Originalartikel 2016

  • Hoppstädter J, Hachenthal N, Valbuena-Perez JV, Lampe S, Astanina K, Kunze MM, Bruscoli S, Riccardi C, Schmid T, Diesel B, Kiemer AK. 2016. Induction of glucocorticoid-induced leucine zipper (GILZ) contributes to anti-inflammatory effects of the natural product curcumin in macrophages. J Biol Chem291:22949-22960
  • Kessler SM, Laggai S, van Wonterghem E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK. 2016. Transient hepatic overexpression of IGF2 induces free cholesterol and lipid droplet formation. Front Physiol 7:147
  • Seif M, Philippi A, Breinig F, Kiemer AK, Hoppstädter J. 2016. Yeast (Saccharomyces cerevisiae) polarizes both M-CSF and GM-CSF differentiated macrophages towards an M1-like phenotype. Inflammation 39:1690-1703
  • Barghash A, Golob-Schwarzl N, Helms V, Haybaeck J, Kessler SM. 2016. Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma. Oncotarget 7:49743-49750
  • Fengler VHI, Macheiner T, Kessler SM, Czepukojc B, Gemperlein K, Müller R, Kiemer AK, Magnes C, Haybaeck J, Lackner C, Sargsyan K. 2016. Susceptibility of different mouse wild type strains to develop diet-induced NAFLD/AFLD-associated liver disease. PLOS One 11:e0155163
  • Abdel-Halim M, Darwish SS, Elhady A, Hoppstädter J, Abadi AA, Hartmann RW, Kiemer AK, Engel M. 2016. Pharmacological inhibition of protein kinase C (PKC)zeta downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Eur J Pharm Sci 93:405-409
  • Schiffer L, Brixius-Anderko S, Hannemann F, Zapp J, Neunzig J, Thevis M, Bernhardt R. 2016. Metabolism of oral turinabol by human steroid hormone-synthesizing cytochrome P450 enzymes. Drug Metab & Dispos 44:227-237
  • Huynh AM, Müller A, Kessler SM, Henrikus S, Hoffmann C, Kiemer AK, Bücker A, Jung G. 2016. Small BODIPY probes for combined dual 19F-MRI and fluorescence imaging. ChemMedChem 1568-1575
  • Jozwik IK, Kiss FM, Gricman L, Abdulmughni A, Brill E, Zapp J, Pleiss J, Bernhardt R, Thunnissen, A-MWH. 2016. Structural basis of steroid binding and oxidation by the cytochrome P 450 CYP109E1 from Bacillus megaterium.FEBSJ 283:4128-4148
  • Wink CSD, Michely JA, Jacobsen-Bauer A, Zapp J, Maurer HH. 2016. Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MSn, and LC-HR-MSn, DrugTest Anal 8:1005-1014
  • Schiffer L, Mueller A-R, Hobler A, Brixius-Anderko S, Zapp J, Hannemann F, Bernhardt R. 2016. Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation. Biochem Mol Biol 163:68-76
  • Ehrhardt M, Gerber A, Zapp J, Hannemann F, Bernhardt R. 2016. Human CYP27A1 catalyzes hydroxylation of ß-sitosterol and ergosterol. Biol Chem 397:513-518
  • Gerber A, Milhim M, Hartz P, Zapp J, Bernhardt R. 2016. Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progrestogens 17a,20ß-di- and 17a,20ß,21a-trihydroxy-4-pregnen-3-one. Metab Eng 36:19-27
  • Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R. 2016. Substrate hunting for the myxobacterial CYP260A1 revealed new 1a-hydroxylated products from C-19 steroids. ChemBioChem 17:90-101