

8   L. Junk, E. Papadopoulos, U. Kazmaier, "Tryptophan N¹-Alkylation: Quick and Simple Access to Diversely Substituted Tryptophans", Synthesis 2021, 53, 2503–2511. DOI: 10.1055/a-1404-5079.

7   L. Junk, U. Kazmaier, "The Allylic Alkylation of Ketone Enolates", ChemistryOpen 2020, 9, 929–952. DOI: 10.1002/open.202000175.

6   P. Servatius, L. Junk, U. Kazmaier, "Peptide Modifications, Versatile Tools in Peptide and Natural Product Syntheses", Synlett 2019, 30, 1289-1302, DOI: 10.1055/s-0037-1612417, DOI: 10.1055/s-0037-1612417.

5   L. Junk, U. Kazmaier, "Total Synthesis and Configurational Revision of Mozamide A – a Hydroxy-Brunsvicamide", J. Org. Chem.  2019, 84, 2489–2500, DOI: 10.1021/acs.joc.8b02836.

4   L. Junk, U. Kazmaier, "Totalsynthese und Konfigurationsrevision der Keramamide A und L aus gemeinsamer Vorstufe via späte Indolsynthese", Angew. Chem. 2018, 130, 11602−11606; Angew. Chem. Int. Ed. 2018, 57, 11432−11435; doi: 10.1002/ange.201806657.

3   L. Junk, U. Kazmaier, "Synthesis of Indoles and Tryptophan Derivatives via Photoinduced Nitrene C-H Insertion", Org. Biomol. Chem.  2016, 14, 2916−2923.

2   L. Junk, U. Kazmaier, "A straightforward protocol for the synthesis of functionalized tryptophan peptides via Stille coupling, azidation and photoinduced nitrene insertion", Synlett  2016, 1531-1536.

1   J. Hoffmann, J. Gorges, L. Junk, U. Kazmaier, "Synthesis of Pretubulysin-Derivatives via the TubUgi-Approach", Org. Biomol. Chem.  2015, 13, 6010–6020.