Publikationen

Originalarbeiten

Feiner LK, Tierling S, Holländer S, Glanemann M, Rubie C. An aging and p53 related marker: HOXA5 promoter methylation negatively correlates with mRNA and protein expression in old age. Aging (Albany NY) 2021. Feb 5;13. doi: 10.18632/aging.202621.

Rubie C, Zimmer J, Lammert F, Gross JC, Weber SN, Kruse B, Halajda B, Wagner M, Wagenpfeil S, Glanemann M. MicroRNA-496 and Mechanistic Target of Rapamycin Expression are Associated with Type 2 Diabetes Mellitus and Obesity in Elderly People. Ann Nutr Metab 2019; 74: 279-286.

Kirchmeyer M, Servais FA, Hamdorf M, Nazarov PV, Ginolhac A, Halder R, Vallar L, Glanemann M, Rubie C, Lammert F, Kreis S, Behrmann I. Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets. J Leukoc Biol 2018; 104: 987-1002.

Rubie C, Kölsch K, Halajda B, Eichler H, Kruse B, Wagenpfeil S, Roemer K and Glanemann M. MicroRNA-496 – a new, potentially ageing-relevant regulator of mTOR. Cell Cycle 2016; 15:1108-16.

Rubie C, Kauffels A, Kölsch K, Glanemann M and Justinger C. CXCL12/CXCR4 display an inverse mRNA expression profile in gastric carcinoma that correlates with tumor progression. Oncology Lett 2016; 11: 360 - 364.

Frick VO, Rubie C, Keilholz U, Ghadjar P. Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview. World J Gastroenterol 2016; 22: 833-41.

Wagner M, Vicinus B, Muthra ST, Richards TA, Linder R, Frick VO, Groh A, Rubie C, Weichert F. Text mining, a race against time? An attempt to quantify possible variations in text corpora of medical publications throughout the years. Comput Biol Med 2016; 73: 173-85.

Shayesteh-Kheslat R, Kauffels A, Rubie C, Frick VO, Wagner M, Kollmar O, Schilling MK. Proangiogenic potency of MUC18 in arteriosclerotic disease. J Cardiovasc Surg 2015; 56: 409-15./p>

Wagner M, Vicinus B, Frick VO, Auchtor M, Rubie C, Jeanmonod P, Richards TA, Linder R, Weichert F. MicroRNA target prediction: theory and practice. Mol Genet Genomics 2014; 289: 1085-101.

Rubie C, Kruse B, Frick VO, Kölsch K, Ghadjar P, Wagner M, Grässer F, Wagenpfeil S, Glanemann M. Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. J Transl Med 2014; 12:12-48.

MicroRNA target prediction: theory and practice. Wagner M, Vicinus B, Frick VO, Auchtor M, Rubie C, Jeanmonod P, Richards TA, Linder R, Weichert F. Mol Genet Genomics. 2014 Jun 18. [Epub ahead of print]

Vicinus B, Rubie C, Stegmaier N, Kölsch K, Frick V, Ghadjar P, Wagner M, Glanemann M. MiR-21 and its target gene CCL20 are both highly over-expressed in the microenvironment of CRC tumors: consequences for their regulation. Oncol Rep 2013:  30:1285-1292.

Frick VO, Rubie C, Kölsch K, Wagner M, Ghadjar P, Graeber S, Glanemann M. CCR6/CCL20 chemokine expression profile in distinct colorectal malignancies. Scand J Immunol 2013; 78:298-305.

Vicinus B, Rubie C, Faust S, Frick V, Ghadjar P, Wagner M,  Graeber S and Schilling MK. miR-21 functionally interacts with
the 3'UTR of Chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. Cancer Lett 2012; 316:105-112.

Frick VO, Justinger C, Rubie C, Graeber S, Schilling MK, Lindemann W. Thoracotomy procedures effect cytokine levels after thoracoabdominal esophagectomy. Oncol Rep 2012; 27: 258-264.

Rubie C, Frick VO, Ghadjar P, Wagner M, Justinger C, Graeber S, Sperling J, Kollmar O, Schilling MK. Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases. World J Gastroenterol 2011; 17: 3109-3116.

Rubie C, Frick VO, Ghadjar P, Wagner M, Justinger C, Faust SK, Vicinus B, Gräber S, Kollmar O, Schilling MK. CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells. J Transl Med 2011; 24: 9:22.

Oliveira Frick V, Rubie C, Ghadjar P, Faust SK, Wagner M, Gräber S, Schilling MK. Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies. Tumour Biol 2011; 32:189-96.

Rubie C, Oliveira Frick V, Ghadjar P, Wagner M, Grimm H, Vicinus B, Justinger C, Graber S, Schilling M. CCL20/CCR6 expression Profile in pancreatic cancer. J Transl Med 2010; 8:45.

Ghadjar P, Rubie C, Aebersold DM, Keilholz U. The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer. Int J Cancer 2009; 125:741-745.

Justinger C, Schlüter C, Frick VO, Kopp B, Rubie C, Schilling MK. Increased growth factor expression after hepatic and
pancreatic resection. Oncol Rep 2008;20:1527-1532.

Rubie C, Kollmar O, Oliveira Frick V, Wagner M, Brittner B, Graeber S,  Schilling MK. Differential CXC receptor expression in colorectal malignancies. Scan J Immunol  2008; 68:635-644.

Oliveira Frick V, Rubie C, Wagner M, Graeber S, Grimm H, Kopp B, Rau B, Schilling MK. Enhanced ENA-78 and IL-8 expression in patients with malignant pancreatic diseases. Pancreatology 2008; 8:488-497.

Rubie C, Oliveira Frick V, Wagner M, Schuld J, Graeber S, Bohle RM, Schilling MK. ELR+ CXC chemokine expression in benign and malignant colorectal conditions. BMC Cancer 2008; 8:178-189.

Rubie C, Oliveira Frick V, Pfeil S, Wagner M, Kollmar, Kopp B, Gräber S, Rau B, Schilling MK. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol 2007; 37: 4996-5002.

Rubie C, Oliveira Frick V, Wagner M, Rau B, Schilling MK. Chemokine Receptor CCR6 expression in Colorectal Liver Metastasis. J Clin Oncol 2006; 24: 5173-5174.

Rubie C, Oliveira Frick V, Wagner M, Weber C, Kruse B, Kempf  K, König J, Rau B, Schilling MK. Chemokine Expression in Hepatocellular Carcinoma versus Colorectal Liver Metastases. World J Gastroenterol 2006; 41: 6627-6633.

Rubie C, Frick VO, Wagner M, Rau B, Weber, C, Kruse B, Kempf K, Tilton J, König J, Schilling M. Enhanced expression and clinical significance of CC-chemokine MIP-3alpha in hepatocellular carcinoma. Scan J Immunol 2006; 63: 468-477.

Rubie C, Oliveira V, Kempf K, Wagner M, Tilton B, Rau B, Kruse B, König J, Schilling M. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Tumor Biol 2006; 27: 166-174.

Rau BM, Kruger CM, Hasel, C, Oliveira V, Rubie C, Beger HG, Schilling MK. Effects of immunosuppressive and immunostimulative treatment on pancreatic injury and mortality in severe acute experimental pancreatitis. Pankreas 2006; 33: 174-183.

Rubie C, Kempf K, Hans J, Su T, Tilton B, Georg T, Brittner B, Ludwig B, Schilling M. Housekeeping gene variability in normal and cancerous colorectal, pancreatic, esophageal, gastric and hepatic tissues. Mol Cell Probe 2005; 19: 101-109.

Vorträge und Abstracts (Auswahl)

Feiner LK, Thomas A, Rubie C, Glanemann M. A new regulatory mechanism associated with aging. 23. Chirurgische Forschungstage, 12 – 14.09.2019, Aachen.

Feiner LK, Thomas A, Rubie C, Glanemann M. 23. Regulation of Diabetes Type 2 and Obesity by the mTOR pathway.  Chirurgische Forschungstage, 12 – 14.09.2019, Aachen.

Feiner LK, Thomas A, Rubie C, Glanemann M. Age-associated changes in the expression profile of aging related plasmaproteins.  23. Chirurgische Forschungstage, 12 – 14.09.2019, Aachen.

Rubie C, Feiner LK and Glanemann M. Symposium of the Heart Centre, University Hospital Halle (Saale) „Epigenetics: Playing with the Game of Life“13.09. – 15.09.2019 Halle. A new regulatory mechanism in ageing.

Rubie C, Feiner LK and Glanemann M. Symposium of the Heart Centre, University Hospital Halle (Saale) „Epigenetics: Playing with the Game of Life “Halle, 13. – 15.09.2019. Diabetes mellitus type 2 and obesity are potentially regulated by the mTOR pathway under the control of miR-496.

Feiner LK, Rubie C, Glanemann M. Ein neuer regulatorischer Mechanismus, der an Alterungsprozessen beteiligt ist. 136. Kongress Deutsche Gesellschaft für Chirurgie, 26 – 29.03.2019, ICM München.

Feiner LK, Thomas A, Rubie C, Zimmer J, Glanemann M. Diabetes mellitus Typ 2 und Fettleibigkeit werden mutmaßlich durch den mTOR Signalweg unter der Kontrolle der miRNA-496 reguliert. Kongress Deutsche Gesellschaft für Chirurgie, 26 – 29.03.2019, ICM München.
Preis: „Best Poster“ für das Poster „Diabetes mellitus Typ 2 und Fettleibigkeit werden mutmaßlich durch den mTOR Signalweg unter der Kontrolle der miRNA-496 reguliert.“

Feiner LK, Thomas A, Rubie C, Glanemann M. Evaluierung des Expressionsprofils altersassoziierter Plasmaproteine. 136. Kongress Deutsche Gesellschaft für Chirurgie, 26 – 29.03.2019, ICM München.

Thomas A, Rubie C und Glanemann M. Evaluierung des Expressionsprofils altersassoziierter Plasmaproteine. Gerontologie und Geriatrie Kongress 2018, Köln, 06.- 08.09.2018.

Rubie C und Glanemann M. A new regulatory mechanism involved in ageing. International Conference on Aging and Disease, Nizza, Frankreich, 05. - 08.10.2018.

C. Rubie, J. Zimmer und M. Glanemann. Diabetes mellitus type 2 and obesity are potentially regulated by the mTOR pathway under the control of miR-496.  International Conference on Aging and Disease, Nizza, Frankreich, 05. - 08.10.2018.

C. Rubie. 17. Konferenz der German Society of Preventive and Anti-Aging Medicine, GSAAM e.V. Die molekularen Grundlagen des Alterns. München, 4. – 6. 05. 2017. Expression and regulation of mTOR, a key modulator of ageing and age-related disease.

Rubie C. 2nd Molecular Biology of Ageing Meeting 2017. Groningen, Holland, 8.-11-10.2017. Expression and regulation of mTOR, a key modulator of ageing and age-related disease.

Kolokotronis T, Avramis D, Rubie C, Glanemann.  12th International Congress of the European-African Hepato-Pancreato-Biliary Association (12th Biennal E-AHPBA), Mainz, 23. - 26.05.2017. Expression and regulation of mTOR, a key modulator of ageing and age-related disease, in pancreatic carcinoma.

Kolokotronis T, Avramis D, Rubie C, Glanemann. DGCH ICM München, 21. – 24.03. 2017.  Expression and regulation of mTOR, a key modulator of ageing and age-related disease, in pancreatic carcinoma.

Kolokotronis T, Rubie C, Halajda B, Glanemann M. Functional interaction of microRNAs with chemokine ligands and their expression in the microenvironment of colorectal tumors. Kolokotronis T, Rubie C, Halajda B, Glanemann M. Viszeralmedizin Dresden - 13.-16.09.2017.

Kolokotronis T, Rubie C, Halajda B, Glanemann M. CXCL12/CXCR4 display an inverse mRNA expression profile in gastric carcinoma which correlates with tumor progression. Viszeralmedizin Dresden - 13.-16.09.2017.

Kolokotronis T, Rubie C, Halajda B, Glanemann M. Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. Viszeralmedizin Dresden - 13.-16.09.2017.

Kolokotronis T, Rubie C, Halajda B, Glanemann M.Expression and regulation of mTOR, a key modulator of ageing and age-related disease, in pancreatic carcinoma. Viszeralmedizin Dresden - 13.-16.09.2017.

Kolokotronis T, Rubie C, Halajda B, Glanemann M.Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. Chirurgische Forschungstage Köln-  21. – 23.09.2017.

Kolokotronis T, Rubie C, Halajda B, Glanemann M. Expression and regulation of mTOR, a key modulator of ageing and age-related disease, in pancreatic carcinoma. Chirurgische Forschungstage Köln-  21. – 23.09.2017.

Kölsch K, Rubie C, Glanemann M. Einfluss der präoperativen FOLFOX Chemotherapie auf die CCL20/CCR6 Expression in kolorektalen Lebermetastasen. 133. Kongress der Deutschen Gesellschaft für Chirurgie, 26.04. – 29.04.2016, ICM Berlin.

Rubie C, Glanemann M. Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. 132. Kongress der Deutschen Gesellschaft für Chirurgie, 28.04. – 01.05.2015, ICM München.

Rubie C, Oliveira Frick V, Glanemann M. Functional interaction of microRNAs with chemokine ligands and their expression in the microenvironment of colorectal tumors. 131. Kongress der Deutschen Gesellschaft für Chirurgie, Berlin 25.-28.03.2014.

Rubie C, Oliveira Frick V, Kölsch K, Glanemann M. MiR-21 functionally interacts with the 3´UTR of chemokine CCL20 and downregulates CCL20 expression in miR-21 transfected colorectal cancer cells. 17. Chirurgische Forschungstage, Frankfurt 2013.

Rubie C, Oliveira Frick V, Kölsch K, Glanemann M. CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells. 17. Chirurgische Forschungstage, Frankfurt 2013.

Oliveira Frick V, Rubie C, Kölsch K, Glanemann M. CCR6/CCL20-Chemokinexpressionsprofil bei Patienten mit malignen kolorektalen Erkrankungen. 17. Chirurgische Forschungstage, Frankfurt 2013.

Oliveira Frick V, Rubie C, Kölsch K, Glanemann M. Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases. 17. Chirurgische Forschungstage, Frankfurt 2013.

Oliveira Frick V, Rubie C, Kölsch K, Glanemann M. Thoracotomy procedures effect cytokine levels after thoracoabdominal esophagectomy. 17. Chirurgische Forschungstage, Frankfurt 2013.

Kölsch K, Oliveira Frick V, Rubie C, Glanemann M. MiR-21 and its target gene CCL20 are both highly over-expressed in the microenvironment of CRC tumors: consequences for their regulation. 17. Chirurgische Forschungstage, Frankfurt 2013.

Kölsch K, Oliveira Frick V, Rubie C, Glanemann M. Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies. 17. Chirurgische Forschungstage, Frankfurt 2013.

Rubie C, Frick V, Faust S, Vicinus B, Schilling MK. CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells. 128. Kongress der Deutschen Gesellschaft für Chirurgie, 03.-05. Mai 2011, München, Langenbecks Archives of Surgery 2011;396:551-583.

Frick V, Rubie C, Wagner M, Schilling MK. Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies. 128. Kongress der Deutschen Gesellschaft für Chirurgie, 03.-05. Mai 2011, München, Langenbecks Archives of Surgery 2011;396:551-583.

Frick V, Rubie C, Wagner M, Schilling MK. Cytogenetic effects of immunosuppressive drugs in vitro and in vivo. 128. Kongress der Deutschen Gesellschaft für Chirurgie, 03.-05. Mai 2011, München, Langenbecks Archives of Surgery 2011;396:551-583.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. Chemokine und Organtropismus. Jahrestagung der Deutschen Gesellschaft für Hämatologie und Onkologie e. V. (DGHO), 01.-05. Oktober 2010, Berlin.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. Changes in CXC-chemokine Expression during early onset of colorectal malignancies. 4th Mildred Scheel Cancer Conference, 19.-21. May 2010, Königswinter.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. IL-8 expression correlates with induction, progression and metastatic potential of colorectal cancer. 4th Mildred Scheel Cancer Conference, 19.-21. May 2010, Königswinter.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. CXC-chemokines in patients with malignant pancreatic diseases. 4th Mildred Scheel Cancer Conference, 19.-21. May 2010, Königswinter.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. CCR6 involvement in metastasis of the liver. 126.Kongress der Deutschen Gesellschaft für Chirurgie, 28.04.-01.05. 2009, München.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. Enhanced CXC-chemokine expression in patients with malignant pancreatic diseases. 126. Kongress der Deutschen Gesellschaft für Chirurgie, 28.04.-01.05. 2009, München.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. Mutagenic and cytotoxic effects of immunosuppressive drugs on human lymphocyte cultures. Chirurgische Forschungstage, 25.-27. September 2008, Freiburg, Langenbecks Archives of Surgery 2008;393:759-815.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. IL-8 expression correlates with induction, progression and metastatic potential of colorectal cancer. Chirurgische Forschungstage, 25.-27. September 2008, Freiburg, Langenbecks Archives of Surgery 2008;393:759-815.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Chirurgische Forschungstage, 25.-27. September 2008, Freiburg, Langenbecks Archives of Surgery 2008;393:759-815.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. Potential biomarkers for colorectal liver metastasis. Chirurgische Forschungstage, 25.-27. September 2008, Freiburg, Langenbecks Archives of Surgery 2008;393:759-815.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. Berlin Conference on Invasion and Metastasis, MDC 26.-29. März 2008, Berlin.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. IL-8 expression correlates with induction, progression and metastatic potential of colorectal cancer. Berlin Conference on Invasion and Metastasis, MDC 26.-29. März 2008, Berlin.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. CXC chemokines in patients with malignant pancreatic diseases. Berlin Conference on Invasion and Metastasis, MDC 26.-29. März 2008, Berlin.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. ENA-78 expression correlates with early stage onset of colorectal carcinoma. 11. Chirurgische Forschungstage, 15.-17. November 2007, Saarbrücken, Langenbecks Archives of Surgery
2007;392:769-838.

Rubie C, Oliveira Frick V, Wagner M, Schilling MK. Differential CXC receptor expression in colorectal cancer. 11. Chirurgische Forschungstage, 15.-17. November 2007, Saarbrücken, Langenbecks Archives of Surgery 2007;392:769-838.

Oliveira Frick V, Rubie C, Wagner M, Schilling MK. CXC-chemokines in patients with malignant pancreatic diseases. Chirurgische Forschungstage, 15.-17. November 2007, Saarbrücken Langenbecks Archives of Surgery 2007;392:769-838.

Rubie C, Kempf K, N, Oliveira V, Tilton B, Rau B, Schilling MK. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. 123. Kongress der Deutschen Gesellschaft für Chirurgie 02.-05. Mai 2006, Berlin.

Rubie C, Oliveira V, Kempf K, Ludwig B Tilton B, Rau B, Schilling MK. Chemokine receptor CCR6 in colorectal cancer metastasis. 4. Biebrich Interdisciplinery Conference (BIC) 29. September 2005, Wiesbaden – Biebrich.

Rubie C, Kempf K, Oliveira Frick V, Forster N, Ludwig B, Tilton B, Schilling M. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. ELS0-European Life Scientist Organization- Meeting combining the 9th International
World Congress of Cell Biology, 03.-06. September 2005, Dresden.

Oliveira Frick V, Kempf K, Forster N, Ludwig B Tilton B, Rau B, Schilling MK, Rubie C,. Detection of MIP3alpha and its receptor CCR6 in human colorectal cancer and colorectal liver metastases. ELS0- European Life Scientist Organization-
Meeting combining the 9th International World Congress of Cell Biology, 03.-06. September 2005, Dresden.

Krüger CM, Behrendt D, Glaser E, Herboth E, Rubie C, Schilling MK, Rau BM. Targeted disruption of monocyte chemoattractant protein-1 (MCP-1) or receptor CCR2b in experimentale acue pancreatitis: influence on local and systemic disease severity. 37th European Pancreatic Club (EPC) Meeting 06.-08. Juli 2005, Graz, Österreich.

Rubie C, Hans J, Su, T, Tilton B, Kempf, K, Brittner, B, Ludwig B, Schilling M. (2004). Housekeeping gene variability in normal and cancerous  colorectal, pancreatic, esophageal, gastric and hepatic tissues. ELS0 - European Life
Scientist Organization - Meeting combining the 8th International World Congress of Cell Biology, 04.-08. September 2004, Nizza/Frankreich.

Abgeschlossene Examensarbeiten (Auswahl)

Bachelorarbeiten (Bachelor of Science):

Jessica Wolf, 07.02.2020
Thema: Expressionsanalyse verschiedener Gene mit altersassoziierten Methylierungsunterschieden

Bianca Kruse, 17.03.2018
Thema: Bioethik in der medizinalfachberuflichen Praxis: Verzicht auf fötales Kälberserum in der Zellkultur

Sarah Wilde, 20.02.2017
Thema: Funktionelle Untersuchungen an der Zelllinie HEK 293T in serumfreiem Medium

Laura-Kim Feiner, 02.03.2016
Thema: Untersuchung funktioneller Wechselwirkungen zwischen mikroRNAs und der mRNA der 3’-UTR des IGF1- Rezeptors

Jessica Frey, 16.02.2015
Thema: Mutageneseuntersuchungen zur Überprüfung funktioneller Wechselwirkungen zwischen mikroRNAs und IGF-1

Nathalie Stegmaier (2012)
Thema: In situ Hybridisierung der miRNA 21 sowie der miRNA 145 an kolorektalem Karzinomparaffingewebe

Viktoria Luise Planz (2010)
Thema: Untersuchungen zum regulatorischen Zusammenhang zwischen dem Chemokin CCL20 und der miRNA-145 im Pankreaskarzinom

 

Praxisphase:

Jessica Wolf, 06.11.2019
Thema: Real-Time PCR Analyse von drei Genen mit unterschiedlichen Methylierungsprofilen

Sarah Wilde, 11.11.2016
Thema: Etablierung verschiedener Zelllinien in serumfreim Medium

 

Mastermodul Laborpraktikum IIIMasterstudiengang Medizinische Biologie

Laura Feiner, 18.02.2018
Thema: Untersuchung der Genexpression altersassoziierter Plasmaproteine auf RNA- und Proteinebene

 

Masterarbeiten (Master of Science):

Laura-Kim Feiner, 11.09.2018
Thema: DNA-Methylierungsanalyse epigenetischer Schaltstellen von altersassoziierten Genen und Untersuchung ihrer mRNA-Expression

Sebastian Bechara, 16.08.2016
Thema: Effects of non-coding RNAs on the protein expression of the IGF/mTOR/S6K

Sabrina Neumann (2012)
Thema: Untersuchungen zur Wechselwirkung des Chemokins CXCL12 mit verschiedenen microRNAs

 

Medizinische Doktorarbeiten:

Dimitrios Avramis, 28.10.2019
Thema: Untersuchung der mTOR-mRNA- und Proteinexpression des duktalen Pankreaskarzinoms, der chronischen Pankreatitis und des Pankreasadenoms

Anne Thomas, 27.06.2019
Thema: Evaluierung des Expressionsprofils altersassoziierter Plasmaproteine und Vitamin D

Jonas Zimmer, 29.04.2019
Thema: Untersuchung des mTOR Signalweges im kolorektalen Karzinom und seinen prämalignen Vorstufen

Hemen Magid, 16.10.2018
Thema: Untersuchung des mTOR Signalweges im kolorektalen Karzinom und seinen prämalignen Vorstufen

Henner Grimm (2011)
Thema: Untersuchung des Expressionsprofils und des Einflusses verschiedener Chemokine und ihrer Rezeptoren auf maligne und nicht-maligne humane Pankreaserkrankungen

Sandra Pfeil (2009)
Thema: Bedeutung der Chemokinliganden Interleukin-8, Gro alpha, ENA78, NAP2 und ihrer Rezeptoren für das metastatische Potential und die Aggressivität humaner kolorektaler Karzinome

 

Naturwissenschaftliche Doktorarbeiten:

Benjamin Vicinus (2013)
Thema: Expression and functional interactions of microRNAs with their target chemokine CCL20 in colorectal cancer