Lehrstuhl für Genetik und Epigenetik

Die wissenschaftlichen Schwerpunkte der Arbeitsgruppe liegen auf der Analyse von Genexpression und epigenetischen Modifikationen im Zusammenhang mit komplexen Erkrankungen. Dabei stehen die Aspekte der Adaptation epigenetischer Signaturen im Kontext von Umwelteinflüssen und Alterungsprozessen, sowie die translationale Epigenomik mit Hinblick auf Diagnostik und Therapie im Vordergrund. Besonderes Interesse liegt dabei auf einem besseren Verständnis von

  • Zusammenhang zwischen genetischer Prädisposition und Umwelteinflüssen auf die Pathogenese neurodegenerativer Erkrankungen
  • Veränderungen epigenetischer Modifikationen im Alterungsprozess
  • das Potential epigenetischer Signaturen für die Diagnose von seltenen Erkrankungen und Syndromen
 

Aktuelles

© Universität des Saarlandes

Center for Gender-specific Biology and Medicine (CGBM)

Project: Integrative analysis of gender-specific epigenetic alterations in Parkinson´s disease 

It becomes more and more evident that biological sex influences Parkinson's symptoms. While the risk of developing Parkinson's disease is twice as high in men as in women, women have a higher mortality rate and a faster progression of the disease. As the molecular mechanisms underlying these differences are still largely unclear, a better understanding is needed to potentially open up new avenues for pharmacological intervention. Here, the epigenome is of particular interest, as sexually dimorphic changes are in part a consequence of underlying differences in gene regulation and epigenetic control. To better understand this regulation, our group became part of the Center for Gender-specific Biology and Medicine (CGBM) and will perfom an integrated analysis of disease-related sex differences in epigenome and transcriptome data from the brain and blood of Parkinson's patients compared to healthy controls. The focus is on changes in only one sex (sex-specific) as well as on changes in both sexes in the opposite direction (sex-dimorphic changes). Further integrated pathway and network analyses will be used to identify coordinated sex-dependent changes. Please find further information here.

 

 
© Neurowissenschaftliche Gesellschaft

16th Göttingen Meeting of the German Neuroscience Society 2025

This meeting contains a program in full length over four days, with unrestricted poster sessions and comprehensive discussions. The core scientific program will be flanked by satellite symposia and special interest workshops covering a broad range of topics. Our group is organizer of the Symposium 10: Sex, glia and disease: understanding sex-specific glia biology in health and disease. Moreover, different companies will showcase their latest products and developments. Get ready for a rich and exciting scientific program that will give you the chance to present your own research in an inspiring atmosphere and to discover the latest scientific and technological developments in neuroscience.

When ? March 26-29, 2025
Where ? Geisteswissenschaftliches Zentrum, Georg-August-Universität in Göttingen

                                                                                                                                   Registration               Program

 
© Genetik

 

NOW AVAILABLE ! The new genome sequencer AvitiTM by Element Biosc. in our Epigenomics Sequencing Facility !

We are pleased to announce that the AvitiTM platform (Element Biosc.) is now ready to use for internal and external users.

Please find more information about the AvitiTM and NGS applications on our Epigenomics Sequencing Facility web site.