Publications

2024

Yao Y, Ritzmann F, Miethe S, Kattler-Lackes K , Colakoglu B, Herr C, Kamyschnikow A, Brand M, Garn H, Yildiz D, Langer F, Bals R, Beisswenger C. Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model. Mol Med 2024 Nov 23;30(1):227. doi: 10.1186/s10020-024-00990-w.

Gharzia FG, Aljohmani A, Beck A, Philipp SE, Yildiz D. Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes. Cell Communication and Signaling 2024 22:531

Zöphel S, Küchler N, Jansky J, Hoxha C, Schäger G, Weise JJ, Vialle J, Kaschek L, Stopper G, Eichler H, Yildiz D, Moter A, Wendel P, UIrich E, Schormann C, Rixecker T, Cetin O, Neumann F, Orth P, Bewarder M, Hoth M, Thurner L, Schwarz EC. CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients. Mol Cancer 2024, 23, 210. Doi: 10.1186/s12943-024-02123-7

Aljohmani A*, Heinze H*, Gharzia FG*, Reda B, Abdrabou AMM, Becker SL, Bischoff M, Hannig M, Yildiz D. Extracellular release of a disintegrin and metalloproteinase correlates with periodontal disease severity. J Clin Periodontol. 2024, 0: 1-12. doi: 10.1111/jcpe.14073. (*shared first authors).

Alexander F. Kiefer, Christian Schütz, Colya N. Englisch, Dominik Kolling, Samira Speicher, Andreas M. Kany, Roya Shafiei, Noran A. Wadood, Ahmad Aljohmani, Niklas Wirschem, Ravindra P. Jumde, Andreas Klein, Asfandyar Sikandar, Yu-Mi Park, Gabriela Krasteva-Christ, Daniela Yildiz, Ahmed S. Abdelsamie, Katharina Rox, Jesko Köhnke, Rolf Müller, Markus Bischoff, Jörg Haupenthal and Anna K. H. Hirsch Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model ChemRxiv 2024 Sep 24; doi: 10.26434/chemrxiv-2024-3mtxb

Mashayekhi V, Schomisch A, Rasheed S, Apricio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, Keller A, Müller R, Fuhrmann G, Hoppstädter J, Kiemer AK. The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer ell-derived extracellular vesicles supporting tumor-associated macrophages. Cell Comm Signal. 2024 Jun 27; 22(1):344. Doi: 10.1186/s12964-024-01701-y.

Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Kirsch SH, Müller R, Yildiz D, Bals R, Beisswenger C. Biochemical and transcriptomic evaluation of a 3D lung organoid platform for preclinical testing of active substances targeting senescence. Resp Res 2024, Vol 25, article number 3

2023

Kuhn T*, Aljohmani A*, Frank N, Zielke L, Mehanny M, Laschke M, Lasche MW, Koch M Hoppstädter J, Kiemer AK, Yildiz D*, Fuhrmann G*. A cell-free, biomimetic hydrogel based on probiotic membrane vesicles ameliorates wound healing. J Control Release 2023 Dec 7:S0168-3659(23)00795-2. doi: 10.1016/j.jconrel.2023.12.011 (*equal contribution)

Cook L, Gharzia FG, Bartsch JW, Yildiz D. A jack of all trades – ADAM8 as a signaling hub in inflammation and cancer. FEBS J 2023 Dec 14. doi: 10.1111/febs.17034. Online ahead of print.

Aljohmani A, Heinze H, Gharzia  FG, Reda B, Abdrabou AMM, Becker S, Bischoff M, Hannig M, Yildiz D. Extracellular release of a disintegrin and metalloproteinases orchestrates periodontal disease severity. bioRxiv 2023 DOI: 10.1101/2023.07.21.550016

Reinhild S, Herr C, Pourrostami M, Ritzmann F, Lehr T, Selzer D, Kohl Y, Yildiz D, Slevogt H, Beisswenger C, Bals R. Modeling of lung-liver interaction during infection in a human microfluidic organ-on-a-chip. bioRxiv 2023 doi: 10.1101/2023.06.01.543192

Jost P, Klein F, Brand B, Wahl V, Wyatt A, Yildiz D, Boehm U, Niemeyer BA, Vaeth M, Alansary D. Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Supressive Capacity of Regulatory CD4 T Cells. Int. J. Mol. Sci. 2023, 24 7772

Yu Q, Gamayun I, Wartenberg P, Zhang Q, Qiao Sen, Kusumakshi S, Candlish S, Götz V, Wen S, Das D, Wyatt A, Wahl V, Ectors F, Kattler K, Yildiz D, Prevot V, Schwaninger M, Ternier G, Giacobini O, Ciofi P, Müller TD, Boehm U. Bitter taste cells in the ventricuar walls oft he murine brain regulate glucose homeostasis. Nat. Commun. 2023, 14:1588

Van der Vorst E, Theodorou K, Peters L, Maas SL, Rademakers T, Gijbels M, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EA, Donners M. Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front. Cardiovasc. Med. 2023 10, 974918

2022

Ahmad-Mansour N, Elhawy M, Huc-Brandt S, Youssouf N, Pätzold L, Martin M, Abdel-Wadood N, Aljohmani A, Krasteva-Christ G, Becker SL, Yildiz D, Lavigne JP, Gannoun-Zaki L, Bischoff M, Molle V Characterization of the Secreted Acid Phosphatase SapS Reveals a Novel Virulence Factor of Staphylococcus aureus That Contributes to Survival and Virulence in mice. Int. J. Mol. Sci. 2022 23(22), 14031

Aljohmani A, Andres NN, Yildiz D. Pseudomonas aeruginosa alters critical lung epithelial cell functions through activation of ADAM17. Cells 2022 11(15), 2303

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, CAPSyS Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022;7(3):e149870

Bienstein, M.; Minond, D.; Schwaneberg, U.; Davari, M.D.; Yildiz, D. In Silico and Experimental ADAM17 Kinetic Modeling as Basis for Future Screening System for Modulators. Int. J. Mol. Sci. 2022, 23, 1368

Aljohmani A, Opitz B, Bischoff M, Yildiz, D. Pseudomonas aeruginosa Triggered Exosomal Release of ADAM10 Mediates Proteolytic Cleavage in Trans. Int. J. Mol. Sci. 2022, 23, 1259

Horstmann JC, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, de Souza Carvalho-Wodarz  C, Lehr CM. Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin. ACS Infect Dis 2022 Jan 14;8(1):137-149

2021

Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. The metalloproteinase ADAM10 requires its activity to sustain surface expression. Cell Mol Life Sci. 2021 Jan;78(2):715-732

Awan T, Babendreyer A, Wozniak J, Alvi AM, Sterzer V, Cook L, Bartsch JW, Liedtke C, Yildiz D and Ludwig A. Expression of the metalloproteinase ADAM8 is upregulated in liver inflammation models and enhances cytokine release in vitro. Mediator of Inflammation Article ID6665028

2020

Winter M, Weissgerber P, Klein K, Lux F, Yildiz D, Wissenbach U, Philipp SE, Meyer MR, Flockerzi V, Fecher-Trost C. Transient receptor potential vanilloid (TRPV6) proteins control the extracellular matrix structure of the placental labyrinth. Int J Mol Sci 2020, 21(24), 9674

Seifert A, Wozniak J, Düsterhöft S, Kasparek P, Sedlacek R, Dreschers S, Orlikowsky TW, Yildiz D*, Ludwig A*. The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. Int J Mol Sci. 2020, 21, 5978;  (*equal contribution)

Aljohmani A, Yildiz D. A Disintegrin and Metalloproteinase—Control elements in infectious diseases. Front Cardiovasc. Med, 16 December 2020

2019

Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells. J Mol Cell Cardiol. 2019 Jul 1;134:51-61.

Schick D, Babendreyer A, Wozniak J, Awan T, Noels H, Liehn E, Bartsch JW, Vlacil AK, Grote K, Zayat R, Goetzenich, Ludwig A, Dreymueller D. Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans. Atherosclerosis. 2019 Jul;286:163-171.

van der Vorst E,  Theodorou K, Rademakers T,  van Buul JD,  Hermans A,  Tomlinson M,  Lehrke M, Lebherz C,  Dreymueller D, Ludwig A,  Bentzon J,  Biessen E,  Donners M. A Disintegrin and Metalloprotease ADAM10 Controls Endothelial Functions in Atherosclerosis. Atherosclerosis 2019 Volume 287, e4-e5

2018

Habib P*, Dreymueller D*, Rösing B, Botung H, Slowik A, Zendedel A, Habib S, Hoffmann S, Beyer C. Estrogen serum concentration affects blood immune cell composition and polarization in human females under controlled ovarian stimulation. J Steroid Biochem Mol Biol 2018 Apr;178:340-347.

2017

Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess FM, Seifert A, Babendreyer A, Bartsch JW, Ludwig A. The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. AJP Lung 2017 Sep 1; 313(3): L602-L614.

Dreymueller D, Theodorou K, Donners M, Ludwig A. Fine tuning cell migration by a disintegrin and metalloproteinases. Mediators Inflamm 2017; 2017:9621724.

Koenen A, Babendreyer A, Schumacher J, Pasqualon T, Schwarz N, Seifert A, Deupi X, Ludwig A*, Dreymueller D*. The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion PLoSOne 2017; e0173486 (*equal contribution).

Rüther BJ, Scheld M, Dreymueller D, Clarner T, Kress E, Brandenburg LO, Swartenbroekx T, Hoornaert C, Ponsaerts P, Fallier-Becker P, Beyer C, Rohr SO, Schmitz C, Chrzanowski U, Hochstrasser T, Nyamoya S, Kipp M. Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression. Glia 2017 Dec; 65(12): 1900.

Babendreyer A, Molls L, Dreymueller D, Uhlig S, Ludwig A. Shear stress counteracts endothelial CX3CL1 induction and monocytic cell adhesion. Mediators Inflamm 2017, ID 1515389.

Maihöfer NA, Suleiman S, Dreymüller D, Manley PW, Rossaint R, Uhlig S, Martin C, Rieg A. Imatinib relaxes the pulmonary venous bed of guinea pigs. Respir Res 2017; 18 (1): 32.

2016

Dreymueller D*, Goetzenich A*, Emontzphol C, Soppert J, Ludwig A*, Stoppe C*. The perioperative time course and clinical significance of the chemokine CXCL16 in patients undergoing cardiac surgery. J Cell Mol Med. 2016; 20:104-15 (*equal contribution).

Madoux F, Dreymueller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minonde D. Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate. Scientific reports 2016; 6: 11.

Groth E, Pruessmeyer J, Babendreyer A, Schumacher J, Pasqualon T, Dreymueller D, Higashiyama S, Lorenzen I, Grotzinger J, Cataldo D, Ludwig A. Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes. Biochim Biophys Acta 2016; 1863: 2795-2808.

Chen J, Deng L, Dreymuller D, Jiang X, Long J, Duan Y, Wang Y, Luo M, Lin F, Mao L, Muller B, Koller G, Bartsch JW. A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models. Scientific reports 2016; 6: 30451.

Dreymueller D, Ludwig A. Considerations on inhibition approaches for proinflammatory functions of ADAM proteases. Platelets 2016; 1-8.

Scheld M, Ruether B, Große-Veldmann R, Ohl K, Tenbrock K, Dreymueller D, Fallier-Becker P, Zendedel A, Beyer C, Clarner T, Kipp M. Neurodegeneration triggers peripheral immune cell recruitment into the forebrain. J Neurosci 2016; 36:1410-5.

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SD. Systemic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife 2016; 5 pil: e12748.

2015

Pasqualon T, Pruessmeyer J, Jankowski V, Babendreyer A, Groth E, Schumacher J, Koenen A, Weidenfeld S, Schwarz N, Denecke B, Jahr H, Dreymueller D, Jankowski J, Ludwig A. A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration. Oncotarget 2015; 6(31):31295-312.

Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, Schwarz N, Denecke B, Jahr H, Zimmermann P, Dreymueller D, Ludwig A. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. Cell Mol Life Sci. 2015 Oct;72(19):3783-801.

Schneider KM, Bieghs V, Heymann F, Hu W, Dreymueller D, Liao L, Frissen M, Ludwig A, Gassler N, Pabst O, Latz E, Sellge G, Penders J, Tacke F, Trautwein C. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 2015 Nov;62(5):1405-16.

van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM. Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. Am JPathol. 2015 Apr;185(4):1145-55.

Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fiels, GB, Minond D.  SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes J Med Chem 2015, 58(15): 5808-24.

Dreymueller D, Uhlig S, Ludwig A. ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L325-43.

2014

Pruessmeyer J*, Hess FM*, Ahlert H, Groth E, Pasqualon T, Schwarz N, Nyamoya S, Kollert J, van der Vorst E, Donners M, Martin C, Uhlig S, Saftig P, Dreymueller D*, Ludwig A*.  Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. Blood 2014 123: 4077-4088 (*equal contribution).

Dreymueller D, Martin C, Schumacher J, Groth E, Boehm JK, Reiss LK, Uhlig S, Ludwig A. Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. Journal of Immunology 2014 192: 722-731.

2013

Dreymueller D, Denecke B, Ludwig A, Jahnen-Dechent W. Embryonic stem cell-derived M2-like macrophages delay cutaneous wound healing. Wound Repair and Regeneration: 2013 21: 44-54.

Habib P, Dreymueller D, Ludwig A, Beyer C, Dang J. Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia. J Steroid Biochem Mol Biol. 2013 Nov;138:195-205.

2012

Dreymueller D, Martin C, Kogel T, Pruessmeyer J, Hess FM, Horiuchi K, Uhlig S, Ludwig A. Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide. EMBO Mol Med 2012 4: 412-423.

Dreymueller D, Pruessmeyer J, Groth E, Ludwig A. The role of ADAM-mediated shedding in vascular biology. Eur J Cell Biol. 2012 Jun-Jul;91(6-7):472-85.

2010

Andrzejewski MG, Koelsch A, Kogel T, Dreymueller D, Schwarz N, Ludwig A. Distinct role of the intracellular C-terminus for subcellular expression, shedding and function of the murine transmembrane chemokine CX3CL1. BiochemBiophys Res Commun. 2010 Apr 30;395(2):178-84.

Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, Sechi AS, Uhlig S, Ludwig A. Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1. Cellular and molecular life sciences. 2010 67: 4233-4248.