Publikationen 2010–2024 (Auswahl)

Weyrich et al. Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease.
Circulation 2024; 150: 746-757

Francis A et al. Chronic kidney disease and the global public health agenda: an international consensus.
Nat Rev Nephrol 2024; 20: 473-485

Arjune S, et al. DKK3 as a potential novel biomarker in patients with autosomal polycystic kidney disease
Clin Kidney J 2024; 17: 1-10

Speer T, et al. Urinary DKK3 as a biomarker for short-term kidney function decline in children with chronic kidney disease: an observational cohort study.
Lancet Child Adolesc Health 2023; 7:405-414

Zewinger S, et al. Reply to Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Nat Immunol 2023; 24: 412-413

Speer T, et al. Targeting innate immunity-driven inflammation in CKD and cardiovascular disease.
Nat Rev Nephrol 2022; 18: 762-778

Schunk SJ, et al. The alarminin interleukin-1α mediates leukocyte adhesion in cardiorenal diseases.
Circulation 2021; 144: 893-908

Schunk SJ, et al. Guanidinylated apolipoprotein C3 (ApoC3) associates with kidney and vascular injury.
J Am Soc Nephrol 2021; 32: 3146-3160

Zoccali C, et al. A randomized multicenter trial on a lung ultrasound-guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk.
Kidney Int 2021; 100: 1325-1333

Fliser D. Urinary Dickkopf-3 and the evaluation of chronic kidney disease progression.
Nephrol Dial Transplant 2021; 36: 21-61-2163

Schunk SJ, et al. Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease.
Kidney Int 2021; 100: 1081-1091

Speer T, et al. Lipoproteins in chronic kidney disease – from bench to bedside.
Eur Heart J 2021; 42: 2170-2185

Schunk SJ, et al. WNT-β-catenin signalling - a versatile player in kidney injury and repair.
Nat Rev Nephrol 2021; 17: 172-184

Jankowski J, et al. Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options.
Circulation 2021; 143: 1157-1172

Schunk SJ, et al. Genetically-determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
Eur Heart J 2021; 42: 1742-1756

Radhakrishnan K, et al. Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
PNAS 2021; 118: e2022841118

Schunk SJ, et al. Dickkopf 3-a novel biomarker of the 'kidney injury continuum'.
Nephrol Dial Transplant 2021; 36: 761-767

Zewinger et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Nat Immunol 2020, 21: 30-41

Stengel B, et al. Adherence to the Kidney Disease: Improving Global Outcomes CKD Guideline in Nephrology Practice Across Countries.
Kidney Int Rep 2020; 6: 437-448

Emrich IE, et al. Hypophosphatemia after high-dose iron repletion with ferric carboxymaltose and ferric derisomaltose-the randomized controlled HOMe aFers study.
BMC Med 2020; 18: 178

Klingele M et al. Therapeutic apheresis within immune-mediated neurological disorders: dosing and its effectiveness.
Sci Rep 2020; 10: 7925

Schunk SJ, et al. Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study.
Lancet 2019; 394: 488-496

Schmid D, et al. Proprotein convertase subtilisin/kexin type 9 in kidney disease.
Nephrol Dial Transplant 2019; 34: 1266-1271

Weingärtner O, et al. Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study.
Clin Res Cardiol 2019; 108: 1381-1385

Emrich IE, et al. Plasma FGF23 does not rise during physical exercise as a physiological model of sympathetic activation.
Clin Res Cardiol 2019; 108: 341-343

Zewinger S, et al. Dickkopf-3 (DKK3) in Urine Identifies Patients with Short-Term Risk of eGFR Loss.
J Am Soc Nephrol 2018; 29: 2722-2733

Fuhrmann A, et al. Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events.
Atherosclerosis 2018: 279: 17-22

Kölling M, et al. The Circular RNA ciRs-126 Predicts Survival in Critically Ill Patients With Acute Kidney Injury.
Kidney Int Rep 2018; 3: 1144-1152

Untersteller K, et al. HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients.
J Lipid Res 2018; 59: 1256-1265

Noels H, et al. The new SFB/TRR219 Research Centre.
Eur Heart J 2018, 39: 975-977

Seiler-Mussler S, et al. Association of Nonoxidized Parathyroid Hormone with Cardiovascular and Kidney Disease Outcomes in Chronic Kidney Disease.
Clin J Am Soc Nephrol 2018; 13: 569-576

Emrich IE, et al. Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
Clin Res Cardiol 2018; 107: 201-213

Untersteller K, et al. Validation of echocardiographic criteria for the clinical diagnosis of heart failure in chronic kidney disease.
Nephrol Dial Transplant 2018: 33: 653-660

Klingele M, et al. Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction.
Crit Care 2017; 21: 294

Zewinger S, et al. Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.
Lancet Diabetes Endocrinol 2017; 5: 534-543

Zoccali C, et al. The systemic nature of CKD.
Nat Rev Nephrol 2017; 13: 344-358

Zewinger S, et al. Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease.
Eur Heart J 2017; 38: 1597-1607

Bauer L, et al. HDL-cholesterol efflux capacity and cardiovascular events in patients with chronic kidney disease.
J Am Coll Cardiol 2017; 69: 246-247

Fliser D, et al. Early low-dose erythropoiesis-stimulating agent therapy and progression of moderate chronic kidney disease: a randomized, placebo-controlled trial.
Nephrol Dial Transplant 2017; 32: 279-287

Zawada AM, et al. MicroRNA profiling of human intermediate monocytes.
Immunobiology 2017; 222: 587-596

Fell LH, et al. Impact of individual intravenous iron preparations on the differentiation of monocytes towards macrophages and dendritic cells.
Nephrol Dial Transplant 2016; 31: 1835-1845

Zewinger S, et al. Innate immunity in CKD-associated vascular diseases.
Nephrol Dial Transplant 2016; 31: 1813-1821

Federico G, et al. Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.
J Clin Invest Insight 2016; 1: e84916

Torino C, et al. Efficacy of a remote web-based lung ultrasound training for nephrologists and cardiologists: a LUST trial sub-project.
Clin J Am Soc Nephrol 2016; 11: 2005-2011

Untersteller K, et al. NT-proBNP and Echocardiographic Parameters for Prediction of Cardiovascular Outcomes in Patients with CKD Stages G2-G4.
Clin J Am Soc Nephrol 2016; 11: 1978-1988

Zawada AM, et al. DNA methylation profiling reveals differences in the 3 human monocyte subsets and identifies uremia to induce DNA methylation changes during differentiation.
Epigenetics 2016; 11: 259-272

Rogacev KS, et al. PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR.
PLoS One 2016; 11: e0146920

Lennartz CS, et al. External Validation of the Kidney Failure Risk Equation and Re-Calibration with Addition of Ultrasound Parameters.
Clin J Am Soc Nephrol 2016; 11: 609-615

Zewinger S, et al. Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk.
Eur Heart J 2015; 36: 3007-3016

Bolignano D, et al. High estimated pulmonary artery systolic pressure predicts adverse cardiovascular outcomes in stage 2-4 chronic kidney disease.
Kidney Int 2015; 88: 130-136

Tripepi G, et al. Competitive interaction between fibroblast growth factor 23 and asymmetric dimethylarginine in patients with CKD.
J Am Soc Nephrol 2015; 26: 935-944

Speer T, et al. A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study.
Crit Care 2015; 19: 190

Leyking S, et al. Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients.
J Trans Med 2015; 13: 51

Emrich IE, et al. Comparison of the performance of 2 GFR estimating equations using creatinine and cystatin C to predict adverse outcomes in elderly individuals.
Am J Kidney Dis 2015; 65: 636-638

Floege J & Fliser D. Klotho Deficiency and the Cardiomyopathy of Advanced CKD.
J Am Soc Nephrol 2015; 26: 1229-1231

Speer T, et al. Carbamylated low-density lipoprotein induces endothelial dysfunction.
Eur Heart J 2014; 35: 3021-3032

Schroff R, et al. HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype.
J Am Soc Nephrol 2014; 25: 2658-2668

Ortiz A, et al. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure.
Lancet 2014; 383: 1831-1843

Zewinger S, et al. HDL cholesterol is not associated with lower mortality in patients with kidney dysfunction.
J Am Soc Nephrol 2014; 25: 1073-1082

Rogacev KS, et al. Lower Apo A-I and lower HDL-C levels are associated with higher intermediate CD14++CD16+ monocyte counts that predict cardiovascular events in chronic kidney disease.
Arterioscler Thromb Vasc Biol 2014; 34: 2120-2127

Schmidt T, et al. BK polyomavirus-specific cellular immune responses are age-dependent and strongly correlate with phases of virus replication.
Am J Transplant 2014; 14: 1334-1345

Leyking S & Fliser D. Insulin resistance in CKD.
Clin J Am Soc Nephrol 2014; 9: 638-640

Seiler S et al. Associations of FGF-23 and sKlotho with cardiovascular outcomes among patients with CKD stages 2-4.
Clin J Am Soc Nephrol 2014; 9: 1049-1058

Zawada AM, et al. S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population.
Atherosclerosis 2014; 234: 17-22

Fell LH, et al. Distinct immunologic effects of different intravenous iron preparations on monocytes.
Nephrol Dial Transplant 2014; 29: 809-822

Rogacev KS, et al. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation incorporating both cystatin C and creatinine best predicts individual risk: a cohort study in 444 patients with chronic kidney disease.
Nephrol Dial Transplant 2014; 29: 348-355

Seiler S, et al. Single FGF-23 measurement and time-averaged plasma phosphate levels in hemodialysis patients.
Clin J Am Soc Nephrol 2013; 8: 1764-1772

Speer T, et al. Abnormal high-density lipoprotein induces endothelial dysfunction via activation of toll-like receptor-2.
Immunity 2013; 38: 754-768

Speer T, et al. Uremic dysplipidemia revisited – role of high-density lipoprotein.
Nephrol Dial Transplant 2013; 28: 2456-2463

Heine GH, et al. Calcium and phosphate impact cardiovascular risk.
Eur Heart J 2013; 34: 1112-1121

Seiler S, et al. Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease.
Kidney Int 2013; 83: 121-128

Zawada AM, et al. SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes.
Circ Cardiovasc Genet 2012; 5: 611-620

Rogacev RS, et al. CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography.
J Am Coll Cardiol 2012; 60: 1512-1520

Hafer C, et al. High-dose erythropoietin has no effect on short- or long-term graft function following deceased donor kidney transplantation.
Kidney Int 2012; 81: 314-320

Rogacev KS, et al. Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients.
Clin J Am Soc Nephrol 2012; 7: 943-948

Fliser D, et al. European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines on acute kidney injury: part 1: definitions, conservative management and contrast-induced nephropathy.
Nephrol Dial Transplant 2012; 27: 4263-4272

Seiler S, et al. Ultrasound renal resistive index is not an organ-specific predictor of allograft outcome.
Nephrol Dial Transplant 2012; 27: 3315-3320

Fliser D, et al. Measurement of serum soluble Klotho levels in CKD 5D patients: useful tool or dispensable biomarker?
Nephrol Dial Transplant 2012; 27: 1702-1703

Grün OS, et al. Does the measurement of the difference of resistive indices in spleen and kidney allow a selective assessment of chronic kidney injury?
Radiology 2012; 264: 894-902

Kirsch S, et al. T-cell numbers and antigen-specific T-cell function follow different circadian Rhythms.
J Clin Immunol 2012; 32: 1381-1389

Heine GH, et al. Monocyte subpopulations and cardiovascular risk in chronic kidney disease.
Nat Rev Nephrol 2012; 8: 362-369

Rogacev KS, ewt al. Bardoxolone methyl, chronic kidney disease, and type 2 diabetes.
N Engl J Med 2011; 365: 1745-1746

Zawada A, et al. SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.
Blood 2011; 118: e50-e61

Seiler S, et al. The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation.
Eur Heart J 2011; 32: 2688-2696

Rogacev KS, et al. CD14++16+ monocytes are independent predictors of cardiovascular outcome in patients with chronic kidney disease.
Eur Heart J 2011; 32: 84-92

Lorenzen JM, et al. Circulating microRNAs in critically ill patients with acute kidney injury.
Clin J Am Soc Nephrol 2011; 6: 1540-1546

Lorenzen J, et al. TLR-4+ peripheral blood monocytes and cardiovascular events in patients with chronic kidney disease – a prospective follow-up study.
Nephrol Dial Transplant 2011; 26:1421-1424

Fliser D, et al. The PRIMAVERA study protocol design: Evaluating the effect of continuous erythropoiesis receptor activator (C.E.R.A.) on renal function in non-anemic patients with chronic kidney disease.
Contemp Clin Trials 2011; 32: 786-792

Ulrich C, et al. Monocyte angiotensin converting enzyme expression may be associated with atherosclerosis rather than arteriosclerosis in hemodialysis patients.
Clin J Am Soc Nephrol 2011; 6: 505-511

Ortiz A, et al. Clinical usefulness of novel prognostic biomarkers in patients on hemodialysis.
Nat Rev Nephrol 2011; 8: 141-150

Weingärtner O, et al. The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
PLOS One 2010: 5: e13467

Krebs S, et al. Benefits of supplementation with wormwood in early stage IgA nephropathy with poor response to dual renin-angiotensin blockade.
Am J Kidney Dis 2010; 56:1095-1099

Seiler S, et al. FGF-23 and future cardiovascular events in patients with chronic kidney diseases before initiation of dialysis treatment.
Nephrol Dial Transplant 2010; 25: 3983-3989

Rogacev KS, et al. Monocyte heterogeneity in obesity and subclinical atherosclerosis.
Eur Heart J 2010; 31: 369-376

Lorenzen JM, et al. Endothelial progenitor cells (EPCs) and survival in patients on maintenance hemodialysis.
PLOS One 2010; 5: e11477