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Evaluation of novel drug candidates against multidrug-resistant microbes
In cooperation with pharmaceutical sciences at UdS and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), IMMH is also addressing the issue of AMR and the need for novel therapeutics by identifying, developing and testing new antimicrobial drug candidates or surface modifications in in vitro and in vivo assays. Susceptibilities of clinical isolates of the ESKAPE (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus spp.) group of MDR bacteria against drug candidates are tested in classical broth microdilution assays for minimal inhibitory concentrations (MICs). Drug candidates displaying a promising in vitro activity against MDR bacteria and little to no toxicity to human cell cultures are subsequently tested in different murine-based local and systemic infection models.
If you are interested to hear more about this part of IMMH research, please feel free to contact us.
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Walter Hofer, Felix Deschner, Gwenaelle Jézéquel, Lais Pessanha de Carvalho, Noran Abdel-Wadood, Linde Pätzold, Steffen Bernecker, Bernd Morgenstern, Andreas Martin Kany, Miriam Große, Mark Stadler, Markus Bischoff, Anna Katharina Herta Hirsch, Jana Held, Jennifer Herrmann, Rolf Müller (2024)
Angew Chem Int Ed Engl. 19:e202319765.
Establishing an Experimental Pseudomonas aeruginosa Keratitis Model in Mice - Challenges and Solutions.
Colya N. Englisch, Noran Abdel Wadood, Linda Pätzold, Andrew Gallagher, Gabriela Krasteva-Christ, Sören L. Becker, Markus Bischoff (2023)
Ann Anat. 249:152099
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives
Walter Hofer, Emilia Oueis, Antoine Abou Fayad, Felix Deschner, Anastasia Andreas, Laìs Pessanha de Carvalho, Stephan Hüttel, Steffen Bernecker, Linda Pätzold, Bernd Morgenstern, Nestor Zaburannyi, Markus Bischoff, Marc Stadler, Jana Held, Jennifer Herrmann, Rolf Müller (2022)
Angew Chem Int Ed Engl. 61(30):e202202816
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-based Wound-Infection Model in SKH1 Mice
Jörg Haupenthal, Yannik Kautz, Walid A M Elgaher, Linda Pätzold, Teresa Röhrig, Matthias W. Laschke, Thomas Tschernig, Anna K. H. Hirsch, Vadim Molodtsov, Katsuhiko S. Murakami, Rolf W. Hartmann, Markus Bischoff (2020)
ACS Infect Dis. 6:2573-2581
Efficacy of Off-Label Anti-Amoebic Agents to Suppress Trophozoite Formation of Acanthamoeba spp. on Non-Nutrient Agar Escherichia Coli Plates
Vithusan Muthukumar, Lei Shi, Ning Chai, Achim Langenbucher, Sören L. Becker, Berthold Seitz, Erika Orosz, Tanja Stachon, Albrecht F. Kiderlen, Markus Bischoff, Nóra Szentmáry (2022)
Microorganisms. 2022 Aug 13;10(8):1642
The effect of antiamoebic agents and Ce6-PDT on Acanthamoeba castellanii trophozoites and cysts, in vitro
Lei Shi, Vithusan Muthukumar, Tanja Stachon, Lorenz Latta, Mohamed Ibrahem Elhawy, Gubesh Gunaratnam, Erika Orosz, Berthold Seitz, Albrecht F. Kiderlen, Markus Bischoff, Nóra Szentmáry (2020)
Transl. Vis. Sci. Technol. 9:29
DOI: 10.1167/tvst.9.12.29
N-Aryl-3-mercaptosuccinimides as antivirulence agents targeting Pseudomonas aeruginosa elastase and Clostridium collagenases
Jelena Konstantinović, Samir Yahiaoui, Alaa Alhayek, Jörg Haupenthal, Esther Schönauer, Anastasia Andreas, Andreas M. Kany, Rolf Müller, Jesko Koehnke, Fabian K. Berger, Markus Bischoff, Rolf W. Hartmann, Hans Brandstetter, Anna K. H. Hirsch (2020)
J Med Chem. 63:8359-8368
