Publications

  • Annika Engel, Nicole Ludwig , Friederike Grandke , Viktoria Wagner , Fabian Kern , Tobias Fehlmann , Georges P Schmartz , Ernesto Aparicio-Puerta , Dominic Henn , Barbara Walch-Rückheim , Matthias Hannig , Stefan Rupf , Eckart Meese , Matthias W Laschke , Andreas Keller  Skin treatment with non-thermal plasma modulates the immune system through miR-223-3p and its target genes RNA Biol. 2024 Jan;21(1):31-44. doi: 10.1080/15476286.2024.2361571
  • Maike Pohlers, Selina Gies, Tanja Tänzer, Russalina Stroeder, Laura Theobald, Nicole Ludwig, Yoo-Jin Kim, Rainer Maria Bohle, Erich Franz Solomayer, Eckart Meese, Martin Hart, Barbara Walch-Rückheim  TH17 cells target the metabolic miR-142-5psuccinate dehydrogenase subunit C/D (SDHC/SDHD) axis, promoting invasiveness and progression of cervical cancers Mol Oncol. 2023 Oct29 doi: 10.1002/1878-0261.13546
  • Selina Gies, Patrick Melchior, Russalina Stroeder, Tanja Tänzer, Laura Theobald, Maike Pohlers, Birgit Glombitza, Martina Sester, Erich Franz Solomayer, Barbara Walch-Rückheim  Immune landscape of vulvar cancer patients treated with surgery and adjuvant radiotherapy revealed restricted T cell functionality and increased IL-17 expression associated with cancer relapse  Int J Cancer. 2023 Oct 3. doi: 10.1002/ijc.34745
  • Diener C, Hart M, Kehl T, Becker-Dorison A, Tänzer T, Schub D, Krammes L, Sester M, Keller A, Unger M, Walch-Rückheim B, Lenhof HP, Meese E. Time-resolved RNA signatures of CD4+ T cells in Parkinson's disease. Cell Death Discov. 2023 Jan 21;9(1):18. doi:10.1038/s41420-023-01333-0.
  • Laura Theobald, Russalina Stroeder, Patrick Melchior, Ioan Iulian Iordache, Tanja Tänzer, Meike Port,Birgit Glombitza, Stefanie Marx, David Schub, Christian Herr, Martin Hart, Nicole Ludwig, Eckart Meese, Yoo-Jin Kim, Rainer Maria Bohle, Sigrun Smola, Christian Rübe, Erich Franz Solomayer, Barbara Walch-Rückheim.Chemoradiotherapy-induced increase in Th17 cell frequency in cervical cancer patients is associated with therapy resistance and early relapse. Mol Oncol. 2021 Sep 1. doi: 10.1002/1878-0261.13095.
  • Hart M, Nickl L, Walch-Rückheim B, Krammes L, Rheinheimer S, Diener C, Tänzer T, Kehl T, Sester M, Lenhof HP, Keller A, Meese E.
    The wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4+, CD8+ T cells and M1 macrophages.
    J Immunother Cancer. 2020 Nov;8(2):e001617. doi: 10.1136/jitc-2020-001617
  • Diener, Caroline; Hart, Martin; Kehl, Tim; Rheinheimer, Stefanie.; Ludwig, Nicole; Krammes, Lena; Pawusch, Sarah; Lenhof, Kerstin; Tänzer, Tanja; Schub, David;  Sester , Martina; Walch-Rückheim , Barbara; Keller, Andreas; Lenhof, Hans-Peter; Meese, Eckart
    Quantitative and time-resolved miRNA pattern of early human T cell activation.
    Nucleic Acids Research, Volume 48, Issue 18, 09 October 2020, Pages 10164–10183, https://doi.org/10.1093/nar/gkaa788
  • Emanuel Wyler, Vedran Franke, Jennifer Menegatti, Christine Kocks, Anastasiya Boltengagen, Samantha Praktiknjo, Barbara Walch-Rückheim, Nikolaus Rajewsky, Friedrich Grässer, Altuna Akalin, Landthaler Markus.
    Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
    Nat Commun. 2019 Oct 25;10(1):4878. doi: 10.1038/s41467-019-12894-z.
  • Hart, M., Walch-Rückheim, B., Krammes, L., Kehl, T., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhoff, H.-P., Keller, A., and Meese, E.
    miR-34a as hub of T cell regulation networks.
    J Immunother Cancer 2019 Jul 16;7(1):187 DOI: 10.1186/s40425-019-0670-5
  • Walch-Rückheim B*, Ströder R, Theobald L, Pahne-Zeppenfeld J, Hegde S, Kim YJ, Bohle RM, Juhasz-Böss I, Solomayer EF, Smola S.
    Cervical cancer-instructed stromal fibroblasts enhance IL-23 expression in dendritic cells via an IL-6/C/EBPb/IL-1b pathway to support Th17 expansion.
    Cancer Res. 2019 Apr 1;79(7):1573-1586. doi: 10.1158/0008-5472.CAN-18-1913. Epub 2019 Jan 29.
  • Hart M, Walch-Rückheim B, Friedmann K, Rheinheimer S, Tänzer T, Glombitza B, Sester M, Lenhof HP, Hoth M, Schwarz E, Keller A, Meese E.
    MiR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.
    Cell Death Dis. 2019 Jan 18;10(2):46. doi: 10.1038/s41419-018-1295-1. 
  • Diener C, Hart M, Alansary D, Poth V, Walch-Rückheim B, Menegatti J, Grässer F, Fehlmann T, Rheinheimer S, Niemeyer BA, Lenhof HP, Keller A, Meese E.
    Modulation of intracellular calcium signaling by microRNA-34a-5p.
    Cell Death Dis. 2018;9(10):1008.
  • Stroeder R, Walch-Rückheim B, Fischbach J, Juhasz-Böss I, Rübe C, Solomayer EF, Smola S.
    OSM treatment increases the responsiveness toward cisplatin-based chemoradiotherapy in cervical cancer cells.
    Oncol Lett 2018 Sep;16(3):3351-3358. 
  • Podgórska M, Ołdak M, Marthaler A, Fingerle A, Walch-Rückheim B, Lohse S, Müller CSL, Vogt T, Ustav M, Wnorowski A, Malejczyk M, Majewski S, Smola S.
    Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPβ to Induce Pro-Inflammatory S100A8/A9 Proteins.
    Front Microbiol. 2018 Mar 7;9:392.
  • Boschi Bazan S*, Walch-Rückheim B*, Schmitt MJ, Breinig F.
    Maturation and cytokine pattern of human dendritic cells in response to different yeasts.
    *geteilte Erst-Autorenschaft,Med Microbiol Immunol 2017 Feb;207(1):75-81 
  • Walch-Rückheim B*, Pahne Zeppenfeld J*, Fischbach J, Wickenhauser C, Horn LC, Tharun L, Büttner R, Mallmann P, Stern P, Kim YJ, Bohle RM, Rübe C, Ströder R, Juhasz-Böss I, Solomayer EF, Smola S.
    STAT3/IRF1 pathway activation sensitizes cervical cancer cells to chemotherapeutic drugs.
    *geteilte Erst-Autorenschaft. Cancer Res 2016;76(13):3872-83.
  • Walch-Rückheim B, Schmitt MJ, Breinig F.
    Coexpression of human perforin improves yeast-mediated delivery of DNA and mRNA to mammalian antigen-presenting cells.
    Gene Ther, 2016 Jan;23:103-7. 
  • Walch-Rückheim B, Mavrova R, Henning M, Vicinus B, Kim YJ, Bohle RM, Juhasz-Böss I, Solomayer EF, Smola S.
    Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during Cervical Cancer Progression.
    Cancer Res. 2015;75(24):5248-59
  • Schmidt SV, Seibert S, Walch-Rückheim B, Vicinus B, Kamionka EM, Pahne-Zeppenfeld J, Solomayer EF, Kim YJ, Bohle RM, Smola S.
    RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1a release, and efficient paracrine dendritic cell activation.
    Oncotarget, 2015;6(11):8635-47. 
  • Walch-Rückheim B, Schmitt MJ, Breinig F.
    Schizosaccharomyces pombe: a novel transport vehicle of functional DNA and mRNA into mammalian antigen-presenting cells.
    Vaccine. 2014;32:6029-33.
  • Pahne-Zeppenfeld J*, Schröer N*, Walch-Rückheim B*, Oldak M, Gorter A, Hegde S, Smola S.
    Cervical cancer cell-derived interleukin-6 impairs CCR7-dependent migration of MMP-9-expressing dendritic cells.
    *geteilte Erst-Autorenschaft. Int J Cancer. 2014;134:2061-73. 
  • Sperling T, Oldak M, Walch-Rückheim B, Wickenhauser C, Pfister H, Malejczyk M, Majewski S, Keates AC and Smola S.
    Human Papillomavirus Type 8 Interferes with a Novel C/EBPβ-Mediated Mechanism of Keratinocyte CCL20 Chemokine Expression and Langerhans Cell Migration.
    PLoS Pathog. 2012;8:e1002833.
  • Walch B, Breinig T, Schmitt MJ und Breinig F.
    Delivery of functional DNA and messenger RNA to mammalian phagocytic cells by recombinant yeast.
    Gene Ther. 2012;19:237-45. 
  • Walch B, Breinig T, Geginat G, Schmitt MJ and Breinig F.
    Yeast-based protein delivery to mammalian phagocytic cells is increased by coexpression of bacterial listeriolysin.
    Microbes Infect. 2011;13:908-13.
  • Schröer N, Pahne J,Walch B, Wickenhauser C and Smola S.
    Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression.
    Cancer Res. 2011;71:87-97.